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ES2184705T3 - 4-OXO-4,7-DIHIDRO-TIENO (2,3-B) PIRIDINA-5-CARBOXAMIDS AS ANTIVIRAL AGENTS. - Google Patents

4-OXO-4,7-DIHIDRO-TIENO (2,3-B) PIRIDINA-5-CARBOXAMIDS AS ANTIVIRAL AGENTS.

Info

Publication number
ES2184705T3
ES2184705T3 ES00913786T ES00913786T ES2184705T3 ES 2184705 T3 ES2184705 T3 ES 2184705T3 ES 00913786 T ES00913786 T ES 00913786T ES 00913786 T ES00913786 T ES 00913786T ES 2184705 T3 ES2184705 T3 ES 2184705T3
Authority
ES
Spain
Prior art keywords
oxo
antiviral agents
carboxamids
piridina
tieno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00913786T
Other languages
Spanish (es)
Inventor
Mark E Schnute
Michele M Cudahy
Allen Scott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of ES2184705T3 publication Critical patent/ES2184705T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención suministra derivados de 4 - oxo - 4, 7 - dihidrotieno[2, 3 - b]piridin - 5 - carboxamida, más concretamente, derivados de 5 - bencilaminocarbonil - 4 - oxo - 4, 7 - dihidrotieno[2, 3 - b]piridina de fórmula (I), que son útiles como agentes antivirales (por ejemplo, como agentes contra virus de la familia del herpes).The present invention provides derivatives of 4-oxo-4,7-dihydrothiene [2,3-b] pyridine-5-carboxamide, more specifically, derivatives of 5-benzylaminocarbonyl-4-oxo-4,7-dihydrothiene [2,3] - b] pyridine of formula (I), which are useful as antiviral agents (for example, as agents against viruses of the herpes family).

ES00913786T 1999-03-09 2000-03-07 4-OXO-4,7-DIHIDRO-TIENO (2,3-B) PIRIDINA-5-CARBOXAMIDS AS ANTIVIRAL AGENTS. Expired - Lifetime ES2184705T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12366099P 1999-03-09 1999-03-09

Publications (1)

Publication Number Publication Date
ES2184705T3 true ES2184705T3 (en) 2003-04-16

Family

ID=22410054

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00913786T Expired - Lifetime ES2184705T3 (en) 1999-03-09 2000-03-07 4-OXO-4,7-DIHIDRO-TIENO (2,3-B) PIRIDINA-5-CARBOXAMIDS AS ANTIVIRAL AGENTS.

Country Status (25)

Country Link
US (2) US6239142B1 (en)
EP (1) EP1159279B1 (en)
JP (1) JP2002539130A (en)
KR (1) KR20010102543A (en)
CN (1) CN1347417A (en)
AT (1) ATE226208T1 (en)
AU (1) AU759875B2 (en)
BR (1) BR0008804A (en)
CA (1) CA2366609A1 (en)
CZ (1) CZ20013028A3 (en)
DE (1) DE60000611T2 (en)
DK (1) DK1159279T3 (en)
EA (1) EA003607B1 (en)
ES (1) ES2184705T3 (en)
HK (1) HK1045518A1 (en)
HU (1) HUP0200324A3 (en)
IL (1) IL145005A0 (en)
NO (1) NO20014363L (en)
NZ (1) NZ513758A (en)
PL (1) PL350651A1 (en)
PT (1) PT1159279E (en)
SK (1) SK12582001A3 (en)
TW (1) TWI222451B (en)
WO (1) WO2000053610A2 (en)
ZA (1) ZA200107255B (en)

Families Citing this family (33)

