ES2134200T3 - Uso de il-4 y tnf para la preparacion de un medicamento para el tratamiento de celulas tumorales. - Google Patents
Uso de il-4 y tnf para la preparacion de un medicamento para el tratamiento de celulas tumorales.Info
- Publication number
- ES2134200T3 ES2134200T3 ES91920247T ES91920247T ES2134200T3 ES 2134200 T3 ES2134200 T3 ES 2134200T3 ES 91920247 T ES91920247 T ES 91920247T ES 91920247 T ES91920247 T ES 91920247T ES 2134200 T3 ES2134200 T3 ES 2134200T3
- Authority
- ES
- Spain
- Prior art keywords
- tnf
- cells
- composition
- growth
- medication
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Output Control And Ontrol Of Special Type Engine (AREA)
- Photoreceptors In Electrophotography (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Liquid Crystal Substances (AREA)
Abstract
SE DESCRIBE UNA COMPOSICION DE SUSTANCIAS QUE COMPRENDE EL FACTOR DE NECROSIS DEL TUMOR (TNF) E INTERLEUKIN-4 (IL-4). ESTA COMPOSICION INHIBE EL CRECIMIENTO DE LAS CELULAS CANCEROSAS DE LOS PULMONES HUMANOS, DE LAS CELULAS DE CARCINOMAS DE VULVAR HUMANOS Y DE LAS CELULAS DE LINFOMAS HISTIOCITICOS HUMANOS DE UNA MANERA DEPENDIENDE DE LA DOSIS. LAS CARACTERISTICAS DE CRECIMIENTO DE LAS CELULAS CANCEROSAS DE LOS PULMONES HUMANOS FUERON MUY POCO AFECTADAS CUANDO SE EXPUSIERON AL TNF O AL IL-4 POR SEPARADO. SIN EMBARGO, LA COMBINACION DE ESTOS DOS CITOCINETOS JUNTOS INHIBIO EL CRECIMIENTO DE ESTAS CELULAS DE UNA MANERA DEPENDIENTE DE LA DOSIS. ADICIONALMENTE, GAMMA-INTERFERONA (IFN-G) CAUSO UNA POSTERIOR POTENCIACION DE LOS EFECTOS ANTIPROLIFERATIVOS DE LA COMPOSICION TNF E IL-4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59097790A | 1990-10-01 | 1990-10-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2134200T3 true ES2134200T3 (es) | 1999-10-01 |
Family
ID=24364509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91920247T Expired - Lifetime ES2134200T3 (es) | 1990-10-01 | 1991-10-01 | Uso de il-4 y tnf para la preparacion de un medicamento para el tratamiento de celulas tumorales. |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0563060B1 (es) |
| JP (1) | JP3226918B2 (es) |
| KR (1) | KR100225322B1 (es) |
| CN (1) | CN1053838C (es) |
| AT (1) | ATE179617T1 (es) |
| AU (1) | AU658588B2 (es) |
| CA (1) | CA2092914C (es) |
| DE (1) | DE69131202T2 (es) |
| DK (1) | DK0563060T3 (es) |
| ES (1) | ES2134200T3 (es) |
| FI (1) | FI931426A7 (es) |
| GR (1) | GR3030930T3 (es) |
| IE (1) | IE913264A1 (es) |
| IL (1) | IL99497A (es) |
| NO (1) | NO931139L (es) |
| NZ (1) | NZ239829A (es) |
| PT (1) | PT99123B (es) |
| RU (1) | RU2114633C1 (es) |
| SA (1) | SA92120509B1 (es) |
| WO (1) | WO1992005805A1 (es) |
| ZA (1) | ZA917424B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1299295A (en) * | 1993-12-02 | 1995-06-19 | President And Fellows Of Harvard College | Improved efficacy of alpha-helical cytokines |
| US5679338A (en) * | 1994-05-12 | 1997-10-21 | Osteoarthritis Science, Inc. | Use of IL-4 for inhibition of the breakdown of articular cartilage and other tissues |
| US6277368B1 (en) | 1996-07-25 | 2001-08-21 | The Regents Of The University Of California | Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine |
| CN1100566C (zh) * | 1998-08-26 | 2003-02-05 | 北京师范大学 | 含有钙调神经磷酸酶b亚基的药物组合物 |
| ID30176A (id) * | 1999-03-12 | 2001-11-08 | Boehringer Ingelheim Pharma | Senyawa-senyawa yang bermanfaat sebagai zat anti-inflamasi |
| UA71952C2 (en) * | 1999-11-16 | 2005-01-17 | Urea aromatic derivatives as antiinflammatory agents | |
| RU2191586C1 (ru) * | 2001-05-15 | 2002-10-27 | Ростовский научно-исследовательский онкологический институт | Способ лечения рака яичников |
| RU2201762C1 (ru) * | 2001-10-09 | 2003-04-10 | Свадовский Александр Игоревич | Способ лечения внутримозговой опухоли головного мозга |
