[go: up one dir, main page]

ES2172549T3 - Nuevas sales por adicion de acidos de cefem, cristalinas, y procedimiento para su preparacion. - Google Patents

Nuevas sales por adicion de acidos de cefem, cristalinas, y procedimiento para su preparacion.

Info

Publication number
ES2172549T3
ES2172549T3 ES95117409T ES95117409T ES2172549T3 ES 2172549 T3 ES2172549 T3 ES 2172549T3 ES 95117409 T ES95117409 T ES 95117409T ES 95117409 T ES95117409 T ES 95117409T ES 2172549 T3 ES2172549 T3 ES 2172549T3
Authority
ES
Spain
Prior art keywords
cefem
crystals
acids
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95117409T
Other languages
English (en)
Inventor
Rudolf Dr Lattrell
Walter Dr Durckheimer
Peter Dr Schmid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Application granted granted Critical
Publication of ES2172549T3 publication Critical patent/ES2172549T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPUESTOS DE LA FORMULA I DONDE N ES IGUAL A 1 O 2 Y M ES 0,4 - 2,6 Y DONDE X SIGNIFICA EL ANION DE UN ACIDO CARBOXILICO, MOSTRANDO UNA ACTIVIDAD ANTIBACTERIAL.
ES95117409T 1994-11-10 1995-11-06 Nuevas sales por adicion de acidos de cefem, cristalinas, y procedimiento para su preparacion. Expired - Lifetime ES2172549T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4440141A DE4440141A1 (de) 1994-11-10 1994-11-10 Neue kristalline Cephem-Säureadditionssalze und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ES2172549T3 true ES2172549T3 (es) 2002-10-01

Family

ID=6532953

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95117409T Expired - Lifetime ES2172549T3 (es) 1994-11-10 1995-11-06 Nuevas sales por adicion de acidos de cefem, cristalinas, y procedimiento para su preparacion.

Country Status (28)

Country Link
US (1) US5747484A (es)
EP (1) EP0711774B1 (es)
JP (1) JP3920939B2 (es)
KR (1) KR100449191B1 (es)
CN (1) CN1066452C (es)
AR (1) AR002246A1 (es)
AT (1) ATE213248T1 (es)
AU (1) AU707730B2 (es)
BR (1) BR9505132A (es)
CA (1) CA2162530C (es)
CZ (1) CZ290936B6 (es)
DE (2) DE4440141A1 (es)
DK (1) DK0711774T3 (es)
ES (1) ES2172549T3 (es)
FI (1) FI120263B (es)
HU (1) HU219475B (es)
IL (1) IL115914A (es)
MA (1) MA23709A1 (es)
NO (1) NO311891B1 (es)
NZ (1) NZ280424A (es)
OA (1) OA10242A (es)
PL (1) PL182806B1 (es)
PT (1) PT711774E (es)
RU (1) RU2161619C2 (es)
SK (1) SK282545B6 (es)
TR (1) TR199501392A2 (es)
TW (1) TW422847B (es)
ZA (1) ZA959510B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2288199A1 (en) * 1997-04-29 1998-11-05 The University Of New Mexico Hydroxynaphthoic acids and derivatives
DE60305728T2 (de) * 2002-10-25 2006-10-12 Intervet International Bv Pharmazeutische Zusammensetzung mit verlängerter Freisetzung
US20080318919A1 (en) * 2005-10-29 2008-12-25 Intervet International B.V. Cefquinome Compositions and Methods of Their Use
TWI400243B (zh) * 2009-07-20 2013-07-01 Intervet Int Bv 製造西喹諾（ｃｅｆｑｕｉｎｏｍｅ）粒子的方法
EP2753326A4 (en) 2011-09-09 2015-04-15 Cubist Pharm Inc METHOD FOR THE TREATMENT OF INTRAPULMONARY INFECTIONS
CN103813803A (zh) * 2011-09-29 2014-05-21 美艾利尔圣地亚哥公司 2-羟基马尿酸衍生物及其它们的合成方法和用途
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
NZ700372A (en) 2013-03-15 2016-01-29 Merck Sharp & Dohme Ceftolozane antibiotic compositions
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3248281A1 (de) * 1982-12-28 1984-06-28 Hoechst Ag, 6230 Frankfurt Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
DE3316797A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
JPH064643B2 (ja) * 1985-12-20 1994-01-19 ファイザー製薬株式会社 セフアロスポリン化合物
DE3706020A1 (de) * 1987-02-25 1988-09-08 Hoechst Ag Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
AR002246A1 (es) 1998-03-11
CZ293395A3 (en) 1996-05-15
NO954511L (no) 1996-05-13
DK0711774T3 (da) 2002-04-22
CA2162530A1 (en) 1996-05-11
CN1129220A (zh) 1996-08-21
FI120263B (fi) 2009-08-31
KR100449191B1 (ko) 2006-01-12
JPH08208662A (ja) 1996-08-13
AU707730B2 (en) 1999-07-15
CA2162530C (en) 2007-07-31
CZ290936B6 (cs) 2002-11-13
ATE213248T1 (de) 2002-02-15
PL182806B1 (pl) 2002-03-29
ZA959510B (en) 1996-05-28
HUT74163A (en) 1996-11-28
TW422847B (en) 2001-02-21
HU9503213D0 (en) 1996-01-29
BR9505132A (pt) 1997-09-09
NO954511D0 (no) 1995-11-09
PT711774E (pt) 2002-07-31
DE4440141A1 (de) 1996-05-15
EP0711774B1 (de) 2002-02-13
IL115914A (en) 2002-08-14
TR199501392A2 (tr) 1996-07-21
FI955382A0 (fi) 1995-11-08
EP0711774A1 (de) 1996-05-15
JP3920939B2 (ja) 2007-05-30
KR960017670A (ko) 1996-06-17
FI955382L (fi) 1996-05-11
SK139795A3 (en) 1996-06-05
PL311326A1 (en) 1996-05-13
IL115914A0 (en) 1996-01-31
HU219475B (hu) 2001-04-28
MA23709A1 (fr) 1996-07-01
US5747484A (en) 1998-05-05
AU3772895A (en) 1996-05-16
OA10242A (fr) 1997-09-19
NO311891B1 (no) 2002-02-11
DE59510048D1 (de) 2002-03-21
RU2161619C2 (ru) 2001-01-10
CN1066452C (zh) 2001-05-30
SK282545B6 (sk) 2002-10-08
NZ280424A (en) 1997-06-24

