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ES2195024T3 - Procedimiento para la preparacion de antibioticos. - Google Patents

Procedimiento para la preparacion de antibioticos.

Info

Publication number
ES2195024T3
ES2195024T3 ES96940163T ES96940163T ES2195024T3 ES 2195024 T3 ES2195024 T3 ES 2195024T3 ES 96940163 T ES96940163 T ES 96940163T ES 96940163 T ES96940163 T ES 96940163T ES 2195024 T3 ES2195024 T3 ES 2195024T3
Authority
ES
Spain
Prior art keywords
antibiotic
lactama
nucleus
reaction
acilation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96940163T
Other languages
English (en)
Inventor
Wilhelmus Hubertus Jos Boesten
Den Tweel Wilhelmus Johann Van
Rocus Marinus Dekkers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of ES2195024T3 publication Critical patent/ES2195024T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UN ANTIBIOTICO, ESPECIALMENTE CEFALEXINA, AMPICILINA, AMOXICILINA, CEFACLOR, CEFRADINA, CEFADROXILO, CEFOTAXIMA Y SIMILARES, DONDE EL NUCLEO DE BE - LACTAMA SE ACILA, SE RECUPERA EL ANTIBIOTICO A PARTIR DE LA MEZCLA DE REACCION, EL LICOR MADRE RESTANTE SE SOMETE A UNA REACCION HIDROLITICA EN LA QUE EL ANTIBIOTICO PRESENTE SE DESCOMPONE EN SUS COMPONENTES INICIALES, ESPECIALMENTE EL NUCLEO DE BE - LACTAMA Y SE HIDROLIZA EL AGENTE ACILANTE. EL NUCLEO DE BE - LACTAMA SE RECUPERA A CONTI NUACION CASI CUANTITATIVAMENTE O RECICLADO HACIA LA REACCION DE ACILACION. ESTO SE DEBE A QUE SE HA ENCONTRADO QUE LA SOLUBILIDAD DEL NUCLEO DE BE - LACTAMA ES INESPERADAMENTE ALTA A CO NCENTRACIONES RELATIVAMENTE ELEVADAS DEL AGENTE DE ACILACION Y DEL ANTIBIOTICO.
ES96940163T 1995-12-08 1996-12-06 Procedimiento para la preparacion de antibioticos. Expired - Lifetime ES2195024T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE9501015 1995-12-08

Publications (1)

Publication Number Publication Date
ES2195024T3 true ES2195024T3 (es) 2003-12-01

Family

ID=3889338

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96940163T Expired - Lifetime ES2195024T3 (es) 1995-12-08 1996-12-06 Procedimiento para la preparacion de antibioticos.

Country Status (10)

Country Link
US (1) US6503727B1 (es)
EP (1) EP0865443B1 (es)
KR (1) KR100455252B1 (es)
CN (1) CN1107070C (es)
AT (1) ATE234846T1 (es)
AU (1) AU7711496A (es)
DE (1) DE69626842D1 (es)
ES (1) ES2195024T3 (es)
PL (1) PL327134A1 (es)
WO (1) WO1997022610A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0924180A4 (en) 1996-07-02 2005-04-20 Toray Finechemicals Co Ltd PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE KETONES
JP2000512860A (ja) * 1997-04-22 2000-10-03 ギスト ブロカデス ベスローテン フェンノートシャップ β―ラクタム抗生物質を調製する方法
NL1007077C2 (nl) * 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007076C2 (nl) * 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007302C2 (nl) 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.
NL1010506C2 (nl) * 1998-11-06 2000-05-09 Dsm Nv Werkwijze voor de bereiding van bêta-lactam antibiotica.
EP2024374A1 (en) * 2006-05-19 2009-02-18 DSMIP Assets B.V. Process for the crystallisation of cefadroxil
CN102392060B (zh) * 2011-09-16 2013-07-31 石药集团中润制药(内蒙古)有限公司 一种利用纳滤回收酶法阿莫西林母液中有效成份的方法
CN103193800B (zh) * 2013-04-08 2016-03-02 中国医药集团总公司四川抗菌素工业研究所 一种从头孢克洛酶促反应液中分离纯化各组分的方法
CN103805672B (zh) * 2014-02-25 2016-05-25 华北制药集团先泰药业有限公司 一种酶法制备氨苄西林的工艺
CN104628587B (zh) * 2015-02-12 2016-06-22 艾美科健（中国）生物医药有限公司 一种回收阿莫西林生产废液中d-对羟基苯甘氨酸的方法
CN105294734B (zh) * 2015-10-16 2018-02-13 华北制药河北华民药业有限责任公司 一种制备头孢尼西二苄基乙二胺盐的方法
CN105603037B (zh) * 2015-12-24 2020-07-31 天津大学 一种酶催化酰化制备头孢菌素的方法
CN105567777A (zh) * 2016-03-07 2016-05-11 内蒙古常盛制药有限公司 一种循环利用阿莫西林母液的方法
CN111269076A (zh) * 2020-03-12 2020-06-12 山东钧睿科技服务有限公司 一种酶法合成β-内酰胺类抗生素离心母液回收处理工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003896A (en) * 1974-12-17 1977-01-18 Novo Industri A/S Method of preparing a sparingly soluble complex of cephalexin
JPS5645196A (en) * 1979-09-19 1981-04-24 Shionogi & Co Ltd Enzymatic synthesis of beta-lactam antibacterial agent
JP3115593B2 (ja) * 1990-07-04 2000-12-11 ジスト―ブロカデス ベスローテン フェンノートシャップ β―ラクタム類の製造方法
US5470717A (en) * 1991-12-19 1995-11-28 Gist-Brocades N.V. Method for the preparation of certain β-lactam antibiotics
ATE204580T1 (de) * 1995-02-02 2001-09-15 Dsm Nv Verfahren zur gewinnung von cephalexin

Also Published As

Publication number Publication date
KR100455252B1 (ko) 2005-01-15
EP0865443B1 (en) 2003-03-19
AU7711496A (en) 1997-07-14
CN1207742A (zh) 1999-02-10
DE69626842D1 (de) 2003-04-24
ATE234846T1 (de) 2003-04-15
WO1997022610A1 (en) 1997-06-26
US6503727B1 (en) 2003-01-07
KR20000064370A (ko) 2000-11-06
CN1107070C (zh) 2003-04-30
PL327134A1 (en) 1998-11-23
EP0865443A1 (en) 1998-09-23

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