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ES2190880A1 - Pre-t cell receptor (pre-tcr) and the characterisation and regulation of the expression and function thereof during the development of t cells in humans - Google Patents

Pre-t cell receptor (pre-tcr) and the characterisation and regulation of the expression and function thereof during the development of t cells in humans

Info

Publication number
ES2190880A1
ES2190880A1 ES200101903A ES200101903A ES2190880A1 ES 2190880 A1 ES2190880 A1 ES 2190880A1 ES 200101903 A ES200101903 A ES 200101903A ES 200101903 A ES200101903 A ES 200101903A ES 2190880 A1 ES2190880 A1 ES 2190880A1
Authority
ES
Spain
Prior art keywords
expression
development
function
during
tcr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200101903A
Other languages
Spanish (es)
Other versions
ES2190880B1 (en
Inventor
Garcia Maria Luisa Toribio
Rosales Graciela Carrillo
Ramiro Almudena Rodriguez
De Yebenes Mena Virgini Garcia
Carrasco Yolanda Rodriguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES200101903A priority Critical patent/ES2190880B1/en
Priority to PCT/ES2002/000387 priority patent/WO2003016355A1/en
Publication of ES2190880A1 publication Critical patent/ES2190880A1/en
Application granted granted Critical
Publication of ES2190880B1 publication Critical patent/ES2190880B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Pre-receptor de las células T (PRE-TCR). Caracterización y regulación de su expresión y función durante el desarrollo de las células T en húmanos. La presente invención proporciona herramientas técnicas para la identificación y selección de subespecies de linfocitos pre-T humanos a partir del pre-receptor de células T (pT{al}). Además, se describen métodos de regulación de la expresión y función de dicho receptor durante el desarrollo de los linfocitos T humanos. Como una realización particular de la presente invención, entre otras, se presenta el anticuerpo monoclonal K5G3 que reconoce específicamente a la isoforma pT{al}{sup,a}, lo que permite por vez primera analizar la expresión de la cadena pT{al} en la superficie celular.T cell pre-receptor (PRE-TCR). Characterization and regulation of its expression and function during human T cell development. The present invention provides technical tools for the identification and selection of human pre-T lymphocyte subspecies from the pre-T cell receptor (pT{al}). In addition, methods of regulating the expression and function of said receptor during the development of human T lymphocytes are described. As a particular embodiment of the present invention, among others, the K5G3 monoclonal antibody that specifically recognizes the pT{al}{sup,a} isoform is presented, which allows for the first time to analyze the expression of the pT{al} chain. on the cell surface.

ES200101903A 2001-08-14 2001-08-14 PRE-RECEIVER OF T-CELLS (PRE-TCR). CHARACTERIZATION AND REGULATION OF ITS EXPRESSION AND FUNCTION DURING THE DEVELOPMENT OF T-CELLS IN HUMANS. Expired - Fee Related ES2190880B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES200101903A ES2190880B1 (en) 2001-08-14 2001-08-14 PRE-RECEIVER OF T-CELLS (PRE-TCR). CHARACTERIZATION AND REGULATION OF ITS EXPRESSION AND FUNCTION DURING THE DEVELOPMENT OF T-CELLS IN HUMANS.
PCT/ES2002/000387 WO2003016355A1 (en) 2001-08-14 2002-08-01 Pre-t cell receptor (pre-tcr) and the characterisation and regulation of the expression and function thereof during the development of t cells in humans

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101903A ES2190880B1 (en) 2001-08-14 2001-08-14 PRE-RECEIVER OF T-CELLS (PRE-TCR). CHARACTERIZATION AND REGULATION OF ITS EXPRESSION AND FUNCTION DURING THE DEVELOPMENT OF T-CELLS IN HUMANS.

Publications (2)

Publication Number Publication Date
ES2190880A1 true ES2190880A1 (en) 2003-08-16
ES2190880B1 ES2190880B1 (en) 2004-11-16

Family

ID=8498719

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200101903A Expired - Fee Related ES2190880B1 (en) 2001-08-14 2001-08-14 PRE-RECEIVER OF T-CELLS (PRE-TCR). CHARACTERIZATION AND REGULATION OF ITS EXPRESSION AND FUNCTION DURING THE DEVELOPMENT OF T-CELLS IN HUMANS.

Country Status (2)

Country Link
ES (1) ES2190880B1 (en)
WO (1) WO2003016355A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021209670A1 (en) 2020-04-17 2021-10-21 Consejo Superior De Investigaciones Científicas Therapeutic treatment for t-cell acute lymphoblastic leukemias using a monoclonal antibody against the pre-t cell receptor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BARBER D.F. et al. "Cutting edge: The expression in vivo of a second isoform of PTalpha: Implications for the Mechanism of PTalpha Action", 1998, J. Immunology, Vol. 161, pßginas 11-16. *
KOSUGI A. et al. "Subunit composition of the pre-T-cell receptor complex analysed by monoclonal antibody against the pre-T-cell receptor alpha chain", 1997, Immunology, Vol. 91, pßginas 618-622. *
RAMIRO A. et al. "Regulation of Pre-T cell Receptor (PTalpha-TCRbeta) Gene Expression during Human Thymic Development", 1996, J. Exp. Med., Vol. 184, pßginas 519-530. *
SAINT-RUF C. et al. "Genomic structure of the human pre-T cell receptor alpha chain and expression of two mRNA isoforms", 1998, Eur. J. Immunol., Vol. 28, pßginas 3824-3831. *
TRIGUEROS C. et al. "Identification of a Late Stage of Small Non-cycling PTalpha- pre-T cells as Immediate Precursors of cell Receptor alpha/beta+ Thymocites", 1998, J. Exp. Med., Vol. 188, pßginas 1401-1412. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021209670A1 (en) 2020-04-17 2021-10-21 Consejo Superior De Investigaciones Científicas Therapeutic treatment for t-cell acute lymphoblastic leukemias using a monoclonal antibody against the pre-t cell receptor

Also Published As

Publication number Publication date
WO2003016355A1 (en) 2003-02-27
ES2190880B1 (en) 2004-11-16

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