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ES2119376T3 - Ensayo de enlace. - Google Patents

Ensayo de enlace.

Info

Publication number
ES2119376T3
ES2119376T3 ES95904616T ES95904616T ES2119376T3 ES 2119376 T3 ES2119376 T3 ES 2119376T3 ES 95904616 T ES95904616 T ES 95904616T ES 95904616 T ES95904616 T ES 95904616T ES 2119376 T3 ES2119376 T3 ES 2119376T3
Authority
ES
Spain
Prior art keywords
test
agent
signal
liquid sample
area
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95904616T
Other languages
English (en)
Inventor
Roger Philip Ekins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Multilyte Ltd
Original Assignee
Multilyte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10747224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2119376(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Multilyte Ltd filed Critical Multilyte Ltd
Application granted granted Critical
Publication of ES2119376T3 publication Critical patent/ES2119376T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA UN METODO, DISPOSITIVO Y EQUIPO DE ENSAYO PARA DETERMINAR LA CONCENTRACION DE ANALITOS EN MUESTRAS LIQUIDAS, EN LAS QUE LA CANTIDAD DE AGENTE AGLOMERANTE CON LOCALIZACIONES DE UNION ESPECIFICAS PARA UN ANALITO DADO EN LA MUESTRA LIQUIDA, SE INMOVILIZA EN UNA ZONA DE ENSAYO SOBRE UN SOPORTE SOLIDO, ESTANDO EL AGENTE AGLOMERANTE DIVIDIDO EN UN CONJUNTO DE LOCALIZACIONES ESPACIALMENTE SEPARADAS EN LA ZONA DE ENSAYO. LA CONCENTRACION DEL ANALITO SE OBTIENE MEDIANTE LA RETRO-VALORACION DEL AGENTE DE UNION OCUPADO CON UN AGENTE DE DESARROLLO QUE TIENE UN MARCADOR, E INTEGRANDO LA SEÑAL DE CADA LOCALIZACION EN EL CONJUNTO. EL ENSAYO TIENE LA VENTAJA DE EVITAR LOS ERRORES ESTADISTICOS CRECIENTES AL REDUCIRSE EL AREA DE MICROLOCALIZACION DE TECNICAS ANTERIORES, MIENTRAS SE OPTIMIZA LA SEÑAL-A-RUIDO Y LA CINETICA DE LA REACCION ENTRE EL ANALITO Y EL AGENTE AGLOMERANTE.
ES95904616T 1993-12-24 1994-12-23 Ensayo de enlace. Expired - Lifetime ES2119376T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939326450A GB9326450D0 (en) 1993-12-24 1993-12-24 Binding assay

Publications (1)

Publication Number Publication Date
ES2119376T3 true ES2119376T3 (es) 1998-10-01

Family

ID=10747224

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95904616T Expired - Lifetime ES2119376T3 (es) 1993-12-24 1994-12-23 Ensayo de enlace.

Country Status (8)

Country Link
US (1) US5837551A (es)
EP (1) EP0736176B1 (es)
JP (1) JP3391459B2 (es)
AU (1) AU1321895A (es)
DE (1) DE69410636T2 (es)
ES (1) ES2119376T3 (es)
GB (1) GB9326450D0 (es)
WO (1) WO1995018377A1 (es)

