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ES2191643T3 - CHALCONA-CUMARINAS. - Google Patents

CHALCONA-CUMARINAS.

Info

Publication number
ES2191643T3
ES2191643T3 ES00965902T ES00965902T ES2191643T3 ES 2191643 T3 ES2191643 T3 ES 2191643T3 ES 00965902 T ES00965902 T ES 00965902T ES 00965902 T ES00965902 T ES 00965902T ES 2191643 T3 ES2191643 T3 ES 2191643T3
Authority
ES
Spain
Prior art keywords
chalcona
certain
avonoids
chalconas
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00965902T
Other languages
Spanish (es)
Inventor
Ezio Bombardelli
Piero Valenti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Application granted granted Critical
Publication of ES2191643T3 publication Critical patent/ES2191643T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Saccharide Compounds (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Glass Compositions (AREA)
  • Fire-Extinguishing Compositions (AREA)
  • Epoxy Compounds (AREA)

Abstract

El presente invento se refiere a una nueva clase de compuestos que tienen estructuras que se refieren a determinadas chalconas sintéticas y de origen natural, así como a métodos de preparación de tales compuestos y a sus utilizaciones farmacéuticas. El compuesto 1, 3-difenil-2-propen-1-ona es conocido con el nombre común de chalcona. Muchos avonoides de origen natural comparten características estructurales con la chalcona y se les conoce con el término genérico de chalconas. Asimismo, se ha demostrado que determinados avonoides, incluyendo los que también se clasifican como chalconas, tienen actividad anti-cáncer y actividad quimiopreventiva en determinados tumores.The present invention relates to a new class of compounds having structures that refer to certain synthetic and naturally occurring chalcones, as well as methods of preparing such compounds and their pharmaceutical uses. The compound 1,3-diphenyl-2-propen-1-one is known by the common name of chalcona. Many naturally occurring avonoids share structural characteristics with the chalcona and are known by the generic term chalconas. Likewise, it has been shown that certain avonoids, including those that are also classified as chalconas, have anti-cancer activity and chemopreventive activity in certain tumors.

ES00965902T 1999-09-03 2000-08-28 CHALCONA-CUMARINAS. Expired - Lifetime ES2191643T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9920908.2A GB9920908D0 (en) 1999-09-03 1999-09-03 Chalcone coumarins

Publications (1)

Publication Number Publication Date
ES2191643T3 true ES2191643T3 (en) 2003-09-16

Family

ID=10860344

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00965902T Expired - Lifetime ES2191643T3 (en) 1999-09-03 2000-08-28 CHALCONA-CUMARINAS.

Country Status (22)

