ES2169067T3 - Derivados de benzoilecgonina, ecgonina y ecgonidina como medicamentos. - Google Patents
Derivados de benzoilecgonina, ecgonina y ecgonidina como medicamentos.Info
- Publication number
- ES2169067T3 ES2169067T3 ES94906466T ES94906466T ES2169067T3 ES 2169067 T3 ES2169067 T3 ES 2169067T3 ES 94906466 T ES94906466 T ES 94906466T ES 94906466 T ES94906466 T ES 94906466T ES 2169067 T3 ES2169067 T3 ES 2169067T3
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- disorders
- ecgonine
- ecgonidine
- benzoilecgonine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HZGRVVUQEIBCMS-HTRCEHHLSA-N (1s,5r)-8-methyl-8-azabicyclo[3.2.1]oct-3-ene-4-carboxylic acid Chemical compound C1C=C(C(O)=O)[C@H]2CC[C@@H]1N2C HZGRVVUQEIBCMS-HTRCEHHLSA-N 0.000 title abstract 3
- PHMBVCPLDPDESM-YWIQKCBGSA-N Ecgonine Natural products C1[C@H](O)[C@@H](C(O)=O)[C@H]2CC[C@@H]1N2C PHMBVCPLDPDESM-YWIQKCBGSA-N 0.000 title abstract 3
- PHMBVCPLDPDESM-UHFFFAOYSA-N d-Pseudoekgonin Natural products C1C(O)C(C(O)=O)C2CCC1N2C PHMBVCPLDPDESM-UHFFFAOYSA-N 0.000 title abstract 3
- PHMBVCPLDPDESM-FKSUSPILSA-N ecgonine Chemical compound C1[C@H](O)[C@H](C(O)=O)[C@H]2CC[C@@H]1N2C PHMBVCPLDPDESM-FKSUSPILSA-N 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- GVGYEFKIHJTNQZ-RFQIPJPRSA-N ecgonine benzoate Chemical class O([C@@H]1[C@@H]([C@H]2CC[C@@H](C1)N2C)C(O)=O)C(=O)C1=CC=CC=C1 GVGYEFKIHJTNQZ-RFQIPJPRSA-N 0.000 abstract 2
- KZFBHCCLJSAHBQ-UHFFFAOYSA-N Benzoylecgonine Natural products CN1C2CCC1C(C(C2)OC(=C)c3ccccc3)C(=O)O KZFBHCCLJSAHBQ-UHFFFAOYSA-N 0.000 abstract 1
- 208000012659 Joint disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000018631 connective tissue disease Diseases 0.000 abstract 1
- 230000004957 immunoregulator effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000018360 neuromuscular disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
UN COMPUESTO DE FORMULA (I), FORMULA (II) O FORMULA (III), DONDE R1 ES SELECCIONADO DEL GRUPO FORMADO POR H; ALQUILO RAMIFICADO O NO RAMIFICADO, ALQUENILO Y ALQUINILO, SIENDO DICHO ALQUILO, ALQUENILO Y ALQUINILO, OPCIONALMENTE SUSTITUIDOS POR OH, SH, NH2, O HALOGENO; COCH3; COPH; Y COBN; R2 ES SELECCIONADO DEL GRUPO FORMADO POR ALQUILO RAMIFICADO O NO RAMIFICADO, ALQUENILO Y ALQUINILO, SIENDO DICHO ALQUILO, ALQUENILO Y ALQUINILO OPCIONALMENTE SUSTITUIDOS POR OH, SH, NH2, O HALOGENO; ARYLO, HET Y BENCILO; R3 ES SELECCIONADO DEL GRUPO FORMADO POR ALQUILO RAMIFICADO O NO RAMIFICADO, ALQUENILO Y ALQUINILO, SIENDO DICHO ALQUILO, ALQUENILO Y ALQUINILO OPCIONALMENTE SUSTITUIDOS POR OH, SH, NH2, O HALOGENO; R4 ES SELECCIONADO DEL GRUPO FORMADO POR H; Y ALQUILO RAMIFICADO O NO RAMIFICADO, ALQUENILO Y ALQUINILO, SIENDO DICHO ALQUILO, ALQUENILO Y ALQUINILO OPCIONALMENTE SUSTITUIDOS POR OH, SH, NH2, O HALOGENO; Y X ES SELECCIONADO DEL GRUPO FORMADO POR OH; SH; NH2; Y HALOGENO: LOS CUALES SON UTILES PARA PALIAR LOS SINTOMAS DE DESARREGLOS INMUNOREGULATORIOS, NEUROMUSCULARES, DE ARTICULACIONES, DEL TEJIDO CONJUNTIVO, CIRCULATORIOS Y DOLOR.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/999,307 US5376667A (en) | 1992-12-31 | 1992-12-31 | Derivatives of benzoylecgonine, ecgonine and their multiple pharmacological properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2169067T3 true ES2169067T3 (es) | 2002-07-01 |