Similar Documents

Publication Publication Date Title
ES2172549T3 (es) Nuevas sales por adicion de acidos de cefem, cristalinas, y procedimiento para su preparacion.
ES2063093T3 (es) Composiciones orales.
ES2102132T3 (es) Amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos.
ES2018111A6 (es) Procedimiento de preparacion de derivados de 4h-1-benzopiran-4-ona o sus sales.
ES8103753A1 (es) Procedimiento para la preparacion de acidos 3-cefem-4-carbo-xilicos sustituidos en la posicion 7
KR950700258A (ko) 레티노이드 수용체(rar)에 결합하는 헤테로고리 탄산유도체(heterocyclic carbonic acid derivatives which bind to retinoid receptors(rar))
DE69737605D1 (de) Sulfonierte aminosäurederivate und metalloproteinase-inhibitoren, die diese enthalten
ES2038251T3 (es) Un procedimiento para producir un derivado de benzamida.
CU22305A3 (es) Procedimiento para la preparacion de un derivado de aminoacidos
SE8005890L (sv) Salter av (+)-katekin, deras framstellning och anvendning, och kompositioner innehallande dessa salter
ES556747A0 (es) Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ATE46501T1 (de) Abkoemmlinge der guanidinomethylbenzoesaeure.
BG50163A3 (bg) Метод за получаване на ацилови производни
ES2053856T3 (es) Derivados del acido 4-quinoleino carboxilico utiles para el tratamiento de enfermedades de la piel y del muco-epitelio.
PT1303267E (pt) Sistema de aplicacao dermico para o acido aminolevulinico
ES8707245A1 (es) Un metodo para preparar nuevos derivados de cefem
CO4290351A1 (es) Proceso
ES2117132T3 (es) Sales de desferrioxamina-b y su uso como queladores de hierro eficaces por via oral.
ES2167100T3 (es) Sales impregnadas, un procedimiento para su obtencion, y su empleo.
NO162722C (no) Fremgangsmaate for fremstilling av 6-alfa-monobrom-penicillansyre-1,1-dioksyd-derivater.
SE8001689L (sv) 6-beta-substituerade penicillansyror med beta-laktamas-inhibitorverkan
ES535624A0 (es) Un procedimiento para la preparacion de 9-deoxo-9a-metil-9a-aza-9a-homoeritromicina b o una sal de la misma
BR8405719A (pt) Composto,composicao e processo para a preparacao de um composto
ES2113851T3 (es) Sales cristalinas estables y muy hidrosolubles antivirales de 2',3'-didesoxiinoxina monohidrato, 2',3'-didesoxi-2',3'-didehidrotimidina monohidrato y 2',3'-didesoxi-2'-fluoroinosina hemihidrato.
ES2099728T3 (es) Procedimiento para la preparacion de acidos 2,3-piridin- y quinolindicarboxilicos sustituidos y no sustituidos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 711774

Country of ref document: ES