[go: up one dir, main page]

ES2134755T3 - Derivados de quinolina como antagonistas de leucotrieno d4, composiciones que contienen los mismos y procedimientos para su preparacion. - Google Patents

Derivados de quinolina como antagonistas de leucotrieno d4, composiciones que contienen los mismos y procedimientos para su preparacion.

Info

Publication number
ES2134755T3
ES2134755T3 ES89306232T ES89306232T ES2134755T3 ES 2134755 T3 ES2134755 T3 ES 2134755T3 ES 89306232 T ES89306232 T ES 89306232T ES 89306232 T ES89306232 T ES 89306232T ES 2134755 T3 ES2134755 T3 ES 2134755T3
Authority
ES
Spain
Prior art keywords
leucotrene
antagonists
procedures
preparation
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89306232T
Other languages
English (en)
Inventor
Fu-Chi Huang
Robert Anthony Galemmo Jr
Henry Flud Campbell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Rorer International Holdings Inc
Original Assignee
Rhone Poulenc Rorer International Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer International Holdings Inc filed Critical Rhone Poulenc Rorer International Holdings Inc
Application granted granted Critical
Publication of ES2134755T3 publication Critical patent/ES2134755T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE QUINOLEINILO DE FORMULA(I) Y A SU EMPLEO COMO AGENTES FARMACOLOGICOS INHIBIDORES DE LIPOXIGENASA Y/O ANTAGONISTAS DE LEUCOTRIENO, QUE POSEEN PROPIEDADES ANTIINFLAMATORIAS Y ANTIALERGICAS, A COMPOSICIONES FARMACEUTICAS BASADAS EN ELLOS Y A PROCESOS PARA SU PREPARACION.
ES89306232T 1988-06-21 1989-06-20 Derivados de quinolina como antagonistas de leucotrieno d4, composiciones que contienen los mismos y procedimientos para su preparacion. Expired - Lifetime ES2134755T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/209,428 US4920131A (en) 1987-11-03 1988-06-21 Quinoline derivatives and use thereof as antagonists of leukotriene D4

Publications (1)

Publication Number Publication Date
ES2134755T3 true ES2134755T3 (es) 1999-10-16

Family

ID=22778718

Family Applications (2)

Application Number Title Priority Date Filing Date
ES97200638T Expired - Lifetime ES2223071T3 (es) 1988-06-21 1989-06-20 Derivados de quinolina como antagonistas del leucotrieno d4, composiciones que los contienen y procesos de preparacion.
ES89306232T Expired - Lifetime ES2134755T3 (es) 1988-06-21 1989-06-20 Derivados de quinolina como antagonistas de leucotrieno d4, composiciones que contienen los mismos y procedimientos para su preparacion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES97200638T Expired - Lifetime ES2223071T3 (es) 1988-06-21 1989-06-20 Derivados de quinolina como antagonistas del leucotrieno d4, composiciones que los contienen y procesos de preparacion.

Country Status (5)

