ES2127036A1 - Water-soluble norfloxacin adduct - Google Patents
Water-soluble norfloxacin adductInfo
- Publication number
- ES2127036A1 ES2127036A1 ES09400594A ES9400594A ES2127036A1 ES 2127036 A1 ES2127036 A1 ES 2127036A1 ES 09400594 A ES09400594 A ES 09400594A ES 9400594 A ES9400594 A ES 9400594A ES 2127036 A1 ES2127036 A1 ES 2127036A1
- Authority
- ES
- Spain
- Prior art keywords
- norfloxacin
- adduct
- water
- soluble
- mole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 title abstract 4
- 229960001180 norfloxacin Drugs 0.000 title abstract 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 229960005070 ascorbic acid Drugs 0.000 abstract 2
- 235000010323 ascorbic acid Nutrition 0.000 abstract 2
- 239000011668 ascorbic acid Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Water-soluble norfloxacin adduct. Addition product comprising an adduct of ascorbic acid and norfloxacin which product is prepared by reacting at least one mole of ascorbic acid for each mole of norfloxacin in the presence of an appropriate solvent such as water, alcohol or a water/alcohol mixture. Pharmaceutical compositions and aqueous solutions containing the said adduct can be used for medical or veterinary purposes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9400594A ES2127036B1 (en) | 1994-03-21 | 1994-03-21 | NORFLOXACINE ADDUCT SOLUBLE IN WATER. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9400594A ES2127036B1 (en) | 1994-03-21 | 1994-03-21 | NORFLOXACINE ADDUCT SOLUBLE IN WATER. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2127036A1 true ES2127036A1 (en) | 1999-04-01 |
| ES2127036B1 ES2127036B1 (en) | 1999-11-16 |
Family
ID=8285633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9400594A Expired - Lifetime ES2127036B1 (en) | 1994-03-21 | 1994-03-21 | NORFLOXACINE ADDUCT SOLUBLE IN WATER. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2127036B1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009136408A1 (en) * | 2008-04-09 | 2009-11-12 | Institute Of Life Sciences | Synergistic pharmaceutical cocrystals |
| WO2012150537A3 (en) * | 2011-05-04 | 2013-01-10 | Laboratorios Senosiain S.A. De C.V. | Novel solid forms of antibiotics |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0067666A1 (en) * | 1981-06-11 | 1982-12-22 | Warner-Lambert Company | Salts of antimicrobial naphthyridine and quinoline compounds and their production |
| US4530928A (en) * | 1982-01-13 | 1985-07-23 | Merck & Co., Inc. | Quinoline carboxylic acid complexes with guanidinium carbonate |
| ES8607021A1 (en) * | 1983-09-17 | 1986-05-16 | Bayer Ag | Solutions of lactic acid salts of piperazinylquinolone and piperazinyl azaquinolonecarboxylic acids |
| ES2039316T1 (en) * | 1986-10-30 | 1993-10-01 | Abic Ltd. | HYDRO-SOLUBLE NORFLOXACINE ADDUCT. |
-
1994
- 1994-03-21 ES ES9400594A patent/ES2127036B1/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0067666A1 (en) * | 1981-06-11 | 1982-12-22 | Warner-Lambert Company | Salts of antimicrobial naphthyridine and quinoline compounds and their production |
| US4530928A (en) * | 1982-01-13 | 1985-07-23 | Merck & Co., Inc. | Quinoline carboxylic acid complexes with guanidinium carbonate |
| ES8607021A1 (en) * | 1983-09-17 | 1986-05-16 | Bayer Ag | Solutions of lactic acid salts of piperazinylquinolone and piperazinyl azaquinolonecarboxylic acids |