Family
ID=25546170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94906466T Expired - Lifetime ES2169067T3 (es) | 1992-12-31 | 1993-12-23 | Derivados de benzoilecgonina, ecgonina y ecgonidina como medicamentos. |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US5376667A (es) |
| EP (1) | EP0677051B1 (es) |
| JP (1) | JP2938188B2 (es) |
| CN (1) | CN1053187C (es) |
| AT (1) | ATE209646T1 (es) |
| AU (1) | AU682677B2 (es) |
| CA (1) | CA2151618C (es) |
| DE (1) | DE69331235T2 (es) |
| DK (1) | DK0677051T3 (es) |
| ES (1) | ES2169067T3 (es) |
| HU (1) | HUT72972A (es) |
| IL (1) | IL108193A (es) |
| NO (1) | NO313830B1 (es) |
| NZ (1) | NZ261420A (es) |
| PL (2) | PL175756B1 (es) |
| PT (1) | PT677051E (es) |
| TW (1) | TW342386B (es) |
| WO (1) | WO1994015935A1 (es) |
| ZA (1) | ZA939807B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030133955A1 (en) * | 1993-02-22 | 2003-07-17 | American Bioscience, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
| US6482831B1 (en) | 1994-06-16 | 2002-11-19 | Entropin, Inc. | Covalently coupled benzoylecgonine, egconine and ecgonidine derivatives |
| US5763456A (en) * | 1995-06-07 | 1998-06-09 | Entropin, Inc. | Benzoylecgonine, ecgonine and ecgonidine derivatives |
| US5525613A (en) * | 1994-06-16 | 1996-06-11 | Entropin, Inc. | Covalently coupled benzoylecgonine ecgonine and ecgonidine |
| US5808074A (en) * | 1996-02-02 | 1998-09-15 | Georgetown University | Benzoylecgonine conjugate diagnostic reagents |
| WO1999051994A1 (en) * | 1998-04-08 | 1999-10-14 | The General Hospital Corporation | Pharmacological mri (phmri) |
| WO2003042209A1 (en) * | 2001-11-13 | 2003-05-22 | Entropin, Inc. | Novel benzoylecgonine compositions and methods for producing them |
| JP2005537311A (ja) * | 2002-08-21 | 2005-12-08 | エントロピン， インコーポレイテッド | ヒドロキシアルキルトロパンエステルを生成するための方法 |
| TW200418856A (en) * | 2002-12-05 | 2004-10-01 | Entropin Inc | Novel tropane esters and methods for producing and using them |
| US7906149B2 (en) * | 2007-05-25 | 2011-03-15 | Boval Company, L.P. | Method for treating allergic dermatitis |
| WO2021231565A1 (en) * | 2020-05-13 | 2021-11-18 | Edgewise Therapeutics, Inc. | Pyridazinone compounds for the treatment of neuromuscular diseases |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US456663A (en) * | 1891-07-28 | Reverberatory furnace | ||
| US2893996A (en) * | 1957-10-14 | 1959-07-07 | Grace W R & Co | N-amino derivatives of tropine alkaloids |
| US2948730A (en) * | 1959-02-04 | 1960-08-09 | Grace W R & Co | 8-aminotropanium compounds |
| US4469700A (en) * | 1981-06-19 | 1984-09-04 | Lowell M. Somers | Benzoylecgonine or benzoylnorecgonine as active agents for the treatment of rheumatoid arthritis |
| US4556663A (en) * | 1982-12-13 | 1985-12-03 | Somers Lowell M | Benzoylecgonine, benzoylnorecgonine and ecgonine as active agents for the treatment of rheumatoid arthritis and osteoarthritis |