Country Link
US (1) US4920131A (es)
EP (2) EP0348155B1 (es)
DE (2) DE68929520T2 (es)
ES (2) ES2223071T3 (es)
WO (1) WO1989012628A1 (es)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6124343A (en) * 1919-01-27 2000-09-26 Rhone-Poulenc Rorer Limited Substituted phenyl compounds with a substituent having a thienyl ring
US5017583A (en) * 1983-04-21 1991-05-21 Merck Frosst Canada, Inc. Leukotriene antagonists
US4920130A (en) * 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US5051427A (en) * 1987-11-03 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Quinoline derivatives as antagonists of leukotriene D4
US5104882A (en) * 1987-11-25 1992-04-14 Merck Frosst Canada, Inc. Diarylstrylquinoline diacids and pharmaceutical compositions thereof
US5204358A (en) * 1987-11-25 1993-04-20 Merck Frosst Canada, Inc. Hetaryl styryl quinolines as leukotriene inhibitors
US5232916A (en) * 1988-06-27 1993-08-03 Merck Frosst Canada, Inc. Quinoline ether alkanoic acids
US5219881A (en) * 1988-12-23 1993-06-15 Imperial Chemical Industries Plc Cyclic ether derivatives
NZ231735A (en) * 1988-12-23 1992-04-28 Ici Plc Alcohol/ether derivatives, preparation and pharmaceutical compositions thereof
IL92620A0 (en) * 1988-12-23 1990-08-31 Ici Pharma Cycloalkane derivatives
GB8926981D0 (en) * 1988-12-23 1990-01-17 Ici Plc Heterocyclic derivatives
US5214069A (en) * 1988-12-23 1993-05-25 Imperial Chemical Industries Plc Alcohol and ether derivatives
GB8927287D0 (en) * 1988-12-23 1990-01-31 Ici Plc Cyclic ether derivatives
US5134148A (en) * 1989-02-28 1992-07-28 Imperial Chemical Industries Plc Heterocycles for use as inhibitors of leukotrienes
US5236919A (en) * 1989-02-28 1993-08-17 Imperial Chemical Industries Plc Quinoxalinyl derivatives suitable for use in leukotriene mediated disease
US5217977A (en) * 1989-02-28 1993-06-08 Imperial Chemical Industries Plc Heterocyclic cycloalkanes
US5202326A (en) * 1989-02-28 1993-04-13 Imperial Chemical Industries Plc Heterocyclic ethers
US5196419A (en) * 1989-02-28 1993-03-23 Imperial Chemical Industries Plc Heterocyclic cyclic ethers
US4977162A (en) * 1989-07-13 1990-12-11 Rorer Pharmaceutical Corporation Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments
IE902113A1 (en) * 1989-07-18 1991-06-19 Ici Plc Diaryl ether cyclic ethers
US5214070A (en) * 1989-07-18 1993-05-25 Imperial Chemical Industries Plc Diaryl ether cycloalkanes
IE64358B1 (en) * 1989-07-18 1995-07-26 Ici Plc Diaryl ether heterocycles
ES2057415T3 (es) * 1989-07-26 1994-10-16 Ici Plc Derivados biciclicos.
PT94960A (pt) * 1989-08-11 1991-04-18 Ici Plc Processo para a preparacao de derivados de quinolina e de composicoes farmaceuticas que as contem
GB8919504D0 (en) * 1989-08-29 1989-10-11 Leo Pharm Prod Ltd Chemical compounds
GB9018134D0 (en) * 1989-09-29 1990-10-03 Ici Plc Heterocyclic derivatives
GB9010394D0 (en) * 1990-05-09 1990-06-27 Ici Plc Heterocyclic compounds
US5041453A (en) * 1990-05-30 1991-08-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4
ATE134630T1 (de) * 1990-06-21 1996-03-15 Zeneca Ltd Bizyklische pyran-derivate und ihre verwendung als 5-lipoxygenasehemmer
AU637500B2 (en) * 1990-06-21 1993-05-27 Zeneca Limited Bicyclic heterocyclic compounds
IE911853A1 (en) * 1990-06-21 1992-01-01 Ici Plc Heterocyclene derivatives
US5254581A (en) * 1990-06-21 1993-10-19 Imperial Chemical Industries Plc Pyran derivatives and their use as inhibitors of 5-lipoxygenase
GB9113137D0 (en) * 1990-07-13 1991-08-07 Ici Plc Thioxo heterocycles
JPH06501019A (ja) * 1990-09-13 1994-01-27 スミスクライン・ビーチャム・コーポレイション ピリジルチオまたはピリジルオキシアルカン酸
EP0480716A1 (en) * 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Saturated hydroxyalkylquinoline acids as leukotriene antagonists
US5266568A (en) * 1990-10-12 1993-11-30 Merck Frosst Canada, Inc. Hydroxyalkylquinoline ether acids as leukotriene antagonists
US5179105A (en) * 1990-10-16 1993-01-12 Terumo Kabushiki Kaisha Phenoxyacetic acid compounds, method for production thereof, and pharmaceutical preparations containing same
GB9025123D0 (en) * 1990-11-19 1991-01-02 Ici Plc Nitrogen compounds
IE913866A1 (en) * 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
US5272173A (en) * 1990-11-28 1993-12-21 Imperial Chemical Industries Plc 5-lipoxygenase inhibitors
IE914005A1 (en) * 1990-12-14 1992-06-17 Zeneca Ltd Novel intermediates
CA2058254A1 (en) * 1991-01-15 1992-07-16 John Francis Kingston Benzodioxole derivatives
IL100483A0 (en) * 1991-01-17 1992-09-06 Ici Plc Sulphonamide derivatives
US5258399A (en) * 1991-01-17 1993-11-02 Imperial Chemical Industries Plc Sulphonamide derivatives
US6004979A (en) * 1991-02-07 1999-12-21 Hoechst Marion Roussel Nitrogenous bicycles
MX9200299A (es) * 1991-02-07 1992-12-01 Roussel Uclaf Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
IL100555A (en) * 1991-02-07 2000-08-31 Hoechst Marion Roussel Inc N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
GB9102804D0 (en) * 1991-02-11 1991-03-27 Ici Plc Heterocyclic derivatives
EP0505122A1 (en) * 1991-03-21 1992-09-23 Zeneca Limited Alpha, alpha-dialkylbenzyl derivatives
