ES2194010T3 - Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi. - Google Patents
Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi.Info
- Publication number
- ES2194010T3 ES2194010T3 ES92922907T ES92922907T ES2194010T3 ES 2194010 T3 ES2194010 T3 ES 2194010T3 ES 92922907 T ES92922907 T ES 92922907T ES 92922907 T ES92922907 T ES 92922907T ES 2194010 T3 ES2194010 T3 ES 2194010T3
- Authority
- ES
- Spain
- Prior art keywords
- burgdorferi
- dna
- ospb
- sample
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000589969 Borreliella burgdorferi Species 0.000 title abstract 6
- 238000003745 diagnosis Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 101001086191 Borrelia burgdorferi Outer surface protein A Proteins 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 2
- 208000016604 Lyme disease Diseases 0.000 abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 241000589968 Borrelia Species 0.000 abstract 1
- 102000034342 Calnexin Human genes 0.000 abstract 1
- 108010056891 Calnexin Proteins 0.000 abstract 1
- 235000012601 Euterpe oleracea Nutrition 0.000 abstract 1
- 244000207620 Euterpe oleracea Species 0.000 abstract 1
- 102000004895 Lipoproteins Human genes 0.000 abstract 1
- 108090001030 Lipoproteins Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 235000003650 acai Nutrition 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
METODOS PARA DIAGNOSTICAR LA BORRELIOSIS, ENFERMEDAD DE LYME, DETECTANDO LA PRESENCIA DE UN ORGANISMO BORRELIA BURGDORFERI EN UNA MUESTRA DE UN ANIMAL, INCLUYENDO EL HOMBRE, POR EL USO DE ANALISIS PCR-DNA, EN EL QUE LOS ORIGINALES SON SUBSECUENCIAS DE LAS SECUENCIAS OSPA Y OSPB DNA DE CUALQUIERA DE TRES ESPECIES B. BURGDORFERI I, II Y III, TAL COMO SECUENCIAS OSPA Y OSPB DNA DE UNA DE LAS SIGUIENTES CEPAS B. BURGDORFERI: B31, IP90 (O IPER90) Y ACAI, RESPECTIVAMENTE. EL METODO PUEDE SER USADO PARA DETECTAR LA PRESENCIA DE B. BURGDORFERI EN UNA MUESTRA CUALQUIERA DE LAS ESPECIES Y CEPAS DEL ORGANISMO B. BURGDORFERI PROPUESTO QUE ESTA EN LA MUESTRA, PERO TAMBIEN PUEDE SER USADO PARA DETECTAR CEPAS ESPECIFICAS, DEPENDIENDO DE LOS ORIGINALES ESCOGIDOS. VACUNAS QUE COMPRENDEN POLIPEPTIDOS CAPACES DE PROVOCAR UNA RESPUESTA INMUNE CONTRA OSPA O OSPB DE ORGANISMOS B. BURGDORFERI PARA ACTIVAR LA INMUNIZACION, ESTANDO LOS POLIPEPTIDOS PREFERIBLEMENTE LIPIDADOS. SECUENCIAS DNA QUE CODIFICAN LOS POLIPEPTIDOS, CON PREFERENCIA TAMBIEN CODIFICAN UN PEPTIDO DE SEÑAL LIPOPROTEINA, POR EJEMPLO, UN PEPTIDO DE SEÑAL QUE COMPRENDE L-X-Y-C EN LA REGION TERMINAL C Y UN METODO PARA PRODUCIR EL POLIPEPTIDO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77918591A | 1991-10-22 | 1991-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2194010T3 true ES2194010T3 (es) | 2003-11-16 |
Family
ID=25115605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92922907T Expired - Lifetime ES2194010T3 (es) | 1991-10-22 | 1992-10-22 | Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi. |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP0650527B1 (es) |
| AT (1) | ATE234365T1 (es) |
| AU (1) | AU2903892A (es) |
| DE (1) | DE69232956T2 (es) |
| DK (1) | DK0650527T3 (es) |
| ES (1) | ES2194010T3 (es) |
