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ES2122941B1 - Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato. - Google Patents

Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.

Info

Publication number
ES2122941B1
ES2122941B1 ES09701169A ES9701169A ES2122941B1 ES 2122941 B1 ES2122941 B1 ES 2122941B1 ES 09701169 A ES09701169 A ES 09701169A ES 9701169 A ES9701169 A ES 9701169A ES 2122941 B1 ES2122941 B1 ES 2122941B1
Authority
ES
Spain
Prior art keywords
quinapril
chlorhydrate
solvate
obtaining
isolation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09701169A
Other languages
English (en)
Other versions
ES2122941A1 (es
Inventor
Llagostera Montser Monsalvatje
Sanmarti Marti Bartra
Navarro Jaime Tomas
Llagostera Montse Montsalvatje
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Quimica SA
Original Assignee
Esteve Quimica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES09701169A priority Critical patent/ES2122941B1/es
Application filed by Esteve Quimica SA filed Critical Esteve Quimica SA
Priority to US09/424,673 priority patent/US6617457B1/en
Priority to DK98920547T priority patent/DK0992495T3/da
Priority to PCT/ES1998/000145 priority patent/WO1998054149A1/es
Priority to KR10-1999-7011151A priority patent/KR100477713B1/ko
Priority to DE1998621483 priority patent/DE69821483T2/de
Priority to AT98920547T priority patent/ATE258920T1/de
Priority to US11/022,424 priority patent/USRE39888E1/en
Priority to CA002293705A priority patent/CA2293705C/en
Priority to AU73365/98A priority patent/AU730140B2/en
Priority to EP98920547A priority patent/EP0992495B1/en
Priority to PT98920547T priority patent/PT992495E/pt
Priority to JP50027999A priority patent/JP2002502386A/ja
Priority to ZA984466A priority patent/ZA984466B/xx
Publication of ES2122941A1 publication Critical patent/ES2122941A1/es
Application granted granted Critical
Publication of ES2122941B1 publication Critical patent/ES2122941B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE QUINAPRIL CLORHIDRATO Y SOLVATOS UTILES PARA EL AISLAMIENTO Y PURIFICACION DE QUINAPRIL CLORHIDRATO. EL PROCEDIMIENTO PARA OBTENER QUINAPRIL CLORHIDRATO (I) COMPRENDE LAS ETAPAS DE: A) HIDROGENOLISIS DEL ESTER BENCILICO DEL QUINAPRIL (II) POR TRATAMIENTO EN UN DISOLVENTE ALCOHOLICO, CON ACIDO CLORHIDICO O CON UNA DISOLUCION DE CLORURO DE HIDROGENO EN ISOPROPANOL E HIDROGENACION; B) RETIRADA DEL DISOLVENTE; C) ADICION DE TOLUENO PARA PRECIPITAR EL QUINAPRIL CLORHIDRATO COMO SOLVATO DE TOLUENO; D) TRATAMIENTO DE DICHO SOLVATO CON UN DISOLVENTE DE LA CLASE 3 QUE FORMA UN SOLVATO DE QUINAPRIL CLORHIDRATO DEL QUE SE PUEDE ELIMINAR POR SECADO SIN DEGRADARLO; Y E) SECADO DEL SOLVATO DE LA ETAPA D) PARA RENDIR (I). ESTOS SOLVATOS SON UTILES PARA AISLAR Y PURIFICAR (I), UN AGENTE ANTIHIPERTENSIVO.
ES09701169A 1997-05-29 1997-05-29 Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato. Expired - Fee Related ES2122941B1 (es)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ES09701169A ES2122941B1 (es) 1997-05-29 1997-05-29 Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.
EP98920547A EP0992495B1 (en) 1997-05-29 1998-05-25 Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride
PCT/ES1998/000145 WO1998054149A1 (es) 1997-05-29 1998-05-25 Procedimiento para la obtención de quinapril clorhidrato y solvatos utiles para el aislamiento y purificación de quinapril clorhidrato
KR10-1999-7011151A KR100477713B1 (ko) 1997-05-29 1998-05-25 퀸아프릴 하이드로클로라이드와 퀸아프릴하이드로클로라이드 분리 및 정제용 용매화합물 제조방법
DE1998621483 DE69821483T2 (de) 1997-05-29 1998-05-25 Verfahren zur gewinnung von chinaprylhydrochlorid und solvaten, die bei der isolierung und reinigung von chinaprylhydrochlorid nützlich sind
AT98920547T ATE258920T1 (de) 1997-05-29 1998-05-25 Verfahren zur gewinnung von chinaprylhydrochlorid und solvaten, die bei der isolierung und reinigung von chinaprylhydrochlorid nützlich sind
US11/022,424 USRE39888E1 (en) 1997-05-29 1998-05-25 Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride
CA002293705A CA2293705C (en) 1997-05-29 1998-05-25 Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride
US09/424,673 US6617457B1 (en) 1997-05-29 1998-05-25 Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride
DK98920547T DK0992495T3 (da) 1997-05-29 1998-05-25 Fremgangsmåde til opnåelse af quinaprilhydrochlorid og solvater, der er nyttige ved isolation og rensning af quinaprilhydrochlorid
PT98920547T PT992495E (pt) 1997-05-29 1998-05-25 Processo pata obter cloridrato de quinapril e solvatos uteis para isolar e purificar o cloridrato de quinapril
JP50027999A JP2002502386A (ja) 1997-05-29 1998-05-25 塩酸キナプリルの製法並びに塩酸キナプリルの単離および精製に有用な溶媒和物
AU73365/98A AU730140B2 (en) 1997-05-29 1998-05-25 Process for obtaining quinapril hydrochloride and solvates useful for the isolation and purification of quinapril hydrochloride
ZA984466A ZA984466B (en) 1997-05-29 1998-05-26 Process for obtaining quinapril hydrochloride and solvates useful for the isolation and purification of quinapril hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09701169A ES2122941B1 (es) 1997-05-29 1997-05-29 Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.

