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ES2120267T3 - Nuevos derivados de 17alfa-cianometilestra-4,9-dieno, un proceso para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de 17alfa-cianometilestra-4,9-dieno, un proceso para su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2120267T3
ES2120267T3 ES96120293T ES96120293T ES2120267T3 ES 2120267 T3 ES2120267 T3 ES 2120267T3 ES 96120293 T ES96120293 T ES 96120293T ES 96120293 T ES96120293 T ES 96120293T ES 2120267 T3 ES2120267 T3 ES 2120267T3
Authority
ES
Spain
Prior art keywords
cianometilestra
17alfa
dieno
contain
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96120293T
Other languages
English (en)
Inventor
Gerhard Teichmuller
Gerd Muller
Sigfrid Prof-Dr Schwarz
Bernd Dr Undeutsch
Harry Henkel
Ronald Gebuhr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jenapharm GmbH and Co KG
Original Assignee
Jenapharm GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1995148449 external-priority patent/DE19548449A1/de
Priority claimed from DE1995148450 external-priority patent/DE19548450A1/de
Application filed by Jenapharm GmbH and Co KG filed Critical Jenapharm GmbH and Co KG
Application granted granted Critical
Publication of ES2120267T3 publication Critical patent/ES2120267T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION TRATA DE NUEVOS DERIVADOS DEL 17 AL CIANOMETILESTRA-4,9-DIENO DE FORMULA GENERAL I EN DONDE R{SUB,1} ES UN GRUPO ALQUILO CON 1 A 2 ATOMOS DE CARBONO, R{SUB,2} ES UN RADICAL ALQUILO, UN RADICAL ACILO CON 1 A 10 ATOMOS DE CARBONO O UN RADICAL TRIALQUILSILILO, R{SUB,3} ES UN ATOMO DE OXIGENO O UN GRUPO R-O-N, EN DONDE R ES UN ATOMO DE HIDROGENO, UN RADICAL ACILO CON 1 A 10 ATOMOS DE CARBONO, UN RADICAL ALQUILO CON 1 A 10 ATOMOS DE CARBONO, UN RADICAL SULFAMOILO, UN RADICAL ALQUILO O TRIALQUILSILILO. LOS COMPUESTOS DE LA INVENCION ESTAN INDICADOS, ENTRE OTRAS COSAS, PARA LA CONTRACEPCION HORMONAL EN COMBINACION CON UN ESTROGENO APROPIADO, Y EN LA TERAPIA DE SUSTITUCION HORMONAL CLIMATERICA (HRT), ASI COMO PARA EL TRATAMIENTO DE LA ENDOMETRIOSIS O DE TUMORES DEPENDIENTES DE GESTAGENO. ADEMAS SE DESCRIBE UN PROCEDIMIENO PARA LA OBTENCION DE NUEVOS ESTEROIDES, ASI COMO PARA LA OBTENCION DE COMPOSICIONES FARMACEUTICAS.
ES96120293T 1995-12-22 1996-12-18 Nuevos derivados de 17alfa-cianometilestra-4,9-dieno, un proceso para su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2120267T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1995148449 DE19548449A1 (de) 1995-12-22 1995-12-22 17alpha-Cyanomethyl-3-oxyiminoestra-4,9-dien-3-on-17beta-yl-derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE1995148450 DE19548450A1 (de) 1995-12-22 1995-12-22 17alpha-Cyanomethylestra-4,9-dien-3-on-17beta-yl- derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
ES2120267T3 true ES2120267T3 (es) 1998-10-16

Family

ID=26021644

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96120293T Expired - Lifetime ES2120267T3 (es) 1995-12-22 1996-12-18 Nuevos derivados de 17alfa-cianometilestra-4,9-dieno, un proceso para su preparacion y composiciones farmaceuticas que los contienen.

Country Status (10)

Country Link
US (1) US5866559A (es)
EP (1) EP0780397B1 (es)
JP (1) JP2834721B2 (es)
AT (1) ATE167190T1 (es)
CA (1) CA2193610A1 (es)
CL (1) CL2004000676A1 (es)
DE (1) DE59600274D1 (es)
DK (1) DK0780397T3 (es)
ES (1) ES2120267T3 (es)
GR (1) GR3027627T3 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040167111A1 (en) * 1998-04-15 2004-08-26 Michael Oettel Pharmaceutical preparations for treating side effects during and/or after GnRHa therapy
US20080214512A1 (en) * 2007-03-01 2008-09-04 Christian Seitz Pharmaceutical preparation containing a gestagen, and kit and method for treating endometriosis using the preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3337537A (en) * 1961-03-31 1967-08-22 Merck & Co Inc 17alpha-unsaturated-halohydrocarbon-17beta-hydroxy-19-nor-4, 9-androstadiene-3-one 17-ethers
US3907844A (en) * 1971-06-17 1975-09-23 Sandoz Ag 3-Oximino-17{60 -propadienyl-substituted-4,9-gonadienes
US3904611A (en) * 1972-10-16 1975-09-09 Syntex Corp Preparation of 17' -propadienyl steroids
US3961053A (en) * 1973-05-08 1976-06-01 Sandoz, Inc. Substituted carbinol derivatives
DE2718872A1 (de) 1976-06-14 1977-12-22 Jenapharm Veb Verfahren zur herstellung von neuen gona-4,9(10)-dienen
US5741787A (en) * 1993-08-04 1998-04-21 Akzo Nobel N.V. Antiglucocorticoid steroids for the treatment of anxiety disorders
CN1072678C (zh) * 1994-05-30 2001-10-10 中国科学院上海有机化学研究所 三氟甲基甾体化合物、制备及其用途

Also Published As

Publication number Publication date
DE59600274D1 (de) 1998-07-16
CA2193610A1 (en) 1997-06-23
EP0780397A3 (de) 1997-07-23
EP0780397A2 (de) 1997-06-25
EP0780397B1 (de) 1998-06-10
JPH09183793A (ja) 1997-07-15
GR3027627T3 (en) 1998-11-30
JP2834721B2 (ja) 1998-12-14
US5866559A (en) 1999-02-02
DK0780397T3 (da) 1999-03-29
CL2004000676A1 (es) 2005-01-14
ATE167190T1 (de) 1998-06-15

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