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ES2171705T3 - Complejos de polipeptido-dendrimero. - Google Patents

Complejos de polipeptido-dendrimero.

Info

Publication number
ES2171705T3
ES2171705T3 ES96927393T ES96927393T ES2171705T3 ES 2171705 T3 ES2171705 T3 ES 2171705T3 ES 96927393 T ES96927393 T ES 96927393T ES 96927393 T ES96927393 T ES 96927393T ES 2171705 T3 ES2171705 T3 ES 2171705T3
Authority
ES
Spain
Prior art keywords
polypeptide
compositions
dendrimer
dendrimero
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96927393T
Other languages
English (en)
Inventor
Pratap Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dade Behring Inc
Original Assignee
Dade Behring Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Inc filed Critical Dade Behring Inc
Application granted granted Critical
Publication of ES2171705T3 publication Critical patent/ES2171705T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE PRESENTAN COMPOSICIONES QUE COMPRENDEN DENDRIMEROS A LOS CUALES SE ACOPLA DE FORMA CONTROLABLE UN PRIMER POLIPEPTIDO. TALES COMPOSICIONES DE POLIPEPTIDO-DENDRIMERO SON EFECTIVAS PAR ACOPLAR DE FORMA CONTROLABLE UN SEGUNDO POLIPEPTIDO AL DENDRIMERO. EL PRIMER Y EL SEGUNDO POLIPEPTIDO TIENEN ACTIVIDADES BIOLOGICAS DEFINIDAS SEPARADAS Y DISTINTAS, POR EJEMPLO, DOS ANTICUERPOS CON UNA PRIMERA Y UNA SEGUNDA ESPECIFICIDAD DE UNION O UN ANTICUERPO Y UN MARCADOR ENZIMATICO. TALES COMPOSICIONES SON UTILES COMO INDICADORES EN ENSAYOS DE UNION ESPECIFICA, POR EJEMPLO, INMUNOENSAYOS. TAMBIEN SE HAN DESCUBIERTO METODOS PARA ACOPLAR SECUENCIALMENTE DOS POLIPEPTIDOS DIFERENTES A UN DENDRIMERO PARA FORMAR LAS COMPOSICIONES DE LA INVENCION.
ES96927393T 1995-08-11 1996-08-09 Complejos de polipeptido-dendrimero. Expired - Lifetime ES2171705T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/514,075 US6083708A (en) 1995-08-11 1995-08-11 Polypeptide: dendrimer complexes

Publications (1)

Publication Number Publication Date
ES2171705T3 true ES2171705T3 (es) 2002-09-16

Family

ID=24045699

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96927393T Expired - Lifetime ES2171705T3 (es) 1995-08-11 1996-08-09 Complejos de polipeptido-dendrimero.

Country Status (9)

