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ES2189404T3 - 1,3,4-tiadiazoles utiles para el tratamiento de infecciones por cmv. - Google Patents

1,3,4-tiadiazoles utiles para el tratamiento de infecciones por cmv.

Info

Publication number
ES2189404T3
ES2189404T3 ES99912221T ES99912221T ES2189404T3 ES 2189404 T3 ES2189404 T3 ES 2189404T3 ES 99912221 T ES99912221 T ES 99912221T ES 99912221 T ES99912221 T ES 99912221T ES 2189404 T3 ES2189404 T3 ES 2189404T3
Authority
ES
Spain
Prior art keywords
cmv
useful
tiadiazols
infections
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99912221T
Other languages
English (en)
Inventor
Steven R Turner
Suvit Thaisrivongs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of ES2189404T3 publication Critical patent/ES2189404T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Un compuesto para uso en terapia como agente antivírico, compuesto que tiene la fórmula I**(Fórmula)** o una de sus sales farmacéuticamente aceptables, en la que Y es (a) -NHR1, o (b) **(Fórmula)** X es (a) -O-, (b) -S(=O)h-, (c) -CH2-, o (d) -NR2-, R1 es (a) alquilo C1-18, (b) -(CH2)i cicloalquilo C3-7, (b) -(CH2)i cicloalquilo C3-7 (c) -bicicloalquilo (CH2)i, (d) -(CH2)j- M (e) -(CH2)j- W, (f) -(CH)k arilo, pudiendo estar sustituido el grupo arilo con 1 a 3 R3, (g) -(CH2)k- het, pudiendo estar sustituido het con 1 a 3 R3, (h) -(CH2)k- Q, pudiendo estar sustituido Q con 1 a 3 R3, o (i) H; R2 es (a) H, (b) alquilo C1-4, (c) -C(=O) alquilo C1-4, (d) -S(=O= alquilo C1-4, (e) CO2 alquilo C1-4, o (f) -CO2CH2 fenilo; R3 es (a) halo, (b) alquilo C1-4, (c) alcoxi C1-4, (d) bencilo, (e) -CN, (f) -SO2F, (g) -SO2NH2, (h) -CF3, (i) -NO2, (j) -OCH2O(k) -CO2 (alquilo C1-4), (l) -C(=O) (alquilo C1-4), (m) -C(=O)NH2, (n) -NHCO2 (alquilo C1-4), o (o) -C(=O)-O-C(=O)-; M es (a) -CN, (b) -halo, (c) -CO2 alquilo C1_4, (d) -CH (fenilo)2, (e) **(Fórmula)** f) **(Fórmula)** W es (a) -OR4, (b) -SR4, (c) -NHR5 o (d) -NR6R7; R4 es (a) alquilo C1-4, (b) cicloalquilo C3-7, o (c) arilo, R5 es (a) alquilo C1-4), (b) cicloalquilo C3-7, (c) arilo, o (d) -C(=O) alquilo C1-4, R6 y R7 son, independientemente (a) alquilo C1-4, o (b) R6 y R7 junto con nitrógeno forman un resto heterocíclico saturado de 4 a 6 miembros que tiene 1 o 2 átomos seleccionados entre el grupo constituido por oxígeno, nitrógeno y azufre; Rx es (a) alquilo C1-18, (b) alquenilo C2-18, (c) alquinilo C2-18, (d) alquilo C2-6 sustituido con 1-3 halos, alcoxi C1-3, -OH, -SH o -CO2H, (e) alquenilo C2-6 sustituido con arilo, pudiendo estar a su vez arilo sustituido con de 1 a 3 R3, (f) -(CH2) arilo, pudiendo estar arilo sustituido con de 1 a 3 R3, (g) -(CH2)j-Q, pudiendo estar sustituido het con 1 a 3 R3, (h) -(CH2)j-U, pudiendo estar sustituido U con 1 a 3 R3, arilo es fenilo o naftilo; het es un resto heterocíclico insaturado de 5 a 10 miembrosque tiene de 1 a 3 átomos seleccionados entre el grupo constituido por oxígeno, nitrógeno y azufre; U es un resto heterocíclico insaturado de 5 o 9 miembros que tiene de 1 a 3 átomos seleccionados entre el grupo constituido por oxígeno, nitrógeno y azufre; Q es un resto heterocíclico insaturado de 5 o 6 miembros que tiene 1 ó 2 átomos seleccionados entre el grupo constituido por oxígeno, nitrógeno y azufre, pudiendo estar a su vez el átomo de nitrógeno sustituido con alquilo C1-4, fenilo, bencilo, -C(=O) alquilo C1-4 o -CO2 alquilo C1-4; h es 0, 1 o 2; i es 0, 1, 2, 3 o 4; j es 2, 3 o 4; y k es 0, 1, 2, 3, 4, 5 o 6.
ES99912221T 1998-03-19 1999-03-16 1,3,4-tiadiazoles utiles para el tratamiento de infecciones por cmv. Expired - Lifetime ES2189404T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7852898P 1998-03-19 1998-03-19

Publications (1)

Publication Number Publication Date
ES2189404T3 true ES2189404T3 (es) 2003-07-01

Family

ID=22144610

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99912221T Expired - Lifetime ES2189404T3 (es) 1998-03-19 1999-03-16 1,3,4-tiadiazoles utiles para el tratamiento de infecciones por cmv.

