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ES2135743T3 - Procedimiento para eliminar sales biliares de un paciente y composiciones alquiladas para ello. - Google Patents

Procedimiento para eliminar sales biliares de un paciente y composiciones alquiladas para ello.

Info

Publication number
ES2135743T3
ES2135743T3 ES95922232T ES95922232T ES2135743T3 ES 2135743 T3 ES2135743 T3 ES 2135743T3 ES 95922232 T ES95922232 T ES 95922232T ES 95922232 T ES95922232 T ES 95922232T ES 2135743 T3 ES2135743 T3 ES 2135743T3
Authority
ES
Spain
Prior art keywords
sub
patient
rental
reaction product
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95922232T
Other languages
English (en)
Inventor
W Harry Mandeville Iii
Stephen Randall Holmes-Farley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geltex Pharmaceuticals Inc
Original Assignee
Geltex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22980525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2135743(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Geltex Pharmaceuticals Inc filed Critical Geltex Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2135743T3 publication Critical patent/ES2135743T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/02—Alkylation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/44—Preparation of metal salts or ammonium salts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/02—Homopolymers or copolymers of vinylamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN METODO PARA ELIMINAR SALES DE BILIS DE UN PACIENTE QUE INCLUYE LA ADMINISTRACION AL PACIENTE DE UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DEL PRODUCTO DE REACCION DE: A) UNO O MAS POLIMEROS ALTAMENTE RETICULADOS CARACTERIZADOS POR UNA UNIDAD DE REPETICION SELECCIONADA DEL GRUPO QUE CONSTA ESENCIALMENTE DE: (1), (2), (3): (()NR-CH{SUB,2}-CH{SUB,2}()){SUB,N}, (4): (()NRCH{SUB,2}-CH{SUB,2}-NR-CH{SUB,2}CH{SUB,2}-NR-CH{SUB,2}CHOHCH{SUB,2}()){SUB,N} Y SALES Y COPOLIMEROS DEL MISMO, DONDE N ES UN ENTERO Y CADA R, INDEPENDIENTEMENTE, ES H O UN GRUPO ALQUILO C{SUB,1}-C{SUB,8}; Y B) AL MENOS UN AGENTE DE ALQUILACION. EL PRODUCTO DE REACCION SE CARACTERIZA EN QUE: (I) AL MENOS PARTE DE LOS ATOMOS DE NITROGENO DE DICHAS UNIDADES DE REPETICION NO SE HACEN REACCIONAR CON DICHO AGENTE DE ALQUILACION; (II) MENOS DEL 10% MOLAR DE LOS ATOMOS DE NITROGENO EN LAS UNIDADES DE REPETICION QUE REACCIONAN CON EL AGENTE DE ALQUILACION FORMAN UNIDADES DE AMONIO CUATERNARIO; Y (III) EL PRODUCTO DE REACCION ES NO TOXICO Y ESTABLE UNA VEZ INGERIDO.
ES95922232T 1994-06-10 1995-06-05 Procedimiento para eliminar sales biliares de un paciente y composiciones alquiladas para ello. Expired - Lifetime ES2135743T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25843194A 1994-06-10 1994-06-10

Publications (1)

Publication Number Publication Date
ES2135743T3 true ES2135743T3 (es) 1999-11-01

Family

ID=22980525

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95922232T Expired - Lifetime ES2135743T3 (es) 1994-06-10 1995-06-05 Procedimiento para eliminar sales biliares de un paciente y composiciones alquiladas para ello.

Country Status (21)

Country Link
US (12) US5693675A (es)
EP (2) EP0909768A3 (es)
JP (1) JP3931217B2 (es)
KR (1) KR100271693B1 (es)
CN (1) CN1150217C (es)
AT (1) ATE184027T1 (es)
AU (1) AU698752C (es)
CA (1) CA2191478C (es)
DE (3) DE69511861T2 (es)
DK (1) DK0764174T3 (es)
ES (1) ES2135743T3 (es)
FR (1) FR04C0021I2 (es)
GR (1) GR3031702T3 (es)
IL (2) IL114073A (es)
LU (1) LU91100I2 (es)
MX (1) MX9606171A (es)
NL (1) NL300159I2 (es)
NZ (1) NZ288076A (es)
RU (1) RU2160742C2 (es)
TW (1) TW474813B (es)
WO (1) WO1995034585A1 (es)

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US6784254B2 (en) 2004-08-31
US20010044519A1 (en) 2001-11-22
EP0764174B1 (en) 1999-09-01
DE122004000034I2 (de) 2006-04-27
US6225355B1 (en) 2001-05-01
US20020095002A1 (en) 2002-07-18
US20090155201A1 (en) 2009-06-18
EP0909768A2 (en) 1999-04-21
IL114073A0 (en) 1995-10-31
WO1995034585A1 (en) 1995-12-21
AU698752B2 (en) 1998-11-05
TW474813B (en) 2002-02-01
LU91100I2 (fr) 2004-11-08
US20040014899A1 (en) 2004-01-22
US7399821B2 (en) 2008-07-15
US5693675A (en) 1997-12-02
DE122004000034I1 (de) 2005-02-24
EP0909768A3 (en) 2001-01-17
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EP0764174A1 (en) 1997-03-26
CA2191478A1 (en) 1995-12-21
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US6066678A (en) 2000-05-23
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US5679717A (en) 1997-10-21
US20050131161A1 (en) 2005-06-16
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US7101960B2 (en) 2006-09-05
US5917007A (en) 1999-06-29
US5981693A (en) 1999-11-09
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