ES2194480T3 - Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. - Google Patents
Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.Info
- Publication number
- ES2194480T3 ES2194480T3 ES99931261T ES99931261T ES2194480T3 ES 2194480 T3 ES2194480 T3 ES 2194480T3 ES 99931261 T ES99931261 T ES 99931261T ES 99931261 T ES99931261 T ES 99931261T ES 2194480 T3 ES2194480 T3 ES 2194480T3
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- coating
- procedure
- oral pharmaceutical
- activity compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Comprende un compuesto de actividad antifúngica como principio activo, un núcleo inerte y un recubrimiento que incluye dicho principio activo, y se caracteriza por el hecho de que dicho núcleo inerte presenta un tamaño de partícula comprendido entre 50-600 µm, y por el hecho de que dicho recubrimiento comprende una única capa que se obtiene por nebulización, sobre dicho núcleo inerte, de una solución que comprende un compuesto de actividad antifúngica, un polímero hidrofílico y un agente tensioactivo no iónico. El procedimiento se lleva a cabo mediante un recubrimiento que comprende una única capa de los núcleos inertes de tamaño entre 50 y 600 µm por nebulización de una solución compuesta por el agente antifúngico, el polímero hidrofílico y el agente tensioactivo no iónico a una velocidad de recubrimiento constante durante todo el proceso; y un solo secado de dicho recubrimiento en el mismo equipo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009801539A ES2157731B1 (es) | 1998-07-21 | 1998-07-21 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2194480T3 true ES2194480T3 (es) | 2003-11-16 |
Family
ID=8304581
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES009801539A Expired - Fee Related ES2157731B1 (es) | 1998-07-21 | 1998-07-21 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
| ES99931261T Expired - Lifetime ES2194480T3 (es) | 1998-07-21 | 1999-07-20 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES009801539A Expired - Fee Related ES2157731B1 (es) | 1998-07-21 | 1998-07-21 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6737082B1 (es) |
| EP (1) | EP1103252B1 (es) |
| JP (1) | JP4190732B2 (es) |
| KR (1) | KR100572135B1 (es) |
| AT (1) | ATE234077T1 (es) |
| AU (1) | AU750730B2 (es) |
| BG (1) | BG65187B1 (es) |
| BR (1) | BR9912300A (es) |
| CA (1) | CA2337509C (es) |
| CZ (1) | CZ291938B6 (es) |
| DE (1) | DE69905905T2 (es) |
| DK (1) | DK1103252T3 (es) |
| EE (1) | EE04415B1 (es) |
| ES (2) | ES2157731B1 (es) |
| HR (1) | HRP20010128B1 (es) |
| HU (1) | HU228895B1 (es) |
| IL (1) | IL140910A (es) |
| ME (1) | MEP26708A (es) |
| MX (1) | MXPA01000681A (es) |
| NO (1) | NO320054B1 (es) |
| NZ (1) | NZ509886A (es) |
| PL (1) | PL194740B1 (es) |
| PT (1) | PT1103252E (es) |
| RS (1) | RS50063B (es) |
| RU (1) | RU2209628C2 (es) |
| SK (1) | SK283279B6 (es) |
| TR (1) | TR200100177T2 (es) |
| UA (1) | UA64009C2 (es) |
| WO (1) | WO2000004881A1 (es) |
| ZA (1) | ZA200101293B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997027764A1 (en) * | 1996-01-31 | 1997-08-07 | South Alabama Medical Science Foundation | Food and vitamin preparations containing the natural isomer of reduced folates |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| SK8562002A3 (en) | 1999-12-23 | 2003-10-07 | Pfizer Prod Inc | Pharmaceutical compositions providing enhanced drug concentrations |