US5157040A (en) * 1991-04-05 1992-10-20 Merck & Co., Inc. Substituted quinolines as angiotensin ii antagonists
IL101860A0 (en) * 1991-05-31 1992-12-30 Ici Plc Heterocyclic derivatives
GB9113626D0 (en) * 1991-06-25 1991-08-14 Ici Plc Heterocyclic compounds
GB9113628D0 (en) * 1991-06-25 1991-08-14 Ici Plc Heterocyclic derivatives
GB9121727D0 (en) * 1991-10-14 1991-11-27 Ici Plc Heterocyclic compounds
US6117885A (en) * 1992-02-14 2000-09-12 E. R. Squibb & Sons, Inc. Biphenyl-substituted quinoline derivatives
US5438141A (en) * 1993-05-21 1995-08-01 Merck Frosst Canada, Inc. Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists
ES2103181B1 (es) * 1994-08-01 1998-04-01 Menarini Lab Amidas naftalenicas con accion antagonista de los leucotrienos.
ES2103180B1 (es) * 1994-08-01 1998-04-01 Menarini Lab Fenilacetamidas con accion antagonista de los leucotrienos.
US5542795A (en) * 1995-01-30 1996-08-06 Kennametal Inc. Plunge and face milling cutter with universal insert seats
EP0725063A1 (de) * 1995-02-01 1996-08-07 Ciba-Geigy Ag Chinolin-Derivate
US5750539A (en) * 1995-06-07 1998-05-12 Merck Frosst Canada Heteroaryl diol acids as leukotriene antagonists
US5770620A (en) * 1995-06-19 1998-06-23 Ontogen Corporation Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors
US6388076B1 (en) 1995-06-19 2002-05-14 Ontogen Corporation Protein tyrosine phosphatase-inhibiting compounds
ES2117551B1 (es) * 1995-12-29 1999-04-01 Menarini Lab Quinolinas naftalenicas con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de las mismas.
US5783586A (en) * 1996-10-01 1998-07-21 Abbott Laboratories Heteroarylmethoxyphenylthioalkyl carboxylates as inhibitors of leukotriene biosynthesis
CA2371308A1 (en) * 1999-04-28 2000-11-02 Aventis Pharma Deutschland Gmbh Tri-aryl acid derivatives as ppar receptor ligands
TW200800872A (en) * 2005-09-07 2008-01-01 Plexxikon Inc PPAR active compounds
EP2590951B1 (en) 2010-07-09 2015-01-07 Pfizer Limited Benzenesulfonamides useful as sodium channel inhibitors
CA2804351A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
WO2012007868A2 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
US9102621B2 (en) 2010-07-12 2015-08-11 Pfizer Limited Acyl sulfonamide compounds
ES2525581T3 (es) 2010-07-12 2014-12-26 Pfizer Limited Derivados de N-sulfonilbenzamida útiles como inhibidores del canal de sodio dependiente de voltaje
EP2593427B1 (en) 2010-07-12 2014-12-24 Pfizer Limited Sulfonamide derivatives as nav1.7 inhibitors for the treatment of pain
HK1203412A1 (en) 2011-12-28 2015-10-30 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
HRP20171665T1 (hr) 2011-12-28 2017-12-15 Global Blood Therapeutics, Inc. Supstituirani spojevi benzaldehida i metode za njihovu primjenu u povećanju oksigenacije tkiva
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
EP2970308B1 (en) 2013-03-15 2021-07-14 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CA2902711C (en) 2013-03-15 2021-07-06 Global Blood Therapeutics, Inc. Substituted pyridinyl-6-methoxy-2-hydroxybenzaldehyde derivatives and pharmaceutical compositions thereof useful for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
PE20161035A1 (es) 2013-03-15 2016-11-13 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulacion de la hemoglobina
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
AP2016009261A0 (en) 2014-02-07 2016-06-30 Global Blood Therapeutics Inc Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
DK3383392T3 (da) 2015-12-04 2025-08-18 Global Blood Therapeutics Inc Doseringsskema for 2.HYDROXY.6.((2.(1.ISOPROPYL.1H.PYRAZOL.5.YL)PYRIDIN.3.YL)METHOXY)BENZALDEHYD
TWI752307B (zh) 2016-05-12 2022-01-11 美商全球血液治療公司 新穎化合物及製造化合物之方法
TW202332423A (zh) 2016-10-12 2023-08-16 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
US11014884B2 (en) 2018-10-01 2021-05-25 Global Blood Therapeutics, Inc. Modulators of hemoglobin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282230A (en) * 1979-11-15 1981-08-04 E. R. Squibb & Sons, Inc. Imidazolylethoxy derivatives of quinoline-2- or 4-methanols, antimicrobial compositions containing them and method for treating bacterial or fungal infections with them
US4407803A (en) * 1981-08-17 1983-10-04 Abbott Laboratories Antiinflammatory 1-(quinolinyl)-2-pyrazoline derivatives
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
IE861607L (en) * 1985-06-18 1986-12-18 Bunce Roger A 2-substituted quinolines
US4661499A (en) * 1985-06-18 1987-04-28 Merck Frosst Canada, Inc. 2-[(substituted)-phenoxymethyl]quinolines
US4732978A (en) * 1985-10-03 1988-03-22 American Home Products Corporation Novel substituted naphthyloxymethyl quinoline derivatives as anti-inflammatory and antiallergy agents
DE3682160D1 (de) * 1985-10-16 1991-11-28 Merck Frosst Canada Inc 2-substituierte chinoline.
IE59889B1 (en) * 1986-02-14 1994-04-20 Merck Frosst Canada Inc 2-substituted quinoline dioic acids
DE3783105T2 (de) * 1986-03-13 1993-04-22 Rhone Poulenc Rorer Int Chinolinylaether tetrazole als mittel zur behandlung von hyperempfindlichen krankheiten.
US4769461A (en) * 1986-09-16 1988-09-06 American Home Products Corporation Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4

