ES2196026T3 - Uso de ndv en la fabricacion de un medicamento para tratar el cancer. - Google Patents
Uso de ndv en la fabricacion de un medicamento para tratar el cancer.Info
- Publication number
- ES2196026T3 ES2196026T3 ES94916604T ES94916604T ES2196026T3 ES 2196026 T3 ES2196026 T3 ES 2196026T3 ES 94916604 T ES94916604 T ES 94916604T ES 94916604 T ES94916604 T ES 94916604T ES 2196026 T3 ES2196026 T3 ES 2196026T3
- Authority
- ES
- Spain
- Prior art keywords
- ndv
- manufacture
- treat cancer
- medicinal product
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 241000711404 Avian avulavirus 1 Species 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/17—Newcastle disease virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION PROPORCIONA UN METODO DE TRATAMIENTO DE CANCER EN UN MAMIFERO QUE COMPRENDE LA ADMINISTRACION AL MAMIFERO DE UNA CANTIDAD EFECTIVA DE VIRUS, PARTICULARMENTE VIRUS DE LA ENFERMEDAD DE NEWCASTLE O OTROS PARAMIXOVIRUS. LA INVENCION ADEMAS PROPORCIONA UN METODO DE TRATAMIENTO DE CANCER EN UN MAMIFERO QUE COMPRENDE LA ADMINISTRACION DE TALES VIRUS AL MAMIFERO EN COMBINACION CON OTRO AGENTE COMO UN COMPUESTO QUIMIOTERAPEUTICO, INMUNOADYUVANTE, CITOQUINA O AGENTE INMUNOSUPRESOR. LA INVENCION PROPORCIONA ADEMAS UN METODO DE DETECCION DE CELULAS CANCERIGENAS EN UN MAMIFERO UTILIZANDO PARAMIXOVIRUS COMO UN AGENTE DE PRESENTACION Y COMO UN INDICADOR DEL CRECIMIENTO DE CELULAS CANCERIGENAS EN EL MAMIFERO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5551993A | 1993-04-30 | 1993-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2196026T3 true ES2196026T3 (es) | 2003-12-16 |
Family
ID=21998395
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94916604T Expired - Lifetime ES2196026T3 (es) | 1993-04-30 | 1994-04-29 | Uso de ndv en la fabricacion de un medicamento para tratar el cancer. |
| ES02026340T Expired - Lifetime ES2310580T3 (es) | 1993-04-30 | 1994-04-29 | Composiciones purificadas del virus de la enfermedad de newcastle. |
| ES04017349T Expired - Lifetime ES2315595T3 (es) | 1993-04-30 | 1994-04-29 | Composiciones para tratar cancer con uso de virus. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02026340T Expired - Lifetime ES2310580T3 (es) | 1993-04-30 | 1994-04-29 | Composiciones purificadas del virus de la enfermedad de newcastle. |
| ES04017349T Expired - Lifetime ES2315595T3 (es) | 1993-04-30 | 1994-04-29 | Composiciones para tratar cancer con uso de virus. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7056689B1 (es) |
| EP (4) | EP2009119A1 (es) |
| JP (3) | JP4338781B2 (es) |
| AT (3) | ATE401092T1 (es) |
| AU (1) | AU699487B2 (es) |
| CA (1) | CA2161671A1 (es) |
| DE (3) | DE69435118D1 (es) |
| DK (3) | DK1314431T3 (es) |
| ES (3) | ES2196026T3 (es) |
| HK (1) | HK1052871A1 (es) |
| PT (3) | PT1486211E (es) |
| WO (1) | WO1994025627A1 (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1486211E (pt) * | 1993-04-30 | 2009-02-02 | Wellstat Biologics Corp | Composições para tratamento do cancro utilizando vírus |
| US20030044384A1 (en) | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US7470426B1 (en) | 1997-10-09 | 2008-12-30 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
| US7780962B2 (en) | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| NZ518945A (en) | 1997-10-09 | 2007-03-30 | Wellstat Biologics Corp | Treatment of neoplasms with viruses |
| FR2788099B1 (fr) | 1999-01-06 | 2001-02-09 | Vallourec Mannesmann Oil & Gas | Assemblage filete de deux tubes metalliques a couple eleve de vissage |