| FR2842736B1 (fr) * | 2002-07-26 | 2005-07-22 | Flamel Tech Sa | Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s) |
| US20040115287A1 (en) * | 2002-12-17 | 2004-06-17 | Lipocine, Inc. | Hydrophobic active agent compositions and methods |
| DK1438961T4 (da) * | 2003-01-14 | 2014-11-17 | Acino Pharma Ag | Bioækvivalent sammensætning af itraconazol dispergeret i en hydrofil polymer |
| DE60312635T3 (de) * | 2003-01-14 | 2013-05-08 | Cimex Pharma Ag | Zusammensetzung in Form eines festen Dispersion enthaltend Itraconazol und ein hydrophilisches Polymer mit einer verbesserten Bioverfügbarkeit |
| FR2852607B1 (fr) * | 2003-03-20 | 2006-07-14 | Procede de fabrication de microspheres de sucre de petite taille, les microspheres susceptibles d'etre obtenues par ce procede et leurs applications | |
| FR2857591B1 (fr) * | 2003-07-17 | 2007-11-02 | Ethypharm Sa | Particules comprenant un principe actif sous forme de co-precipite |
| DK1648467T3 (en) * | 2003-07-17 | 2018-06-25 | Janssen Sciences Ireland Uc | PROCEDURE FOR MANUFACTURING PARTICLES CONTAINING AN ANTIVIRUS AGENT |
| FR2883179B1 (fr) | 2005-03-18 | 2009-04-17 | Ethypharm Sa | Comprime enrobe |
| CA2619889C (en) | 2005-08-22 | 2020-05-05 | The Johns Hopkins University | Use of itraconazole and salts thereof for treating cancer |
| CN101283984B (zh) * | 2007-04-12 | 2010-05-26 | 永胜药品工业股份有限公司 | 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物 |
| US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
| WO2011107466A2 (de) * | 2010-03-05 | 2011-09-09 | Basf Se | Schmelzüberzogene arzneiformen |
| US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
| US20170246187A1 (en) | 2014-08-28 | 2017-08-31 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
| US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
| MA40982A (fr) * | 2014-11-19 | 2017-09-26 | Biogen Ma Inc | Formulation de bille pharmaceutique comprenant du fumarate de diméthyle |
| MX2017015137A (es) * | 2015-05-25 | 2018-03-28 | Sun Pharmaceutical Ind Ltd | Composicion farmaceutica oral de dosis diaria de isotretinoin. |
| US20160361322A1 (en) | 2015-06-15 | 2016-12-15 | Lipocine Inc. | Composition and method for oral delivery of androgen prodrugs |
| AU2017310506B2 (en) | 2016-08-11 | 2019-11-21 | Dmk Pharmaceuticals Corporation | Drug compositions |
| JP2020503269A (ja) | 2016-11-28 | 2020-01-30 | リポカイン インコーポレーテッド | 経口ウンデカン酸テストステロン療法 |
| WO2019113493A1 (en) | 2017-12-08 | 2019-06-13 | Adamis Pharmaceuticals Corporation | Drug compositions |
| WO2019208801A1 (ja) * | 2018-04-27 | 2019-10-31 | 凸版印刷株式会社 | 徐放性複合粒子、徐放性複合粒子の製造方法、乾燥粉体及び壁紙 |
| CA3107214A1 (en) | 2018-07-20 | 2020-01-23 | Lipocine Inc. | Liver disease |
| CN118695852A (zh) * | 2021-12-22 | 2024-09-24 | 帕劳制药有限公司 | 多颗粒阿巴康唑组合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267179A (en) * | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| US4916134A (en) * | 1987-03-25 | 1990-04-10 | Janssen Pharmacuetica N.V. | 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones |
| IE61651B1 (en) * | 1990-07-04 | 1994-11-16 | Zambon Spa | Programmed release oral solid pharmaceutical dosage form |
