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ES2102417T3 - 9-aminotetrahidroacridinas y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos. - Google Patents

9-aminotetrahidroacridinas y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos.

Info

Publication number
ES2102417T3
ES2102417T3 ES92102332T ES92102332T ES2102417T3 ES 2102417 T3 ES2102417 T3 ES 2102417T3 ES 92102332 T ES92102332 T ES 92102332T ES 92102332 T ES92102332 T ES 92102332T ES 2102417 T3 ES2102417 T3 ES 2102417T3
Authority
ES
Spain
Prior art keywords
low
elevated
hydrogen
alkyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92102332T
Other languages
English (en)
Inventor
Gregory Michael Shutske
Kevin James Kapples
John Dick Tomer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ES2102417T3 publication Critical patent/ES2102417T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/12—Organo silicon halides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A 9-AMINO-1, 2, 3, 4-TETRAHIDROACRIDINAS Y COMPUESTOS RELACIONADOS DE FORMULA 1, EN DONDE Y ES C=0 O CHOH; R ELEVADO 1 ES HIDROGENO O ALQUILO BAJO; R (AL CUADRADO) ES HIDROGENO, ALQUILO BAJO, O FENILBAJOALQUILO; R ELEVADO 3 ES HIDROGENO, OR ELEVADO 4 EN DONDE R ELEVADO 4 ES HIDROGENO O COR ELEVADO 5 ES ALQUILO BAJO; X ES HIDROGENO, ALQUILO BAJO, HALOGENO, ALCOXI BAJO, HIDROXI, O TRIFLUORMETIL, SUS ISOMEROS OPTICOS O GEOMETRICOS, N-OXIDOS DE LOS ANTERIORES, O LAS SALES DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLE DE LO ANTERIOR, QUE SON UTILES EN EL ALIVIO DE LAS DISFUNCIONES DE LA MEMORIA Y SON, POR LO TANTO INDICADAS EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER. ESTA INVENCION ADEMAS SE REFIERE A UN PROCESO PARA LA PREPARACION DE LOS COMPUESTOS ANTERIORES.
ES92102332T 1991-02-13 1992-02-12 9-aminotetrahidroacridinas y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos. Expired - Lifetime ES2102417T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/654,691 US5210087A (en) 1991-02-13 1991-02-13 9-aminotetrahydroacridines and related compounds

Publications (1)

Publication Number Publication Date
ES2102417T3 true ES2102417T3 (es) 1997-08-01

Family

ID=24625869

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92102332T Expired - Lifetime ES2102417T3 (es) 1991-02-13 1992-02-12 9-aminotetrahidroacridinas y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos.

Country Status (25)

Country Link
US (3) US5210087A (es)
EP (1) EP0499231B1 (es)
JP (1) JPH07121915B2 (es)
KR (1) KR100223132B1 (es)
AT (1) ATE153331T1 (es)
AU (1) AU664165B2 (es)
BR (1) BR9200475A (es)
CA (1) CA2061084A1 (es)
CZ (1) CZ281927B6 (es)
DE (1) DE69219801T2 (es)
DK (1) DK0499231T3 (es)
ES (1) ES2102417T3 (es)
FI (2) FI96308C (es)
GR (1) GR3024310T3 (es)
HU (1) HU219451B (es)
IE (1) IE920459A1 (es)
IL (3) IL117795A (es)
MX (1) MX9200607A (es)
NO (1) NO177933C (es)
NZ (3) NZ241586A (es)
PL (6) PL168906B1 (es)
RO (1) RO112354B1 (es)
RU (1) RU2083564C1 (es)
TW (1) TW221426B (es)
ZA (1) ZA921004B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210087A (en) * 1991-02-13 1993-05-11 Hoechst-Roussel Pharmaceuticals Inc. 9-aminotetrahydroacridines and related compounds
GB2264707A (en) * 1991-06-18 1993-09-08 Roger Michael Marchbanks Acridine derivatives for treating alzheimer's disease
ES2059263B1 (es) * 1992-10-27 1995-10-01 Vita Invest Sa Procedimiento para la obtencion del (+)-9-amino-1,2,3,4-tetrahidroacridin-1-ol.
US5434170A (en) * 1993-12-23 1995-07-18 Andrulis Pharmaceuticals Corp. Method for treating neurocognitive disorders
ES2144353B1 (es) * 1997-12-26 2001-01-01 Consejo Superior Investigacion Nuevos analogos de tacrina: potenciales agentes neuroprotectores para las enfermedades de alzheimer y parkinson. su procedimiento de obtencion.
DE19830105C1 (de) * 1998-07-06 2000-02-17 Gruenenthal Gmbh Acridinderivate
WO2003076419A1 (en) 2002-03-08 2003-09-18 Japan Science And Technology Agency Isoxazole derivatives and process for producing the same
RU2616247C1 (ru) * 2016-03-28 2017-04-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Осетинский государственный университет имени Коста Левановича Хетагурова" (СОГУ) Твердая лекарственная форма, обладающая холинопозитивным действием, на основе 9-бутиламино-3,3-диметил-1,2,4-тригидроакридина

