[go: up one dir, main page]

ES2177103T3 - Terapia de combinacion para el tratamiento del sida. - Google Patents

Terapia de combinacion para el tratamiento del sida.

Info

Publication number
ES2177103T3
ES2177103T3 ES98959424T ES98959424T ES2177103T3 ES 2177103 T3 ES2177103 T3 ES 2177103T3 ES 98959424 T ES98959424 T ES 98959424T ES 98959424 T ES98959424 T ES 98959424T ES 2177103 T3 ES2177103 T3 ES 2177103T3
Authority
ES
Spain
Prior art keywords
aids
treatment
combination therapy
pharmaceutically acceptable
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98959424T
Other languages
English (en)
Inventor
Joseph P Vacca
Jiunn H Lin
Kuang C Yeh
Jeffrey A Chodakewitz
Paul J Deutsch
William D Ju
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9807938.7A external-priority patent/GB9807938D0/en
Priority claimed from GBGB9819590.2A external-priority patent/GB9819590D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2177103T3 publication Critical patent/ES2177103T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Una composición que comprende (a) el Compuesto A de la fórmula o una sal o un éster farmacéuticamente aceptable del mismo y (b) un compuesto seleccionado entre Indinavir, Ritonavir, Nelfinavir, Delavirdina, 141-W94 y las sales y los ésteres farmacéuticamente aceptables de los mismos.
ES98959424T 1997-11-13 1998-11-12 Terapia de combinacion para el tratamiento del sida. Expired - Lifetime ES2177103T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6542197P 1997-11-13 1997-11-13
GBGB9807938.7A GB9807938D0 (en) 1998-04-15 1998-04-15 Combination therapy for the treatment of AIDS
US9094098P 1998-06-26 1998-06-26
GBGB9819590.2A GB9819590D0 (en) 1998-09-08 1998-09-08 Combination therapy for the treatment of aids

Publications (1)

Publication Number Publication Date
ES2177103T3 true ES2177103T3 (es) 2002-12-01

Family

ID=27451773

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98959424T Expired - Lifetime ES2177103T3 (es) 1997-11-13 1998-11-12 Terapia de combinacion para el tratamiento del sida.

Country Status (24)

Country Link
EP (1) EP1044000B1 (es)
JP (1) JP2001522889A (es)
KR (1) KR20010032055A (es)
CN (1) CN1285747A (es)
AR (1) AR013758A1 (es)
AT (1) ATE218866T1 (es)
AU (1) AU749795B2 (es)
BG (1) BG104507A (es)
BR (1) BR9814146A (es)
CA (1) CA2309164A1 (es)
CO (1) CO4970782A1 (es)
DE (1) DE69806062T2 (es)
EA (1) EA200000513A1 (es)
ES (1) ES2177103T3 (es)
HU (1) HUP0100365A3 (es)
ID (1) ID24922A (es)
IL (1) IL135994A0 (es)
IS (1) IS5481A (es)
NO (1) NO20002481L (es)
PE (1) PE20000020A1 (es)
PL (1) PL340430A1 (es)
SK (1) SK6842000A3 (es)
TR (1) TR200001938T2 (es)
WO (1) WO1999025352A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9820417D0 (en) * 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
WO2003011221A2 (en) 2001-07-30 2003-02-13 University Of Southern California PREPARATION AND USE OF α-KETO PHOSPHONATES
AU2004206821C1 (en) 2003-01-14 2009-10-01 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
GB2400553A (en) * 2003-04-14 2004-10-20 Cipla Ltd Antiviral pharmaceutical combination of lamivudine, stavudine and efavirenz, or derivatives thereof
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100234863B1 (ko) * 1993-12-15 1999-12-15 폴락 돈나 엘 사람 면역결핍 바이러스 프로테아제 억제제

