[go: up one dir, main page]

ES2188649T3 - Fenil-alquil-imidazoles como antagonistas del receptor h3. - Google Patents

Fenil-alquil-imidazoles como antagonistas del receptor h3.

Info

Publication number
ES2188649T3
ES2188649T3 ES95902442T ES95902442T ES2188649T3 ES 2188649 T3 ES2188649 T3 ES 2188649T3 ES 95902442 T ES95902442 T ES 95902442T ES 95902442 T ES95902442 T ES 95902442T ES 2188649 T3 ES2188649 T3 ES 2188649T3
Authority
ES
Spain
Prior art keywords
phenyl
imidazols
rent
antagonists
receiver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95902442T
Other languages
English (en)
Inventor
Robert G Aslanian
Michael J Green
Neng-Yang Shih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2188649T3 publication Critical patent/ES2188649T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION PROPORCIONA IMIDAZOLAS DE FENIL-ALQUILO NUEVAS DE FORMULA (I) EN LA QUE A, R{SUP,1}, R{SUP,2}, M Y N SE DEFINEN EN LA ESPECIFICACION, Y EL GRUPO -(CH{SUB,2}){SUB,N}-A-R{SUP,1} ESTA EN LA POSICION 3 O 4, JUNTO CON SUS SALES FARMACEUTICAMENTE ACEPTABLES. ESTAS IMIDAZOLAS DE FENIL-ALQUILO Y SALES POSEEN PROPIEDADES FARMACOLOGICAS VALIOSAS, ESPECIALMENTE ACTIVIDADES CNS Y UNA ACTIVIDAD CONTRA LAS ENFERMEDADES INFLAMATORIAS.
ES95902442T 1993-11-15 1994-11-10 Fenil-alquil-imidazoles como antagonistas del receptor h3. Expired - Lifetime ES2188649T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15323193A 1993-11-15 1993-11-15

Publications (1)

Publication Number Publication Date
ES2188649T3 true ES2188649T3 (es) 2003-07-01

Family

ID=22546320

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95902442T Expired - Lifetime ES2188649T3 (es) 1993-11-15 1994-11-10 Fenil-alquil-imidazoles como antagonistas del receptor h3.

Country Status (10)

Country Link
US (1) US5578616A (es)
EP (1) EP0729459B1 (es)
JP (1) JPH09505298A (es)
AT (1) ATE234290T1 (es)
AU (1) AU693142B2 (es)
DE (1) DE69432263T2 (es)
ES (1) ES2188649T3 (es)
HU (1) HUT74386A (es)
NZ (2) NZ330898A (es)
WO (1) WO1995014007A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19615262A1 (de) * 1996-04-18 1997-10-23 Bayer Ag Heteroverknüpfte Phenylglycinolamide
SG72827A1 (en) * 1997-06-23 2000-05-23 Hoffmann La Roche Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives
GB9715814D0 (en) * 1997-07-25 1997-10-01 Black James Foundation Histamine H3 receptor ligands
GB2344588B (en) * 1997-07-25 2001-11-14 Black James Foundation 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands
US6407132B1 (en) * 1997-07-25 2002-06-18 James Black Foundation Limited Substituted imidazole derivatives and their use as histamine H3 receptor ligands
US6034251A (en) * 1997-11-07 2000-03-07 Schering Corporation Phenyl-alkyl-imidazoles
JP2001522836A (ja) * 1997-11-07 2001-11-20 シェーリング コーポレイション Ｈ３レセプターアンタゴニストとしてのフェニル−アルキル−イミダゾール
EP1028947B8 (en) * 1997-11-07 2004-01-28 Schering Corporation H3 receptor ligands of the phenyl-alkyl-imidazoles type
US5990147A (en) * 1997-11-07 1999-11-23 Schering Corporation H3 receptor ligands of the phenyl-alkyl-imidazoles type
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
US6133291A (en) * 1998-10-16 2000-10-17 Schering Corporation N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists
US6100279A (en) * 1998-11-05 2000-08-08 Schering Corporation Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
WO2000042023A1 (en) 1999-01-18 2000-07-20 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US6211182B1 (en) 1999-03-08 2001-04-03 Schering Corporation Imidazole compounds substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms
US6908926B1 (en) 1999-04-16 2005-06-21 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US6610721B2 (en) 2000-03-17 2003-08-26 Novo Nordisk A/S Imidazo heterocyclic compounds
US6437147B1 (en) 2000-03-17 2002-08-20 Novo Nordisk Imidazole compounds
WO2002012214A2 (en) 2000-08-08 2002-02-14 Ortho Mcneil Pharmaceutical Inc. Non-imidazole aryloxyalkylamines as h3 receptor ligands
WO2002012224A2 (en) * 2000-08-08 2002-02-14 Ortho Mcneil Pharmaceutical, Inc. Bicyclic compounds as h3 receptor ligands
CA2419036A1 (en) 2000-08-08 2002-02-14 Ortho-Mcneil Pharmaceutical, Inc. Non-imidazole aryloxypiperidines as h3 receptor ligands
AU2002241459A1 (en) 2000-09-20 2002-06-11 Schering Corporation Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists
MY117975A (en) 2000-09-20 2004-08-30 Schering Corp Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists
MXPA03002447A (es) 2000-09-20 2003-07-21 Schering Corp Imidazoles sustituidos como agonistas o antagonistas duales h1 y h3 de histamina.
ES2311544T3 (es) 2000-09-20 2009-02-16 Schering Corp Imidazoles sustituidos como agonistas o antagonistas duales de histamina h1 y h3.
PE20020507A1 (es) 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3
AU2002256967A1 (en) * 2000-10-30 2002-09-12 Schering Corporation Treating or reducing the risk of cardiovascular disease
WO2002072093A2 (en) 2001-02-08 2002-09-19 Schering Corporation Use of dual h3/m2 antagonists with a bipiperidinic structure in the treatment of cognition deficit disorders
EP1373251A2 (en) 2001-03-13 2004-01-02 Schering Corporation Non-imidazole compounds as histamine h3 antagonists
US7183305B2 (en) * 2003-11-11 2007-02-27 Allergan, Inc. Process for the synthesis of imidazoles
US7880017B2 (en) * 2003-11-11 2011-02-01 Allergan, Inc. Process for the synthesis of imidazoles
EP1707203A1 (en) 2005-04-01 2006-10-04 Bioprojet Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands
EP1717233A1 (en) * 2005-04-29 2006-11-02 Bioprojet Histamine H3-receptor ligands and their therapeutic application
EP1717235A3 (en) 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
WO2007035703A1 (en) 2005-09-20 2007-03-29 Schering Corporation 1- [ [1- [ (2-amin0-6-methyl-4-pyridinyl) methyl] -4-flu0r0-4-piperidinyl,] carbonyl] -4- [2- (2-pyridinyl) -3h-imidaz0 [4 , 5-b] pyridin-3-yl] piperidine useful as histamine h3 antagonist
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
US8492422B2 (en) 2010-09-16 2013-07-23 Allergan, Inc. Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions
AU2012340806B2 (en) 2011-11-21 2017-10-19 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole derivatives for treating retinal diseases
AU2013307688A1 (en) * 2012-08-29 2015-04-09 Merck Patent Gmbh Ddr2 inhibitors for the treatment of osteoarthritis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU518569B2 (en) * 1979-08-07 1981-10-08 Farmos-Yhtyma Oy 4-benzyl- and 4-benzoyl imidazole derivatives
GB8626287D0 (en) * 1986-11-04 1986-12-03 Ucb Sa Substituted 1h-imidazoles
JPH01242571A (ja) * 1988-03-22 1989-09-27 Mitsui Petrochem Ind Ltd イミダゾール誘導体の製造方法
GB8810067D0 (en) * 1988-04-28 1988-06-02 Ucb Sa Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides
GB8916947D0 (en) * 1989-07-25 1989-09-13 Smith Kline French Lab Medicaments
GB9115740D0 (en) * 1991-07-20 1991-09-04 Smithkline Beecham Plc Medicaments
FR2686084B1 (fr) * 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.

