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ES2123460A1 - beta-Lactam antibiotic production from amino acid derivative and amino-beta-lactam compound - by enzymatic coupling, with purification of product stream by electrodialysis - Google Patents

beta-Lactam antibiotic production from amino acid derivative and amino-beta-lactam compound - by enzymatic coupling, with purification of product stream by electrodialysis

Info

Publication number
ES2123460A1
ES2123460A1 ES9700732A ES9700732A ES2123460A1 ES 2123460 A1 ES2123460 A1 ES 2123460A1 ES 9700732 A ES9700732 A ES 9700732A ES 9700732 A ES9700732 A ES 9700732A ES 2123460 A1 ES2123460 A1 ES 2123460A1
Authority
ES
Spain
Prior art keywords
beta
lactam
amino
electrodialysis
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9700732A
Other languages
Spanish (es)
Other versions
ES2123460B1 (en
Inventor
Veerle Cauwenberg
Marinus Petrus Rijkers
Den Tweel Wilhelmus J Van
Geert Wytze Meindersma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemferm VoF
Original Assignee
Chemferm VoF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemferm VoF filed Critical Chemferm VoF
Publication of ES2123460A1 publication Critical patent/ES2123460A1/en
Application granted granted Critical
Publication of ES2123460B1 publication Critical patent/ES2123460B1/en
Anticipated expiration legal-status Critical
Withdrawn - After Issue legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Method for the preparation of β-lactam antibiotics using enzyme acylation of an amino acid derivative and an amino-β-lactam compound, at a pH level in which the β-lactam antibiotic is fully soluble, and where, from the flow of remaining products after acylation, when the pH is modified, the expected β-lactam antibiotic is precipitated and the remaining aqueous mixture undergoes electrodialysis at a pH between 2 and 8.<IMAGE>
ES9700732A 1996-04-09 1997-04-08 METHOD FOR THE PREPARATION OF BETA-LACTAMA ANTIBIOTICS. Withdrawn - After Issue ES2123460B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL1002818A NL1002818C2 (en) 1996-04-09 1996-04-09 Method for the preparation of beta-lactam antibiotics.

Publications (2)

Publication Number Publication Date
ES2123460A1 true ES2123460A1 (en) 1999-01-01
ES2123460B1 ES2123460B1 (en) 1999-10-01

Family

ID=19762642

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9700732A Withdrawn - After Issue ES2123460B1 (en) 1996-04-09 1997-04-08 METHOD FOR THE PREPARATION OF BETA-LACTAMA ANTIBIOTICS.

Country Status (3)

Country Link
ES (1) ES2123460B1 (en)
IT (1) IT1291132B1 (en)
NL (1) NL1002818C2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1007077C2 (en) * 1997-09-19 1999-03-22 Dsm Nv Method for the recovery of a ß-lactam antibiotic.
NL1007076C2 (en) * 1997-09-19 1999-03-22 Dsm Nv Method for the recovery of a ß-lactam antibiotic.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5876099A (en) * 1981-10-28 1983-05-09 Sanraku Inc Antibiotic purification method
JPH0263527A (en) * 1988-08-30 1990-03-02 Tosoh Corp Method for desalting biochemical substance

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU558684A1 (en) * 1975-04-04 1977-05-25 Кемеровский Научно-Исследовательский Институт Химической Промышленности The method of electrochemical regeneration of ion exchangers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5876099A (en) * 1981-10-28 1983-05-09 Sanraku Inc Antibiotic purification method
JPH0263527A (en) * 1988-08-30 1990-03-02 Tosoh Corp Method for desalting biochemical substance

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BASE DE DATOS PAJ en EPOQUE. Japanese Patent Inf. Organization (TOKYO, JP) & JP 2063527 A (TOSOH CORP.) 02.03.1990 *
BASE DE DATOS PAJ en EPOQUE. Japanese Patent Inf. Organization (TOKYO, JP) & JP 58076099 A (SANRAKU OCEAN KK) 09.05.1983 *

Also Published As

Publication number Publication date
ITRM970193A1 (en) 1998-10-04
NL1002818C2 (en) 1997-10-15
ES2123460B1 (en) 1999-10-01
IT1291132B1 (en) 1998-12-29

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