| AU2005201079C1 (en) * | 1999-04-15 | 2008-11-06 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
| AU4246900A (en) * | 1999-04-15 | 2000-11-02 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US8147822B1 (en) | 1999-09-17 | 2012-04-03 | Wellstat Biologics Corporation | Oncolytic virus |
| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
| US7306902B2 (en) | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
| AR028039A1 (es) | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas |
| US8491884B2 (en) | 2000-05-03 | 2013-07-23 | Oncolytics Biotech Inc. | Virus clearance of neoplastic cells from mixed cellular compositions |
| WO2002000233A2 (en) | 2000-06-26 | 2002-01-03 | Wellstat Biologics Corporation | Purging of cells using viruses |
| AR035227A1 (es) | 2001-02-20 | 2004-05-05 | Oncolytics Biotech Inc | Uso de un agente quimioterapeutico para la manufactura de un medicamento para la sensibilizacion de celulas neoplasicas resistentes a agentes quimioterapeuticos con reovirus |
| DE60239394D1 (de) | 2001-05-11 | 2011-04-21 | Wellstat Biologics Corp | Onkolytische virustherapie |
| IL145397A0 (en) * | 2001-09-12 | 2002-06-30 | Yissum Res Dev Co | Compositions and methods for treatment of cancer |
| US7615209B2 (en) * | 2001-09-12 | 2009-11-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions of NDV and methods of use thereof for treatment of cancer |
| US20040005546A1 (en) | 2002-02-28 | 2004-01-08 | Oncolytics Biotech Inc. | Use of ribozymes in the detection of adventitious agents |
| CA2374388C (en) | 2002-02-28 | 2005-07-12 | Matthew C. Coffey | The use of ribozymes in the detection of adventitious agents |
| RU2314830C2 (ru) * | 2002-06-21 | 2008-01-20 | Веллстат Байолоджикс Корпорейшн | Введение терапевтических вирусов |
| EP1578451A4 (en) * | 2002-11-05 | 2007-01-24 | Wellstat Biologics Corp | TREATMENT OF CARCINOID TUMORS WITH THERAPEUTIC VIRUSES |
| AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
| NZ543056A (en) * | 2003-03-24 | 2008-04-30 | Wellstat Biologics Corp | Newcastle disease virus comprising a plurality of doses for treating a mammalian subject having a tumour |
| JPWO2005042737A1 (ja) * | 2003-11-04 | 2007-05-10 | 株式会社ディナベック研究所 | 遺伝子導入された樹状細胞の製造方法 |
| US20060018884A1 (en) * | 2003-11-25 | 2006-01-26 | United Cancer Research Institute | Method for treating human tumor cells with a newcastle disease virus strain and a chemotherapeutic agent |
| NZ550430A (en) * | 2004-04-27 | 2009-06-26 | Wellstat Biologics Corp | Cancer treatment using viruses and camptothecins |
| CA2571849A1 (en) * | 2004-06-24 | 2006-01-05 | Dnavec Research Inc. | Anticancer agent containing dendritic cell having rna virus transferred thereinto |
| MX2007015407A (es) * | 2005-07-14 | 2008-02-19 | Wellstat Biologics Corp | Tratamiento del cancer utilizando virus, fluoropirimidinas y camptotecinas. |
| PT2529747T (pt) | 2005-12-02 | 2018-05-09 | Icahn School Med Mount Sinai | Vírus da doença de newcastle quiméricos que apresentam proteínas de superfície não nativas e suas utilizações |
| US20090175826A1 (en) * | 2006-06-05 | 2009-07-09 | Elankumaran Subbiah | Genetically-engineered newcastle disease virus as an oncolytic agent, and methods of using same |
| WO2008144067A1 (en) * | 2007-05-21 | 2008-11-27 | Board Of Regents, University Of Texas System | Methods and compositions for treatment of cancer using oncolytic rsv activity |
| ES2532808T3 (es) | 2008-09-16 | 2015-03-31 | Genomidea Inc. | Agente terapéutico/profiláctico para cáncer de próstata |
| EP2987856B1 (en) | 2009-02-05 | 2018-07-25 | Icahn School of Medicine at Mount Sinai | Chimeric newcastle disease viruses and uses thereof |