Also Published As

Publication number Publication date
US4920131A (en) 1990-04-24
DE68929520T2 (de) 2005-09-29
EP0348155B1 (en) 1999-05-12
DE68928992T2 (de) 2000-01-27
WO1989012628A1 (en) 1989-12-28
ES2223071T3 (es) 2005-02-16
EP0348155A1 (en) 1989-12-27
EP0784052A1 (en) 1997-07-16
EP0784052B1 (en) 2004-09-01
DE68929520D1 (de) 2004-10-07
DE68928992D1 (de) 1999-06-17

Similar Documents

Publication Publication Date Title
ES2134755T3 (es) Derivados de quinolina como antagonistas de leucotrieno d4, composiciones que contienen los mismos y procedimientos para su preparacion.
ATE180773T1 (de) N-sulfonyl-2-oxoindol-derivate mit einer affinität für die vasopressin und/oder ocytocin rezeptoren
ES2147739T3 (es) Fosfonooximetil-eteres de derivados de taxano.
ES2168737T3 (es) Inhibidores de la oxido nitrico sintasa.
ES2153907T3 (es) Compuestos espiro tetraciclicos, procedimiento para su preparacion y su uso como antagonistas del receptor 5ht1d.
ES2185711T3 (es) 1,4-benzotiazepina-1,1-dioxidoshipolipimemicos.
MX9204111A (es) Triazoles substituidos y procedimiento para su obtencion.
UY24555A1 (es) Nuevos compuestos
ES2058527T3 (es) Derivados de pirimidina condensados procedimiento y compuestos intermedios para su preparacion y composiciones farmaceuticas que los contienen.
YU157191A (sh) Antagonisti receptora fibrinogena
ES2196377T3 (es) Derivados de naftiridina.
ES2100151T3 (es) Nuevos derivados de benzopirano, procedimientos para su preparacion y su uso y composiciones que contienen los compuestos.
AR002268A1 (es) Antagonistas de vasopresina de benzacepina triciclicos, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso dedichos compuestos para preparar composiciones farmaceuticas.
ES2094380T3 (es) Nuevos pirazolilpirazoles sustituidos, procedimientos para su preparacion, asi como compuestos intermedios, y su uso como herbicidas.
ES2052603T3 (es) Derivados de bencimidazol, procedimiento para su produccion y composicion farmaceutica que los contienen.
ES2178055T3 (es) Derivados aminicos substituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2174298T3 (es) Derivados de aminotiazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2120145T3 (es) Compuestos bi-aromaticos acetilenados con grupo adamantilo, composiciones farmaceuticas y cosmeticas que los contienen y utilizaciones.
ES2098505T3 (es) Nuevos derivados de la talidomida, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ES2043665T3 (es) 6,11-dihidro-11-(4-piperidiliden)-5h-benzo-(5,6)-ciclohepta-(1,2-b)-piridinas y composiciones y metodos de uso.
HN2001000235A (es) Derivados puentes de piperazina
ES2032752T3 (es) Procedimiento de preparacion de derivados de la 1-bencenosulfonil-2-oxo-5-alcoxi-pirrolidina.
ES2135722T3 (es) 1,5-benzodiacepinas 5-heterociclicas moduladoras de la cck o de la gastrina.
ES2191062T3 (es) Derivados de pirazolil-pirazol sustituidos, procedimientos para su preparacion y su utilizacion como agentes con accion herbicida.
MX9302034A (es) Bencidazoles, medicamentos que contienen estos compuestos y procedimientos para su preparacion.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 348155

Country of ref document: ES