ES2174075T3 - Librerias combinatorias de compuestos bioquimicos marcados y metodos para producir las mismas. - Google Patents
Librerias combinatorias de compuestos bioquimicos marcados y metodos para producir las mismas.Info
- Publication number
- ES2174075T3 ES2174075T3 ES96919473T ES96919473T ES2174075T3 ES 2174075 T3 ES2174075 T3 ES 2174075T3 ES 96919473 T ES96919473 T ES 96919473T ES 96919473 T ES96919473 T ES 96919473T ES 2174075 T3 ES2174075 T3 ES 2174075T3
- Authority
- ES
- Spain
- Prior art keywords
- labeled
- produce
- methods
- biochemical compounds
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 9
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Peptides Or Proteins (AREA)
Abstract
LIBRERIAS DE COMBINACION DE COMPUESTOS BIOQUIMICOS MARCADOS Y METODOS DE PRODUCCION DE DICHAS LIBRERIAS DE COMBINACION QUE CONSTAN DE LOS PASOS DE PRODUCIR UNIDADES INDIVIDUALES MARCADAS, LA COMBINACION DE AL MENOS DOS UNIDADES MARCADAS PARA PRODUCIR UN COMPUESTO BIOQUIMICO MARCADO, Y LA REPETICION DE ESTE PROCESO AL MENOS EN UNA OCASION PARA PRODUCIR UNA LIBRERIA DE COMBINACION DE COMPUESTOS BIOQUIMICOS MARCADOS. ADEMAS, SE PRESENTAN LOS METODOS PARA DETERMINAR LA CONFORMACION DE UN COMPUESTO BIOQUIMICO QUE CONSISTEN EN LA PRODUCCION DE UNA LIBRERIA DE COMBINACION DE COMPUESTOS BIOQUIMICOS MARCADOS, LA PUESTA EN CONTACTO DE LA LIBRERIA DE COMBINACION DE COMPUESTOS BIOQUIMICOS MARCADOS CON UNA MOLECULA DEL RECEPTOR DIANA DE MODO QUE EL COMPUESTO BIOQUIMICO MARCADO SELECCIONADO SE UNA A LA MOLECULA DEL RECEPTOR DIANA, Y LA DETERMINACION DE LA CONFORMACION DEL COMPUESTO BIOQUIMICO MARCADO SELECCIONADO CUANDO SE UNE A LA MOLECULA DEL RECEPTOR.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49330095A | 1995-06-21 | 1995-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2174075T3 true ES2174075T3 (es) | 2002-11-01 |
Family
ID=23959668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96919473T Expired - Lifetime ES2174075T3 (es) | 1995-06-21 | 1996-06-13 | Librerias combinatorias de compuestos bioquimicos marcados y metodos para producir las mismas. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5741713A (es) |
| EP (1) | EP0839152B1 (es) |
| JP (1) | JPH11509086A (es) |
| AT (1) | ATE214396T1 (es) |
| AU (1) | AU6180696A (es) |
| CA (1) | CA2225313A1 (es) |
| DE (1) | DE69619825T2 (es) |
| DK (1) | DK0839152T3 (es) |
| ES (1) | ES2174075T3 (es) |
| PT (1) | PT839152E (es) |
| WO (1) | WO1997000887A1 (es) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1073707A4 (en) * | 1998-04-30 | 2002-03-13 | Mirus Corp | TECHNIQUE FOR MANUFACTURING A COMPOUND BY FORMING A POLYMER FROM A MATRIX DRUG |
| AU2105601A (en) * | 1999-12-17 | 2001-06-25 | Maxygen, Inc. | Methods for parallel detection of compositions having desired characteristics bymeans of mri spectroscopy |
| JP5305553B2 (ja) | 2000-10-12 | 2013-10-02 | ユニバーシティー オブ ロチェスター | 癌細胞の増殖を阻害する組成物 |
| US7367155B2 (en) | 2000-12-20 | 2008-05-06 | Monsanto Technology Llc | Apparatus and methods for analyzing and improving agricultural products |
| EP2311852A1 (en) | 2002-02-06 | 2011-04-20 | Stasys Technologies, Inc. | Anti-infarction molecules |
| AU2003253580A1 (en) * | 2002-02-26 | 2003-11-17 | University Of Minnesota | Variants of nedd4l associated with hypertension and viral budding |
| PT1499545E (pt) | 2002-04-04 | 2008-03-20 | Monsanto Technology Llc | Sistema automatizado de triagem, pesagem e recolha de matéria particulada |
| CA2495478A1 (en) | 2002-08-05 | 2004-02-12 | University Of Rochester | Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof |
| US20040214232A1 (en) * | 2002-08-16 | 2004-10-28 | Burke Martin D. | Generation of skeletal diversity within a combinatorial library |
| US6878871B2 (en) | 2002-09-05 | 2005-04-12 | Nanosys, Inc. | Nanostructure and nanocomposite based compositions and photovoltaic devices |
| MXPA06003184A (es) | 2003-09-23 | 2006-06-23 | Monsanto Technology Llc | Sistema automatizado de alto rendimiento para analisis de semillas. |
| US7703238B2 (en) | 2004-08-26 | 2010-04-27 | Monsanto Technology Llc | Methods of seed breeding using high throughput nondestructive seed sampling |
