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ES2196207T3 - Antagonista heterociclicos de bradicinina sustituidos con fluoroalquilo y fluoroalcoxi. - Google Patents

Antagonista heterociclicos de bradicinina sustituidos con fluoroalquilo y fluoroalcoxi.

Info

Publication number
ES2196207T3
ES2196207T3 ES97103611T ES97103611T ES2196207T3 ES 2196207 T3 ES2196207 T3 ES 2196207T3 ES 97103611 T ES97103611 T ES 97103611T ES 97103611 T ES97103611 T ES 97103611T ES 2196207 T3 ES2196207 T3 ES 2196207T3
Authority
ES
Spain
Prior art keywords
sup
rent
sub
replaced
fluoroalquilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97103611T
Other languages
English (en)
Inventor
Adalbert Dr Wagner
Holger Dr Heitsch
Gerhard Dr Nolkne
Klaus Dr Wirth
Prof-Dr Bernard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2196207T3 publication Critical patent/ES2196207T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D257/12—Six-membered rings having four nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBEN FLUORALQUIDERIVADOS Y FLUORALCOXIDERIVADOS HETEROCICLICOS CON LA FORMULA (I) CON EFECTO ANTAGONISTA DE LA BRADIQUININA, DONDE X{SUB,1}-X{SUB,3}N O CR{SUP,5}, R{SUP,1} Y R{SUP,2} SIGNIFICAN H O HALOGENO, R{SUP,3} Y R{SUP,4} H, HALOGENO, ALQUILO O ALQUENILO, R{SUP,5} H, HALOGENO, ALQUILO (SUSTITUIDO), OR{SUP,6}, S-R{SUP,6}, NHR{SUP,6}, ARILO (SUSTITUIDO), ARILALQUILO (SUSTITUIDO), - C(O) - OR{SUP,6} O - C(O) - H, R{SUP,6} Y R{SUP,8} H, ALQUILO, ALQUENILO O ARIL - ALQUILO, R{SUP,7} ALQUILO (SUSTITUIDO) O ALCOXI (SUSTITUIDO), B UN GRUPO AMINOCARBOXILICO, D ALQUENDIILO, ALCANDIILO O (CH{SUB,2}){SUB,N} - Y{SUB,P} - (CH{SUB,2}){SUB,M} -, E OXIGENO O AZUFRE, Y OXIGENO, AZUFRE O NR{SUP,8}, N Y M UN NUMERO DE 0 A 3, O UN NUMERO DE 1 A 3 Y P 0 O 1, ASI COMO SUS SALES FISIOLOGICAMENTE TOLERABLES Y UN METODO PARA SU PREPARACION.
ES97103611T 1996-03-19 1997-03-05 Antagonista heterociclicos de bradicinina sustituidos con fluoroalquilo y fluoroalcoxi. Expired - Lifetime ES2196207T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19610784A DE19610784A1 (de) 1996-03-19 1996-03-19 Fluoralkyl- und Fluoralkoxysubstituierte heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung

Publications (1)

Publication Number Publication Date
ES2196207T3 true ES2196207T3 (es) 2003-12-16

Family

ID=7788755

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97103611T Expired - Lifetime ES2196207T3 (es) 1996-03-19 1997-03-05 Antagonista heterociclicos de bradicinina sustituidos con fluoroalquilo y fluoroalcoxi.

Country Status (24)