Also Published As

Publication number Publication date
HUP0100365A2 (hu) 2002-05-29
AR013758A1 (es) 2001-01-10
KR20010032055A (ko) 2001-04-16
EP1044000B1 (en) 2002-06-12
NO20002481L (no) 2000-07-12
EA200000513A1 (ru) 2000-10-30
CA2309164A1 (en) 1999-05-27
DE69806062D1 (de) 2002-07-18
CN1285747A (zh) 2001-02-28
IS5481A (is) 2000-05-09
ATE218866T1 (de) 2002-06-15
EP1044000A1 (en) 2000-10-18
CO4970782A1 (es) 2000-11-07
TR200001938T2 (tr) 2001-07-23
AU749795B2 (en) 2002-07-04
PE20000020A1 (es) 2000-01-27
BG104507A (bg) 2001-03-30
DE69806062T2 (de) 2003-03-20
ID24922A (id) 2000-08-31
JP2001522889A (ja) 2001-11-20
HUP0100365A3 (en) 2002-06-28
AU1522599A (en) 1999-06-07
WO1999025352A1 (en) 1999-05-27
IL135994A0 (en) 2001-05-20
SK6842000A3 (en) 2000-12-11
PL340430A1 (en) 2001-02-12
NO20002481D0 (no) 2000-05-12
BR9814146A (pt) 2000-10-03

Similar Documents

Publication Publication Date Title
ES2076935T3 (es) Compuesto de pirazolopiridina y procedimientos para su preparacion.
MX9204625A (es) Composicion farmaceutica para el tratamiento de una especie de mamifero, que sufre de deficiencia cardiaca congestiva.
MX9700538A (es) Uso de droloxifeno y sus sales farmaceuticamente aceptables en la preparacion de remedios para las enfermedades cardiovasculares.
CO4950529A1 (es) Dihidropirimidinas y productos que las contienen
MX9300014A (es) Nuevos derivados de 1,2,4-triaminobenceno y procedimiento para su elaboracion.
ES2175127T3 (es) Derivados de la quinazolina y su uso.
AR013742A1 (es) Metodo para el tratamiento de la hipercolesterolemia con polidialilamina no substituida
UY25242A1 (es) Inhibidores de benzotiazol de la proteína tirosina cinasa
ES2233931T3 (es) Fenilacetato y derivados, solos o en combinacion con otros compuestos, contra estados neoplasicos y otros trastornos.
RU94015838A (ru) Производные бензофуранил- или бензотиофенилалкан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли
ES2145774T3 (es) Derivados de adenosina que tienen actividad agonista en a2.
CO4940450A1 (es) Formulaciones farmaceuticas que contienen voriconazol
ES2083668T3 (es) Combinaciones antiviricas que contienen analogos de nucleosidos.
ES2057124T3 (es) Producto terapeutico para el tratamiento de estados peri- o post-menopausicos.
ES2008580A6 (es) Forma de dosificacion para la liberacion rapida y lenta de agente beneficioso.
AR042345A2 (es) Un procedimiento para la preparacion de una composicion farmaceutica para el tratamiento de aterosclerosis que contiene 8.9 - dehidroesterona o sus sales de la misma
ES2196190T3 (es) Inhibidores de metaloproteinasas matriciales, con hidroxamato bifenlico.
DK0840606T3 (da) Små di- og trivalente molekyler som selectininhibitorer
ES2045182T3 (es) Substancias fisiologicamente activas, un proceso para la preparacion de las mismas y composiciones farmaceuticas que las contienen.
GT199900015A (es) Procedimiento para tratar la insuficiencia cardiaca
MX9306311A (es) Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
MX9706957A (es) Composicion que contiene amlodipina, o una sal, o felodipina y un inhibidor de enzima convertidora de angiotensina.
UY26920A1 (es) 7 - oxo piridopirimidinas
CO5040027A1 (es) Mezclas fungicidas de eteres fenilbencilicos y/o cabamatos con dinitrofenoles, procedimieto para combatir hongos dani- nos con dichas mezclas; utiliacion de dichos compuestos en la preparacion de dichas mezclas y agentes fungicidas for- mulados con d
ES2123499T3 (es) Metodos y composiciones para tratamiento de infecciones virales.