| MX2007002307A (es) | 2004-08-26 | 2007-04-16 | Monsanto Technology Llc | Prueba automatizada de semillas. |
| WO2006108183A2 (en) | 2005-04-05 | 2006-10-12 | Corning Incorporated | Label free biosensors and cells |
| EP3827747A1 (en) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
| EP2371843B1 (en) | 2005-05-19 | 2014-09-17 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services | Functional epitopes of streptococcus pneumoniae psaA antigen and uses thereof |
| MX338235B (es) | 2005-06-07 | 2016-04-08 | Dsm Nutritional Products Ag | Microorganismos eucarioticos para producir lipidos y antioxidantes. |
| US8080534B2 (en) | 2005-10-14 | 2011-12-20 | Phigenix, Inc | Targeting PAX2 for the treatment of breast cancer |
| EP2189522A1 (en) | 2005-10-14 | 2010-05-26 | MUSC Foundation For Research Development | Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy |
| AU2006308863A1 (en) * | 2005-10-31 | 2007-05-10 | Janssen Pharmaceutica N.V. | A polypeptide complex of TRPM8 and calmodulin and its uses thereof |
| US8028469B2 (en) | 2006-03-02 | 2011-10-04 | Monsanto Technology Llc | Automated high-throughput seed sampler and methods of sampling, testing and bulking seeds |
| US7998669B2 (en) | 2006-03-02 | 2011-08-16 | Monsanto Technology Llc | Automated contamination-free seed sampler and methods of sampling, testing and bulking seeds |
| GB0605584D0 (en) * | 2006-03-20 | 2006-04-26 | Olink Ab | Method for analyte detection using proximity probes |
| EP3162454B1 (en) | 2006-06-28 | 2019-04-24 | Monsanto Technology LLC | Small object sorting method |
| EP2082053B1 (en) * | 2006-08-01 | 2016-04-13 | DSM Nutritional Products AG | Process for producing microbial oil comprising polyunsaturated fatty acids |
| EP2066812A4 (en) | 2006-09-21 | 2010-04-28 | Univ Rochester | COMPOSITIONS AND METHODS RELATED TO PROTEIN SHIFT THERAPY FOR MYOTONE DYSTROPHY |
| EP2104516B1 (en) | 2006-11-01 | 2015-01-07 | University of Rochester | Methods and compositions related to the structure and function of apobec3g |
| EP2097448A4 (en) | 2006-12-22 | 2010-07-21 | Univ Utah Res Found | PROCEDURE FOR THE EVIDENCE OF EYE DISEASES AND SUFFERINGS AND THEIR TREATMENT |
| JP2010514839A (ja) | 2007-01-03 | 2010-05-06 | バーナム インスティテュート フォー メディカル リサーチ | クロット結合化合物に関連する方法および組成物 |
| EP2117576B1 (en) | 2007-02-08 | 2014-04-16 | University Of Utah Research Foundation | Methods and compositions related to inhibition of viral entry |
| ES2428571T3 (es) | 2007-05-31 | 2013-11-08 | Monsanto Technology, Llc | Clasificador de semillas |
| US8961412B2 (en) | 2007-09-25 | 2015-02-24 | Proteus Digital Health, Inc. | In-body device with virtual dipole signal amplification |
| US8816095B2 (en) * | 2008-08-15 | 2014-08-26 | Georgetown University | Na channels, disease, and related assays and compositions |
| US20120070443A1 (en) | 2008-12-02 | 2012-03-22 | University Of Utah Research Foundation | Pde1 as a target therapeutic in heart disease |
| US10481167B2 (en) | 2008-12-05 | 2019-11-19 | C2N Diagnostics | Methods for measuring concentrations of biomolecules |
| BR122013009559A2 (pt) | 2009-04-28 | 2019-08-06 | Proteus Digital Health, Inc. | Marcadores de evento de ingerível altamente confiável e métodos para usar os mesmos |
| WO2011022502A1 (en) | 2009-08-18 | 2011-02-24 | Georgetown University | Boronic acid compositions and methods related to cancer |
| EP2485768A1 (en) | 2009-10-07 | 2012-08-15 | Sanford-Burnham Medical Research Institute | Methods and compositions related to clot-binding lipid compounds |
| JP2013515008A (ja) | 2009-12-18 | 2013-05-02 | サンフォード−バーナム メディカル リサーチ インスティテュート | 凝血塊結合化合物に関連する方法および組成物 |
| GB201004292D0 (en) * | 2010-03-15 | 2010-04-28 | Olink Ab | Assay for localised detection of analytes |
| GB201101621D0 (en) | 2011-01-31 | 2011-03-16 | Olink Ab | Method and product |
| CA2868735C (en) | 2011-03-28 | 2020-02-25 | University Of Utah Research Foundation | D-peptide conjugates comprising a membrane localizing potency-enhancing cargo molecule for inhibiting hiv entry |
| PE20141562A1 (es) | 2011-10-14 | 2014-11-12 | Genentech Inc | Anticuerpos anti-htra1 y metodos de uso |