Country Link
US (1) US6767916B2 (en)
EP (1) EP1212311B1 (en)
JP (1) JP2003508523A (en)
KR (1) KR100819574B1 (en)
CN (1) CN1142927C (en)
AT (1) ATE235480T1 (en)
AU (1) AU775083B2 (en)
CA (1) CA2382112A1 (en)
CZ (1) CZ2002786A3 (en)
DE (1) DE60001850T2 (en)
DK (1) DK1212311T3 (en)
ES (1) ES2191643T3 (en)
GB (1) GB9920908D0 (en)
HK (1) HK1043997B (en)
HU (1) HUP0202581A3 (en)
NO (1) NO20021048L (en)
PL (1) PL353245A1 (en)
PT (1) PT1212311E (en)
RU (1) RU2266291C2 (en)
SE (1) SE1212311T5 (en)
SK (1) SK3102002A3 (en)
WO (1) WO2001017984A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030229136A1 (en) 2002-04-18 2003-12-11 Nurulain Zaveri Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
US7638554B2 (en) 2002-04-18 2009-12-29 Sri International Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
WO2006132947A2 (en) 2005-06-08 2006-12-14 Temple University- Of The Commonwealth System Of Higher Education 3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof
CN101041646B (en) * 2007-04-30 2011-07-20 浙江大学 Preparation method and usage for nitrogen-containing chalcone derivatives
CN101121706B (en) * 2007-09-18 2010-11-24 南京中瑞药业有限公司 Coumarin derivatives, preparation method and use thereof
JP5479105B2 (en) * 2007-11-05 2014-04-23 国立大学法人佐賀大学 Novel ubiquitin-binding small molecule
EP2601183A1 (en) 2010-08-05 2013-06-12 Council Of Scientific & Industrial Research Coumarin-chalcones as anticancer agents
US10071945B2 (en) 2011-06-15 2018-09-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nuclear receptor modulators and their use for the treatment and prevention of cancer
CN104987328A (en) * 2012-05-23 2015-10-21 复旦大学 7-oxygen, sulphur or aza-substituent coumarin and derivative and application thereof
CN102731457A (en) * 2012-06-25 2012-10-17 西南石油大学 Water-soluble fluorescent tracing polymer and its preparation method
WO2019096397A1 (en) * 2017-11-16 2019-05-23 The Institute Of Cancer Research: Royal Cancer Hospital Coumarin derivative for therapy or prophylaxis of a cell proliferative disorder
CN109293616B (en) * 2018-09-29 2022-06-21 贵州大学 Coumarin-containing chalcone derivatives, and preparation method and application thereof
JP2022547358A (en) 2019-09-13 2022-11-14 ジ インスティテュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル THERAPEUTIC COMPOSITIONS, COMBINATIONS AND METHODS OF USE
US11873296B2 (en) 2022-06-07 2024-01-16 Verastem, Inc. Solid forms of a dual RAF/MEK inhibitor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387956A1 (en) * 1977-04-20 1978-11-17 Unicler Pyridyl ethyl and vinyl ketone cardiovascular agents - prepd. from 4-formyl pyridine and a methyl aryl ketone
US5399561A (en) * 1989-09-19 1995-03-21 Allergan, Inc. Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-oxochromanyl, 2-oxothiochromanyl or 2-oxo-1,2,3,4-tetrahydro-quinolinyl group having retinoid-like biological activity
US5023341A (en) * 1989-09-19 1991-06-11 Allergan, Inc. Compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity
CA2084208A1 (en) * 1990-05-17 1991-11-18 Barry Markaverich Growth inhibitors and methods of treating cancer and cell proliferative diseases
IT1271301B (en) 1994-12-20 1997-05-27 Indena Spa NATURAL AND SYNTHETIC CALCONES AND THEIR ESTERS WITH ANTI-PROLIFERATIVE ACTIVITY IN CANCER OF THE UTERUS, OVARIAN AND BREAST AND FORMULATIONS CONTAINING THEM
US5525625A (en) 1995-01-24 1996-06-11 Warner-Lambert Company 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders

Also Published As

Publication number Publication date
NO20021048D0 (en) 2002-03-01
NO20021048L (en) 2002-05-03
KR100819574B1 (en) 2008-04-04
ATE235480T1 (en) 2003-04-15
AU775083B2 (en) 2004-07-15
EP1212311B1 (en) 2003-03-26
CZ2002786A3 (en) 2002-06-12
CN1371370A (en) 2002-09-25
RU2266291C2 (en) 2005-12-20
DE60001850D1 (en) 2003-04-30
KR20020030800A (en) 2002-04-25
US20020161036A1 (en) 2002-10-31
AU7648800A (en) 2001-04-10
HK1043997B (en) 2003-08-15
SE1212311T3 (en) 2003-05-06
CA2382112A1 (en) 2001-03-15
DE60001850T2 (en) 2003-12-11
CN1142927C (en) 2004-03-24
US6767916B2 (en) 2004-07-27
RU2002108567A (en) 2004-01-10
EP1212311A1 (en) 2002-06-12
JP2003508523A (en) 2003-03-04
SK3102002A3 (en) 2003-10-07
WO2001017984A1 (en) 2001-03-15
HUP0202581A3 (en) 2003-07-28
HK1043997A1 (en) 2002-10-04
DK1212311T3 (en) 2003-06-23
HUP0202581A2 (en) 2002-11-28
SE1212311T5 (en) 2003-06-10
GB9920908D0 (en) 1999-11-10
PL353245A1 (en) 2003-11-03
PT1212311E (en) 2003-08-29

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