| US4512996A (en) * | 1982-12-13 | 1985-04-23 | Lowell Somers | Benzoylecgonine or benzoylnorecgonine as active agents for the treatment of rheumatoid arthritis |
-
1992
- 1992-12-31 US US07/999,307 patent/US5376667A/en not_active Expired - Lifetime
-
1993
- 1993-12-23 ES ES94906466T patent/ES2169067T3/es not_active Expired - Lifetime
- 1993-12-23 DK DK94906466T patent/DK0677051T3/da active
- 1993-12-23 DE DE69331235T patent/DE69331235T2/de not_active Expired - Fee Related
- 1993-12-23 PL PL93309664A patent/PL175756B1/pl not_active IP Right Cessation
- 1993-12-23 AU AU60160/94A patent/AU682677B2/en not_active Ceased
- 1993-12-23 HU HU9502008A patent/HUT72972A/hu unknown
- 1993-12-23 WO PCT/US1993/012625 patent/WO1994015935A1/en not_active Ceased
- 1993-12-23 NZ NZ261420A patent/NZ261420A/xx unknown
- 1993-12-23 AT AT94906466T patent/ATE209646T1/de not_active IP Right Cessation
- 1993-12-23 PL PL93321837A patent/PL174826B1/pl not_active IP Right Cessation
- 1993-12-23 PT PT94906466T patent/PT677051E/pt unknown
- 1993-12-23 EP EP94906466A patent/EP0677051B1/en not_active Expired - Lifetime
- 1993-12-23 JP JP6516076A patent/JP2938188B2/ja not_active Expired - Fee Related
- 1993-12-23 CA CA002151618A patent/CA2151618C/en not_active Expired - Fee Related
- 1993-12-27 IL IL10819393A patent/IL108193A/en not_active IP Right Cessation
- 1993-12-27 TW TW082111002A patent/TW342386B/zh active
- 1993-12-30 ZA ZA939807A patent/ZA939807B/xx unknown
- 1993-12-30 CN CN93121730A patent/CN1053187C/zh not_active Expired - Fee Related
-
1994
- 1994-10-07 US US08/320,050 patent/US5559123A/en not_active Expired - Fee Related
-
1995
- 1995-06-05 US US08/463,123 patent/US5663345A/en not_active Expired - Fee Related
- 1995-06-29 NO NO19952611A patent/NO313830B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ261420A (en) | 1997-08-22 |
| NO313830B1 (no) | 2002-12-09 |
| CN1053187C (zh) | 2000-06-07 |
| EP0677051A1 (en) | 1995-10-18 |
| PT677051E (pt) | 2002-05-31 |
| DE69331235T2 (de) | 2002-07-25 |
| ZA939807B (en) | 1994-08-18 |
| TW342386B (en) | 1998-10-11 |
| PL309664A1 (en) | 1995-10-30 |
| NO952611D0 (no) | 1995-06-29 |
| US5663345A (en) | 1997-09-02 |
| IL108193A (en) | 1998-12-06 |
| US5559123A (en) | 1996-09-24 |
| AU6016094A (en) | 1994-08-15 |
| JP2938188B2 (ja) | 1999-08-23 |
| DE69331235D1 (de) | 2002-01-10 |
| CA2151618C (en) | 2000-08-01 |
| DK0677051T3 (da) | 2002-02-25 |
| JPH08507751A (ja) | 1996-08-20 |
| PL175756B1 (pl) | 1999-02-26 |
| WO1994015935A1 (en) | 1994-07-21 |
| IL108193A0 (en) | 1994-04-12 |
| PL174826B1 (pl) | 1998-09-30 |
| CA2151618A1 (en) | 1994-07-21 |
| CN1095720A (zh) | 1994-11-30 |
| ATE209646T1 (de) | 2001-12-15 |
| HK1012627A1 (en) | 1999-08-06 |
| AU682677B2 (en) | 1997-10-16 |
| NO952611L (no) | 1995-08-30 |
| EP0677051B1 (en) | 2001-11-28 |
| HUT72972A (en) | 1996-06-28 |
| HU9502008D0 (en) | 1995-09-28 |
| US5376667A (en) | 1994-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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