Publications (2)

Publication Number Publication Date
ES2122941A1 ES2122941A1 (es) 1998-12-16
ES2122941B1 true ES2122941B1 (es) 1999-07-01

Family

ID=8299498

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09701169A Expired - Fee Related ES2122941B1 (es) 1997-05-29 1997-05-29 Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.

Country Status (13)

Country Link
US (2) USRE39888E1 (es)
EP (1) EP0992495B1 (es)
JP (1) JP2002502386A (es)
KR (1) KR100477713B1 (es)
AT (1) ATE258920T1 (es)
AU (1) AU730140B2 (es)
CA (1) CA2293705C (es)
DE (1) DE69821483T2 (es)
DK (1) DK0992495T3 (es)
ES (1) ES2122941B1 (es)
PT (1) PT992495E (es)
WO (1) WO1998054149A1 (es)
ZA (1) ZA984466B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225124A1 (en) * 1999-08-31 2003-12-04 Spiridon Spireas Stable formulations of ACE inhibitors, and methods for preparation thereof
AU2002361494A1 (en) * 2002-12-16 2004-07-09 Lupin Limited Crystalline form of quinapril hydrochloride and process for preparing the same
CL2004000541A1 (es) 2003-03-31 2005-02-04 Warner Lambert Co Procedimiento de preparacion de clorhidrato de quinapril por reaccion entre una 2,5-dioxo-oxazolidina y un ester terbutilico de una tetrahidro isoquinolina, util como principio activo para tratar la hipertension y la insuficiencia cardiaca congestiva
WO2007054966A2 (en) * 2005-09-13 2007-05-18 Aarti Healthcare Limited A process for the preparation of highly pure crystalline quinapril hydrochloride
WO2007069268A2 (en) * 2005-10-14 2007-06-21 Sun Pharmaceutical Industries Limited A process for the preparation of substantially pure 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives
WO2009053994A1 (en) * 2007-10-26 2009-04-30 Matrix Laboratories Limited Process for preparing pure amorphous quinapril hydrochloride

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
IN156096B (es) * 1981-03-19 1985-05-11 Usv Pharma Corp
JPS58188857A (ja) * 1982-04-26 1983-11-04 Takeda Chem Ind Ltd テトラヒドロイソキノリン誘導体
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
US4761479A (en) * 1987-03-30 1988-08-02 Warner-Lambert Company Crystalline quinapril and a process for producing the same
JPH01275546A (ja) * 1988-04-26 1989-11-06 Nisso Yuka Kogyo Kk 安息香酸ソーダの単離方法
DE4206697A1 (de) * 1992-03-04 1993-09-09 Hoechst Ag Verfahren zur herstellung von modifizierten phenolharzen
JP3211396B2 (ja) * 1992-08-26 2001-09-25 住友化学工業株式会社 アクリル酸及び酢酸の回収方法

Also Published As

Publication number Publication date
CA2293705A1 (en) 1998-12-03
ATE258920T1 (de) 2004-02-15
USRE39888E1 (en) 2007-10-16
KR100477713B1 (ko) 2005-03-18
WO1998054149A1 (es) 1998-12-03
DE69821483T2 (de) 2005-01-13
ZA984466B (en) 1998-12-01
AU7336598A (en) 1998-12-30
ES2122941A1 (es) 1998-12-16
EP0992495A1 (en) 2000-04-12
PT992495E (pt) 2004-06-30
DE69821483D1 (de) 2004-03-11
US6617457B1 (en) 2003-09-09
EP0992495B1 (en) 2004-02-04
JP2002502386A (ja) 2002-01-22
DK0992495T3 (da) 2004-06-01
CA2293705C (en) 2008-03-18
KR20010013167A (ko) 2001-02-26
AU730140B2 (en) 2001-03-01

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