ES2187505T3 - Elementos cis de proteinas de cuerpo oleoso como señales reguladoras. - Google Patents
Elementos cis de proteinas de cuerpo oleoso como señales reguladoras.Info
- Publication number
- ES2187505T3 ES2187505T3 ES93907716T ES93907716T ES2187505T3 ES 2187505 T3 ES2187505 T3 ES 2187505T3 ES 93907716 T ES93907716 T ES 93907716T ES 93907716 T ES93907716 T ES 93907716T ES 2187505 T3 ES2187505 T3 ES 2187505T3
- Authority
- ES
- Spain
- Prior art keywords
- oil body
- cis elements
- body proteins
- regulatory signs
- constructions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 230000001105 regulatory effect Effects 0.000 title 1
- 101100020619 Arabidopsis thaliana LATE gene Proteins 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 210000001161 mammalian embryo Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
- C12N15/823—Reproductive tissue-specific promoters
- C12N15/8234—Seed-specific, e.g. embryo, endosperm
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Peptides Or Proteins (AREA)
- Fats And Perfumes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
SE PRESENTAN CONSTRUCCIONES DE DNA QUE COMPRENDEN SECUENCIAS INSATURADAS 5'' DE GENES ACTIVOS A PARTIR DE LA ETAPA GLOBULAR TARDIA PARA LA MADUREZ DEL EMBRION. ESTAS CONSTRUCCIONES PUEDEN UTILIZARSE PARA OBTENER EXPRESIONES DE UNA SECUENCIA DE DNA DE INTERES DURANTE LAS FASES DE EMBRIOGENESIS QUE PRECEDEN A LA ACUMULACION DE PROTEINAS DE ALMACENAMIENTO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86235592A | 1992-04-02 | 1992-04-02 | |
| PCT/CA1992/000161 WO1993021320A1 (en) | 1991-02-22 | 1992-04-15 | Oil-body proteins as carriers of high-value peptides in plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2187505T3 true ES2187505T3 (es) | 2003-06-16 |
Family
ID=25683013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93907716T Expired - Lifetime ES2187505T3 (es) | 1992-04-02 | 1993-04-02 | Elementos cis de proteinas de cuerpo oleoso como señales reguladoras. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5792922A (es) |
| EP (1) | EP0633940B1 (es) |
| JP (1) | JP3660354B2 (es) |
| KR (1) | KR100278456B1 (es) |
| AT (1) | ATE229076T1 (es) |
| AU (1) | AU678154B2 (es) |
| DE (1) | DE69332538T2 (es) |
| ES (1) | ES2187505T3 (es) |
| FI (1) | FI120314B (es) |
| NO (1) | NO321501B1 (es) |
| RU (1) | RU2148647C1 (es) |
| UA (1) | UA41319C2 (es) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6586661B1 (en) * | 1997-06-12 | 2003-07-01 | North Carolina State University | Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid |
| US6635806B1 (en) * | 1998-05-14 | 2003-10-21 | Dekalb Genetics Corporation | Methods and compositions for expression of transgenes in plants |
| DE19923571A1 (de) * | 1999-05-21 | 2000-11-23 | Kws Saat Ag | Nukleotid-Sequenz zur Erhöhung der Abwehrreaktion einer Pflanze gegen Pathogenbefall |
| US20030140372A1 (en) * | 1999-06-07 | 2003-07-24 | Shen Jennie Bih-Jien | Genes for desaturases to alter lipid profiles in corn |
| US6784342B1 (en) | 1999-08-04 | 2004-08-31 | The University Of British Columbia | Regulation of embryonic transcription in plants |
| RU2164944C1 (ru) * | 1999-12-09 | 2001-04-10 | Институт молекулярной биологии им. В.А. Энгельгардта РАН | Способ изменения генетических свойств организма |
| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
| JP4932125B2 (ja) | 2000-08-25 | 2012-05-16 | ビーエーエスエフ プラント サイエンス ゲーエムベーハー | 新規プレニルプロテアーゼをコードする植物ポリヌクレオチド |
| CN1330753C (zh) * | 2000-08-30 | 2007-08-08 | 北卡罗莱纳州立大学 | 含有可改变蛋白含量的分子诱导物的转基因植物 |
| US20030167524A1 (en) * | 2000-12-19 | 2003-09-04 | Rooijen Gijs Van | Methods for the production of multimeric protein complexes, and related compositions |
| KR20030066732A (ko) * | 2000-12-19 | 2003-08-09 | 셈비오시스제네틱스인코포레이티드 | 다량체 단백질의 제조 방법 및 관련 조성물 |
| US7122720B2 (en) | 2001-04-24 | 2006-10-17 | Cornell Research Foundation, Inc. | Synthetic nucleic acid molecule for imparting multiple traits |
| US20050287647A9 (en) | 2001-05-30 | 2005-12-29 | Carl Perez | Plant artificial chromosomes, uses thereof and methods of preparing plant artificial chromosomes |
| US20060179514A1 (en) * | 2001-07-05 | 2006-08-10 | Sembiosys Genetics, Inc. | Methods for the production of multimeric protein complexes, and related compositions |
| CA2462930C (en) | 2001-10-10 | 2012-07-10 | Shawn De Frees | Remodeling and glycoconjugation of peptides |
| AU2003245772A1 (en) | 2002-06-28 | 2004-01-19 | University Of Guelph | Harvest-inducible genes form alfalfa (medicago sativa) and methods of use thereof |
