[go: up one dir, main page]

ES2103768T3 - Procedimiento de preparacion de derivados sustituidos de benzofurano. - Google Patents

Procedimiento de preparacion de derivados sustituidos de benzofurano.

Info

Publication number
ES2103768T3
ES2103768T3 ES91121073T ES91121073T ES2103768T3 ES 2103768 T3 ES2103768 T3 ES 2103768T3 ES 91121073 T ES91121073 T ES 91121073T ES 91121073 T ES91121073 T ES 91121073T ES 2103768 T3 ES2103768 T3 ES 2103768T3
Authority
ES
Spain
Prior art keywords
sub
group
preparation
benzofurano
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91121073T
Other languages
English (en)
Inventor
Angelo Bedeschi
Walter Cabri
Ilaria Candiani
Bernardinis Silvia De
Marcello Marchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of ES2103768T3 publication Critical patent/ES2103768T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Paper (AREA)
  • Saccharide Compounds (AREA)
  • Battery Electrode And Active Subsutance (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA LA PREPARACION DE UN PROCESO DE LA FORMULA (I) EN LA QUE UNA DE ENTRE R SUB 1 Y R SUB 2 ES HIDROGENO O HALOGENO Y LA OTRA ES INDEPENDIENTEMENTE, UN GRUPO AMINO O UN GRUPO AMINO ALCANOIL C SUB 2-C SUB 4; R SUB 3 ES HIDROGENO; UN ALQUIL LINEAL O RAMIFICADO, UN GRUPO ALQUILCARBONIL C SUB 2-C SUB 4 O ALCOXIDO C SUB 1-C SUB 4; HALOGENO O FENIL SUBSTITUIDO O INSUBSTITUIDO POR UN GRUPO ALQUIL C SUB 1-C SUB 4; A ES UN GRUPO -(CH SUB 2) SUB N-HET EN EL QUE HET ES UN ANILLO HETEROMONOCICLICO O HETEROBICICLICO OPCIONALMENTE SUBSTITUIDO QUE CONTIENE UNO O DOS ATOMOS DE NITROGENO Y N ES 0 O UN ENTERO ENTRE 1 Y 3; Y EL SIMBOLO ..... REPRESENTA UN ENLACE SIMPLE O DOBLE. ASI MISMO SE PRESENTAN LAS SALES FARMACEUTICAMENTE ACEPTABLES DEL COMPUESTO. EL COMPUESTO DE LA INVENCION PUEDE SER UTIL COMO ANTAGONISTA DEL RECEPTOR DEL 5HT3.
ES91121073T 1990-12-27 1991-12-09 Procedimiento de preparacion de derivados sustituidos de benzofurano. Expired - Lifetime ES2103768T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909028105A GB9028105D0 (en) 1990-12-27 1990-12-27 Process for the preparation of substituted benzofuran derivatives

Publications (1)

Publication Number Publication Date
ES2103768T3 true ES2103768T3 (es) 1997-10-01

Family

ID=10687632

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91121073T Expired - Lifetime ES2103768T3 (es) 1990-12-27 1991-12-09 Procedimiento de preparacion de derivados sustituidos de benzofurano.

Country Status (22)

Country Link
US (1) US5459161A (es)
EP (1) EP0496064B1 (es)
JP (1) JPH06504042A (es)
KR (1) KR930703309A (es)
AT (1) ATE152109T1 (es)
AU (1) AU653977B2 (es)
CA (1) CA2099107A1 (es)
DE (1) DE69125811T2 (es)
DK (1) DK0496064T3 (es)
ES (1) ES2103768T3 (es)
FI (1) FI932904A0 (es)
GB (1) GB9028105D0 (es)
GR (1) GR3023286T3 (es)
HU (1) HU212421B (es)
IE (1) IE914537A1 (es)
IL (1) IL100481A0 (es)
MX (1) MX9102808A (es)
NZ (1) NZ241157A (es)
PT (1) PT99930A (es)
RU (1) RU2098415C1 (es)
WO (1) WO1992012147A1 (es)
ZA (1) ZA9110125B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100432A (en) * 1990-12-27 1996-01-19 Erba Carlo Spa Dihydrobenzofuran carboxamide derivatives their preparation and pharmaceutical compositions containing them
WO1993016072A1 (en) * 1992-02-06 1993-08-19 Smithkline Beecham Plc Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
TW490465B (en) * 1994-11-24 2002-06-11 Janssen Pharmaceutica Nv Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
AR036041A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
EA007429B1 (ru) 2001-10-02 2006-10-27 Фармация Энд Апджон Компани Азабициклические замещённые конденсированные гетероарильные соединения
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
US7043077B2 (en) * 2001-11-07 2006-05-09 International Business Machines Corporation System and method for efficient compression of raster image data
CA2466344A1 (en) 2001-11-09 2003-05-22 Pharmacia & Upjohn Company Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands
CA2476624A1 (en) 2002-02-19 2003-08-28 Pharmacia & Upjohn Company Azabicyclic compounds for the treatment of disease
AU2003219690A1 (en) 2002-02-19 2003-09-09 Pharmacia And Upjohn Company Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
RU2429235C2 (ru) * 2009-01-26 2011-09-20 Государственное образовательное учреждение высшего профессионального образования "Ярославский государственный технический университет" Способ получения замещенных бензофуран-5,6-дикарбонитрилов
WO2017137910A1 (en) 2016-02-11 2017-08-17 Symed Labs Limited Processes for the preparation of highly pure prucalopride succinate and its intermediates

