ES2104509A1 - New compounds derived from 2-[3,4-disubstituted-1- piperazinyl]-5-fluoropyrimidine - Google Patents
New compounds derived from 2-[3,4-disubstituted-1- piperazinyl]-5-fluoropyrimidineInfo
- Publication number
- ES2104509A1 ES2104509A1 ES09501182A ES9501182A ES2104509A1 ES 2104509 A1 ES2104509 A1 ES 2104509A1 ES 09501182 A ES09501182 A ES 09501182A ES 9501182 A ES9501182 A ES 9501182A ES 2104509 A1 ES2104509 A1 ES 2104509A1
- Authority
- ES
- Spain
- Prior art keywords
- fluoropyrimidine
- disubstituted
- piperazinyl
- new compounds
- compounds derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 2-[3,4-disubstituted-1- piperazinyl]-5-fluoropyrimidine Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
New compounds derived from 2-[3,4-disubstituted-1- piperazinyl]-5-fluoropyrimidine New compounds derived from 2-[3,4-disubstituted-1- piperazinyl]-5-fluoropyrimidine of general formula I: < IMAGE > where R indicates methyl and X indicates carbonyl or hydroxymethyl, and their stereoisomers and pharmaceutically acceptable addition salts useful in the treatment of psychosis, schizophrenia and anxiety.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9501182A ES2104509B1 (en) | 1995-06-13 | 1995-06-13 | NEW COMPOUNDS DERIVED FROM 2- (3,4-DISSTITUTED-1-PIPERAZINYL) -5-FLUOROPYRIMIDINE. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9501182A ES2104509B1 (en) | 1995-06-13 | 1995-06-13 | NEW COMPOUNDS DERIVED FROM 2- (3,4-DISSTITUTED-1-PIPERAZINYL) -5-FLUOROPYRIMIDINE. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2104509A1 true ES2104509A1 (en) | 1997-10-01 |
| ES2104509B1 ES2104509B1 (en) | 1998-07-01 |
Family
ID=8290727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9501182A Expired - Fee Related ES2104509B1 (en) | 1995-06-13 | 1995-06-13 | NEW COMPOUNDS DERIVED FROM 2- (3,4-DISSTITUTED-1-PIPERAZINYL) -5-FLUOROPYRIMIDINE. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2104509B1 (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7592450B2 (en) * | 2002-03-13 | 2009-09-22 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as inhibitors of histone deacetylase |
| US8071615B2 (en) | 2002-03-13 | 2011-12-06 | Janssen Pharmaceutica N.V. | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
| US8101616B2 (en) | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| US8114999B2 (en) | 2002-03-13 | 2012-02-14 | Janssen Pharmaceutica N.V. | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
| US8114876B2 (en) | 2006-01-19 | 2012-02-14 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| US8119650B2 (en) | 2006-01-19 | 2012-02-21 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as novel inhibitors of histone deacetylase |
| US8138198B2 (en) | 2005-05-18 | 2012-03-20 | Angibaud Patrick Rene | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
| US8163733B2 (en) | 2002-03-13 | 2012-04-24 | Janssen Pharmaceutica N.V. | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase |
| US8163765B2 (en) | 2006-01-19 | 2012-04-24 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| US9636341B2 (en) | 2004-07-28 | 2017-05-02 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2979508A (en) * | 1959-10-12 | 1961-04-11 | Paul A J Janssen | Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols |
| US2985657A (en) * | 1959-10-12 | 1961-05-23 | Paul A J Janssen | 1-(aroylalkyl)-4-heterocyclylpiperazines |
| FR2073326A1 (en) * | 1969-11-04 | 1971-10-01 | Sumitomo Chemical Co | |
| ES8607254A1 (en) * | 1984-03-06 | 1986-05-16 | Bristol Myers Co | Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives |
| EP0400661A1 (en) * | 1989-06-01 | 1990-12-05 | Bristol-Myers Squibb Company | Agents for treatment of brain ischemia |
-
1995
- 1995-06-13 ES ES9501182A patent/ES2104509B1/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2979508A (en) * | 1959-10-12 | 1961-04-11 | Paul A J Janssen | Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols |
| US2985657A (en) * | 1959-10-12 | 1961-05-23 | Paul A J Janssen | 1-(aroylalkyl)-4-heterocyclylpiperazines |
| FR2073326A1 (en) * | 1969-11-04 | 1971-10-01 | Sumitomo Chemical Co | |
| ES8607254A1 (en) * | 1984-03-06 | 1986-05-16 | Bristol Myers Co | Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives |
| EP0400661A1 (en) * | 1989-06-01 | 1990-12-05 | Bristol-Myers Squibb Company | Agents for treatment of brain ischemia |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8268833B2 (en) | 2002-03-13 | 2012-09-18 | Janssen Pharmaceutica, N.V. | Inhibitors of histone deacetylase |
| US8455498B2 (en) | 2002-03-13 | 2013-06-04 | Janssen Pharmaceutica N.V. | Inhibitors of histone deacetylase |
| US8501737B2 (en) | 2002-03-13 | 2013-08-06 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
| US8114999B2 (en) | 2002-03-13 | 2012-02-14 | Janssen Pharmaceutica N.V. | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
| US7592450B2 (en) * | 2002-03-13 | 2009-09-22 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as inhibitors of histone deacetylase |
| US9556161B2 (en) | 2002-03-13 | 2017-01-31 | Janssen Pharmaceutica Nv | Inhibitors of histone deacetylase |
| US8524711B2 (en) | 2002-03-13 | 2013-09-03 | Janssen Pharmaceutica N.V. | Amino-derivatives as novel inhibitors of histone deacetylase |
| US8163733B2 (en) | 2002-03-13 | 2012-04-24 | Janssen Pharmaceutica N.V. | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase |
| US8071615B2 (en) | 2002-03-13 | 2011-12-06 | Janssen Pharmaceutica N.V. | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
| US8513237B2 (en) | 2002-03-13 | 2013-08-20 | Janssen Pharmaceutica N.V. | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase |
| US8343988B2 (en) | 2002-03-13 | 2013-01-01 | Janssen Pharmaceutica, N.V | Inhibitors of histone deacetylase |
| US8394831B2 (en) | 2002-03-13 | 2013-03-12 | Janssen Pharmaceutica, N.V. | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
| US9636341B2 (en) | 2004-07-28 | 2017-05-02 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
| US8138198B2 (en) | 2005-05-18 | 2012-03-20 | Angibaud Patrick Rene | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
| US8114876B2 (en) | 2006-01-19 | 2012-02-14 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| US8163765B2 (en) | 2006-01-19 | 2012-04-24 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| US8664223B2 (en) | 2006-01-19 | 2014-03-04 | Janssen Pharmaceutica N.V | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| US8119650B2 (en) | 2006-01-19 | 2012-02-21 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as novel inhibitors of histone deacetylase |
| US8101616B2 (en) | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2104509B1 (en) | 1998-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19971001 Kind code of ref document: A1 Effective date: 19971001 |
|
| FD1A | Patent lapsed |
Effective date: 20020401 |