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ES2167720T3 - 1-PHENYLPIRAZOL COMPOUNDS AND MEDICINAL APPLICATIONS OF THE SAME. - Google Patents

1-PHENYLPIRAZOL COMPOUNDS AND MEDICINAL APPLICATIONS OF THE SAME.

Info

Publication number
ES2167720T3
ES2167720T3 ES97909603T ES97909603T ES2167720T3 ES 2167720 T3 ES2167720 T3 ES 2167720T3 ES 97909603 T ES97909603 T ES 97909603T ES 97909603 T ES97909603 T ES 97909603T ES 2167720 T3 ES2167720 T3 ES 2167720T3
Authority
ES
Spain
Prior art keywords
compounds
phenylpirazol
same
medicinal applications
hyperuricacidemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97909603T
Other languages
Spanish (es)
Inventor
Seigo Ishibuchi
Hiroshi Morimoto
Atsushi Fukunari
Hiroyoshi Inoue
Yoichi Naka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Application granted granted Critical
Publication of ES2167720T3 publication Critical patent/ES2167720T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)

Abstract

1-Phenylpyrazole compounds of the formula (1): <CHEM> which is exemplified by 5-amino-1-(3-cyano-4-isobutoxyphenyl)pyrazole-4-carboxylic acid, an optical isomer thereof and a pharmaceutically acceptable salt thereof. These compounds have a xanthine oxidase inhibitory activity and are useful as therapeutic agents for diseases such as hyperuricacidemia and gout.
ES97909603T 1996-10-25 1997-10-22 1-PHENYLPIRAZOL COMPOUNDS AND MEDICINAL APPLICATIONS OF THE SAME. Expired - Lifetime ES2167720T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28447996 1996-10-25
JP5578697 1997-03-11
JP26130597 1997-09-26

Publications (1)

Publication Number Publication Date
ES2167720T3 true ES2167720T3 (en) 2002-05-16

Family

ID=27295710

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97909603T Expired - Lifetime ES2167720T3 (en) 1996-10-25 1997-10-22 1-PHENYLPIRAZOL COMPOUNDS AND MEDICINAL APPLICATIONS OF THE SAME.

Country Status (16)

Country Link
US (1) US6015829A (en)
EP (1) EP0936217B1 (en)
JP (1) JP3220987B2 (en)
KR (1) KR100345942B1 (en)
CN (1) CN1105708C (en)
AT (1) ATE208379T1 (en)
AU (1) AU731055B2 (en)
CA (1) CA2269721C (en)
DE (1) DE69708142T2 (en)
DK (1) DK0936217T3 (en)
ES (1) ES2167720T3 (en)
ID (1) ID21775A (en)
IL (1) IL129409A (en)
PL (1) PL332946A1 (en)
PT (1) PT936217E (en)
WO (1) WO1998018765A1 (en)