Country Link
US (1) US5859025A (es)
EP (1) EP0796848B1 (es)
JP (1) JP4199315B2 (es)
KR (1) KR970065522A (es)
AR (1) AR006261A1 (es)
AT (1) ATE242215T1 (es)
AU (1) AU1628397A (es)
BR (1) BR9701332A (es)
CA (1) CA2199925A1 (es)
CZ (1) CZ81097A3 (es)
DE (2) DE19610784A1 (es)
DK (1) DK0796848T3 (es)
ES (1) ES2196207T3 (es)
HR (1) HRP970155A2 (es)
HU (1) HUP9700595A1 (es)
ID (1) ID16274A (es)
IL (1) IL120477A0 (es)
NO (1) NO971238L (es)
PL (1) PL318924A1 (es)
PT (1) PT796848E (es)
SI (1) SI0796848T1 (es)
SK (1) SK34897A3 (es)
TR (1) TR199700206A2 (es)
ZA (1) ZA972328B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19712960A1 (de) * 1997-03-27 1998-10-01 Hoechst Ag Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten
ES2211460T3 (es) * 1999-12-10 2004-07-16 Pfizer Inc. Compuestos de 1,4-dihidropiridina sustituidos con un heteroalrilo de 5 miembros como antagonistas de la bradiquinina.
CA2481855A1 (en) 2002-04-10 2003-10-23 Ortho-Mcneil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
EP1914236A1 (en) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
ITMI20021247A1 (it) * 2002-06-07 2003-12-09 Menarini Ricerche Spa Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche
US7256207B2 (en) * 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
JP2008531709A (ja) 2005-03-01 2008-08-14 ワイス シンノリン化合物および肝臓ｘ受容体調節物質としてのそれらの使用
TWI407960B (zh) 2007-03-23 2013-09-11 Jerini Ag 小分子緩激肽ｂ２受體調節劑
AR085073A1 (es) * 2012-01-11 2013-09-11 Richmond Sa Com Ind Y Financiera Lab Compuestos con actividad antibacteriana, un procedimiento para su obtencion y composiciones farmaceuticas que los comprenden
LT3713928T (lt) 2017-11-24 2022-05-10 Pharvaris Netherlands B.V. Nauji bradikinino b2 receptoriaus antagonistai
AR118982A1 (es) 2019-05-23 2021-11-17 Pharvaris Gmbh Antagonistas cíclicos del receptor b2 de bradiquinina
UY38707A (es) 2019-05-23 2020-12-31 Pharvaris Gmbh Nuevos antagonistas cíclicos del receptor b2 de bradiquinina
MX2024001711A (es) 2021-08-05 2024-03-05 Pharvaris Gmbh Composición lípidica para la administración oral de antagonistas del receptor de bradicinina b2.
TW202345810A (zh) 2022-03-25 2023-12-01 瑞士商帕法瑞斯有限責任公司 包含緩激肽ｂ２受體拮抗劑之固態延長釋放組成物
EP4499100A1 (en) 2022-03-25 2025-02-05 Pharvaris GmbH Therapeutic uses of bradykinin b2-receptor antagonists
IL315699A (en) 2022-03-25 2024-11-01 Pharvaris Gmbh A solid composition comprising dissolved bradykinin B2 receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216165A (en) * 1990-10-03 1993-06-01 American Home Products Corporation N-substituted aminoquinolines as analgesic agents
US5212182A (en) * 1990-10-03 1993-05-18 American Home Products Corpooration Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics
US5438064A (en) * 1991-12-23 1995-08-01 American Home Products Corporation Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic agents
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
WO1996005202A1 (en) * 1994-08-17 1996-02-22 Nippon Hypox Laboratories Inc. Imidazoquinoline derivative
KR970707098A (ko) * 1994-10-27 1997-12-01 후지야마 아키라 브라디키닌 길항제로서 피리도피리미돈, 퀴놀린 및 융합된 N-헤테로사이클(Pyridopyrimidones, quinolines and fused N-heterocycles as bradykinin antagonists)

Also Published As

Publication number Publication date
CZ81097A3 (en) 1997-10-15
EP0796848B1 (de) 2003-06-04
JP4199315B2 (ja) 2008-12-17
HU9700595D0 (en) 1997-05-28
ID16274A (id) 1997-09-18
DK0796848T3 (da) 2003-09-22
TR199700206A2 (xx) 1997-10-21
JPH107656A (ja) 1998-01-13
PL318924A1 (en) 1997-09-29
DE59710191D1 (de) 2003-07-10
AU1628397A (en) 1997-09-25
SK34897A3 (en) 1998-01-14
ATE242215T1 (de) 2003-06-15
HUP9700595A1 (hu) 2000-08-28
HRP970155A2 (en) 1998-04-30
IL120477A0 (en) 1997-07-13
NO971238L (no) 1997-09-22
PT796848E (pt) 2003-08-29
BR9701332A (pt) 1998-08-18
US5859025A (en) 1999-01-12
ZA972328B (en) 1997-09-19
NO971238D0 (no) 1997-03-18
EP0796848A1 (de) 1997-09-24
CA2199925A1 (en) 1997-09-19
MX9702028A (es) 1997-09-30
SI0796848T1 (en) 2003-12-31
AR006261A1 (es) 1999-08-11
KR970065522A (ko) 1997-10-13
DE19610784A1 (de) 1997-09-25

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