Country Status (11)

Country Link
US (1) US6150385A (es)
EP (1) EP1064273B1 (es)
JP (1) JP2002506858A (es)
AT (1) ATE229945T1 (es)
AU (1) AU743489B2 (es)
CA (1) CA2320167A1 (es)
DE (1) DE69904576T2 (es)
DK (1) DK1064273T3 (es)
ES (1) ES2189404T3 (es)
NZ (1) NZ507032A (es)
WO (1) WO1999047507A2 (es)

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CA2366607A1 (en) 1999-03-08 2000-09-14 Bayer Aktiengesellschaft Thiazolyl urea derivatives and their utilization as antiviral agents
DOP2000000109A (es) 1999-12-23 2002-08-30 Gerald Kleymann Derivados de tiazolilamida
DE10129714A1 (de) 2001-06-22 2003-01-02 Bayer Ag Topische Anwendung von Thiazolylamiden
MXPA04005427A (es) * 2001-12-10 2005-04-19 Amgen Inc Ligandos de receptor vainilloide y su uso en tratamientos.
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
TWI345974B (en) 2003-07-30 2011-08-01 Xenon Pharmaceuticals Inc Pyridazine derivatives and their use in the inhibition of stearoyl-coa desaturase
WO2005072731A1 (en) * 2004-01-29 2005-08-11 X-Ceptor Therapeutics, Inc. 3-phenyl-n- ((1, 3, 4) thiadiazol-2-yl) -acrylamide derivatives and related compounds as modulators of estrogen-related receptors for the treatment of e.g. cancer, rheumatoid arthritis or neurological disorders
CN101084211A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为治疗剂的用途
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
CA2580855A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
JP4958785B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼインヒビターとしてのそれらの使用
BRPI0515483A (pt) * 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase
WO2006034441A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
TW200626155A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
DE102005014248A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid
US8101618B2 (en) * 2005-04-06 2012-01-24 Msd K.K. 1,4-substituted piperazine derivatives
WO2007130075A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
JP2010501567A (ja) 2006-08-24 2010-01-21 ノバルティス アクチエンゲゼルシャフト 代謝系、心血管系および他の障害の処置のためのステアロイル−ＣｏＡ不飽和化酵素（ＳＣＤ）阻害剤としての２−（ピラジン−２−イル）−チアゾールおよび２−（１Ｈ−ピラゾール−３−イル）チアゾール誘導体ならびに関連化合物
BRPI0906797A2 (pt) 2008-01-09 2015-07-14 Molecular Insight Pharm Inc Inibidores de anidrase carbônica ix
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BR112012000209B8 (pt) 2009-06-15 2021-07-27 Molecular Insight Pharm Inc heterodímeros de ácido glutâmico e seus processos de preparação
SG185414A1 (en) 2010-05-12 2012-12-28 Univ Vanderbilt Heterocyclic sulfone mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
RU2448961C1 (ru) * 2011-02-03 2012-04-27 Открытое акционерное общество "Всероссийский научный центр по безопасности биологически активных веществ" (ОАО "ВНЦ БАВ") Фармацевтическая композиция, обладающая противовоспалительной, бронхолитической, противотуберкулезной активностями
CA2860504A1 (en) 2012-01-06 2013-07-11 Molecular Insight Pharmaceuticals Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase ix
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GEP20207128B (en) 2016-04-06 2020-07-10 Molecules Gm Innovative Aminothiazole derivatives useful as antiviral agents
KR102708082B1 (ko) 2017-10-05 2024-09-19 이노베이티브 몰리큘스 게엠베하 항바이러스 화합물로서 치환된 티아졸의 거울상 이성질체
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CA3155287A1 (en) 2019-09-26 2021-04-01 Novartis Ag Antiviral pyrazolopyridinone compounds
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IT8148047A0 (it) * 1981-03-18 1981-03-18 Manetti & Roberts Italo Brit Composti organici derivati da 2-ami no-5-(o-solfamidofenil)-1,3,4-tiadiazolo loro applicazione terapeutica e procedimento per la loro preparazione
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EP0591486A1 (de) * 1992-04-22 1994-04-13 PEUSCHEL, Karin, Elisabeth Immunaktivierende und damit antivirale wirking von 4- 3-(subst.-amino)-2-hydroxypropoxy]-1,2,5-thiadiazolverbindungen
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US5948916A (en) * 1994-09-22 1999-09-07 Rational Drug Design Laboratories Arylthiadiazole derivative and antiviral agent containing the same

Also Published As

Publication number Publication date
WO1999047507A3 (en) 1999-12-09
EP1064273A2 (en) 2001-01-03
AU3063999A (en) 1999-10-11
DE69904576T2 (de) 2003-07-10
DK1064273T3 (da) 2003-03-31
CA2320167A1 (en) 1999-09-23
ATE229945T1 (de) 2003-01-15
EP1064273B1 (en) 2002-12-18
JP2002506858A (ja) 2002-03-05
NZ507032A (en) 2003-06-30
WO1999047507A2 (en) 1999-09-23
DE69904576D1 (de) 2003-01-30
AU743489B2 (en) 2002-01-24
US6150385A (en) 2000-11-21

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