ES2170628B1 - SMALL INHIBITORS OF MOLECULES OF THE ACTIVITY OF ENZYMES OF ROTAMASA - Google Patents
SMALL INHIBITORS OF MOLECULES OF THE ACTIVITY OF ENZYMES OF ROTAMASAInfo
- Publication number
- ES2170628B1 ES2170628B1 ES9950069A ES9950069A ES2170628B1 ES 2170628 B1 ES2170628 B1 ES 2170628B1 ES 9950069 A ES9950069 A ES 9950069A ES 9950069 A ES9950069 A ES 9950069A ES 2170628 B1 ES2170628 B1 ES 2170628B1
- Authority
- ES
- Spain
- Prior art keywords
- activity
- enzymes
- rotamasa
- molecules
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 102000000521 Immunophilins Human genes 0.000 abstract 2
- 108010016648 Immunophilins Proteins 0.000 abstract 2
- 101710103508 FK506-binding protein Proteins 0.000 abstract 1
- 101710104425 FK506-binding protein 2 Proteins 0.000 abstract 1
- 101710104423 FK506-binding protein 3 Proteins 0.000 abstract 1
- 101710104333 FK506-binding protein 4 Proteins 0.000 abstract 1
- 101710104342 FK506-binding protein 5 Proteins 0.000 abstract 1
- 101710149710 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710121306 FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710180800 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA Proteins 0.000 abstract 1
- 102000004195 Isomerases Human genes 0.000 abstract 1
- 108090000769 Isomerases Proteins 0.000 abstract 1
- 101710104030 Long-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710114693 Outer membrane protein MIP Proteins 0.000 abstract 1
- 101710116692 Peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710111764 Peptidyl-prolyl cis-trans isomerase FKBP10 Proteins 0.000 abstract 1
- 101710111749 Peptidyl-prolyl cis-trans isomerase FKBP11 Proteins 0.000 abstract 1
- 101710111747 Peptidyl-prolyl cis-trans isomerase FKBP12 Proteins 0.000 abstract 1
- 101710111757 Peptidyl-prolyl cis-trans isomerase FKBP14 Proteins 0.000 abstract 1
- 101710111682 Peptidyl-prolyl cis-trans isomerase FKBP1A Proteins 0.000 abstract 1
- 101710111689 Peptidyl-prolyl cis-trans isomerase FKBP1B Proteins 0.000 abstract 1
- 101710147154 Peptidyl-prolyl cis-trans isomerase FKBP2 Proteins 0.000 abstract 1
- 101710147149 Peptidyl-prolyl cis-trans isomerase FKBP3 Proteins 0.000 abstract 1
- 101710147152 Peptidyl-prolyl cis-trans isomerase FKBP4 Proteins 0.000 abstract 1
- 101710147150 Peptidyl-prolyl cis-trans isomerase FKBP5 Proteins 0.000 abstract 1
- 101710147138 Peptidyl-prolyl cis-trans isomerase FKBP7 Proteins 0.000 abstract 1
- 101710147137 Peptidyl-prolyl cis-trans isomerase FKBP8 Proteins 0.000 abstract 1
- 101710147136 Peptidyl-prolyl cis-trans isomerase FKBP9 Proteins 0.000 abstract 1
- 102100038809 Peptidyl-prolyl cis-trans isomerase FKBP9 Human genes 0.000 abstract 1
- 101710174853 Peptidyl-prolyl cis-trans isomerase Mip Proteins 0.000 abstract 1
- 101710200991 Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme Proteins 0.000 abstract 1
- 101710092145 Peptidyl-prolyl cis-trans isomerase-like 1 Proteins 0.000 abstract 1
- 101710092146 Peptidyl-prolyl cis-trans isomerase-like 2 Proteins 0.000 abstract 1
- 101710092148 Peptidyl-prolyl cis-trans isomerase-like 3 Proteins 0.000 abstract 1
- 101710092149 Peptidyl-prolyl cis-trans isomerase-like 4 Proteins 0.000 abstract 1
- 101710113444 Probable parvulin-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710090737 Probable peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710133309 Putative peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710124237 Short-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- -1 esters compounds Chemical class 0.000 abstract 1
- 230000000508 neurotrophic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Esta invención se refiere a compuestos de esteres de prolilo N-glioxilo neurotróficos que tengan una afinidad para las inmunofilinas del tipo FKBP, su preparación y uso como inhibidores de la actividad de enzimas asociadas con las proteínas inmunofilinas, y particularmente inhibidores de la actividad de la enzima de rotamasa o isomerasa de prolilopeptidilo.This invention relates to neurotrophic N-glyoxyl esters compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the activity of enzymes associated with immunophilin proteins, and particularly inhibitors of the activity of the Rotamase enzyme or prolylpeptidyl isomerase.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/479,436 US5614547A (en) | 1995-06-07 | 1995-06-07 | Small molecule inhibitors of rotamase enzyme |
| US08/650,461 US5859031A (en) | 1995-06-07 | 1996-05-21 | Small molecule inhibitors of rotamase enzyme activity |
| ES009650030A ES2131457B1 (en) | 1995-06-07 | 1996-06-05 | SMALL INHIBITORS OF ROTAMASA ENZYMES ACTIVITY MOLECULES. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2170628A1 ES2170628A1 (en) | 2002-08-01 |
| ES2170628B1 true ES2170628B1 (en) | 2003-06-16 |
Family
ID=27240554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9950069A Expired - Fee Related ES2170628B1 (en) | 1995-06-07 | 1996-06-05 | SMALL INHIBITORS OF MOLECULES OF THE ACTIVITY OF ENZYMES OF ROTAMASA |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2170628B1 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2091194A1 (en) * | 1992-04-08 | 1993-10-09 | Richard D. Connell | 2-oxo-ethyl derivatives as immunosuppressants |
-
1996
- 1996-06-05 ES ES9950069A patent/ES2170628B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2170628A1 (en) | 2002-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20020801 Kind code of ref document: A1 Effective date: 20020801 |
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| FG2A | Definitive protection |
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| PC2A | Transfer granted | ||
| FD1A | Patent lapsed |
Effective date: 20100315 |