ES2171465T3 - Inhibidor de la esterasa de c1 para reducir lesiones de miocardio durante un infarto de miocardio agudo. - Google Patents
Inhibidor de la esterasa de c1 para reducir lesiones de miocardio durante un infarto de miocardio agudo.Info
- Publication number
- ES2171465T3 ES2171465T3 ES94929047T ES94929047T ES2171465T3 ES 2171465 T3 ES2171465 T3 ES 2171465T3 ES 94929047 T ES94929047 T ES 94929047T ES 94929047 T ES94929047 T ES 94929047T ES 2171465 T3 ES2171465 T3 ES 2171465T3
- Authority
- ES
- Spain
- Prior art keywords
- miocard
- acute
- inhibitor
- esterase inhibitor
- infratement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001154 acute effect Effects 0.000 title abstract 4
- 229940009550 c1 esterase inhibitor Drugs 0.000 title abstract 3
- 208000027418 Wounds and injury Diseases 0.000 title 1
- 230000006378 damage Effects 0.000 title 1
- 208000014674 injury Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 108090000371 Esterases Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Electrotherapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
UN METODO DE TRATAMIENTO TERAPEUTICO O PROFILACTICO DE LA INFARTACION MIOCARDICA AGUDA, QUE CONSISTE EN ADMINISTRAR UN INHIBIDOR DE LA ESTERASA C1 EXOGENO, POR SI SOLO O COMBINADO CON OTROS FARMACOS, A UN PACIENTE CON INFARTACION MIOCARDICA AGUDO O A UN PACIENTE CON RIESGO DE PADECER UN INFARTO DE MIOCARDIO AGUDO. EL TRATAMIENTO INHIBE LA REACCION INFLAMATORIA, Y DE MANERA MAS ESPECIFICA LA ACTIVACION DEL SISTEMA COMPLEMENTO, QUE TIENE LUGAR DURANTE UNA INFARTACION MIOCARDICA AGUDO. EL INHIBIDOR DE LA ESTERASA C1 PUEDE INCLUIR UN INHIBIDOR DE LA ESTERASA C1 PURIFICADO A PARTIR DE UN PLASMA O DE OTROS MATERIALES BIOLOGICOS, O UN INHIBIDOR DE LA ESTERASA C1 RECOMBINANTE, O ESTRUCTURAS RECOMBINANTES DE OTROS INHIBIDORES QUE POSEEN UNA ESPECIFICIDAD SIMILAR A LA DEL INHIBIDOR DE LA ESTERASA C1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93202572 | 1993-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2171465T3 true ES2171465T3 (es) | 2002-09-16 |
Family
ID=8214075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94929047T Expired - Lifetime ES2171465T3 (es) | 1993-09-01 | 1994-08-31 | Inhibidor de la esterasa de c1 para reducir lesiones de miocardio durante un infarto de miocardio agudo. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6090777A (es) |
| EP (1) | EP0716611B1 (es) |
| JP (2) | JP4077030B2 (es) |
| AT (1) | ATE212859T1 (es) |
| AU (1) | AU678064B2 (es) |
| DE (1) | DE69429816T2 (es) |
| DK (1) | DK0716611T3 (es) |
| ES (1) | ES2171465T3 (es) |
| PT (1) | PT716611E (es) |
| WO (1) | WO1995006479A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19829014A1 (de) * | 1998-06-30 | 2000-01-05 | Centeon Pharma Gmbh | Modifizierter C1-Esterase-Inhibitor zur Blockierung der Infektiosität von HIV |
| US7008645B2 (en) * | 1998-07-14 | 2006-03-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of inhibiting restenosis using bisphosphonates |
| CA2426115A1 (en) * | 2003-04-18 | 2004-10-18 | Victor Gurewich | Methods, devices, and compositions for lysis of occlusive blood clots while sparing wound sealing clots |
| US20060051407A1 (en) * | 2003-06-27 | 2006-03-09 | Yoram Richter | Method of treating ischemia-reperfusion injury |
| US10517883B2 (en) * | 2003-06-27 | 2019-12-31 | Zuli Holdings Ltd. | Method of treating acute myocardial infarction |
| US20070196367A1 (en) * | 2006-02-22 | 2007-08-23 | Valentin Dinu | Methods of preventing and treating Alzheimer's disease, age related macular degeneration and other diseases involving extra-cellular debris through the inhibition of the complement system |