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US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US6387707B1 (en) 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
JPH10246725A (ja) * 1997-03-03 1998-09-14 Mikio Nakayama 抗体又は抗原の検出方法
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
DE19715484A1 (de) * 1997-04-14 1998-10-15 Boehringer Mannheim Gmbh Verfahren zum Aufbringen von Reagenzspots
AU756945B2 (en) * 1997-05-23 2003-01-30 Bioarray Solutions Ltd Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US7157234B2 (en) 1997-10-24 2007-01-02 Beckman Coulter, Inc. Detection of very low quantities of analyte bound to a solid phase
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
US6242246B1 (en) 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
JP2002502977A (ja) 1998-02-04 2002-01-29 インビトロジェン コーポレイション マイクロアレイとその使用
US6271044B1 (en) * 1998-05-06 2001-08-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method and kit for detecting an analyte
GB9903555D0 (en) * 1999-02-16 1999-04-07 The Technology Partnership Plc Chemical and biological assay method and apparatus
AU6834700A (en) 1999-08-13 2001-03-13 Zeptosens Ag Device and method for determining multiple analytes
EP1283909A4 (en) 2000-05-04 2006-06-07 Univ Yale HIGH DENSITY PROTEIN ARRAYS FOR SCREENING PROTEIN ACTIVITY
US20030138208A1 (en) * 2000-05-06 2003-07-24 Michael Pawlak Grating optical waveguide structure for multi-analyte determinations and the use thereof
EP1287360A2 (de) * 2000-06-02 2003-03-05 Zeptosens AG Kit und verfahren zur multianalytbestimmung
ATE319087T1 (de) 2000-06-21 2006-03-15 Bioarray Solutions Ltd Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
AU2002224831A1 (en) * 2000-11-17 2002-05-27 Zeptosens Ag Kit and method for determining multiple analytes
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
AU2002361223A1 (en) * 2001-08-27 2003-03-18 Zeptosens Ag Bioanalytical recognition surface with optimised recognition element density
JP4377689B2 (ja) 2001-10-15 2009-12-02 バイオアレイ ソリューションズ リミテッド 同時尋問及び酵素仲介検出による多型遺伝子座の複合分析
US7335153B2 (en) 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
EP1481090A4 (en) 2002-02-15 2006-08-09 Somalogic Inc METHOD AND REAGENTS FOR DETECTING BINDING OF TARGET MOLECULES BY NUCLEIC ACID ELECTRODES
EP1506403A2 (de) * 2002-05-13 2005-02-16 Zeptosens AG Kit for the development of analysis in parallel
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
EP1660858A4 (en) * 2003-07-21 2007-10-24 Amplified Proteomics Inc MULTIPLEX analyte
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
AU2004276761B2 (en) 2003-09-22 2009-12-24 Bioarray Solutions, Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
CA2544041C (en) 2003-10-28 2015-12-08 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
ES2533876T3 (es) 2003-10-29 2015-04-15 Bioarray Solutions Ltd Análisis multiplexado de ácidos nucleicos mediante fragmentación de ADN bicatenario
EP1682261B1 (en) * 2003-11-12 2012-08-15 BIO-RAD Haifa Ltd. Method for carrying out multiple binding reactions in an array format
US7887750B2 (en) * 2004-05-05 2011-02-15 Bayer Healthcare Llc Analytical systems, devices, and cartridges therefor
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
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EP1715341B1 (de) * 2005-04-04 2008-02-27 Micronas Holding GmbH Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von mindestens zwei Liganden
US9050615B2 (en) * 2005-04-26 2015-06-09 Bayer Intellectual Property Gmbh Apparatus and method for coating substrates for analyte detection by means of an affinity assay method
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US7855054B2 (en) 2007-01-16 2010-12-21 Somalogic, Inc. Multiplexed analyses of test samples
US20110136099A1 (en) 2007-01-16 2011-06-09 Somalogic, Inc. Multiplexed Analyses of Test Samples
US8906700B2 (en) 2007-11-06 2014-12-09 Ambergen, Inc. Methods and compositions for phototransfer
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US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events

Also Published As

Publication number Publication date
WO1995018377A1 (en) 1995-07-06
EP0736176A1 (en) 1996-10-09
GB9326450D0 (en) 1994-02-23
JPH09510539A (ja) 1997-10-21
JP3391459B2 (ja) 2003-03-31
DE69410636T2 (de) 1998-11-26
US5837551A (en) 1998-11-17
EP0736176B1 (en) 1998-05-27
AU1321895A (en) 1995-07-17
DE69410636D1 (de) 1998-07-02

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