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ES2107545T3 - Anticuerpos policlonales dirigidos contra la hirudina y su utilizacion para la identificacion, la purificacion inmunologica y la determinacion cuantitativa de la hirudina. - Google Patents

Anticuerpos policlonales dirigidos contra la hirudina y su utilizacion para la identificacion, la purificacion inmunologica y la determinacion cuantitativa de la hirudina.

Info

Publication number
ES2107545T3
ES2107545T3 ES92914181T ES92914181T ES2107545T3 ES 2107545 T3 ES2107545 T3 ES 2107545T3 ES 92914181 T ES92914181 T ES 92914181T ES 92914181 T ES92914181 T ES 92914181T ES 2107545 T3 ES2107545 T3 ES 2107545T3
Authority
ES
Spain
Prior art keywords
hirudine
identification
directed against
polyclonal antibodies
antibodies directed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92914181T
Other languages
English (en)
Inventor
Antonio Molinari
Marco Gerna
Carla Giorgetti
Jacqueline Lansen
Romeo Roncucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of ES2107545T3 publication Critical patent/ES2107545T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

EN LA INVENCION SE PRESENTA UN METODO PARA LA PRODUCCION DE UN INMUNOGEN, CUYO METODO CONSISTE EN POLIMERIZAR UNA HIRUDINA Y/O UNA PROTEINA TIPO HIRUDINA. NORMALMENTE ESTO SE CONSIGUE MEDIANTE LA INCUBACION CON UN GLUTARALDEHIDO. EL INMUNOGENO PRODUCIDO SE PUEDE UTILIZAR PARA LA PRODUCCION DE ANTICUERPOS POLICLONALES O MONOCLONALES CAPACES DE ENLAZARSE A LA HIRUDINA O A LA PROTEINA TIPO HIRUDINA.
ES92914181T 1991-06-27 1992-06-26 Anticuerpos policlonales dirigidos contra la hirudina y su utilizacion para la identificacion, la purificacion inmunologica y la determinacion cuantitativa de la hirudina. Expired - Lifetime ES2107545T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911767A IT1248565B (it) 1991-06-27 1991-06-27 Anticorpi policlonali anti-irudina e loro utilizzo per la identificazione, l`immunopurificazione e la determinazione quantitativa dell`uridina.

Publications (1)

Publication Number Publication Date
ES2107545T3 true ES2107545T3 (es) 1997-12-01

Family

ID=11360217

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92914181T Expired - Lifetime ES2107545T3 (es) 1991-06-27 1992-06-26 Anticuerpos policlonales dirigidos contra la hirudina y su utilizacion para la identificacion, la purificacion inmunologica y la determinacion cuantitativa de la hirudina.

Country Status (11)

Country Link
EP (2) EP0600901B1 (es)
JP (1) JPH06509070A (es)
AU (1) AU2193792A (es)
DE (1) DE69221882T2 (es)
ES (1) ES2107545T3 (es)
IE (1) IE922081A1 (es)
IT (1) IT1248565B (es)
MX (1) MX9203242A (es)
NZ (1) NZ243355A (es)
WO (1) WO1993000363A1 (es)
ZA (1) ZA924773B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1266561B1 (it) * 1993-07-22 1997-01-09 Mini Ricerca Scient Tecnolog Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione
FI951541A0 (fi) * 1993-08-04 1995-03-31 Ciba Geigy Ag Suurimolekyylipainoinen desulfatohirudiini
US5710413A (en) * 1995-03-29 1998-01-20 Minnesota Mining And Manufacturing Company H-field electromagnetic heating system for fusion bonding
CN115572329B (zh) * 2021-06-21 2024-02-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU554859B2 (en) * 1981-09-04 1986-09-04 Regents Of The University Of California, The Polymerized albumin vaccine
EP0380443B2 (en) * 1989-01-25 1999-06-30 Novartis AG Monoclonal antibodies specific for thrombin hirudin

Also Published As

Publication number Publication date
JPH06509070A (ja) 1994-10-13
DE69221882D1 (de) 1997-10-02
EP0600901B1 (en) 1997-08-27
EP0520502A2 (en) 1992-12-30
IE922081A1 (en) 1992-12-30
EP0520502A3 (en) 1993-06-23
ITMI911767A0 (it) 1991-06-27
IT1248565B (it) 1995-01-19
MX9203242A (es) 1994-04-29
WO1993000363A1 (en) 1993-01-07
AU2193792A (en) 1993-01-25
ZA924773B (en) 1993-03-31
ITMI911767A1 (it) 1992-12-27
DE69221882T2 (de) 1998-01-02
NZ243355A (en) 1993-09-27
EP0600901A1 (en) 1994-06-15

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