ES2114817B1 - Asociacion farmacologica entre n-acetilcisteina y levulosa para la prevencion de la muerte celular y enfermedades asociadas. - Google Patents
Asociacion farmacologica entre n-acetilcisteina y levulosa para la prevencion de la muerte celular y enfermedades asociadas.Info
- Publication number
- ES2114817B1 ES2114817B1 ES09601091A ES9601091A ES2114817B1 ES 2114817 B1 ES2114817 B1 ES 2114817B1 ES 09601091 A ES09601091 A ES 09601091A ES 9601091 A ES9601091 A ES 9601091A ES 2114817 B1 ES2114817 B1 ES 2114817B1
- Authority
- ES
- Spain
- Prior art keywords
- association
- prevention
- cell death
- pharmacological
- levulosa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000030833 cell death Effects 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 230000000144 pharmacologic effect Effects 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229960002737 fructose Drugs 0.000 abstract 2
- 206010001488 Aggression Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 206010006895 Cachexia Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 206010061598 Immunodeficiency Diseases 0.000 abstract 1
- 208000029462 Immunodeficiency disease Diseases 0.000 abstract 1
- 206010038910 Retinitis Diseases 0.000 abstract 1
- 229960004308 acetylcysteine Drugs 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000016571 aggressive behavior Effects 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000007813 immunodeficiency Effects 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 201000009240 nasopharyngitis Diseases 0.000 abstract 1
- 201000008383 nephritis Diseases 0.000 abstract 1
- 230000036542 oxidative stress Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 230000001173 tumoral effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
ASOCIACION FARMACOLOGICA ENTRE N-ACETILCISTEINA Y LEVULOSA PARA LA PREVENCION DE LA MUERTE CELULAR Y ENFERMEDADES ASOCIADAS. CUANDO LA APLICACION DE LOS MENCIONADOS PRODUCTOS SE HACE SIMULTANEAMENTE SE PRODUCE UN CLARO EFECTO SINERGICO PROTECTOR DE LAS CELULAS PREVINIENDO LA MUERTE CELULAR PRODUCIDA POR DIFERENTES TIPOS DE AGRESIONES RELACIONADAS CON EL STRESS OXIDATIVO. LA RELACION PREFERENTE ENTRE LOS COMPUESTOS DE LA ASOCIACION ES DE LEVULOSA/NAC= 4/1. LA ASOCIACION FARMACOLOGICA SE USA PARA EL TRATAMIENTO DE DIVERSAS CLINICAS, COMO POR EJEMPLO: RINOFARINGITIS Y BRONQUITIS, HEPATOPATIAS AGUDAS Y CRONICAS, INMUNODEFICIENCIAS, INFARTO DE MIOCARDIO, ARTERIOESCLEROSIS, ALZHEIMER, RETINITIS, IMPOTENCIA SEXUAL, NEFRITIS, DERMATITIS Y CAQUEXIA TUMORAL.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES09601091A ES2114817B1 (es) | 1996-05-16 | 1996-05-16 | Asociacion farmacologica entre n-acetilcisteina y levulosa para la prevencion de la muerte celular y enfermedades asociadas. |
| PCT/ES1997/000122 WO1997042961A1 (es) | 1996-05-16 | 1997-05-13 | Asociacion farmacologica entre n-acetilcisteina y levulosa para la prevencion de la muerte celular y enfermedades asociadas |
| DK97920756T DK0839534T3 (da) | 1996-05-16 | 1997-05-13 | Farmakologisk kombination af N-acetylcystein og levulose til forebyggelse af celledød og relaterede sygdomme |
| AT97920756T ATE222496T1 (de) | 1996-05-16 | 1997-05-13 | Pharmakologische kombination aus n-acetylcystein und levulose zur verhütung des zelltods und verwandter erkrankungen |
| EP97920756A EP0839534B1 (en) | 1996-05-16 | 1997-05-13 | Pharmacological association between n-acetylcystein and levulose for preventing cellular death and related diseases |
