ES2168926B1 - DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION. - Google Patents
DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION.Info
- Publication number
- ES2168926B1 ES2168926B1 ES9902726A ES9902726A ES2168926B1 ES 2168926 B1 ES2168926 B1 ES 2168926B1 ES 9902726 A ES9902726 A ES 9902726A ES 9902726 A ES9902726 A ES 9902726A ES 2168926 B1 ES2168926 B1 ES 2168926B1
- Authority
- ES
- Spain
- Prior art keywords
- sub
- derivatives
- pharmaceutical composition
- quinoleina
- ciclohexa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- XNMYNYSCEJBRPZ-UHFFFAOYSA-N 2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine Chemical compound C1=CC=C2C(OCCN(C)C)=NC(CCCC)=CC2=C1 XNMYNYSCEJBRPZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- -1 methoxymethylene group Chemical group 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados de ciclopenta-, ciclohexa- y ciclohepta[b]quinoleína, procedimiento para su fabricación, utilización y composición farmacéutica correspondiente, o una sal o solvato farmaceuticamente aceptable de los mismos, de fórmula general (I), donde: - X{sub,1} y X{sub,2} son cada uno independientemente hidrógeno, flúor, cloro, metilo, etilo, hidroxi o amino. - Los sustituyentes X{sub,1} y X{sub,2} sobre el anillo fenilo pueden estar en cualquier posición. - X{sub,1} X{sub,2} pueden formar conjuntamente un grupo metoximetilen. - n = 3, 4, 5 - X{sub,3} y X{sub,4} son cada uno independientemente metilo, etilo, metoxi, etoxi - X{sub,3} y X{sub,4} pueden formar conjuntamente un ciclo conteniendo 2 heteroátomos de oxígeno o nitrógeno. La utilización es para la manufactura de medicamentos destinados al tratamiento de patologías con déficit del sistema colinérgico, como la enfermedad de Alzheimer. El procedimiento comprende la condensación de las correspondientes ciclopenta-, ciclohexa- y ciclohepta[b]quinoleínas con derivados del tipo (IV), donde - R = C{sub,1}-C{sub,4} alquilo.Derivatives of cyclopenta-, cyclohexa- and cyclohepta [b] quinolein, process for their manufacture, use and corresponding pharmaceutical composition, or a pharmaceutically acceptable salt or solvate thereof, of general formula (I), where: - X {sub, 1} and X {sub, 2} are each independently hydrogen, fluorine, chlorine, methyl, ethyl, hydroxy or amino. - The substituents X {sub, 1} and X {sub, 2} on the phenyl ring may be in any position. - X {sub, 1} X {sub, 2} can together form a methoxymethylene group. - n = 3, 4, 5-X {sub, 3} and X {sub, 4} are each independently methyl, ethyl, methoxy, ethoxy-X {sub, 3} and X {sub, 4} can form together a cycle containing 2 oxygen or nitrogen heteroatoms. The use is for the manufacture of medicines for the treatment of pathologies with deficits of the cholinergic system, such as Alzheimer's disease. The process comprises the condensation of the corresponding cyclopenta-, cyclohexa- and cyclohepta [b] quinoleins with derivatives of type (IV), where - R = C {sub, 1} -C {sub, 4} alkyl.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9902726A ES2168926B1 (en) | 1999-12-14 | 1999-12-14 | DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9902726A ES2168926B1 (en) | 1999-12-14 | 1999-12-14 | DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2168926A1 ES2168926A1 (en) | 2002-06-16 |
| ES2168926B1 true ES2168926B1 (en) | 2003-10-16 |
Family
ID=8310894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9902726A Expired - Fee Related ES2168926B1 (en) | 1999-12-14 | 1999-12-14 | DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2168926B1 (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0268871A1 (en) * | 1986-10-31 | 1988-06-01 | Sumitomo Pharmaceuticals Company, Limited | Quinoline derivatives |
