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ES2103180A1 - Phenylacetamides having leukotriene-antagonistic action - Google Patents

Phenylacetamides having leukotriene-antagonistic action

Info

Publication number
ES2103180A1
ES2103180A1 ES09401695A ES9401695A ES2103180A1 ES 2103180 A1 ES2103180 A1 ES 2103180A1 ES 09401695 A ES09401695 A ES 09401695A ES 9401695 A ES9401695 A ES 9401695A ES 2103180 A1 ES2103180 A1 ES 2103180A1
Authority
ES
Spain
Prior art keywords
hydrogen
phenylacetamides
leukotriene
antagonistic action
chlorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09401695A
Other languages
Spanish (es)
Other versions
ES2103180B1 (en
Inventor
Casellas David Mauleon
Germano Carganico
Perez Maria Luisa Garcia
Torro M Desamoarados Fos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES9401695A priority Critical patent/ES2103180B1/en
Priority to AU32219/95A priority patent/AU3221995A/en
Priority to PCT/EP1995/002958 priority patent/WO1996004246A1/en
Publication of ES2103180A1 publication Critical patent/ES2103180A1/en
Application granted granted Critical
Publication of ES2103180B1 publication Critical patent/ES2103180B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Phenylacetamides of formula (I) wherein the substituent containing a -CONR<3>- is bound to the 3- or 4- position of the phenol system the substituent containing B is bound to the benzene ring at any free position R<1> is hydrogen, fluorine, chlorine or -OCH3 R<2> is hydrogen, fluorine, chlorine or bromine R<3> is hydrogen or methyl B is a 5-tetrazolyl group or -COOR<4>, wherein R<4> is hydrogen, a (C1-C4)-alkyl or a phenylalkyl group of less than 10 carbon atoms m and n are integers from 0 to 6, with the proviso that m + n is less or equal to 6 have leukotriene antagonistic action.
ES9401695A 1994-08-01 1994-08-01 PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. Expired - Fee Related ES2103180B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES9401695A ES2103180B1 (en) 1994-08-01 1994-08-01 PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES.
AU32219/95A AU3221995A (en) 1994-08-01 1995-07-26 Phenylacetamides having leukotriene-antagonistic action
PCT/EP1995/002958 WO1996004246A1 (en) 1994-08-01 1995-07-26 Phenylacetamides having leukotriene-antagonistic action

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9401695A ES2103180B1 (en) 1994-08-01 1994-08-01 PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES.

Publications (2)

Publication Number Publication Date
ES2103180A1 true ES2103180A1 (en) 1997-08-16
ES2103180B1 ES2103180B1 (en) 1998-04-01

Family

ID=8287120

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9401695A Expired - Fee Related ES2103180B1 (en) 1994-08-01 1994-08-01 PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES.

Country Status (3)

Country Link
AU (1) AU3221995A (en)
ES (1) ES2103180B1 (en)
WO (1) WO1996004246A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2117551B1 (en) * 1995-12-29 1999-04-01 Menarini Lab NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME.
FR2761687B1 (en) * 1997-04-08 2000-09-15 Centre Nat Rech Scient QUINOLEIN DERIVATIVES, ESPECIALLY HAVING ANTIVIRAL PROPERTIES, THEIR PREPARATIONS AND THEIR BIOLOGICAL APPLICATIONS
IT1320162B1 (en) * 2000-02-09 2003-11-18 Rotta Research Lab DERIVATIVES OF THYROSIN WITH ANTI LEUKOTRIENIC ACTIVITY, PROCEDURES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4579866A (en) * 1984-05-29 1986-04-01 Usv Pharmaceutical Corp. Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents
EP0315399A2 (en) * 1987-11-03 1989-05-10 Rhone-Poulenc Rorer International (Holdings) Inc. Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same
WO1989005294A1 (en) * 1987-12-01 1989-06-15 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis Substituted quinolines
EP0348155A1 (en) * 1988-06-21 1989-12-27 Rhone-Poulenc Rorer International (Holdings) Inc. Quinoline derivatives as antagonists of leukotriene D4, compositions containing the same and processes for their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3900261A1 (en) * 1988-05-31 1989-12-07 Bayer Ag SUBSTITUTED 4- (CHINOLIN-2-YL-METHOXY) PHENYL-ACETIC ACID DERIVATIVES
DE4129742A1 (en) * 1991-09-06 1993-03-11 Bayer Ag HETEROCYCLICALLY SUBSTITUTED CHINOLYLMETHOXY-PHENYLACETAMIDE

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4579866A (en) * 1984-05-29 1986-04-01 Usv Pharmaceutical Corp. Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents
EP0315399A2 (en) * 1987-11-03 1989-05-10 Rhone-Poulenc Rorer International (Holdings) Inc. Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same
WO1989005294A1 (en) * 1987-12-01 1989-06-15 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis Substituted quinolines
EP0348155A1 (en) * 1988-06-21 1989-12-27 Rhone-Poulenc Rorer International (Holdings) Inc. Quinoline derivatives as antagonists of leukotriene D4, compositions containing the same and processes for their preparation

Also Published As

Publication number Publication date
ES2103180B1 (en) 1998-04-01
WO1996004246A1 (en) 1996-02-15
AU3221995A (en) 1996-03-04

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Legal Events

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EC2A Search report published

Date of ref document: 19970816

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