Country Link
US (1) US6083708A (es)
EP (1) EP0786087B1 (es)
JP (1) JPH10507778A (es)
AT (1) ATE213837T1 (es)
AU (1) AU6722796A (es)
CA (1) CA2201712A1 (es)
DE (1) DE69619493T2 (es)
ES (1) ES2171705T3 (es)
WO (1) WO1997007398A1 (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
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US7074904B2 (en) * 1994-07-29 2006-07-11 Altor Bioscience Corporation MHC complexes and uses thereof
CA2376619A1 (en) * 1999-06-29 2001-01-11 Dako A/S Detection using dendrimers bearing labels and probes
US20040146918A1 (en) * 2000-02-18 2004-07-29 Weiner Michael L. Hybrid nucleic acid assembly
US20020106648A1 (en) * 2000-05-05 2002-08-08 Lizardi Paul M. Highly multiplexed reporter carrier systems
US6471968B1 (en) * 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
KR100377946B1 (ko) * 2000-07-15 2003-03-29 한국과학기술원 덴드리머를 이용한 단분자막의 제조방법
CA2463678A1 (en) * 2000-10-17 2002-04-25 Besst-Test Aps Assay for directly detecting a rs virus related biological cell in a body fluid sample
AU2002217863A1 (en) * 2000-12-01 2002-06-11 Conforma Therapeutic Corporation Homing peptide multimers, their preparation and uses
WO2002057745A2 (en) * 2001-01-08 2002-07-25 Tropix, Inc. Dendritic chemiluminescent substrates
US7338805B2 (en) 2001-05-04 2008-03-04 Bio Merieux Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
US20040058865A1 (en) * 2001-11-26 2004-03-25 Danishefsky Samuel J Homing peptide multimers, their preparation and uses
US20040009495A1 (en) * 2001-12-07 2004-01-15 Whitehead Institute For Biomedical Research Methods and products related to drug screening using gene expression patterns
US20040023248A1 (en) * 2001-12-07 2004-02-05 Whitehead Institiute For Biomedical Research Methods and reagents for improving nucleic acid detection
AU2003256038A1 (en) * 2002-08-30 2004-03-19 Ramot At Tel Aviv University Ltd. Self-immolative dendrimers releasing many active moieties upon a single activating event
US7138121B2 (en) * 2003-01-23 2006-11-21 Spangler Brenda D Biosensors utilizing dendrimer-immobilized ligands and there use thereof
WO2004081055A1 (ja) * 2003-02-21 2004-09-23 Terumo Kabushiki Kaisha 架橋性多糖誘導体、その製造方法、架橋性多糖組成物および医療用処置材
EP2264191A1 (en) * 2003-11-21 2010-12-22 ANP Technologies, Inc. Asymmetrically branched polymer conjugates and microarray assays
FR2868071B1 (fr) * 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
FR2873388B1 (fr) * 2004-07-23 2012-04-06 Biomerieux Sa Procede de marquage et de purification d'acides nucleiques d'interet presents dans un echantillon biologique a traiter dans un unique recipient reactionnel
WO2006102484A2 (en) * 2005-03-21 2006-09-28 Anp Technologies, Inc. Symmetrically branched polymer conjugates and microarray assays
EP2208998A3 (en) 2005-05-02 2011-03-16 ANP Technologies, Inc. Polymer conjugate enhanced bioassays
US20060269480A1 (en) * 2005-05-31 2006-11-30 Ramot At Tel Aviv University Ltd. Multi-triggered self-immolative dendritic compounds
FR2886735B1 (fr) * 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
GB2433505A (en) * 2005-12-20 2007-06-27 Sharp Kk Capture agents for binding a ligand
GB2433506A (en) * 2005-12-20 2007-06-27 Sharp Kk A method of producing a multimeric capture agent
GB2433591A (en) * 2005-12-20 2007-06-27 Sharp Kk Method for functionalising a hydrophobic substrate
FR2917090B1 (fr) * 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
AU2009205935B9 (en) 2008-01-18 2014-11-13 Ffa Sciences, Llc Development and use of cysteine - labeled fluorescent probes of unbound analytes
KR101644144B1 (ko) * 2008-07-11 2016-07-29 유니버셜 바이오센서스 피티와이 엘티디. 향상된 면역분석 센서
FR2934595B1 (fr) * 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
WO2010039861A2 (en) 2008-09-30 2010-04-08 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010054321A2 (en) 2008-11-07 2010-05-14 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
AU2010318637A1 (en) 2009-10-13 2012-05-31 The Regents Of The University Of Michigan Dendrimer compositions and methods of synthesis
US8912323B2 (en) 2009-10-30 2014-12-16 The Regents Of The University Of Michigan Multifunctional small molecules
US9733242B2 (en) 2012-10-07 2017-08-15 Sevident, Inc. Devices for capturing analyte
CN103038639B (zh) * 2009-11-24 2017-03-29 赛维登特公司 用于检测分析物的装置
US9910040B2 (en) 2012-07-09 2018-03-06 Sevident, Inc. Molecular nets comprising capture agents and linking agents
WO2013085718A1 (en) 2011-12-08 2013-06-13 The Regents Of The University Of Michigan Multifunctional small molecules
US9366669B2 (en) 2011-12-20 2016-06-14 Siemens Healthcare Diagnostics Inc. Coated substrates for high energy capture phase binding and methods of production and use thereof
JP7436838B2 (ja) * 2020-05-20 2024-02-22 藤倉化成株式会社 抗体－デンドリマー複合体を用いるヘモグロビンＡ１ｃの測定方法
CN112305222A (zh) * 2020-11-05 2021-02-02 东莞市医本生物科技有限公司 一种小多聚体酶-抗体片段及其制备与应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4363634A (en) * 1980-07-18 1982-12-14 Akzona Incorporated Glass support coated with synthetic polymer for bioprocess
US4517288A (en) * 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US4568737A (en) * 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US4507466A (en) * 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US5482830A (en) * 1986-02-25 1996-01-09 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US4694064A (en) * 1986-02-28 1987-09-15 The Dow Chemical Company Rod-shaped dendrimer
ES2054678T5 (es) * 1986-08-18 1997-09-16 Dow Chemical Co Conjugados estrella.
US5338532A (en) * 1986-08-18 1994-08-16 The Dow Chemical Company Starburst conjugates
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
US5914095A (en) * 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
US5541057A (en) * 1989-09-18 1996-07-30 Biostar, Inc. Methods for detection of an analyte
US5171264A (en) * 1990-02-28 1992-12-15 Massachusetts Institute Of Technology Immobilized polyethylene oxide star molecules for bioapplications
US5418136A (en) * 1991-10-01 1995-05-23 Biostar, Inc. Devices for detection of an analyte based upon light interference
US6113946A (en) * 1992-04-03 2000-09-05 The Regents Of The University Of California Self-assembling polynucleotide delivery system comprising dendrimer polycations
WO1994003774A1 (en) * 1992-07-31 1994-02-17 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US6121056A (en) * 1993-02-24 2000-09-19 Dade Behring Inc. Random detection of antigens with antibodies immobilized on soluble submicron particles
US5898005A (en) * 1993-02-24 1999-04-27 Dade Behring Inc. Rapid detection of analytes with receptors immobilized on soluble submicron particles
ATE178717T1 (de) * 1993-02-24 1999-04-15 Dade Behring Inc Immobilisierung von reagenzien für spezifische bindungsassay
US5718915A (en) * 1994-10-31 1998-02-17 Burstein Laboratories, Inc. Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme

Also Published As

Publication number Publication date
JPH10507778A (ja) 1998-07-28
US6083708A (en) 2000-07-04
AU6722796A (en) 1997-03-12
ATE213837T1 (de) 2002-03-15
EP0786087A1 (en) 1997-07-30
WO1997007398A1 (en) 1997-02-27
CA2201712A1 (en) 1997-02-27
DE69619493T2 (de) 2002-10-31
DE69619493D1 (de) 2002-04-04
EP0786087B1 (en) 2002-02-27

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