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ES2180769T3 - Inhibicion de la liberacion de amilina. - Google Patents

Inhibicion de la liberacion de amilina.

Info

Publication number
ES2180769T3
ES2180769T3 ES96914208T ES96914208T ES2180769T3 ES 2180769 T3 ES2180769 T3 ES 2180769T3 ES 96914208 T ES96914208 T ES 96914208T ES 96914208 T ES96914208 T ES 96914208T ES 2180769 T3 ES2180769 T3 ES 2180769T3
Authority
ES
Spain
Prior art keywords
compound
sstr
release
ligand
amylin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96914208T
Other languages
English (en)
Inventor
Simon Jon Dunmore
Michelle Davenport
Michael Anthony Cawthorne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BUCKINGHAM, University of
Original Assignee
BUCKINGHAM, University of
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BUCKINGHAM, University of filed Critical BUCKINGHAM, University of
Application granted granted Critical
Publication of ES2180769T3 publication Critical patent/ES2180769T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/655—Somatostatins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

UN METODO PARA DETERMINAR LA CAPACIDAD DE UN COMPUESTO PARA UNIRSE AL RECEPTOR DE SOMATOSTATINA TIPO-5 ("SSTR-5") E INHIBIR A LA VEZ LA LIBERACION DE AMILINA. EL METODO INCLUYE LA OBTENCION DE UNA PREPARACION, YA SEA UNA PREPARACION DE CELULAS O UNA PREPARACION DE MEMBRANAS, QUE CONTIENE SSTR-5; LA INCUBACION DE LA PREPARACION, EL COMPUESTO, Y UN LIGANDO DE SSTR-5, ESTANDO POR LO MENOS UNO ENTRE EL LIGANDO Y EL COMPUESTO MARCADO DE FORMA DETECTABLE; LA DETERMINACION DE LA CAPACIDAD DEL COMPUESTO PARA COMPETIR CON EL LIGANDO POR LA UNION AL SSTR-5; SI Y SOLO SI SE DETERMINA QUE EL COMPUESTO ES CAPAZ DE UNIRSE A SSTR-5, LA OBTENCION DE CELULAS PANCREATICAS; LA INCUBACION DEL COMPUESTO, LAS CELULAS PANCREATICAS, Y UN ESTIMULANTE DE LA LIBERACION DE AMILINA EN CONDICIONES EN QUE EL ESTIMULANTE DE LA LIBERACION DE AMILINA INDUCIRIA LA LIBERACION DE AMILINA POR LAS CELULAS PANCREATICAS; Y LA DETERMINACION DE LA CAPACIDAD DEL COMPUESTO PARA INHIBIR LA LIBERACION DE AMILINA. SE DESCRIBE TAMBIEN UNMETODO PARA TRATAR LA HIPERAMILINEMIA CON UN LIGANDO SELECTIVO DEL SSTR-5.
ES96914208T 1995-05-12 1996-05-11 Inhibicion de la liberacion de amilina. Expired - Lifetime ES2180769T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/440,061 US5763200A (en) 1995-05-12 1995-05-12 Inhibition of amylin release

Publications (1)

Publication Number Publication Date
ES2180769T3 true ES2180769T3 (es) 2003-02-16

Family

ID=23747259

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96914208T Expired - Lifetime ES2180769T3 (es) 1995-05-12 1996-05-11 Inhibicion de la liberacion de amilina.

Country Status (13)

Country Link
US (3) US5763200A (es)
EP (1) EP0829011B1 (es)
JP (1) JPH11505611A (es)
AT (1) ATE223045T1 (es)
AU (1) AU694360B2 (es)
CA (1) CA2220106A1 (es)
DE (1) DE69623280T2 (es)
DK (1) DK0829011T3 (es)
ES (1) ES2180769T3 (es)
MX (1) MX9708740A (es)
NZ (1) NZ308105A (es)
PT (1) PT829011E (es)
WO (1) WO1996035950A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT980253E (pt) * 1997-05-13 2004-08-31 Conseils De Rec Appl Scient S Somatostatina e agonistas de somatostatina para tratar a insensibilidade a insulina e a sindrome x
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
US7034003B1 (en) 1997-05-13 2006-04-25 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Somatostatin and somatostatin agonists for decreasing body weight
WO1998051330A1 (en) * 1997-05-13 1998-11-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) Method and compositions for treating hyperlipidemia and other conditions
WO1999012572A1 (en) * 1997-09-10 1999-03-18 University Of Florida Compounds and method for the prevention and treatment of diabetic retinopathy
CA2325169A1 (en) 1999-12-03 2001-06-03 Ndsu Research Foundation Somatostatins and method
EP1369698A1 (en) * 2002-06-07 2003-12-10 Bayer Ag Diagnostics and therapeutics for diseases associated with somatostatin receptor 5 (SSTR5)
US7611693B2 (en) * 2003-09-17 2009-11-03 Board Of Regents, The Univerisity Of Texas System Mechanism-based targeted pancreatic beta cell imaging and therapy
JP4365743B2 (ja) * 2004-07-27 2009-11-18 富士通マイクロエレクトロニクス株式会社 撮像装置
EP3746459A1 (en) 2018-02-02 2020-12-09 Univerza V Ljubljani Affinity ligands for antibody fc region

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260275A (en) * 1990-08-14 1993-11-09 Amylin Pharmaceuticals, Inc. Hypoglycemics
US5234906A (en) * 1991-01-10 1993-08-10 Amylin Pharmaceuticals, Inc. Hyperglycemic compositions
US5436155A (en) * 1991-12-31 1995-07-25 Arch Development Corporation Isolated DNA encoding a somatostatin receptor

Also Published As

Publication number Publication date
PT829011E (pt) 2003-01-31
EP0829011A1 (en) 1998-03-18
DE69623280T2 (de) 2003-05-22
US20010006790A1 (en) 2001-07-05
ATE223045T1 (de) 2002-09-15
JPH11505611A (ja) 1999-05-21
DK0829011T3 (da) 2002-10-28
DE69623280D1 (de) 2002-10-02
AU5764596A (en) 1996-11-29
NZ308105A (en) 1999-04-29
WO1996035950A1 (en) 1996-11-14
US5763200A (en) 1998-06-09
US6774109B2 (en) 2004-08-10
AU694360B2 (en) 1998-07-16
EP0829011B1 (en) 2002-08-28
CA2220106A1 (en) 1996-11-14
US20040146951A1 (en) 2004-07-29
MX9708740A (es) 1997-12-31

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