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US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
JO3429B1 (en) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv Hiv inhibiting pyrimidines derivatives
EP1421089A1 (en) * 2001-08-30 2004-05-26 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO 2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS
WO2003020728A1 (en) * 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS
MXPA04005863A (en) * 2001-12-20 2004-10-29 Osi Pharm Inc Pancreatic lipase inhibitor compounds, their synthesis and use.
AR038294A1 (en) * 2002-01-14 2005-01-12 Upjohn Co OXOTIENE (3,2-B) PYRIDINCARBOXAMIDS AS ANTIVIRAL AGENTS
AR038117A1 (en) * 2002-01-14 2004-12-29 Upjohn Co ANTIVIRAL AGENTS DERIVED FROM 4- OXO-4,7 -DIHYDROFIDE [2,3-B] PIRIDIN-5-CARBOXAMIDA
AR038118A1 (en) 2002-01-14 2004-12-29 Upjohn Co COMPOUNDS DERIVED FROM ACID BENCINAMIDE 7-OXO-4,7-DIHIDROTIEN [2,3-B [PIRIDIN-6-CARBOXYLIC 3-REPLACED WHICH ARE USEFUL AS ANTIVIRAL
US20030212271A1 (en) * 2002-04-22 2003-11-13 Allen Scott Trifluoroacetic acid process to prepare [2,3-B]pyridine intermediates
CN101481356B (en) 2002-08-09 2012-07-11 詹森药业有限公司 Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
US20040067947A1 (en) * 2002-08-30 2004-04-08 Wathen Michael W Method of preventing or treating atherosclerosis or restenosis
WO2004019939A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2004019933A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
US20040186131A1 (en) * 2002-08-30 2004-09-23 Wathen Michael W Method of preventing or treating atherosclerosis or restenosis
WO2004106345A2 (en) * 2002-09-04 2004-12-09 Pharmacia & Upjohn Company Heteroaryl-ethanolamine derivatives as antiviral agents
US20040110787A1 (en) * 2002-09-04 2004-06-10 Schnute Mark E. Heteroaryl-ethanolamine derivatives as antiviral agents
US20040116464A1 (en) * 2002-09-04 2004-06-17 Schnute Mark E. Aryl-ethanolamine derivatives as antiviral agents
WO2004022566A1 (en) * 2002-09-04 2004-03-18 Pharmacia & Upjohn Company Llc 4-OXO-4,7-DIHYDROTHIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS
WO2005003140A1 (en) * 2003-07-02 2005-01-13 Pharmacia & Upjohn Company Llc 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
EP1756082A1 (en) * 2004-04-13 2007-02-28 Astex Therapeutics Limited 5-morpholinylmethylthiophenyl pharmaceutial compounds as p38 map kinase modulators
SE0401578D0 (en) 2004-06-18 2004-06-18 Active Biotech Ab Novel compounds
WO2006093518A2 (en) * 2004-06-25 2006-09-08 Apath, Llc Thienyl compounds for treating virus-related conditions
AP3069A (en) * 2009-02-27 2014-12-31 Siga Technologies Inc Thienopyridine derivatives for the treatment and prvention of dengue virus infection
MX385975B (en) 2016-02-16 2025-03-18 Univ Vanderbilt POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1.
US10899759B2 (en) 2016-09-30 2021-01-26 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M1
WO2020053654A1 (en) 2018-09-12 2020-03-19 Novartis Ag Antiviral pyridopyrazinedione compounds
CA3155287A1 (en) 2019-09-26 2021-04-01 Novartis Ag Antiviral pyrazolopyridinone compounds
CN115073489B (en) * 2021-03-15 2023-11-28 同济大学 A kind of thiophenepyridone compound, preparation method and an antifungal drug
WO2022221602A2 (en) * 2021-04-14 2022-10-20 University Of Virginia Patent Foundation Compositions and methods for treating and/or preventing lung injury

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Also Published As

Publication number Publication date
EA003607B1 (en) 2003-06-26
CA2366609A1 (en) 2000-09-14
PL350651A1 (en) 2003-01-27
IL145005A0 (en) 2002-06-30
EP1159279A2 (en) 2001-12-05
HUP0200324A3 (en) 2003-07-28
AU759875B2 (en) 2003-05-01
KR20010102543A (en) 2001-11-15
TWI222451B (en) 2004-10-21
ZA200107255B (en) 2002-12-02
DE60000611T2 (en) 2003-06-26
CZ20013028A3 (en) 2002-03-13
DK1159279T3 (en) 2003-02-17
PT1159279E (en) 2003-02-28
DE60000611D1 (en) 2002-11-21
NO20014363L (en) 2001-11-08
SK12582001A3 (en) 2002-02-05
NZ513758A (en) 2001-09-28
WO2000053610A2 (en) 2000-09-14
AU3516200A (en) 2000-09-28
US6495683B2 (en) 2002-12-17
EP1159279B1 (en) 2002-10-16
EA200100955A1 (en) 2002-02-28
HUP0200324A2 (en) 2002-06-29
CN1347417A (en) 2002-05-01
HK1045518A1 (en) 2002-11-29
BR0008804A (en) 2002-04-16
US20020006937A1 (en) 2002-01-17
US6239142B1 (en) 2001-05-29
ATE226208T1 (en) 2002-11-15
JP2002539130A (en) 2002-11-19
NO20014363D0 (en) 2001-09-07
WO2000053610A3 (en) 2001-01-25

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