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ES2124710T3 - Procedimiento para el acoplamiento pinacolinico reductor diastereoselectivo de alfa-aminoaldehidos homoquirales. - Google Patents

Procedimiento para el acoplamiento pinacolinico reductor diastereoselectivo de alfa-aminoaldehidos homoquirales.

Info

Publication number
ES2124710T3
ES2124710T3 ES92104085T ES92104085T ES2124710T3 ES 2124710 T3 ES2124710 T3 ES 2124710T3 ES 92104085 T ES92104085 T ES 92104085T ES 92104085 T ES92104085 T ES 92104085T ES 2124710 T3 ES2124710 T3 ES 2124710T3
Authority
ES
Spain
Prior art keywords
procedure
pinacolinic
aminoaldehyde
diastereoselective
reducer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92104085T
Other languages
English (en)
Inventor
Joachim-Heiner Dr Jendralla
Detlef Dr Jacobi
Bernhard Dr Kammermeier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4122911A external-priority patent/DE4122911A1/de
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2124710T3 publication Critical patent/ES2124710T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Lubricants (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA PRODUCCION DE COMPUESTOS SIMETRICOS PUROS OPTICAMENTE DE LA FORMULA *FIG* EN DONDE R1, R2 Y R3 ESTAN EXPLICADOS EN LA DESCRIPCION, BAJO CONTROL SIMULTANEO DE LOS CUATRO CENTROS DE QUIRALIDAD MARCADOS CON *.
ES92104085T 1991-03-15 1992-03-10 Procedimiento para el acoplamiento pinacolinico reductor diastereoselectivo de alfa-aminoaldehidos homoquirales. Expired - Lifetime ES2124710T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4108357 1991-03-15
DE4122911A DE4122911A1 (de) 1991-07-11 1991-07-11 Verfahren zur diastereoselektiven reduktiven pinakol-kupplung von homochiralen (alpha)-aminoaldehyden

Publications (1)

Publication Number Publication Date
ES2124710T3 true ES2124710T3 (es) 1999-02-16

Family

ID=25901877

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92104085T Expired - Lifetime ES2124710T3 (es) 1991-03-15 1992-03-10 Procedimiento para el acoplamiento pinacolinico reductor diastereoselectivo de alfa-aminoaldehidos homoquirales.

Country Status (16)

Country Link
US (1) US5519113A (es)
EP (1) EP0503561B1 (es)
JP (1) JP3254238B2 (es)
KR (1) KR920018013A (es)
AT (1) ATE172713T1 (es)
AU (1) AU664696B2 (es)
CA (1) CA2063013A1 (es)
CS (1) CS76792A3 (es)
DE (1) DE59209540D1 (es)
DK (1) DK0503561T3 (es)
ES (1) ES2124710T3 (es)
FI (1) FI921069L (es)
HU (1) HUT62851A (es)
IE (1) IE920828A1 (es)
MX (1) MX9201116A (es)
NO (1) NO920984L (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362912A (en) * 1989-05-23 1994-11-08 Abbott Laboratories Process for the preparation of a substituted diaminodiol
RU2274642C2 (ru) 1998-03-19 2006-04-20 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы каспаз
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
WO2003068242A1 (en) * 2002-02-11 2003-08-21 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
US7531570B2 (en) * 2004-05-27 2009-05-12 Vertex Pharmaceuticals Incorporated Treatment of diseases using ICE inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
FI925441A7 (fi) * 1990-06-01 1992-11-30 The Du Pont Merck Pharmaceutical Company 1,4-diamino-2,3-dihydroksibutaaneja
HU9203505D0 (en) * 1990-06-01 1993-01-28 Du Pont Merck Pharma 1,4-diamino-2,3-dihydroxi-butane compounds

Also Published As

Publication number Publication date
CS76792A3 (en) 1992-10-14
NO920984D0 (no) 1992-03-13
NO920984L (no) 1992-09-16
CA2063013A1 (en) 1992-09-16
HU9200864D0 (en) 1992-05-28
IE920828A1 (en) 1992-09-23
FI921069A0 (fi) 1992-03-12
AU664696B2 (en) 1995-11-30
EP0503561A2 (de) 1992-09-16
KR920018013A (ko) 1992-10-21
EP0503561A3 (en) 1993-05-05
ATE172713T1 (de) 1998-11-15
FI921069A7 (fi) 1992-09-16
JP3254238B2 (ja) 2002-02-04
MX9201116A (es) 1992-10-01
US5519113A (en) 1996-05-21
FI921069L (fi) 1992-09-16
HUT62851A (en) 1993-06-28
JPH0578290A (ja) 1993-03-30
AU1284092A (en) 1992-09-17
DK0503561T3 (da) 1999-07-05
EP0503561B1 (de) 1998-10-28
DE59209540D1 (de) 1998-12-03

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