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US6569885B1 (en) * 1999-12-23 2003-05-27 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US7112594B2 (en) 2000-08-09 2006-09-26 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
JP4532408B2 (en) * 2003-03-13 2010-08-25 田辺三菱製薬株式会社 Tumor formation inhibitor
DK1757610T3 (en) * 2004-06-14 2011-08-01 Nippon Chemiphar Co Condensed pyrimidine derivative and xanthine oxidase inhibitor
WO2006022375A1 (en) 2004-08-27 2006-03-02 Astellas Pharma Inc. 2-phenylthiophene derivative
ES2331579T3 (en) 2004-08-27 2010-01-08 Astellas Pharma Inc. DERIVED FROM 2-PHENYLPIRIDINE.
JP2008545627A (en) * 2005-05-09 2008-12-18 タツプ・フアーマシユーテイカル・プロダクツ・インコーポレイテツド How to treat nephrolithiasis
EP1940397A4 (en) * 2005-08-03 2010-01-20 Takeda Pharmaceuticals North A Methods for treating hypertension
EP1932833B1 (en) * 2005-10-07 2012-08-01 Kissei Pharmaceutical Co., Ltd. Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
CN101282934A (en) 2005-10-07 2008-10-08 安斯泰来制药株式会社 Triaryl carboxylic acid derivatives
ES2383766T3 (en) * 2006-02-24 2012-06-26 Astellas Pharma Inc. Remedy or preventive for digestive ulcer
US8318792B2 (en) 2006-07-19 2012-11-27 Nippon Medical School Foundation Therapeutic agent for amyotrophic lateral sclerosis
US20080269226A1 (en) * 2006-11-13 2008-10-30 Christopher Lademacher Methods for Preserving Renal Function Using Xanthine Oxidoreductase Inhibitors
US20090124623A1 (en) * 2006-11-13 2009-05-14 Christopher Lademacher Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors
JP2010516691A (en) * 2007-01-19 2010-05-20 タケダ ファーマシーティカルズ ノース アメリカ，アイエヌシー． Method for suppressing or reducing the number of gout suddenly using anti-inflammatory agent and xanthine oxidoreductase inhibitor
WO2008126901A1 (en) * 2007-04-11 2008-10-23 Kissei Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic compound and pharmaceutical composition containing the same
WO2008126899A1 (en) * 2007-04-11 2008-10-23 Kissei Pharmaceutical Co., Ltd. 5-membered heterocyclic derivative and use thereof for medical purposes
SI2133332T1 (en) * 2007-04-11 2014-02-28 Kissei Pharmaceutical Co., Ltd. (aza)indole derivative and use thereof for medical purposes
CN101386605B (en) * 2008-10-23 2010-09-08 中国科学院上海药物研究所 Novel crystal of febuxostat and preparation method thereof
US20100311756A1 (en) * 2009-01-22 2010-12-09 Takeda Pharmaceuticals North America, Inc. Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof
EP2754658A1 (en) 2009-02-27 2014-07-16 Teijin Pharma Limited Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst
CN101580495A (en) * 2009-05-25 2009-11-18 沈阳药科大学 5-substituted phenyl-3-isoxazole carboxylic acid and ester compounds, compositions and preparation method thereof
TWI423962B (en) 2009-10-07 2014-01-21 Lg Life Sciences Ltd Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same
WO2011103439A1 (en) * 2010-02-19 2011-08-25 Takeda Pharmaceuticals North America, Inc. Methods for stabilizing joint damage in subjects using xanthine oxidoreductase inhibitors
PT2610248T (en) 2010-08-27 2016-08-23 Teijin Pharma Ltd Method for producing phenyl-substituted heterocyclic derivative by means of coupling method using a palladium compound
ES2532210T3 (en) 2010-09-10 2015-03-25 Takeda Pharmaceuticals U.S.A., Inc. Methods for the concomitant treatment of theophylline and febuxostat
CN102766099B (en) * 2012-08-07 2015-09-23 沈阳药科大学 There is compound and salt, preparation method and the purposes of xanthine oxidase inhibitory activity
CN103848798B (en) 2012-11-30 2016-01-06 镇江新元素医药科技有限公司 2-aryl selenazoles compound and pharmaceutical composition thereof
CN105189476B (en) 2013-03-29 2017-07-07 帝人制药株式会社 Pyrazole derivatives
CN105294584A (en) * 2015-11-30 2016-02-03 中国医科大学 1-substituted phenyl-1H-1,2,3-triazole compound as well as preparation method and application thereof
CN106279024B (en) * 2016-07-19 2018-09-14 华南理工大学 A kind of xanthine oxidoreductase inhibitors and the preparation method and application thereof
CN106632245B (en) * 2016-09-30 2019-11-15 华南理工大学 Nitrogen substituent phenylpyrazole xanthine oxidoreductase inhibitor and its preparation and application
CN108218777A (en) * 2017-12-13 2018-06-29 华南理工大学 A kind of sulphur substituted phenyl pyrazole class XOR inhibitor and preparation and application
CN110078668B (en) * 2019-05-16 2023-03-24 华南理工大学 Phenyl imidazole XOR inhibitor, preparation and application
CN119431324B (en) * 2024-10-23 2025-10-31 沈阳药科大学 1- (4/5-Cyano-6-substituted pyrimidine-2-yl) -1H-pyrazole-4-formic acid compound, and preparation method and application thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5527916B2 (en) * 1973-02-05 1980-07-24
JPS5527916A (en) * 1978-08-17 1980-02-28 Arekusandorouitsuchi B Nikorai Detecting icing on objects in gas flow and device therefor
US4346094A (en) * 1980-09-22 1982-08-24 Eli Lilly And Company 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels
DE3129429A1 (en) * 1981-07-25 1983-02-10 Basf Ag, 6700 Ludwigshafen 5-AMINO-1-PHENYL-PYRAZOL-4-CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR CONTROLLING UNWANTED PLANT GROWTH
US4495195A (en) * 1982-11-01 1985-01-22 Eli Lilly And Company Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
ZA847986B (en) * 1983-10-15 1985-06-26 Bayer Ag Substituted 5-acylamino-1-phenylpyrazoles
DE3420985A1 (en) * 1983-10-15 1985-04-25 Bayer Ag, 5090 Leverkusen SUBSTITUTED 5-ACYLAMINO-1-PHENYLPYRAZOLE
IL73419A (en) * 1983-11-07 1988-02-29 Lilly Co Eli 1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
IL73418A (en) * 1983-11-07 1988-02-29 Lilly Co Eli 5-cyano-1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
DE3423582A1 (en) * 1984-06-27 1986-01-09 Bayer Ag, 5090 Leverkusen SUBSTITUTED 5-ACYLAMINO-1-PHENYLPYRAZOLE
US4666504A (en) * 1984-09-25 1987-05-19 Eli Lilly And Company Pollen formation inhibiting 1-phenyl-4-carboxy-5-pyrazolecarboxamides
US5064851A (en) * 1990-07-24 1991-11-12 Pfizer Inc. 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
KR100221041B1 (en) * 1990-11-30 1999-09-15 야스이 쇼사꾸 2-arylthiazole derivatives and pharmaceutical compositions thereof
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
JP3113110B2 (en) * 1993-01-19 2000-11-27 帝人株式会社 Isoxazole and isothiazole derivatives

Also Published As

Publication number Publication date
EP0936217A4 (en) 2000-01-05
CA2269721C (en) 2003-04-29
CN1240432A (en) 2000-01-05
KR20000052738A (en) 2000-08-25
EP0936217A1 (en) 1999-08-18
ID21775A (en) 1999-07-22
AU731055B2 (en) 2001-03-22
US6015829A (en) 2000-01-18
CN1105708C (en) 2003-04-16
WO1998018765A1 (en) 1998-05-07
DE69708142D1 (en) 2001-12-13
ATE208379T1 (en) 2001-11-15
IL129409A (en) 2002-02-10
JP3220987B2 (en) 2001-10-22
HK1021982A1 (en) 2000-07-21
DK0936217T3 (en) 2002-03-04
PT936217E (en) 2002-05-31
CA2269721A1 (en) 1998-05-07
EP0936217B1 (en) 2001-11-07
PL332946A1 (en) 1999-10-25
AU4723097A (en) 1998-05-22
IL129409A0 (en) 2000-02-17
DE69708142T2 (en) 2002-07-11
KR100345942B1 (en) 2002-07-27

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