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ES2101306T3 - Procedimiento para la obtencion de vitamina e. - Google Patents

Procedimiento para la obtencion de vitamina e.

Info

Publication number
ES2101306T3
ES2101306T3 ES93906485T ES93906485T ES2101306T3 ES 2101306 T3 ES2101306 T3 ES 2101306T3 ES 93906485 T ES93906485 T ES 93906485T ES 93906485 T ES93906485 T ES 93906485T ES 2101306 T3 ES2101306 T3 ES 2101306T3
Authority
ES
Spain
Prior art keywords
acid
procedure
mixture
transformation
obtaining vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93906485T
Other languages
English (en)
Inventor
Paul Grafen
Hans Kiefer
Hagen Jaedicke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2101306T3 publication Critical patent/ES2101306T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCESO PARA LA ELABORACION DE DL-ALFA-TOCOFEROL O DL-ALFAACETATO TOCOFERIL A TRAVES DE TRANSFORMACION CATALIZADA ACIDA DE 2,3,5 TRIMETILHIDROQUINONA (TMH) CON CITOL O ISOCITOL EN UN DISOLVENTE EN TEMPERATURA ELEVADA Y EVENTUALMENTE ESTERIFICACION A CONTINUACION DEL TOCOFEROL OBTENIDO CON ACETANHIDRIDO, QUE ESTA CARACTERIZADO, PORQUE LA TRANSFORMACION SE REALIZA EN PRESENCIA DE UNA MEZCLA DE ACIDO ORTOBORICO Y ACIDOS DI O TRICARBOXILICIOS ALIFATICOS DETERMINADOS, CON PREFERENCIA EN PRESENCIA DE UNA MEZCLA DE ACIDO ORTOBORICO Y ACIDO AXALICO.
ES93906485T 1992-03-17 1993-03-05 Procedimiento para la obtencion de vitamina e. Expired - Lifetime ES2101306T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4208477A DE4208477A1 (de) 1992-03-17 1992-03-17 Verfahren zur herstellung von vitamin e

Publications (1)

Publication Number Publication Date
ES2101306T3 true ES2101306T3 (es) 1997-07-01

Family

ID=6454252

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93906485T Expired - Lifetime ES2101306T3 (es) 1992-03-17 1993-03-05 Procedimiento para la obtencion de vitamina e.

Country Status (10)

Country Link
US (1) US5468883A (es)
EP (1) EP0631577B1 (es)
JP (1) JP2550288B2 (es)
CA (1) CA2091729C (es)
CZ (1) CZ281829B6 (es)
DE (2) DE4208477A1 (es)
ES (1) ES2101306T3 (es)
HU (1) HU214095B (es)
SK (1) SK112094A3 (es)
WO (1) WO1993019057A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3416281B2 (ja) * 1994-04-12 2003-06-16 エーザイ株式会社 α−トコフェロール誘導体の製造方法および触媒
US5663376A (en) † 1994-07-27 1997-09-02 Eisai Co., Ltd. Process for the preparation of α-tocopherol
DE19524928A1 (de) * 1995-07-08 1997-01-09 Basf Ag Verfahren zur Rektifikation von Gemischen hochsiedender luft- und/oder temperaturempfindlicher Substanzen, die eine hohe Trennleistung erfordern, im Feinvakuum, sowie für dieses Verfahren geeignete Kolonnen
US5886196A (en) * 1996-01-12 1999-03-23 Roche Vitamins Inc. Method of catalyzing condensation reactions
RU2163600C2 (ru) * 1998-12-04 2001-02-27 Общество с ограниченной ответственностью конструкторское бюро "Пульс" СПОСОБ ПОЛУЧЕНИЯ α-ТОКОФЕРОЛА (ВИТАМИНА E)
DE10011403A1 (de) * 2000-03-09 2001-09-13 Degussa Verfahren zur Herstellung von alpha-Tocopherolacetat durch Kondensation von Trimethylhydrochinon mit Isophytol unter Recyclierung einer essigsauren Katalysatorlösung
US6784303B2 (en) 2000-11-22 2004-08-31 Basf Aktiengesellschaft Method for continuously acylating chromanol ester derivatives
DE10135714A1 (de) * 2001-07-21 2003-02-06 Basf Ag Verbessertes Verfahren zur Aufarbeitung eines Vitamin-E-Acetat-haltigen Produktstromes
EP2269998A3 (en) 2004-08-19 2011-03-30 DSM IP Assets B.V. Process for the rectification of mixtures of high-boiling air- and/or temperature-sensitive useful products
CN101006070B (zh) * 2004-08-19 2012-11-07 帝斯曼知识产权资产管理有限公司 包含维生素e和维生素e乙酸酯的混合物或产品流的整理方法
DE102005013103A1 (de) 2005-03-18 2006-09-28 Sms Demag Ag Kontrollierte Dickenreduktion bei schmelztauchbeschichtetem warmgewalztem Stahlband und hierbei eingesetzte Anlage
CN106478581A (zh) * 2016-08-30 2017-03-08 芜湖华海生物工程有限公司 一种维生素e醋酸酯的制备方法
CN113083339B (zh) * 2021-04-15 2022-11-08 万华化学(四川)有限公司 一种用于制备维生素e的催化剂及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459773A (en) * 1966-12-27 1969-08-05 Takasago Perfumery Co Ltd Process for producing alpha-tocopherol and its esters
US3708505A (en) * 1971-02-25 1973-01-02 Diamond Shamrock Corp Process for preparation of d,l-alpha tocopherol
BE810299A (fr) * 1974-01-29 1974-05-16 Procede de fabrication de composes contenant un noyau chromane.
JPS6019309B2 (ja) * 1976-09-29 1985-05-15 日清製粉株式会社 高純度ｄｌ−α−トコフエロ−ルの製造法
US4217285A (en) * 1976-09-29 1980-08-12 Nisshin Flour Milling Co., Ltd. Process for the preparation of Dl-α-tocopherol of high purity
DE3367100D1 (en) * 1982-07-29 1986-11-27 Basf Wyandotte Corp Alpha tocopherol process

Also Published As

Publication number Publication date
EP0631577A1 (de) 1995-01-04
SK112094A3 (en) 1995-04-12
DE4208477A1 (de) 1993-09-23
US5468883A (en) 1995-11-21
CZ281829B6 (cs) 1997-02-12
WO1993019057A1 (de) 1993-09-30
JPH07507274A (ja) 1995-08-10
HU214095B (hu) 1998-03-02
DE59306604D1 (de) 1997-07-03
HUT71257A (en) 1995-11-28
CZ225094A3 (en) 1995-04-12
HU9402669D0 (en) 1995-02-28
CA2091729C (en) 1999-11-23
JP2550288B2 (ja) 1996-11-06
EP0631577B1 (de) 1997-05-28
CA2091729A1 (en) 1993-09-18

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