| WO2013082307A1 (en) * | 2011-12-02 | 2013-06-06 | C2N Diagnostics | Methods for measuring concentrations of biomolecules |
| GB201201547D0 (en) | 2012-01-30 | 2012-03-14 | Olink Ab | Method and product |
| WO2014139980A1 (en) | 2013-03-12 | 2014-09-18 | Ventana Medical Systems, Inc. | Proximity assay for in situ detection of targets |
| WO2014139979A1 (en) | 2013-03-12 | 2014-09-18 | Ventana Medical Systems, Inc. | Quantum dot in situ hybridization |
| EP2970926B1 (en) | 2013-03-13 | 2018-01-31 | DSM Nutritional Products AG | Engineering microorganisms |
| AU2015352625B2 (en) | 2014-11-25 | 2019-07-25 | Ventana Medical Systems, Inc. | Proximity assays using chemical ligation and hapten transfer |
| GB201518655D0 (en) | 2015-10-21 | 2015-12-02 | Olink Ab | Method for generating proximity probes |
| SI3368578T1 (sl) | 2015-10-30 | 2021-08-31 | F. Hoffmann-La Roche Ag | Protitelesa proti HtrA1 in postopki uporabe |
| US12025615B2 (en) | 2017-09-15 | 2024-07-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods of classifying response to immunotherapy for cancer |
| US12357653B2 (en) | 2017-12-15 | 2025-07-15 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides and uses thereof |
| KR20210134716A (ko) | 2019-03-01 | 2021-11-10 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 폴리리보뉴클레오티드의 전달을 위한 조성물, 방법, 및 키트 |
| WO2020198403A2 (en) | 2019-03-25 | 2020-10-01 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising modified circular polyribonucleotides and uses thereof |
| WO2020252436A1 (en) | 2019-06-14 | 2020-12-17 | Flagship Pioneering Innovations Vi, Llc | Circular rnas for cellular therapy |
| JP2022536951A (ja) | 2019-06-19 | 2022-08-22 | フラッグシップ パイオニアリング イノベーションズ シックス,エルエルシー | 環状ポリリボヌクレオチドを投与する方法 |
| WO2021067550A1 (en) | 2019-10-02 | 2021-04-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and compositions for identifying neoantigens for use in treating and preventing cancer |
| US20230104113A1 (en) | 2020-01-29 | 2023-04-06 | Flagship Pioneering Innovations Vi, Llc | Delivery of compositions comprising circular polyribonucleotides |
| BR112022025113A2 (pt) | 2020-06-30 | 2022-12-27 | Monsanto Technology Llc | Sistemas automatizados para uso em separação de pequenos objetos, e métodos relacionados |
| EP4266991A4 (en) | 2021-01-29 | 2025-01-01 | The Regents of University of California | IMPLANTABLE IMAGING DEVICES FOR IN VIVO IMAGING |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0474790T3 (da) * | 1989-06-14 | 1997-07-07 | Martek Corp | Medier til cellevækst og fremgangsmåde til fremstilling deraf |
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| CA2143848C (en) * | 1992-10-01 | 2007-09-11 | W. Clark Still | Complex combinatorial chemical libraries encoded with tags |
-
1996
- 1996-06-13 EP EP96919473A patent/EP0839152B1/en not_active Expired - Lifetime
- 1996-06-13 AU AU61806/96A patent/AU6180696A/en not_active Abandoned
- 1996-06-13 WO PCT/US1996/010526 patent/WO1997000887A1/en not_active Ceased
- 1996-06-13 DE DE69619825T patent/DE69619825T2/de not_active Expired - Fee Related
- 1996-06-13 ES ES96919473T patent/ES2174075T3/es not_active Expired - Lifetime
- 1996-06-13 PT PT96919473T patent/PT839152E/pt unknown
- 1996-06-13 DK DK96919473T patent/DK0839152T3/da active
- 1996-06-13 JP JP9503898A patent/JPH11509086A/ja active Pending
- 1996-06-13 AT AT96919473T patent/ATE214396T1/de not_active IP Right Cessation
- 1996-06-13 CA CA002225313A patent/CA2225313A1/en not_active Abandoned
- 1996-06-21 US US08/667,723 patent/US5741713A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0839152A1 (en) | 1998-05-06 |
| DK0839152T3 (da) | 2002-07-08 |
| DE69619825T2 (de) | 2002-10-10 |
| JPH11509086A (ja) | 1999-08-17 |
| ATE214396T1 (de) | 2002-03-15 |
| PT839152E (pt) | 2002-09-30 |
| WO1997000887A1 (en) | 1997-01-09 |
| DE69619825D1 (de) | 2002-04-18 |
| EP0839152B1 (en) | 2002-03-13 |
| US5741713A (en) | 1998-04-21 |
| CA2225313A1 (en) | 1997-01-09 |
| AU6180696A (en) | 1997-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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