Also Published As

Publication number Publication date
ATE234290T1 (de) 2003-03-15
EP0729459A1 (en) 1996-09-04
HU9601282D0 (en) 1996-07-29
HUT74386A (en) 1996-12-30
NZ276883A (en) 1998-08-26
NZ330898A (en) 2000-01-28
AU693142B2 (en) 1998-06-25
US5578616A (en) 1996-11-26
JPH09505298A (ja) 1997-05-27
DE69432263D1 (de) 2003-04-17
DE69432263T2 (de) 2003-12-04
EP0729459B1 (en) 2003-03-12
WO1995014007A1 (en) 1995-05-26
AU1171295A (en) 1995-06-06

Similar Documents

Publication Publication Date Title
ES2188649T3 (es) Fenil-alquil-imidazoles como antagonistas del receptor h3.
ES2180338T3 (es) Antagonistas del receptor de crf y metodos relacionados.
EA199800340A1 (ru) Производные пиримидина как антагонисты 5нт2с
DE69229674D1 (de) 5-ht4 rezeptor antagonisten
ES2117014T3 (es) Quinazolinonas substituidas en las posiciones 2,3,6 bloqueadoras del receptor de la angiotensina ii.
BG101110A (bg) Заместени пиримидинови съединения и тяхното използване
LV11688A (lv) Morfolina tahikinina receptoru antagonistu priekstecvielas
NO952398L (no) Pyrrolpyrimidiner som CRF antagonister
DE69818831D1 (de) Indolderivate als mcp-1 rezeptor antagonisten
ES2108700T3 (es) Derivados de diazabiciclonolilo como antagonistas del receptor 5-ht3.
NO963064D0 (no) Behandling av normotensive glaukoma med angiotensin-II-antagonister
DK1588706T3 (da) Valsartantablet
PT1129096E (pt) Antagonistas de receptor de crf e metodos de tratamento relacionados com os mesmos
TR200401546T4 (tr) Piperazin türevleri, hazırlanmaları ve merkezi sinir sistemi (CNS) bozukluklarının tedavisinde kullanımları
NO904799L (no) Substituerte n-(imidazolyl)alkylalanin-derivater.
DE60112574D1 (de) Bicyclische cyclohexylamine und ihre verwendung als nmda-rezeptor antagonisten
IT1282705B1 (it) Uso di antagonisti del recettore serotoninergico 5-ht|a per il trattamento dell'incontinenza urinaria
WO1999047132A3 (en) Heterocyclic compounds, their production and use as tachykinin receptor antagonists
BR0307156A (pt) Derivado de pirimidina bicìclica fundida, composto, antagonistas de receptores e agentes profiláticos e terapêuticos
ATE343578T1 (de) Tri- und tetraaza-acenaphthylen-derivate als crf- rezeptor-antagonisten
PT896822E (pt) 4-aminopirrolo (3,2-d)pirimidinas como antagonistas do receptor de neuropeptideo y
DE60100811D1 (de) Crf rezeptor-antagonisten und darauf bezogene methoden
ES2164328T3 (es) Derivados de 2,1,3-benzotia(oxa)diazol con efecto antagonista del receptor de endotelina.
DE60102231D1 (de) Crf rezeptor-antagonisten und darauf bezogene methoden
CA2176557A1 (en) Phenyl-alkyl imidazoles as h3-receptor antagonists