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ES2190311B1 - CHEMICAL GENE FOR THE DEVELOPMENT OF THERAPEUTIC APPROXIMATIONS TO HEREDITARY INTOLERANCE TO FRUCTOSE. - Google Patents

CHEMICAL GENE FOR THE DEVELOPMENT OF THERAPEUTIC APPROXIMATIONS TO HEREDITARY INTOLERANCE TO FRUCTOSE.

Info

Publication number
ES2190311B1
ES2190311B1 ES200002221A ES200002221A ES2190311B1 ES 2190311 B1 ES2190311 B1 ES 2190311B1 ES 200002221 A ES200002221 A ES 200002221A ES 200002221 A ES200002221 A ES 200002221A ES 2190311 B1 ES2190311 B1 ES 2190311B1
Authority
ES
Spain
Prior art keywords
fructose
hereditary
intolerance
development
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES200002221A
Other languages
Spanish (es)
Other versions
ES2190311A1 (en
Inventor
Juan Emilio Feliu Albiñana
Julio Cesar Sanchez Gutierrez
Fatima Bosch Tubert
Anna Pujol Altarriba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad Autonoma de Madrid
Universitat Autonoma de Barcelona UAB
Original Assignee
Universidad Autonoma de Madrid
Universitat Autonoma de Barcelona UAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Autonoma de Madrid, Universitat Autonoma de Barcelona UAB filed Critical Universidad Autonoma de Madrid
Priority to ES200002221A priority Critical patent/ES2190311B1/en
Publication of ES2190311A1 publication Critical patent/ES2190311A1/en
Application granted granted Critical
Publication of ES2190311B1 publication Critical patent/ES2190311B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Gen quimérico para el desarrollo de aproximaciones terapéuticas a la intolerancia hereditaria a la fructosa. Comprende un promotor unido al gen o al ADNc de la fructoquinasa. Dicho gen quimérico se inserta en una célula hepática, permitiendo la expresión de fructoquinasa. También se refiere a un animal transgénico cuyo genoma comprende dicho gen quimérico y desarrollando, dicho animal transgénico, alteraciones asociadas a la intolerancia hereditaria a la fructosa tras la administración de fructosa, sorbitol o sacarosa.Chimeric gene for the development of therapeutic approaches to hereditary fructose intolerance. It comprises a promoter linked to the gene or the cDNA of the fructokinase. Said chimeric gene is inserted into a liver cell, allowing the expression of fructokinase. It also refers to a transgenic animal whose genome comprises said chimeric gene and developing, said transgenic animal, alterations associated with hereditary fructose intolerance after administration of fructose, sorbitol or sucrose.

ES200002221A 2000-08-31 2000-08-31 CHEMICAL GENE FOR THE DEVELOPMENT OF THERAPEUTIC APPROXIMATIONS TO HEREDITARY INTOLERANCE TO FRUCTOSE. Expired - Lifetime ES2190311B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES200002221A ES2190311B1 (en) 2000-08-31 2000-08-31 CHEMICAL GENE FOR THE DEVELOPMENT OF THERAPEUTIC APPROXIMATIONS TO HEREDITARY INTOLERANCE TO FRUCTOSE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002221A ES2190311B1 (en) 2000-08-31 2000-08-31 CHEMICAL GENE FOR THE DEVELOPMENT OF THERAPEUTIC APPROXIMATIONS TO HEREDITARY INTOLERANCE TO FRUCTOSE.

Publications (2)

Publication Number Publication Date
ES2190311A1 ES2190311A1 (en) 2003-07-16
ES2190311B1 true ES2190311B1 (en) 2004-06-16

Family

ID=27589265

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200002221A Expired - Lifetime ES2190311B1 (en) 2000-08-31 2000-08-31 CHEMICAL GENE FOR THE DEVELOPMENT OF THERAPEUTIC APPROXIMATIONS TO HEREDITARY INTOLERANCE TO FRUCTOSE.

Country Status (1)

Country Link
ES (1) ES2190311B1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075229A (en) * 1987-06-16 1991-12-24 Ohio University Edison Animal Biotechnology Center Dietary and hormonal regulation of expression of exogenous genes in transgenic animals under control of the promoter of the gene for phosphoenolpyruvate carboxykinase
WO1995025169A1 (en) * 1994-03-14 1995-09-21 Universitat Autonoma De Barcelona CHIMERIC GENE USING THE GENE OR cDNA OF INSULINE, SPECIALLY FOR THE GENE THERAPY OF DIABETES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075229A (en) * 1987-06-16 1991-12-24 Ohio University Edison Animal Biotechnology Center Dietary and hormonal regulation of expression of exogenous genes in transgenic animals under control of the promoter of the gene for phosphoenolpyruvate carboxykinase
WO1995025169A1 (en) * 1994-03-14 1995-09-21 Universitat Autonoma De Barcelona CHIMERIC GENE USING THE GENE OR cDNA OF INSULINE, SPECIALLY FOR THE GENE THERAPY OF DIABETES

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAYWARD B.E. et al. Structure and alternative splicing of the ketohexokinase gene. Eur. J. Biochem., Octubre 1998, Vol. 257, Nº 1, páginas 85-91. *

Also Published As

Publication number Publication date
ES2190311A1 (en) 2003-07-16

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