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3232945A (en) * 1962-08-13 1966-02-01 S E Massengill Company 7,8,9,10-tetrahalo-6h-cyclohepta-(b)-quinolines
US4631286A (en) * 1984-10-25 1986-12-23 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
DE3582995D1 (de) * 1984-10-25 1991-07-04 Hoechst Roussel Pharma 9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives
MX13270A (es) * 1987-10-05 1993-06-01 Pfizer Procedimiento para la preparacion de derivados de 4-aminopiridina
GB8827704D0 (en) * 1988-11-28 1988-12-29 Fujisawa Pharmaceutical Co New acridine derivatives & processes for their production
US5441727A (en) * 1989-06-21 1995-08-15 The Procter & Gamble Company Diketone deodorant composition and method of deodorization
US5053513A (en) * 1990-03-29 1991-10-01 Hoechst-Roussel Pharmaceuticals Incorporated Method of reducing a carbonyl containing acridine
US5210087A (en) * 1991-02-13 1993-05-11 Hoechst-Roussel Pharmaceuticals Inc. 9-aminotetrahydroacridines and related compounds
GB2264707A (en) * 1991-06-18 1993-09-08 Roger Michael Marchbanks Acridine derivatives for treating alzheimer's disease

Also Published As

Publication number Publication date
DE69219801D1 (de) 1997-06-26
PL168153B1 (pl) 1996-01-31
DE69219801T2 (de) 1997-11-27
IE920459A1 (en) 1992-08-12
AU664165B2 (en) 1995-11-09
PL293443A1 (en) 1993-03-08
NZ260694A (en) 1996-02-27
RU2083564C1 (ru) 1997-07-10
JPH07121915B2 (ja) 1995-12-25
HUT67032A (en) 1995-01-30
NO920547D0 (no) 1992-02-12
HU219451B (hu) 2001-04-28
NZ270647A (en) 1996-02-27
ATE153331T1 (de) 1997-06-15
FI945854L (fi) 1994-12-13
IL100921A (en) 1998-12-27
PL168862B1 (pl) 1996-04-30
NZ241586A (en) 1996-02-27
TW221426B (es) 1994-03-01
NO920547L (no) 1992-08-14
PL169095B1 (pl) 1996-05-31
RO112354B1 (ro) 1997-08-29
FI945854A0 (fi) 1994-12-13
HU9200423D0 (en) 1992-04-28
NO177933B (no) 1995-09-11
FI96308B (fi) 1996-02-29
PL166939B1 (pl) 1995-07-31
US5502203A (en) 1996-03-26
BR9200475A (pt) 1992-10-20
NO177933C (no) 1995-12-20
CS42692A3 (en) 1992-09-16
FI97056B (fi) 1996-06-28
CA2061084A1 (en) 1992-08-14
EP0499231B1 (en) 1997-05-21
US5382594A (en) 1995-01-17
JPH04312578A (ja) 1992-11-04
ZA921004B (en) 1992-10-28
FI97056C (fi) 1996-10-10
PL296320A1 (en) 1993-07-12
GR3024310T3 (en) 1997-10-31
AU1090392A (en) 1992-08-20
IL117795A0 (en) 1996-08-04
DK0499231T3 (da) 1997-12-01
PL168906B1 (pl) 1996-05-31
FI96308C (fi) 1996-06-10
FI920566L (fi) 1992-08-14
PL296319A1 (en) 1993-07-12
US5210087A (en) 1993-05-11
IL117795A (en) 1998-01-04
EP0499231A1 (en) 1992-08-19
KR920016426A (ko) 1992-09-24
MX9200607A (es) 1992-11-30
FI920566A0 (fi) 1992-02-11
PL168861B1 (pl) 1996-04-30
CZ281927B6 (cs) 1997-04-16
KR100223132B1 (ko) 1999-10-15

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