| US20090010916A1 (en) * | 2006-06-22 | 2009-01-08 | Victor Gurewich | C-1 Inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis |
| CA3154415A1 (en) | 2006-10-10 | 2008-04-17 | Regenesance B.V. | Anti-sense oligonucleotide for use in facilitating axonal regeneration |
| CN110818798A (zh) | 2012-10-25 | 2020-02-21 | 美国比奥维拉迪维股份有限公司 | 抗补体C1s抗体和其用途 |
| RS63212B1 (sr) | 2012-11-02 | 2022-06-30 | Bioverativ Usa Inc | Antikomplementna c1s antitela i njihove primene |
| JP6289511B2 (ja) * | 2013-02-28 | 2018-03-07 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 羊水塞栓の治療剤 |
| AU2014224599B2 (en) * | 2013-03-08 | 2018-11-08 | Csl Behring Gmbh | Treatment and prevention of remote ischemia-reperfusion injury |
| US9993427B2 (en) | 2013-03-14 | 2018-06-12 | Biorest Ltd. | Liposome formulation and manufacture |
| SMT201700415T1 (it) | 2013-03-15 | 2017-11-15 | Shire Viropharma Inc | Composizioni di c1-inh per l’uso nella prevenzione e nel trattamento dell’angioedema ereditario (hae) |
| JP2017501968A (ja) * | 2013-06-28 | 2017-01-19 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 第ｘｉｉ因子インヒビターおよびｃ１−インヒビターを使用する組合せ療法 |
| HUE061076T2 (hu) | 2015-04-06 | 2023-05-28 | Bioverativ Usa Inc | Humanizált anti-C1s ellenanyagok alkalmazási eljárások |
| DK3525583T3 (da) | 2016-10-12 | 2025-10-27 | Bioverativ Usa Inc | Anti-c1s-antistoffer og fremgangsmåder til anvendelse deraf |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3228502A1 (de) * | 1982-07-30 | 1984-02-02 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung des c1-inaktivators und seine verwendung |
| FR2601034B1 (fr) * | 1986-07-03 | 1989-11-17 | Pasteur Institut | Inhibiteur de l'activite de la c1-esterase plasmatique (c1-inhibiteur) et d'autres enzymes proteolytiques du groupe des proteases a serine, son procede de preparation, acides nucleiques codant pour cet inhibiteur, methodes de detection d'affections correlees aux defauts dudit inhibiteur a l'aide d'anticorps ou de sondes nucleotidiques et medicaments contenant ledit inhibiteur de synthese |
| WO1991006650A1 (en) * | 1989-10-27 | 1991-05-16 | Cetus Corporation | C1 inhibitor muteins and uses thereof |
| WO1992022320A1 (en) * | 1991-06-14 | 1992-12-23 | Genentech, Inc. | C1 inhibitor variants and treating inflammatory response with c1 inhibitor |
-
1994
- 1994-08-31 AT AT94929047T patent/ATE212859T1/de active
- 1994-08-31 AU AU78239/94A patent/AU678064B2/en not_active Expired
- 1994-08-31 ES ES94929047T patent/ES2171465T3/es not_active Expired - Lifetime
- 1994-08-31 WO PCT/NL1994/000208 patent/WO1995006479A1/en not_active Ceased
- 1994-08-31 US US08/604,933 patent/US6090777A/en not_active Expired - Lifetime
- 1994-08-31 EP EP94929047A patent/EP0716611B1/en not_active Expired - Lifetime
- 1994-08-31 DK DK94929047T patent/DK0716611T3/da active
- 1994-08-31 DE DE69429816T patent/DE69429816T2/de not_active Expired - Lifetime
- 1994-08-31 JP JP50804995A patent/JP4077030B2/ja not_active Expired - Lifetime
- 1994-08-31 PT PT94929047T patent/PT716611E/pt unknown
-
2007
- 2007-11-21 JP JP2007301371A patent/JP2008056705A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008056705A (ja) | 2008-03-13 |
| JPH09501946A (ja) | 1997-02-25 |
| PT716611E (pt) | 2002-06-28 |
| EP0716611B1 (en) | 2002-02-06 |
| JP4077030B2 (ja) | 2008-04-16 |
| US6090777A (en) | 2000-07-18 |
| DE69429816T2 (de) | 2002-09-19 |
| EP0716611A1 (en) | 1996-06-19 |
| AU678064B2 (en) | 1997-05-15 |
| DK0716611T3 (da) | 2002-05-21 |
| ATE212859T1 (de) | 2002-02-15 |
| WO1995006479A1 (en) | 1995-03-09 |
| AU7823994A (en) | 1995-03-22 |
| DE69429816D1 (de) | 2002-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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