| DE10321725A1 (de) * | 2003-05-14 | 2004-12-02 | Mucos Pharma Gmbh & Co | Enzymhaltige Zusammensetzungen, daraus hergestellte diätetische Lebensmittel und Arzneimittel und ihre Verwendung für medizinische Zwecke |
| RU2389502C2 (ru) * | 2004-07-29 | 2010-05-20 | Займодженетикс, Инк. | Применение il-28 и il-29 для лечения карциномы и аутоиммунных нарушений |
| CN100482683C (zh) * | 2005-06-09 | 2009-04-29 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 人富含甘氨酸蛋白的活性片段及其应用 |
| CN113368219B (zh) * | 2021-06-28 | 2024-05-10 | 广东工业大学 | Globulol的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4650674A (en) * | 1984-07-05 | 1987-03-17 | Genentech, Inc. | Synergistic cytotoxic composition |
| US4770995A (en) | 1985-08-29 | 1988-09-13 | New York Blood Center, Inc | Detection of the sensitivity of cells to the effects of tumor necrosis factor and lymphotoxin |
| US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
-
1991
- 1991-09-16 IE IE326491A patent/IE913264A1/en not_active IP Right Cessation
- 1991-09-16 IL IL99497A patent/IL99497A/xx not_active IP Right Cessation
- 1991-09-17 NZ NZ239829A patent/NZ239829A/xx not_active IP Right Cessation
- 1991-09-18 ZA ZA917424A patent/ZA917424B/xx unknown
- 1991-09-28 CN CN91109425A patent/CN1053838C/zh not_active Expired - Fee Related
- 1991-09-30 PT PT99123A patent/PT99123B/pt not_active IP Right Cessation
- 1991-10-01 EP EP91920247A patent/EP0563060B1/en not_active Expired - Lifetime
- 1991-10-01 FI FI931426A patent/FI931426A7/fi unknown
- 1991-10-01 KR KR1019930700996A patent/KR100225322B1/ko not_active Expired - Fee Related
- 1991-10-01 RU RU93032615A patent/RU2114633C1/ru not_active IP Right Cessation
- 1991-10-01 AU AU89508/91A patent/AU658588B2/en not_active Ceased
- 1991-10-01 DK DK91920247T patent/DK0563060T3/da active
- 1991-10-01 ES ES91920247T patent/ES2134200T3/es not_active Expired - Lifetime
- 1991-10-01 WO PCT/US1991/007234 patent/WO1992005805A1/en not_active Ceased
- 1991-10-01 JP JP50065192A patent/JP3226918B2/ja not_active Expired - Fee Related
- 1991-10-01 DE DE69131202T patent/DE69131202T2/de not_active Expired - Fee Related
- 1991-10-01 AT AT91920247T patent/ATE179617T1/de not_active IP Right Cessation
- 1991-10-01 CA CA002092914A patent/CA2092914C/en not_active Expired - Fee Related
-
1992
- 1992-05-11 SA SA92120509A patent/SA92120509B1/ar unknown
-
1993
- 1993-03-26 NO NO93931139A patent/NO931139L/no unknown
-
1999
- 1999-08-06 GR GR990402011T patent/GR3030930T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2092914A1 (en) | 1992-04-02 |
| IL99497A0 (en) | 1992-08-18 |
| CN1053838C (zh) | 2000-06-28 |
| JPH06501704A (ja) | 1994-02-24 |
| WO1992005805A1 (en) | 1992-04-16 |
| CN1060788A (zh) | 1992-05-06 |
| AU658588B2 (en) | 1995-04-27 |
| EP0563060B1 (en) | 1999-05-06 |
| NO931139D0 (no) | 1993-03-26 |
| DE69131202D1 (de) | 1999-06-10 |
| GR3030930T3 (en) | 1999-11-30 |
| AU8950891A (en) | 1992-04-28 |
| DE69131202T2 (de) | 2000-01-05 |
| SA92120509B1 (ar) | 2005-11-23 |
| FI931426L (fi) | 1993-04-27 |
| NZ239829A (en) | 1993-03-26 |
| EP0563060A4 (fr) | 1993-08-04 |
| JP3226918B2 (ja) | 2001-11-12 |
| CA2092914C (en) | 2002-12-03 |
| FI931426A7 (fi) | 1993-04-27 |
| RU2114633C1 (ru) | 1998-07-10 |
| DK0563060T3 (da) | 1999-11-08 |
| PT99123B (pt) | 1999-02-26 |
| FI931426A0 (fi) | 1993-03-30 |
| EP0563060A1 (en) | 1993-10-06 |
| PT99123A (pt) | 1992-08-31 |
| NO931139L (no) | 1993-05-05 |
| IL99497A (en) | 1997-03-18 |
| KR100225322B1 (ko) | 1999-10-15 |
| IE913264A1 (en) | 1992-04-08 |
| ATE179617T1 (de) | 1999-05-15 |
| ZA917424B (en) | 1992-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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