| EP2327764B1 (en) | 2009-11-30 | 2011-12-28 | United Cancer Research Institute | New clone of Newcastle disease virus, its manufacture and its application in the medical treatment of cancer |
| MD4655C1 (ro) | 2013-03-14 | 2020-06-30 | Icahn School Of Medicine At Mount Sinai | Virusurile bolii de Newcastle şi utilizarea acestora |
| US20170000832A1 (en) | 2014-02-27 | 2017-01-05 | Viralytics Limited | Combination method for treatment of cancer |
| CA3026892A1 (en) | 2017-05-10 | 2018-11-15 | Wellstat Immunotherapeutics, Llc | Enveloped virus resistant to complement inactivation for the treatment of cancer |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| US12391957B2 (en) | 2018-08-17 | 2025-08-19 | Icahn School Of Medicine At Mount Sinai | Recombinant Newcastle disease viruses and uses thereof for the prevention of RSV disease or human metapneumovirus disease |
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| JPH08508641A (ja) | 1993-03-16 | 1996-09-17 | ブリテイツシユ・テクノロジー・グループ・リミテツド | ウイルスタンパク質による免疫応答刺激 |
| PT1486211E (pt) * | 1993-04-30 | 2009-02-02 | Wellstat Biologics Corp | Composições para tratamento do cancro utilizando vírus |
| US20030044384A1 (en) * | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| EP1578451A4 (en) * | 2002-11-05 | 2007-01-24 | Wellstat Biologics Corp | TREATMENT OF CARCINOID TUMORS WITH THERAPEUTIC VIRUSES |
-
1994
- 1994-04-29 PT PT04017349T patent/PT1486211E/pt unknown
- 1994-04-29 DK DK02026340T patent/DK1314431T3/da active
- 1994-04-29 AT AT02026340T patent/ATE401092T1/de not_active IP Right Cessation
- 1994-04-29 ES ES94916604T patent/ES2196026T3/es not_active Expired - Lifetime
- 1994-04-29 AU AU68213/94A patent/AU699487B2/en not_active Ceased
- 1994-04-29 AT AT94916604T patent/ATE236271T1/de not_active IP Right Cessation
- 1994-04-29 JP JP52456394A patent/JP4338781B2/ja not_active Expired - Fee Related
- 1994-04-29 EP EP08166836A patent/EP2009119A1/en not_active Withdrawn
- 1994-04-29 EP EP94916604A patent/EP0696326B1/en not_active Expired - Lifetime
- 1994-04-29 DE DE69435118T patent/DE69435118D1/de not_active Expired - Lifetime
- 1994-04-29 WO PCT/US1994/004732 patent/WO1994025627A1/en not_active Ceased
- 1994-04-29 EP EP02026340A patent/EP1314431B1/en not_active Expired - Lifetime
- 1994-04-29 EP EP04017349A patent/EP1486211B1/en not_active Expired - Lifetime
- 1994-04-29 ES ES02026340T patent/ES2310580T3/es not_active Expired - Lifetime
- 1994-04-29 DE DE69435155T patent/DE69435155D1/de not_active Expired - Lifetime
- 1994-04-29 PT PT02026340T patent/PT1314431E/pt unknown
- 1994-04-29 AT AT04017349T patent/ATE411809T1/de not_active IP Right Cessation
- 1994-04-29 CA CA002161671A patent/CA2161671A1/en not_active Abandoned
- 1994-04-29 DE DE69432409T patent/DE69432409T2/de not_active Expired - Lifetime
- 1994-04-29 ES ES04017349T patent/ES2315595T3/es not_active Expired - Lifetime
- 1994-04-29 DK DK94916604T patent/DK0696326T5/da active
- 1994-04-29 DK DK04017349T patent/DK1486211T3/da active
- 1994-04-29 PT PT94916604T patent/PT696326E/pt unknown
- 1994-06-16 US US08/260,536 patent/US7056689B1/en not_active Expired - Lifetime
-
2003
- 2003-07-12 HK HK03105047.9A patent/HK1052871A1/en unknown
-
2005
- 2005-03-24 JP JP2005087342A patent/JP2005187484A/ja not_active Withdrawn
-
2006
- 2006-05-26 US US11/441,201 patent/US7736640B2/en not_active Expired - Fee Related
-
2009
- 2009-03-26 JP JP2009077773A patent/JP2009149689A/ja not_active Withdrawn
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