| DE69714821T DE69714821T2 (de) | 1996-05-16 | 1997-05-13 | Pharmakologische kombination aus n-acetylcystein und levulose zur verhütung des zelltods und verwandter erkrankungen |
| PT97920756T PT839534E (pt) | 1996-05-16 | 1997-05-13 | Associacao farmacologica entre n-acetilcisteina e levulose para prevencao da morte celular e doencas relacionadas |
| US09/007,071 US5962421A (en) | 1996-05-16 | 1998-01-14 | Pharmacological association between N-acetylcysteine and levulose for preventing cellular death and related diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES09601091A ES2114817B1 (es) | 1996-05-16 | 1996-05-16 | Asociacion farmacologica entre n-acetilcisteina y levulosa para la prevencion de la muerte celular y enfermedades asociadas. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2114817A1 ES2114817A1 (es) | 1998-06-01 |
| ES2114817B1 true ES2114817B1 (es) | 1999-02-16 |
Family
ID=8294833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09601091A Expired - Fee Related ES2114817B1 (es) | 1996-05-16 | 1996-05-16 | Asociacion farmacologica entre n-acetilcisteina y levulosa para la prevencion de la muerte celular y enfermedades asociadas. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0839534B1 (es) |
| AT (1) | ATE222496T1 (es) |
| DE (1) | DE69714821T2 (es) |
| DK (1) | DK0839534T3 (es) |
| ES (1) | ES2114817B1 (es) |
| PT (1) | PT839534E (es) |
| WO (1) | WO1997042961A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19819616A1 (de) * | 1998-05-04 | 1999-11-11 | Hexal Ag | Verwendung von Antioxidantien zur Behandlung von entzündlichen Hauterkrankungen |
| IT1312086B1 (it) * | 1999-04-21 | 2002-04-04 | Zambon Spa | Uso della nac per la preparazione di un medicamento adatto allasomministrazione endovenosa per la prevenzione dello stress |
| FR2815042B1 (fr) * | 2000-10-06 | 2005-01-07 | Haguenauer Odile Cohen | Utilisation d'une composition a activite antioxydante pour le conditionnement de cellules souches |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3026368A1 (de) * | 1980-07-11 | 1982-02-18 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Naehrloesung fuer die vollstaendige parenterale ernaehrung und fuer gesteigerte energieproduktion |
| IT1217445B (it) * | 1988-04-29 | 1990-03-22 | Altergon Sa | Composizione farmaceutiche orosolubili contenti acetilcisteina |
| DE4134723C1 (es) * | 1991-10-21 | 1993-02-11 | Pfrimmer Kabi Gmbh & Co Kg, 8520 Erlangen, De | |
| US5292538A (en) * | 1992-07-22 | 1994-03-08 | Metagenics, Inc. | Improved sustained energy and anabolic composition and method of making |
-
1996
- 1996-05-16 ES ES09601091A patent/ES2114817B1/es not_active Expired - Fee Related
-
1997
- 1997-05-13 DE DE69714821T patent/DE69714821T2/de not_active Expired - Fee Related
- 1997-05-13 PT PT97920756T patent/PT839534E/pt unknown
- 1997-05-13 AT AT97920756T patent/ATE222496T1/de not_active IP Right Cessation
- 1997-05-13 DK DK97920756T patent/DK0839534T3/da active
- 1997-05-13 EP EP97920756A patent/EP0839534B1/en not_active Expired - Lifetime
- 1997-05-13 WO PCT/ES1997/000122 patent/WO1997042961A1/es not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69714821D1 (de) | 2002-09-26 |
| PT839534E (pt) | 2002-12-31 |
| WO1997042961A1 (es) | 1997-11-20 |
| EP0839534B1 (en) | 2002-08-21 |
| ATE222496T1 (de) | 2002-09-15 |
| EP0839534A1 (en) | 1998-05-06 |
| DK0839534T3 (da) | 2002-12-23 |
| DE69714821T2 (de) | 2003-04-10 |
| ES2114817A1 (es) | 1998-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19980601 Kind code of ref document: A1 Effective date: 19980601 |
|
| FD1A | Patent lapsed |
Effective date: 20060517 |