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984003281A1 (en) * 1983-02-19 1984-08-30 Beecham Group Plc Azabicycloalkyl benzamide and anilide derivatives
CA1297877C (en) * 1983-12-22 1992-03-24 Daniel Lednicer Benzofurancarboxamides useful as antiemetic or antipsychotic agents
US5175173A (en) * 1983-12-22 1992-12-29 Sun Jung Hui Carboxamides useful as antiemetic or antipsychotic agents
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
GB8508079D0 (en) * 1985-03-28 1985-05-01 Erba Farmitalia Antitumor anthracyclines
GB2196626B (en) * 1986-10-15 1990-09-19 Erba Farmitalia Antitumor anthracycline glycosides, their preparation, intermediates thereof, and compositions and use therefor
ZA886585B (en) * 1987-09-08 1990-05-30 Lilly Co Eli Specific 5-ht,antagonists
GB2212154B (en) * 1987-11-10 1991-03-27 Erba Carlo Spa New 4-demethoxy anthracycline derivatives
GB8803076D0 (en) * 1988-02-10 1988-03-09 Erba Carlo Spa 3'-deamino-4'-deoxy-4'-amino anthracyclines
GB8818167D0 (en) * 1988-07-29 1988-09-01 Erba Carlo Spa Novel 4-substituted anthracyclinones & process for their preparation
IL100432A (en) * 1990-12-27 1996-01-19 Erba Carlo Spa Dihydrobenzofuran carboxamide derivatives their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATE152109T1 (de) 1997-05-15
JPH06504042A (ja) 1994-05-12
RU2098415C1 (ru) 1997-12-10
NZ241157A (en) 1993-05-26
FI932904A7 (fi) 1993-06-23
IL100481A0 (en) 1992-09-06
GB9028105D0 (en) 1991-02-13
HUT67463A (en) 1995-04-28
MX9102808A (es) 1992-06-01
AU9111191A (en) 1992-08-17
HU9301878D0 (en) 1993-09-28
AU653977B2 (en) 1994-10-20
CA2099107A1 (en) 1992-06-28
GR3023286T3 (en) 1997-07-30
DK0496064T3 (es) 1997-05-20
HU212421B (en) 1996-06-28
EP0496064B1 (en) 1997-04-23
US5459161A (en) 1995-10-17
DE69125811T2 (de) 1997-08-07
FI932904A0 (fi) 1993-06-23
ZA9110125B (en) 1993-04-28
WO1992012147A1 (en) 1992-07-23
IE914537A1 (en) 1992-07-01
PT99930A (pt) 1993-01-29
KR930703309A (ko) 1993-11-29
DE69125811D1 (de) 1997-05-28
EP0496064A1 (en) 1992-07-29

Similar Documents

Publication Publication Date Title
ES2103768T3 (es) Procedimiento de preparacion de derivados sustituidos de benzofurano.
ES2150918T3 (es) 1h-imidazo(4,5-c)quinolin-4-aminas 1-sustituidas; compuestos intermedios y composiciones farmaceuticas.
ES2093753T3 (es) Derivados de estireno.
DK157552C (da) Analogifremgangsmaade til fremstilling af thieno (3,2-c) pyridinderivater
AR060598A1 (es) Derivados de anilino-pirimidina inhibidores de proteinquinasas de la ruta nf-kb
AR032072A1 (es) Derivados de quinuclidina novedosos y composiciones medicinales que los contienen
HRP20080052T3 (hr) Derivati tropana supstituirani imidazopiridinom santagonističkim djelovanjem na ccr5 receptor za liječenje hiv-a i upala
AR009413A1 (es) Un compuesto, el cual es un derivado de distamicina benzoheterociclico, su utilizacion, un procedimiento para producirlo y una composicionfarmaceutica que lo comprende
AR017189A1 (es) Antagonistas del receptor de trombina triciclico sustituido, composicion farmaceutica que lo contiene y su uso para la manufactura de un medicamento
AR012157A1 (es) Derivados de piridina, composiciones farmaceuticas que los contienen y procedimiento para la preparacion de dichos derivados.
MY101261A (en) New 4-pyridone derivatives, method of their production and their pharmaceutical compositions.
ES2115608T3 (es) Procedimiento para preparar derivados lactamicos.
ES2143630T3 (es) Derivados azabicicloalquilos de imidazo(1,5-a)indol-3-ona utilizados como antagonistas de 5ht3.
ES2070154T3 (es) Derivados de piridoindol y procedimientos para su preparacion.
DE3872722D1 (de) Indol-derivate.
PE86698A1 (es) Derivados de indolina
MX9305300A (es) Nuevos derivados de 3-oxadiazolil-1-6-naftiridina y proceso para supreparacion.
FI891807A0 (fi) Menetelmä terapeuttisesti aktiivisten oktahydropyrrolo-pyratsino/2,1-i/indol-2-oni-johdannaisten valmistamiseksi
ES506313A0 (es) Un procedimiento para la preparacion de derivados de benzo (4,5 pinano 2,3c) pirrol.
ES2038532B1 (es) Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol.
ES2019826A6 (es) Procedimiento de preparacion de derivados quinazolinos.
ES2032838T3 (es) Un procedimiento para preparar derivados tetrahidropirido (1,2-a)indol.
NO20053302D0 (no) Imidazolderivater med affinitet for alfa 2-reseptoraktivitet.
RU2007125692A (ru) Тетрагидропиридин-4-ил индолы с комбинацией свойств-сродства к допаминовым рецепторам d2 и центрами обратного захвата серотонина
UY24547A1 (es) Procedimiento para preparar derivados de quinolina

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 496064

Country of ref document: ES