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ES2178301T3 - Derivados del acido penicilanico 2-beta-sustituido-6-alquilideno como inhibidores de la beta-lactama. - Google Patents

Derivados del acido penicilanico 2-beta-sustituido-6-alquilideno como inhibidores de la beta-lactama.

Info

Publication number
ES2178301T3
ES2178301T3 ES98964952T ES98964952T ES2178301T3 ES 2178301 T3 ES2178301 T3 ES 2178301T3 ES 98964952 T ES98964952 T ES 98964952T ES 98964952 T ES98964952 T ES 98964952T ES 2178301 T3 ES2178301 T3 ES 2178301T3
Authority
ES
Spain
Prior art keywords
beta
sup
formula
lactama
rented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98964952T
Other languages
English (en)
Inventor
John D Buynak
Akireddy Srinivasa Rao
Venkata Ramana Doppalapudi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Application granted granted Critical
Publication of ES2178301T3 publication Critical patent/ES2178301T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LOS COMPUESTOS DE FORMULA (I), EN LA QUE R 1 A Y R SUP,2 A SON CADA UNO, INDEPENDIENTEMENTE, HIDROGENO, ALQUILO (C SUB,1 C 10 ), CICLOALQUILO (C 3 - C 8 ), ALQUENI LO (C 2 - C 10 ), ALQUINILO (C 2 - C 10 ), COOR A , - CONR B R C , CIANO, - C(=O)R D , OR SUB,E , ARILO, HETEROARILO, OXAZOLIDINILO, ISOXAZOLIDINILO, MORFOLINILO, - S(O) M R F , - NR G R H , AZIDO O HALO; R 3 A ES ALQUILO (C 3 - C 10 , ALQUENILO (C2 - C 10 ), ALQUINILO (C 2 - C 10 ), ALCANO ILO (C 1 - C 10 ), CICLOALQUILO (C 3 C 8 ), ARILO, HETEROARILO, ARILALQUILO (C 1 - C 10 ), HETEROARILALQUILO (C 1 - C 10 ) O - CH 2 R I , EN Q UE R I ES HALO, CIANO, CIANATO, - OR J , NR K R SUB,L , AZIDO, - SR M O CICLOALQUILO (C 3 C 8 ); R 4 A ES HIDROGENO, ALQUILO (C 1 - C 10 ), CICLOALQUILO (C 3 - C 8 ), ALQUENILO (C 2 C 10 ), ALQUINILO (C 2 - C 10 ), ARILO O HETEROARILO; M Y N SON CADA UNO, INDEPENDIENTEMENTE, 0, 1 O 2; Y SUS SALES FARMACEUTICAMENTE ACEPTABLES SON UTILES PARA INHIBIR ENZIMAS BE - L ACTAMASA, PARA AUMENTAR LA ACTIVIDAD DEANTIBIOTICOS BE LACTAMA Y PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS RESISTENTES A LA BE - LACTAMA EN UN MAMIFERO. EN LA INVENCION TAMBIEN SE PRESENTAN COMPOSICIONES FARMACEUTICAS, PROCEDIMIENTOS PARA LA PREPARACION DE COMPUESTOS DE FORMULA (I) Y NUEVOS ELEMENTOS INTERMEDIOS UTILES EN LA SINTESIS DE COMPUESTOS DE FORMULA (I).
ES98964952T 1997-12-29 1998-12-29 Derivados del acido penicilanico 2-beta-sustituido-6-alquilideno como inhibidores de la beta-lactama. Expired - Lifetime ES2178301T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7024097P 1997-12-29 1997-12-29

Publications (1)

Publication Number Publication Date
ES2178301T3 true ES2178301T3 (es) 2002-12-16

Family

ID=22094065

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98964952T Expired - Lifetime ES2178301T3 (es) 1997-12-29 1998-12-29 Derivados del acido penicilanico 2-beta-sustituido-6-alquilideno como inhibidores de la beta-lactama.

Country Status (8)

Country Link
US (4) US6156745A (es)
EP (1) EP0966471B1 (es)
JP (1) JP3866298B2 (es)
AT (1) ATE219085T1 (es)
CA (1) CA2282461C (es)
DE (1) DE69805975T2 (es)
ES (1) ES2178301T3 (es)
WO (1) WO1999033838A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2282461C (en) * 1997-12-29 2004-04-20 John D. Buynak 2-.beta.-substituted-6-alkylidene penicillanic acid derivatives as .beta.-lactamase inhibitors
US6407091B1 (en) * 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
WO2003020732A2 (en) * 2001-07-24 2003-03-13 Alamx, L.L.C. 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors.
US20040072815A1 (en) * 2002-02-12 2004-04-15 Koppel Gary A. Antibiotic composition and method
AU2003224874A1 (en) * 2002-04-04 2003-10-27 Alamx, L.L.C. INHIBITORS OF SERINE AND METALLO-ss-LACTAMASES
US20050245498A1 (en) * 2002-05-14 2005-11-03 Shoichet Brian K Sterically-awkward beta-lactamase inhibitors
CA2528065A1 (en) * 2003-06-05 2004-12-16 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
US7687488B2 (en) * 2006-07-12 2010-03-30 Orchid Chemicals & Pharmaceuticals Ltd. 2-substituted methyl penam derivatives
US8299051B2 (en) 2008-05-13 2012-10-30 Southern Methodist University Beta-lactamase inhibitory compounds
WO2014070774A1 (en) 2012-10-29 2014-05-08 Southern Methodist University Methods of generating beta-lactamase resistant carbapenem compounds
GB201319776D0 (en) 2013-11-08 2013-12-25 Allecra Therapeutics Sas Compound
CN114423766B (zh) * 2019-09-11 2024-05-17 丹诺医药(苏州）有限公司 用于治疗细菌感染的青霉烷衍生物
CN112174983B (zh) * 2020-10-21 2021-12-31 山东安信制药有限公司 一种他唑巴坦二苯甲酯的制备方法