| WO (1) | WO1993008306A1 (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6054296A (en) * | 1988-10-24 | 2000-04-25 | Symbicom Ab | 66 kDa antigen from Borrelia |
| US6676942B1 (en) | 1991-08-15 | 2004-01-13 | Smithkline Beecham Biologicals (S.A.) | Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines |
| EP0598816B1 (en) * | 1991-08-15 | 1999-06-23 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Osp a proteins of borrelia burgdorferi subgroups, encoding genes and vaccines |
| BE1006728A3 (fr) * | 1993-02-19 | 1994-11-29 | Wallone Region | Sondes d'acides nucleiques specifiques au spirochete borrelia burgdorferi. |
| NZ262821A (en) * | 1993-02-26 | 1997-03-24 | Cambridge Biotech Corp | Detecting the ability of borrelia burgdofori antiserum to inhibit b. burgdofori growth and vaccines against the bacteria especially for treating lyme disease |
| US5656451A (en) * | 1993-07-30 | 1997-08-12 | Yale University | OspE, OspF, and S1 polypeptides in borrelia burgdorferi |
| US6716591B1 (en) | 1993-07-30 | 2004-04-06 | Yale University | B. burgdorferi polypeptides |
| US7008625B2 (en) | 1993-11-01 | 2006-03-07 | Research Foundation Of The State University Of New York | Recombinant constructs of Borrelia burgdorferi |
| ATE263836T1 (de) * | 1993-11-01 | 2004-04-15 | Brookhaven Science Ass Llc | Chimere proteine, welche borrelia polypeptide beinhalten, verwendungen dafür |
| US6248562B1 (en) | 1993-11-01 | 2001-06-19 | Research Foundation State University Of New York | Chimeric proteins comprising borrelia polypeptides and uses therefor |
| PT757556E (pt) * | 1994-04-11 | 2006-10-31 | Wyeth Corp | Bacterina borrelia burgdorferi |
| US6087097A (en) * | 1994-05-12 | 2000-07-11 | Mayo Foundation For Medical Education And Research | PCR detection of Borrelia burgdorferi |
| US6251405B1 (en) * | 1995-06-07 | 2001-06-26 | Connaught Laboratories, Inc. | Immunological combination compositions and methods |
| ATE339436T1 (de) * | 1995-06-07 | 2006-10-15 | Sanofi Pasteur Inc | Expression von lipoproteinen |
| ZA964896B (en) | 1995-06-07 | 1997-01-08 | Connaught Lab | Expression of lipoproteins |
| DE19605475C1 (de) * | 1996-02-14 | 1997-11-20 | Deutsches Krebsforsch | Verfahren zur Erkennung des Erkrankungsrisikos nach Arthropodenstich |
| US6045804A (en) * | 1996-03-07 | 2000-04-04 | Mayo Foundation For Medical Educational Research | Method for detecting B. burgdorferi infection |
| DE19632862B4 (de) | 1996-08-14 | 2006-08-03 | Mikrogen Molekularbiologische Entwicklungs-Gmbh | Immunologisch aktive Proteine von Borrelia burgdorferi, dafür kodierende Nukleinsäuren sowie deren Verwendung in Testkits und als Impfstoffe |
| CA2300365A1 (en) * | 1997-09-10 | 1999-03-18 | Symbicom Aktiebolag | P13 antigens from borrelia |
| US6224882B1 (en) | 1997-11-07 | 2001-05-01 | Protein Science Corp. | Insect cells or fractions as adjuvant for antigens |
| EP1311540B1 (en) | 2000-08-18 | 2007-12-19 | Research Foundation Of State University Of New York | Altered ospa of borrelia burgdorferi |
| KR102428294B1 (ko) | 2006-01-19 | 2022-08-01 | 마리 케이 인코포레이티드 | 카카두 플럼 추출물 또는 아카이 베리 추출물을 포함하는 조성물 |
| US8137678B2 (en) | 2006-11-03 | 2012-03-20 | Intervet Inc. | Canine lyme disease vaccine |