| PH30929A (en) * | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
| TW349870B (en) * | 1993-09-30 | 1999-01-11 | Janssen Pharmaceutica Nv | An antifungal pharmaceutical composition for oral administration and a process for the preparation thereof |
| US5567441A (en) * | 1995-03-24 | 1996-10-22 | Andrx Pharmaceuticals Inc. | Diltiazem controlled release formulation |
| CN1165291C (zh) * | 1996-05-20 | 2004-09-08 | 詹森药业有限公司 | 具有改进的生物利用度的抗真菌组合物 |
| HU221371B1 (en) * | 1996-05-24 | 2002-09-28 | Schering Corp | Antifungal pharmaceutical composition with enhanced bioavailability |
| CZ421498A3 (cs) * | 1996-06-28 | 1999-06-16 | Schering Corporation | Orální prostředek obsahující triazolovou antifungální sloučeninu |
| DE19626924C2 (de) * | 1996-07-04 | 1999-08-19 | Epazon B V | Gerät zur Bereitstellung eines Atemgases |
| JP3608800B2 (ja) | 1997-03-26 | 2005-01-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗真菌剤およびポリマーでコートされたコアを有するペレット剤 |
-
1998
- 1998-07-21 ES ES009801539A patent/ES2157731B1/es not_active Expired - Fee Related
-
1999
- 1999-07-20 RU RU2001104894/14A patent/RU2209628C2/ru not_active IP Right Cessation
- 1999-07-20 CZ CZ2001175A patent/CZ291938B6/cs not_active IP Right Cessation
- 1999-07-20 PL PL99345625A patent/PL194740B1/pl not_active IP Right Cessation
- 1999-07-20 EP EP99931261A patent/EP1103252B1/en not_active Expired - Lifetime
- 1999-07-20 DK DK99931261T patent/DK1103252T3/da active
- 1999-07-20 HR HR20010128A patent/HRP20010128B1/xx not_active IP Right Cessation
- 1999-07-20 MX MXPA01000681A patent/MXPA01000681A/es active IP Right Grant
- 1999-07-20 SK SK86-2001A patent/SK283279B6/sk not_active IP Right Cessation
- 1999-07-20 ME MEP-267/08A patent/MEP26708A/xx unknown
- 1999-07-20 WO PCT/ES1999/000230 patent/WO2000004881A1/es not_active Ceased
- 1999-07-20 KR KR1020017000783A patent/KR100572135B1/ko not_active Expired - Fee Related
- 1999-07-20 EE EEP200100041A patent/EE04415B1/xx not_active IP Right Cessation
- 1999-07-20 AU AU47821/99A patent/AU750730B2/en not_active Ceased
- 1999-07-20 NZ NZ509886A patent/NZ509886A/xx not_active IP Right Cessation
- 1999-07-20 UA UA2001021260A patent/UA64009C2/uk unknown
- 1999-07-20 US US09/744,322 patent/US6737082B1/en not_active Expired - Fee Related
- 1999-07-20 TR TR2001/00177T patent/TR200100177T2/xx unknown
- 1999-07-20 ES ES99931261T patent/ES2194480T3/es not_active Expired - Lifetime
- 1999-07-20 RS YUP-39/01A patent/RS50063B/sr unknown
- 1999-07-20 BR BR9912300-2A patent/BR9912300A/pt not_active Application Discontinuation
- 1999-07-20 IL IL14091099A patent/IL140910A/en not_active IP Right Cessation
- 1999-07-20 DE DE69905905T patent/DE69905905T2/de not_active Expired - Lifetime
- 1999-07-20 JP JP2000560874A patent/JP4190732B2/ja not_active Expired - Fee Related
- 1999-07-20 HU HU0103708A patent/HU228895B1/hu not_active IP Right Cessation
- 1999-07-20 CA CA002337509A patent/CA2337509C/en not_active Expired - Fee Related
- 1999-07-20 PT PT99931261T patent/PT1103252E/pt unknown
- 1999-07-20 AT AT99931261T patent/ATE234077T1/de active
-
2001
- 2001-01-17 NO NO20010289A patent/NO320054B1/no not_active IP Right Cessation
- 2001-02-15 ZA ZA200101293A patent/ZA200101293B/en unknown
- 2001-02-21 BG BG105282A patent/BG65187B1/bg unknown
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