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ES2118650T3 - Derivados de la quinolina-4-carbonilguanidina, procedimiento para la preparacion de los mismos y preparaciones farmaceuticas que contienen los compuestos. - Google Patents

Derivados de la quinolina-4-carbonilguanidina, procedimiento para la preparacion de los mismos y preparaciones farmaceuticas que contienen los compuestos.

Info

Publication number
ES2118650T3
ES2118650T3 ES96101831T ES96101831T ES2118650T3 ES 2118650 T3 ES2118650 T3 ES 2118650T3 ES 96101831 T ES96101831 T ES 96101831T ES 96101831 T ES96101831 T ES 96101831T ES 2118650 T3 ES2118650 T3 ES 2118650T3
Authority
ES
Spain
Prior art keywords
quinoline
compounds
same
carbonylguanidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96101831T
Other languages
English (en)
Inventor
Junya Fujiwara
Haruki Mori
Hiroyuki Yamashita
Takashi Kitamori
Junko Hosoya
Hitoshi Banno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Inc
Original Assignee
Mitsui Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Application granted granted Critical
Publication of ES2118650T3 publication Critical patent/ES2118650T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN DERIVADO DE LA QUINOLINA-4CARBONILGUANIDINA REPRESENTANDO POR LA FORMULA (I) Y A LAS SALES FARMACOLOGICAMENTE ACEPTABLES DEL MISMO, A UN PROCEDIMIENTO PARA PRODUCIR EL MISMO, Y A UN INHIBIDOR DEL INTERCAMBIADOR DEL NA{SUP,+}/H{SUP,+} QUE CONTIENE EL COMPUESTO COMO INGREDIENTE ACTIVO. LOS COMPUESTOS DE LA INVENCION SON UTILES COMO AGENTES PARA EL TRATAMIENTO O PREVENCION DE DIFERENTES ENFERMEDADES PRODUCIDAS POR LA HIPERFUNCION DEL INTERCAMBIADOR DE NA{SUP,+}/H{SUP,+} Y COMO AGENTES DE DIAGNOSTICO PARA ESTAS ENFERMEDADES.
ES96101831T 1995-02-09 1996-02-08 Derivados de la quinolina-4-carbonilguanidina, procedimiento para la preparacion de los mismos y preparaciones farmaceuticas que contienen los compuestos. Expired - Lifetime ES2118650T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2176595 1995-02-09

Publications (1)

Publication Number Publication Date
ES2118650T3 true ES2118650T3 (es) 1998-09-16

Family

ID=12064172

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96101831T Expired - Lifetime ES2118650T3 (es) 1995-02-09 1996-02-08 Derivados de la quinolina-4-carbonilguanidina, procedimiento para la preparacion de los mismos y preparaciones farmaceuticas que contienen los compuestos.

Country Status (5)

Country Link
US (1) US5627193A (es)
EP (1) EP0726254B1 (es)
AT (1) ATE165822T1 (es)
DE (1) DE69600272T2 (es)
ES (1) ES2118650T3 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ314105A (en) * 1996-02-02 1997-12-19 Sumitomo Pharma Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
JPH09291076A (ja) * 1996-04-24 1997-11-11 Sumitomo Pharmaceut Co Ltd 置換グアニジン誘導体およびその製法
AP1201A (en) * 1997-09-17 2003-09-01 Smithkline Beecham Corp Method for the synthesis of quinoline derivatives.
AUPQ223999A0 (en) * 1999-08-16 1999-09-09 University Of Sydney, The Intracellular feedback controls in the diagnosis and treatment of human disease
JP4299144B2 (ja) * 2001-12-26 2009-07-22 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー フッ素化フェニルピリジン、フェニルピリミジン、およびフェニルキノリンを含むエレクトロルミネッセンスイリジウム化合物ならびにこのような化合物を用いて製造されるデバイス
DE10206358A1 (de) * 2002-02-14 2003-08-28 Aventis Pharma Gmbh Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Behandlung von thrombotischer und inflammatorischer Erkrankungen
KR100518184B1 (ko) * 2003-12-27 2005-10-04 한국화학연구원 퓨란카보닐구아니딘 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물
JP5634985B2 (ja) 2008-05-09 2014-12-03 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ インスリン抵抗性およびβ−細胞機能障害に関連する疾患を治療するためのリメポリドを含む医薬組成物
US20120214803A1 (en) 2011-02-18 2012-08-23 Vifor (International) Ag Novel Sulfonaminoquinoline Hepcidin Antagonists
CN102417479B (zh) * 2011-08-29 2014-02-26 南京大学 Stat3小分子选择性抑制剂及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
JPS59189633A (ja) * 1983-04-13 1984-10-27 Fujitsu Ltd 半導体装置の製造方法
US4680299A (en) * 1984-04-30 1987-07-14 E.I. Du Pont De Nemours And Company 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof
JPS63119455A (ja) * 1986-06-27 1988-05-24 Nippon Shinyaku Co Ltd グリシン誘導体
DE3905339A1 (de) * 1989-02-22 1990-09-06 Basf Ag Chinolin-4-carbonsaeurederivate und deren verwendung
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
US5204329A (en) * 1990-06-11 1993-04-20 Du Pont Merck Pharmaceutical Company Treatment of organ transplantation rejection
DK0556674T3 (da) * 1992-02-15 1996-10-14 Hoechst Ag 3,5-Substituerede benzoylguanidiner med antiarytmisk virkning og inhiberende virkning på celleproliferation
DK0590455T3 (da) * 1992-09-28 2001-01-22 Hoechst Ag Antiarrytmiske og cardioprotektive substiuerede 1(2H)-isoquinoliner, fremgangsmåde til deres fremstilling, lægemiddel indeh
CA2121391A1 (en) * 1993-04-28 1994-10-29 Atsuyuki Kojima Indoloylguanidine derivatives
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4415873A1 (de) * 1994-05-05 1995-11-09 Hoechst Ag Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
DE69600272T2 (de) 1998-09-17
ATE165822T1 (de) 1998-05-15
EP0726254A1 (en) 1996-08-14
DE69600272D1 (de) 1998-06-10
EP0726254B1 (en) 1998-05-06
US5627193A (en) 1997-05-06

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