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ES2196263T3 - Agente antihipertension. - Google Patents

Agente antihipertension.

Info

Publication number
ES2196263T3
ES2196263T3 ES97305820T ES97305820T ES2196263T3 ES 2196263 T3 ES2196263 T3 ES 2196263T3 ES 97305820 T ES97305820 T ES 97305820T ES 97305820 T ES97305820 T ES 97305820T ES 2196263 T3 ES2196263 T3 ES 2196263T3
Authority
ES
Spain
Prior art keywords
antihipertension
agent
effective amount
pro
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97305820T
Other languages
English (en)
Inventor
Naoyuki Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Soft Drinks Co Ltd
Original Assignee
Calpis Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calpis Co Ltd filed Critical Calpis Co Ltd
Application granted granted Critical
Publication of ES2196263T3 publication Critical patent/ES2196263T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

SE DESCRIBE UN AGENTE ANTIHIPERTENSOR QUE CONTIENE UNA CANTIDAD EFICAZ DEL DIPEPTIDO TYR MENTE ACEPTABLE DEL MISMO, SIENDO LA CANTIDAD EFICAZ DESDE 0,05 A 10 MG/KG DE PESO CORPORAL/DIA, Y UN PROCEDIMIENTO PARA PRODUCIR EL MISMO.
ES97305820T 1996-08-02 1997-08-01 Agente antihipertension. Expired - Lifetime ES2196263T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20466596 1996-08-02

Publications (1)

Publication Number Publication Date
ES2196263T3 true ES2196263T3 (es) 2003-12-16

Family

ID=16494265

Family Applications (2)

Application Number Title Priority Date Filing Date
ES02080463T Expired - Lifetime ES2291417T3 (es) 1996-08-02 1997-08-01 Metodo para preparar un agente antihipertensor que contiene un dipeptido como ingrediente activo.
ES97305820T Expired - Lifetime ES2196263T3 (es) 1996-08-02 1997-08-01 Agente antihipertension.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES02080463T Expired - Lifetime ES2291417T3 (es) 1996-08-02 1997-08-01 Metodo para preparar un agente antihipertensor que contiene un dipeptido como ingrediente activo.

Country Status (8)

Country Link
US (1) US5854029A (es)
EP (2) EP1302207B1 (es)
JP (2) JP3364579B2 (es)
AT (2) ATE238825T1 (es)
DE (2) DE69721407T2 (es)
DK (2) DK1302207T3 (es)
ES (2) ES2291417T3 (es)
PT (1) PT1302207E (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998259B1 (en) 1999-05-20 2006-02-14 Davisco Foods International Enzymatic treatment of whey proteins for the production of antihypertensive peptides and the resulting products
US6630320B1 (en) 2000-05-08 2003-10-07 Devisco Foods International, Inc. Treatment of hypertension in mammals with hydrolyzed whey proteins
FI113741B (fi) * 1999-11-01 2004-06-15 Valio Oy Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi
TWI225070B (en) 1999-12-01 2004-12-11 Food Industry Res & Dev Inst Novel peptides used as angiotensin converting enzyme inhibitor and preparation process thereof
WO2001068114A1 (en) * 2000-03-10 2001-09-20 Monsanto Company Novel peptides with anti-hypertensive activity
WO2001068113A1 (en) * 2000-03-10 2001-09-20 Monsanto Technology Llc Anti-hypertensive peptides
JP2004519204A (ja) * 2000-05-08 2004-07-02 ダビスコ フーズ インターナショナル インコーポレーテッド 抗高血圧ペプチドの生成のための乳漿タンパク質の酵素処理、得られた産物、および哺乳動物における高血圧の処置
WO2004015125A1 (en) 2002-08-09 2004-02-19 Chr. Hansen A/S Process for preparing peptides with anti-hypertensive properties
US7718171B2 (en) 2003-04-07 2010-05-18 Chr. Hansen A/S Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
EP1466529A1 (en) * 2003-04-07 2004-10-13 Chr. Hansen A/S Composition with heart rate reducing properties
JP4680571B2 (ja) * 2003-12-25 2011-05-11 カルピス株式会社 経口摂取用保湿剤
CA2577613C (en) 2004-09-03 2015-12-15 Chr. Hansen A/S Fermented milk or vegetable proteins comprising receptor ligand and uses thereof
JP4868619B2 (ja) * 2005-09-05 2012-02-01 独立行政法人農業・食品産業技術総合研究機構 ビタミンＵ、タウリン、カルノシン、Ｔｙｒ−Ｐｒｏおよび／またはＬ−カルニチンを高濃度に含有する食用植物体及びその製造方法
JP4635159B2 (ja) * 2005-09-05 2011-02-16 独立行政法人農業・食品産業技術総合研究機構 Ｇａｂａを高濃度に含有する食用植物体及びその製造方法
EP2161029A1 (en) * 2008-09-09 2010-03-10 Unilever N.V. Composition comprising peptides
DE602008004345D1 (de) * 2008-09-09 2011-02-17 Unilever Nv Nahrungsmittel enthaltend Dipeptide mit blutdrucksenkenden Eigenschaften.
WO2010110439A1 (ja) * 2009-03-27 2010-09-30 カルピス株式会社 自律神経活動調節用組成物および自律神経を調節する方法
WO2012063826A1 (ja) * 2010-11-09 2012-05-18 カルピス株式会社 高タンパク質分解活性を有するラクトバチルス・ヘルベティカス菌
US8673862B1 (en) 2012-09-06 2014-03-18 Food Industry Research And Development Institute Peptides and use thereof in the inhibition of angiotensin converting enzyme
US10780127B2 (en) 2016-06-23 2020-09-22 National University Corporation Tottori University Method for producing fermented milk having high angiotensin converting enzyme inhibitory activity and method for producing physiologically active peptide
JP7453665B2 (ja) * 2019-01-29 2024-03-21 国立大学法人鳥取大学 ジペプチジルペプチダーゼｉｖ阻害活性が高い発酵乳およびその製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3047596A1 (de) * 1980-12-17 1982-07-22 Victor Dipl.- Chem. 8000 München Brantl Pharmakologisch aktive dipeptide
JP3782837B2 (ja) * 1995-04-10 2006-06-07 カルピス株式会社 血圧降下剤及びその製造法

Also Published As

Publication number Publication date
JP4713053B2 (ja) 2011-06-29
DE69721407T2 (de) 2004-05-06
EP0821968A2 (en) 1998-02-04
EP0821968A3 (en) 1999-07-14
ATE374617T1 (de) 2007-10-15
PT1302207E (pt) 2007-11-08
DK1302207T3 (da) 2007-11-05
EP1302207B1 (en) 2007-10-03
DK0821968T3 (da) 2003-06-02
DE69738185D1 (de) 2007-11-15
US5854029A (en) 1998-12-29
EP0821968B1 (en) 2003-05-02
DE69738185T2 (de) 2008-07-10
DE69721407D1 (de) 2003-06-05
ES2291417T3 (es) 2008-03-01
ATE238825T1 (de) 2003-05-15
EP1302207A2 (en) 2003-04-16
EP1302207A3 (en) 2003-04-23
JP3364579B2 (ja) 2003-01-08
JP2003048849A (ja) 2003-02-21
JPH1095736A (ja) 1998-04-14

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