| ES2039316T1 (en) * | 1986-10-30 | 1993-10-01 | Abic Ltd. | HYDRO-SOLUBLE NORFLOXACINE ADDUCT. |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009136408A1 (en) * | 2008-04-09 | 2009-11-12 | Institute Of Life Sciences | Synergistic pharmaceutical cocrystals |
| WO2012150537A3 (en) * | 2011-05-04 | 2013-01-10 | Laboratorios Senosiain S.A. De C.V. | Novel solid forms of antibiotics |
| US9290492B2 (en) | 2011-05-04 | 2016-03-22 | Laboratorios Senosiain S.A. De C.V. | Solid forms of antibiotics |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2127036B1 (en) | 1999-11-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU575612B2 (en) | (piperidine-4-yl-amino)-benzimidazoles/imida-20 pyrines | |
| IE873125L (en) | Benzimidazole derivatives | |
| OA09772A (en) | "mometasone furoate monohydrate, process for making same and pharmaceutical compositions". | |
| IL108625A0 (en) | Heterocyclically substituted phenyl-cyclohexane-carboxylic acid derivatives, their prepatation and pharmaceutical compositions containing them | |
| ECSP034883A (en) | AMIDAS OF ANTRANILIC ACIDS WITH SIDE CHAIN OF HETEROARILSULFONILO, PROCEDURE FOR THEIR PREPARATION, ITS EMPLOYMENT AS A MEDICINAL OR DIAGNOSTIC AGENT, AS WELL AS PHARMACEUTICAL PREPARATIONS CONTAINING THEM | |
| DE3460035D1 (en) | 1'-ethoxycarbonyloxyethyl ester of valproic acid, its preparation and formulations containing it | |
| DE2966179D1 (en) | Pyridyl- and imidazopyridyloxypropanolamines, process for preparing the same and pharmaceutical compositions containing the same | |
| ES2058117T3 (en) | LIQUID STERILIZING COMPOSITION. | |
| HUT51221A (en) | Process for producing pharmaceutical compositions comprising 3-demethyl-4-fluoromevalonic acid derivatives and the active ingredients | |
| DE3361757D1 (en) | Salicylic-acid derivatives, process for their preparation, pharmaceutical preparations based on these compounds and their use | |
| SE8002831L (en) | OXITETRACYKLINBEREDNINGAR | |
| ES2127036A1 (en) | Water-soluble norfloxacin adduct | |
| AU7125991A (en) | Novel antiulcer substance | |
| AU536582B2 (en) | Plenylpiperazine derivatives of 1,3,4-oxiadiazolylphends | |
| AU551938B2 (en) | 6-chloro 4-phenyl quinazoline derivatives | |
| GR1002576B (en) | Pharmaceutical compositions and a process for the preparation thereof. | |
| ZA882854B (en) | Substituted quinoxalyl-imidazolidine-2,4-diones,processes for their preparation,their use as medicaments and pharmaceutical preparations | |
| AR008474A1 (en) | DERIVATIVE OF 9-DIHYDROERYTHROMYCIN A 6.9; 11,12-DICICLOCARBONATO, PHARMACEUTICAL COMPOSITION AND BACTERICIDE PREPARATION THAT CONTAIN IT AND ITS USE | |
| IL63022A (en) | Nonapeptide having gonadoliberine activity,its preparation and compositions containing it | |
| AU7971182A (en) | Anthranilic acid derivatives | |
| HUT59011A (en) | Process for producing composition, and its active ingredient, suitable for inactivating or removing harmful compounds in blood and other extracellular liquids | |
| EP0043976A3 (en) | Anti-tumor agent | |
| HUT55341A (en) | Process for producing vanillic acid alkyl esters, pharmaceutical compositions comprising same, as well as biocidal preparations containing vanillic acid alkyl esters | |
| GR900100554A (en) | Compositions and in situ methods for forming films on body tissue | |
| UY24851A1 (en) | DERIVATIVES OF N-ACIL-ALPHA-AMINATED ACIDS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19990401 Kind code of ref document: A1 Effective date: 19990401 |
|
| FA2A | Application withdrawn |
Effective date: 20001102 |