| EP2361930A3 (en) | 2007-03-26 | 2011-10-26 | Dako Denmark A/S | Multimers of MHC-peptide complexes and uses thereof in Borrelia infectious diseases |
| EP2167537A2 (en) | 2007-07-03 | 2010-03-31 | Dako Denmark A/S | Compiled methods for analysing and sorting samples |
| WO2009039854A2 (en) | 2007-09-27 | 2009-04-02 | Dako Denmark A/S | Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics |
| US10968269B1 (en) | 2008-02-28 | 2021-04-06 | Agilent Technologies, Inc. | MHC multimers in borrelia diagnostics and disease |
| CA2723226A1 (en) | 2008-05-02 | 2009-05-11 | Cancer Research Technology Ltd | Products and methods for stimulating an immune response |
| WO2010009735A2 (en) | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Combinatorial analysis and repair |
| GB0817244D0 (en) | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
| US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
| US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| US8048456B2 (en) | 2009-08-28 | 2011-11-01 | Mary Kay Inc. | Skin care formulations |
| US20130011424A1 (en) | 2010-03-09 | 2013-01-10 | Timur ARTEMEV | Polyepitope constructs and methods for their preparation and use |
| US9109007B2 (en) | 2010-08-18 | 2015-08-18 | Purdue Pharma L.P. | MHC-I restricted epitopes containing non-natural amino acid residues |
| WO2013110026A1 (en) | 2012-01-20 | 2013-07-25 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Compositions and methods relating to lyme disease |
| US12258373B2 (en) | 2018-12-17 | 2025-03-25 | Immudex Aps | Panel comprising Borrelia MHC multimers |
| CN115521987A (zh) * | 2021-06-25 | 2022-12-27 | 中国人民解放军军事科学院军事医学研究院 | 一种基于探针法的回归热螺旋体荧光定量检测方法及其应用 |
| CA3258639A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharma | Multispecific molecules to modulate T lymphocyte activity, and their uses |
| WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK590288D0 (da) * | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
| DE4015911A1 (de) * | 1989-09-19 | 1991-03-28 | Max Planck Gesellschaft | Impfstoff gegen die lyme-krankheit |
| WO1992000055A1 (en) * | 1990-06-15 | 1992-01-09 | Yale University | Compositions and methods for the prevention and diagnosis of lyme disease |
-
1992
- 1992-10-22 ES ES92922907T patent/ES2194010T3/es not_active Expired - Lifetime
- 1992-10-22 AT AT92922907T patent/ATE234365T1/de active
- 1992-10-22 EP EP92922907A patent/EP0650527B1/en not_active Expired - Lifetime
- 1992-10-22 EP EP92610073A patent/EP0540457A1/en not_active Withdrawn
- 1992-10-22 WO PCT/US1992/008972 patent/WO1993008306A1/en not_active Ceased
- 1992-10-22 DE DE69232956T patent/DE69232956T2/de not_active Expired - Lifetime
- 1992-10-22 AU AU29038/92A patent/AU2903892A/en not_active Abandoned
- 1992-10-22 DK DK92922907T patent/DK0650527T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993008306A1 (en) | 1993-04-29 |
| EP0650527A1 (en) | 1995-05-03 |
| DE69232956T2 (de) | 2003-10-02 |
| EP0650527B1 (en) | 2003-03-12 |
| EP0540457A1 (en) | 1993-05-05 |
| DK0650527T3 (da) | 2003-07-14 |
| DE69232956D1 (de) | 2003-04-17 |
| AU2903892A (en) | 1993-05-21 |
| ATE234365T1 (de) | 2003-03-15 |
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