| IL85741A (en) * | 1987-03-17 | 1996-05-14 | Hoechst Roussel Pharma | Substituted tetrahydroacridines a process for their preparation and pharmaceutical compositions containing substituted alpha-amino-tetrahydroacridines |
| US4957915A (en) * | 1989-02-27 | 1990-09-18 | Biomeasure, Inc. | Benzodiazepine analogs |
| US4999430A (en) * | 1989-07-31 | 1991-03-12 | Warner-Lambert Company | Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine |
| US5783584A (en) * | 1995-12-11 | 1998-07-21 | Mayo Foundation For Medical Education And Research | THA analogs useful as cholinesterase inhibitors |
-
1999
- 1999-12-14 ES ES9902726A patent/ES2168926B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2168926A1 (en) | 2002-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2023251416B2 (en) | Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof | |
| AU2004213616B2 (en) | A process of preparing imatinib | |
| US7419975B2 (en) | Organic compounds | |
| AU655798B2 (en) | 2,4-diaminoquinazolines derivatives for enhancing antitumor activity | |
| RU2346945C2 (en) | Derivatives of n-heterocyclylmethylmenzamides, obtainment and application in therapy | |
| BR0015718A (en) | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | |
| GB1573809A (en) | Basically substituted indole derivative and process for their manufacture | |
| BRPI0411713B1 (en) | COMPOUNDS, PROCESS FOR MANUFACTURING, PHARMACEUTICAL COMPOSITIONS UNDERSTANDING THEME, METHOD FOR TREATMENT AND / OR PROPHYLAXY OF NURSES THAT ARE ASSOCIATED WITH DPP-IV AND THEIR USE | |
| PL170736B1 (en) | Method for the production of new isatin PL derivatives | |
| JP2000512645A (en) | Sulfonamide derivatives and their use in treating CNS disorders | |
| UY27592A1 (en) | NEW USE | |
| NO310658B1 (en) | Quinozoline derivatives, pharmaceutical preparations containing such derivatives, their use, and their method of preparation | |
| YU50002A (en) | Substituted piperidines, medicaments containing these compounds,and methods for the production thereof | |
| US20070004761A1 (en) | Pyrazolo [3,4-d] pyrimidine derivatives and their use in the treatment of h.pylori infection | |
| PT94521B (en) | 5,11-DIHYDRO-6H-DIPYRIDO- {3,2-B: 2 ', 3'-E} {1,4} -DIAZEPINO-6-ONES AND THIONES AND PHARMACEUTICAL COMPOSITIONS FOR PREPARATION AIDS TREATMENT OR PROPHYLAXY | |
| ZA200504042B (en) | Tetracyclic-3-substituted indoles having serotonin receptor affinity | |
| DK213087A (en) | 1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES AND PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF, THEIR PREPARATION AND USE | |
| DE60209362D1 (en) | 3-SUBSTITUTED CHINOLIN-4-CARBOXYLIC ACID AMID DERIVATIVES AS NK-3 AND NK-2 RECEPTOR ANTAGONISTS | |
| RU2436786C1 (en) | Substituted indoles, antiviral active component, synthesis and application method | |
| KR101435496B1 (en) | Benzimidazole derivatives as mitochondrial function modulators | |
| DK0509400T3 (en) | 1- (Pyrido (3,4-b) -1,4-oxazinyl-4-yl) -1H-indoles, intermediates and a process for their preparation, and their use as pharmaceuticals | |
| IL95250A (en) | 1-(pyridinylamino)-2-pyrrolidinones, a process for their preparation and their use as medicaments | |
| ES2168926B1 (en) | DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION. | |
| Teitel et al. | Alkaloids in mammalian tissues. 4. Synthesis of (+)-and (-)-salsoline and isosalsoline | |
| EP3484867A1 (en) | Inhibitors of tryptophan 2,3-dioxygenase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20020616 Kind code of ref document: A1 Effective date: 20020616 |
|
| FG2A | Definitive protection |
Ref document number: 2168926B1 Country of ref document: ES |
|
| PC2A | Transfer granted | ||
| FD1A | Patent lapsed |
Effective date: 20101018 |