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US4053468A (en) * 1976-02-25 1977-10-11 Smithkline Corporation Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
FI75163C (fi) 1979-02-24 1988-05-09 Erba Farmitalia Foerfarande foer framstaellning av nya penemkarboxylsyror eller -estrar.
ZA80993B (en) 1979-02-24 1981-02-25 Erba Farmitalia -lactam-containing antibacterial agents and -lactamase inhibitors and preparation thereof
GB2076812A (en) 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use
DE3173613D1 (en) * 1980-07-04 1986-03-13 Fujisawa Pharmaceutical Co 7-oxo-cephalosporins and 6-oxo-penicillins, their analogues and process for their preparation
CA1180005A (en) 1980-10-24 1984-12-27 Solange Adam-Molina .beta.-LACTAMS
ZA826687B (en) * 1981-09-14 1983-07-27 Pfizer Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
US4559157A (en) * 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) * 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
DE3584015D1 (de) * 1984-01-30 1991-10-17 Pfizer 6-(substituierte) methylen-penicillansaeure und 6-(substituierte) hydroxymethyl-penicillansaeure und deren derivate.
PT79893B (en) 1984-01-30 1987-02-03 Pfizer Process for preparing 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicilanic and derivatives thereof
US4826833A (en) * 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
EP0170192B1 (en) 1984-07-30 1992-05-13 Merck & Co. Inc. Penicillin derivatives as anti-inflammatory and antidegenerative agents
JPS62198687A (ja) 1986-02-27 1987-09-02 Taiho Yakuhin Kogyo Kk ２β−置換チオメチルペニシリン誘導体
US4861768A (en) * 1986-02-27 1989-08-29 Taiho Pharmaceutical Company, Limited 2 β-substituted thiomethylpenicillin derivatives and their preparation and use
US4820508A (en) * 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
JP2603082B2 (ja) 1987-09-07 1997-04-23 大塚化学株式会社 ペニシラン酸誘導体の製造法
US4992478A (en) * 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) * 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
IT1227462B (it) * 1988-11-04 1991-04-11 Glaxo Spa Procedimento di preparazione di 6-ossopenicillanati
TW383308B (en) * 1993-08-24 2000-03-01 Hoffmann La Roche 2-beta-alkenyl penam sulfones as beta-lactamase inhibitors
US5629306A (en) 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
US5597817A (en) * 1994-12-09 1997-01-28 Southern Methodist University 7-vinylidene cephalosporins and methods of using the same
US5760027A (en) * 1996-12-06 1998-06-02 Research Corporation Technologies, Inc. Use of 7-alkylidene cephalosporins to inhibit elastase activity
CA2282461C (en) * 1997-12-29 2004-04-20 John D. Buynak 2-.beta.-substituted-6-alkylidene penicillanic acid derivatives as .beta.-lactamase inhibitors
US6395726B1 (en) * 1999-01-26 2002-05-28 American Cyanamid Company 3,6-disubstituted penam sulfone derivatives
AU773013B2 (en) 1999-04-15 2004-05-13 Research Corporation Technologies, Inc. Beta-lactamase inhibiting compounds
US6391855B1 (en) * 1999-06-02 2002-05-21 Adherex Technologies, Inc. Compounds and methods for modulating junctional adhesion molecule-mediated functions
WO2003020732A2 (en) 2001-07-24 2003-03-13 Alamx, L.L.C. 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors.

Also Published As

Publication number Publication date
US6770759B2 (en) 2004-08-03
US6156745A (en) 2000-12-05
JP2001501978A (ja) 2001-02-13
US20020198180A1 (en) 2002-12-26
EP0966471B1 (en) 2002-06-12
DE69805975D1 (de) 2002-07-18
WO1999033838A1 (en) 1999-07-08
EP0966471A1 (en) 1999-12-29
ATE219085T1 (de) 2002-06-15
US6436398B2 (en) 2002-08-20
US20040220399A1 (en) 2004-11-04
US7125986B2 (en) 2006-10-24
CA2282461A1 (en) 1999-07-08
DE69805975T2 (de) 2002-12-19
CA2282461C (en) 2004-04-20
JP3866298B2 (ja) 2007-01-10
US20010021706A1 (en) 2001-09-13

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