| US7329798B2 (en) * | 2002-06-28 | 2008-02-12 | University Of Guelph | Harvest-inducible regulatory elements and methods of using same |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US8119150B2 (en) * | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
| JP2006505583A (ja) | 2002-10-25 | 2006-02-16 | フォーミックス エルティーディー. | 化粧剤および医薬用フォーム |
| US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| EA200700469A1 (ru) | 2003-02-14 | 2008-10-30 | Байоджен Айдек Ма Инк. | Экспрессионная кассета и вектор для временной или постоянной экспрессии экзогенных молекул |
| US20070026485A1 (en) | 2003-04-09 | 2007-02-01 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
| EA014887B1 (ru) | 2003-06-17 | 2011-02-28 | Сембайосиз Джинетикс Инк. | Способ экспрессии инсулина в семенах растения, способ получения семян растений, содержащих инсулин, и растения, способные производить семена, содержащие инсулин |
| US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
| WO2005041151A2 (en) * | 2003-10-02 | 2005-05-06 | Vector Tobacco Ltd. | Tobacco product labeling system |
| WO2006007432A2 (en) * | 2004-06-16 | 2006-01-19 | Basf Plant Science Gmbh | Nucleic acid molecules encoding wrinkled1-like polypeptides and methods of use in plants |
| CA2609953A1 (en) | 2005-05-09 | 2007-04-12 | Foamix Ltd. | Saccharide foamable compositions |
| AU2006249983B2 (en) | 2005-05-23 | 2011-03-17 | Arcadia Biosciences, Inc. | Safflower with elevated gamma-linolenic acid |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| US20090049569A1 (en) * | 2007-08-13 | 2009-02-19 | Pioneer Hi-Bred International, Inc. | Seed-Preferred Regulatory Elements |
| WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
| WO2010041141A2 (en) | 2008-10-07 | 2010-04-15 | Foamix Ltd. | Oil-based foamable carriers and formulations |
| WO2009090495A2 (en) | 2007-12-07 | 2009-07-23 | Foamix Ltd. | Oil and liquid silicone foamable carriers and formulations |
| AU2009205314A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| CA2725674A1 (en) * | 2008-05-28 | 2009-12-03 | Kyoto University | Selection marker gene and use thereof |
| CN102575257B (zh) | 2009-04-22 | 2014-11-05 | 巴斯夫植物科学有限公司 | 全种子特异性启动子 |
| WO2010125470A2 (en) | 2009-04-28 | 2010-11-04 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
| CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| WO2011013008A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| US8945516B2 (en) | 2009-10-02 | 2015-02-03 | Foamix Pharmaceuticals Ltd. | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| US12433312B2 (en) | 2014-05-06 | 2025-10-07 | Conopco, Inc. | Composition in the form of an oil-in-water emulsion comprising ground white or yellow mustard seed |
| MX377365B (es) | 2016-09-08 | 2025-03-10 | Journey Medical Corp | Composiciones y métodos para tratar rosácea y acné. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ221259A (en) * | 1986-07-31 | 1990-05-28 | Calgene Inc | Seed specific transcriptional regulation |
| EP0667906A1 (en) * | 1991-11-15 | 1995-08-23 | E.I. Du Pont De Nemours And Company | $g(b)-KETOACYL-ACP SYNTHETASE II GENES FROM PLANTS |
-
1993
- 1993-04-02 AT AT93907716T patent/ATE229076T1/de active
- 1993-04-02 JP JP51693593A patent/JP3660354B2/ja not_active Expired - Lifetime
- 1993-04-02 ES ES93907716T patent/ES2187505T3/es not_active Expired - Lifetime
- 1993-04-02 DE DE69332538T patent/DE69332538T2/de not_active Expired - Lifetime
- 1993-04-02 EP EP93907716A patent/EP0633940B1/en not_active Expired - Lifetime
- 1993-04-02 KR KR1019940703487A patent/KR100278456B1/ko not_active Expired - Fee Related
- 1993-04-02 AU AU38844/93A patent/AU678154B2/en not_active Expired
- 1993-04-02 US US08/313,098 patent/US5792922A/en not_active Expired - Lifetime
- 1993-04-02 RU RU94046161A patent/RU2148647C1/ru active
- 1993-04-02 UA UA94105980A patent/UA41319C2/uk unknown
-
1994
- 1994-09-30 NO NO19943664A patent/NO321501B1/no not_active IP Right Cessation
- 1994-09-30 FI FI944550A patent/FI120314B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69332538T2 (de) | 2003-11-06 |
| KR950700995A (ko) | 1995-02-20 |
| FI120314B (fi) | 2009-09-15 |
| RU94046161A (ru) | 1997-05-10 |
| JP3660354B2 (ja) | 2005-06-15 |
| FI944550A0 (fi) | 1994-09-30 |
| US5792922A (en) | 1998-08-11 |
| ATE229076T1 (de) | 2002-12-15 |
| RU2148647C1 (ru) | 2000-05-10 |
| AU3884493A (en) | 1993-11-08 |
| AU678154B2 (en) | 1997-05-22 |
| NO321501B1 (no) | 2006-05-15 |
| DE69332538D1 (de) | 2003-01-16 |
| JPH07505525A (ja) | 1995-06-22 |
| NO943664D0 (no) | 1994-09-30 |
| EP0633940A1 (en) | 1995-01-18 |
| UA41319C2 (uk) | 2001-09-17 |
| NO943664L (no) | 1994-11-15 |
| FI944550L (fi) | 1994-11-30 |
| KR100278456B1 (ko) | 2001-01-15 |
| EP0633940B1 (en) | 2002-12-04 |
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