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ES2112916T3 - Ensayo de union que utiliza un reactivo marcado. - Google Patents

Ensayo de union que utiliza un reactivo marcado.

Info

Publication number
ES2112916T3
ES2112916T3 ES92922800T ES92922800T ES2112916T3 ES 2112916 T3 ES2112916 T3 ES 2112916T3 ES 92922800 T ES92922800 T ES 92922800T ES 92922800 T ES92922800 T ES 92922800T ES 2112916 T3 ES2112916 T3 ES 2112916T3
Authority
ES
Spain
Prior art keywords
analyte
binding
binding agent
pct
capture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92922800T
Other languages
English (en)
Inventor
Roger Philip Ekins
Frederick Woodnam Chu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Multilyte Ltd
Original Assignee
Multilyte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26299698&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2112916(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB919121873A external-priority patent/GB9121873D0/en
Application filed by Multilyte Ltd filed Critical Multilyte Ltd
Application granted granted Critical
Publication of ES2112916T3 publication Critical patent/ES2112916T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

UN PROCESO DE ENSAYO DE UNION PARA UN ANALITO, EN CUYO PROCESO SE USA UN AGENTE DE UNION DE CAPTURA QUE TIENE ZONAS DE UNION ESPECIFICAS PARA EL ANALITO Y UN MATERIAL DE UNION EN DESARRROLLO CAPAZ DE UNIRSE CON EL ANALITO UNIDO O CON LAS ZONAS DE UNION EN EL AGENTE DE UNION DE CAPTURA OCUPADO POR EL ANALITO UNIDO O CON LAS ZONAS DE UNION QUE PERMANECEN SIN OCUPAR EN EL AGENTE DE UNION DE CAPTURA, EMPLEA EL AGENTE DE UNION DE CAPTURA EN UNA CANTIDAD TAL, QUE SOLO UNA FRACCION INSIGNIFICANTE DEL ANALITO EN LA MUESTRA LLEGA A UNIRSE AL AGENTE DE UNION DE CAPTURA, EL AGENTE DE UNION DE CAPTURA ESTA PREFERIBLEMENTE PRESENTE EN DENSIDAD DE SUPERFICIE ALTA EN MICROPUNTOS. UNA ETIQUETA SE USA EN EL ENSAYO EN RELACION AL MATERIAL DE UNION EN DESARROLLO, LA ETIQUETA QUE SE PROPORCIONA MEDIANTE MICROESFERAS TIENE UN TAMAÑO DE MENOS DE 5(MU)M Y TRANSPORTA UN INDICADOR, PREFERIBLEMENTE MOLECULAS DE TINTE FLUORESCENTES CONTENIDAS DENTRO DE LAS MICROESFERAS. PARA LA DETERMINACION DE LA CONCENTRACION DEL ANALITO EN LA MUESTRA, LA FORTALEZA DE LA SEÑAL ES REPRESENTATIVA DE LA OCUPACION FRACCIONAL DE LOS SITIOS DE UNION SOBRE EL AGENTE DE UNION DE CAPTURA A TRAVES DEL ANALITO Y SE HACE UNA COMPARACION CON UNA CURVA DE RESPUESTA DE DOSIS COMPUTADA DESDE MUESTRAS ESTANDAR. PARA LA DETECCION DE UN ANALITO QUE CONSTA DE UNA SECUENCIA DE DNA DE HEBRA UNICA, LA PRESENCIA DE UN ANALITO SE DETECTA MEDIANTE LA EXISTENCIA DE UNA SEÑAL. UN EQUIPO PARA EL PROCESO CONSTA DE UN SOPORTE SOLIDO QUE TIENE UN AGENTE DE UNION DE CAPTURA INMOBILIZADO SOBRE EL. UN REAGENTE DE DESARROLLO CONSTA DE UN MATERIAL DE UNION DE DESARROLLO UNIDO A LAS MICROESFERAS Y, DONDE LAS CONCENTRACIONES VAN A SER MEDIDAS ESTANDARES QUE TIENEN CANTIDADES O CONCENTRACIONES CONOCIDAS DEL ANALITO A DETERMINAR.
ES92922800T 1991-10-15 1992-10-15 Ensayo de union que utiliza un reactivo marcado. Expired - Lifetime ES2112916T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919121873A GB9121873D0 (en) 1991-10-15 1991-10-15 Improved non-competitive sandwich immunoassay system
GB929221094A GB9221094D0 (en) 1991-10-15 1992-10-07 Binding assay employing labelled reagent

Publications (1)

Publication Number Publication Date
ES2112916T3 true ES2112916T3 (es) 1998-04-16

Family

ID=26299698

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92922800T Expired - Lifetime ES2112916T3 (es) 1991-10-15 1992-10-15 Ensayo de union que utiliza un reactivo marcado.

Country Status (9)

Country Link
US (1) US5516635A (es)
EP (1) EP0608370B1 (es)
JP (1) JP3097866B2 (es)
AT (1) ATE161964T1 (es)
AU (1) AU2872092A (es)
DE (1) DE69223980T2 (es)
DK (1) DK0608370T3 (es)
ES (1) ES2112916T3 (es)
WO (1) WO1993008472A1 (es)

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* Cited by examiner, † Cited by third party
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DE69223980T2 (de) 1998-05-28
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EP0608370B1 (en) 1998-01-07
JP3097866B2 (ja) 2000-10-10
WO1993008472A1 (en) 1993-04-29
ATE161964T1 (de) 1998-01-15
US5516635A (en) 1996-05-14
DK0608370T3 (da) 1998-09-07
DE69223980D1 (de) 1998-02-12

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