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ES2167634T3 - Procedimiento y dispositivo para la aglomeracion de sustancias sensibles a la hidrolisis mediante vapor de agua. - Google Patents

Procedimiento y dispositivo para la aglomeracion de sustancias sensibles a la hidrolisis mediante vapor de agua.

Info

Publication number
ES2167634T3
ES2167634T3 ES97105180T ES97105180T ES2167634T3 ES 2167634 T3 ES2167634 T3 ES 2167634T3 ES 97105180 T ES97105180 T ES 97105180T ES 97105180 T ES97105180 T ES 97105180T ES 2167634 T3 ES2167634 T3 ES 2167634T3
Authority
ES
Spain
Prior art keywords
procedure
vapor
water vapor
fall
aglomeration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97105180T
Other languages
English (en)
Inventor
Ina Seyffert
Hans Uhlemann
Reinhard Walter
Joachim Martin Maasz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1996123410 external-priority patent/DE19623410A1/de
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2167634T3 publication Critical patent/ES2167634T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Drying Of Solid Materials (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Glanulating (AREA)
  • Medicinal Preparation (AREA)
  • Dairy Products (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Processing Of Solid Wastes (AREA)
  • Fertilizers (AREA)

Abstract

EN EL PROCEDIMIENTO PARA LA AGLOMERACION DE SUSTANCIAS DIFICILMENTE SOLUBLES Y SENSIBLES A LA HIDROLISIS SE HACE PASAR EL POLVO DE LA SUSTANCIA DIFICILMENTE SOLUBLE JUNTO CON AL MENOS UN AGLUTINANTE HIDROSOLUBLE EN CAIDA LIBRE POR UNA ATMOSFERA DE VAPOR DE AGUA A UNA TEMPERATURA DE ENTRE 85 (GRADOS) C Y 105 (GRADOS) C BASICAMENTE SIN INFLUENCIA DE FUERZAS COMPACTADORAS. EL TIEMPO DE PERMANENCIA EN LA ATMOSFERA DE VAPOR DE AGUA ES DE ENTRE 0,5 Y 10 SEGUNDOS APROXIMADAMENTE. A CONTINUACION, LOS AGLOMERADOS FORMADOS SE SECAN EN CAIDA LIBRE, DE TAL MANERA QUE EN LOS PUNTOS DE CONTACTO ENTRE LAS PARTICULAS PRIMARIAS PROCEDENTES DE LOS PUENTES DE LIQUIDO-AGLUTINANTE FORMADOS SE FORMAN UNOS PEQUEÑOS PUENTES DE SOLIDO. EN UN SECADOR DE LECHO FLUIDIZADO INTEGRADO A CONTINUACION TIENE LUGAR EL SECADO FINAL HASTA QUE EL CONTENIDO DE AGUA SEA INFERIOR A UN 0,5 % EN PESO. EL PROCEDIMIENTO SE REALIZA EN UN AGLOMERADOR DE CHORRO DE VAPOR EN EL QUE UN VELO DE PRODUCTO QUE CAE LIBREMENTE PROCEDENTE DE LA MEZCLA PULVERULENTA A AGLOMERAR ES CARGADO CON VAPOR DE AGUA PROCEDENTE DE UNOS INYECTORES DE CHORRO DE VAPOR (5,6). EN LA PARTE INFERIOR DEL AGLOMERADOR (1) HAY CONECTADO UN SECADOR DE LECHO FLUIDIZADO (2) DE MANERA QUE LAS PARTICULAS AGLOMERADAS (4) CAEN DIRECTAMENTE EN EL LECHO FLUIDIZADO.
ES97105180T 1996-04-09 1997-03-27 Procedimiento y dispositivo para la aglomeracion de sustancias sensibles a la hidrolisis mediante vapor de agua. Expired - Lifetime ES2167634T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19614063 1996-04-09
DE1996123410 DE19623410A1 (de) 1996-06-12 1996-06-12 Verfahren und Vorrichtung zur Agglomeration von hydrolyseempfindlichen Stoffen mittels Wasserdampf

Publications (1)

Publication Number Publication Date
ES2167634T3 true ES2167634T3 (es) 2002-05-16

Family

ID=26024604

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97105180T Expired - Lifetime ES2167634T3 (es) 1996-04-09 1997-03-27 Procedimiento y dispositivo para la aglomeracion de sustancias sensibles a la hidrolisis mediante vapor de agua.

Country Status (16)

Country Link
US (2) US5917081A (es)
EP (1) EP0800860B1 (es)
JP (1) JPH1033973A (es)
CN (1) CN1087185C (es)
AR (1) AR006566A1 (es)
AU (1) AU723590B2 (es)
BR (1) BR9701721A (es)
CA (1) CA2201808A1 (es)
CO (1) CO4520308A1 (es)
DE (1) DE59705322D1 (es)
ES (1) ES2167634T3 (es)
HU (1) HUP9700725A1 (es)
MX (1) MX9702466A (es)
PL (1) PL319399A1 (es)
RU (1) RU2191065C2 (es)
TR (1) TR199700281A3 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6296868B1 (en) * 1998-11-19 2001-10-02 Advanced Technology Pharmaceuticals Corporation Chewable tablets containing mannitol and aspartame
ES2221347T3 (es) 1999-08-10 2004-12-16 Aboca S.P.A. Procedimiento para la produccion de capsulas y de comprimidos de sustancias naturales de origen vegetal.
AU2001257359A1 (en) 2000-04-27 2001-11-07 Verion Inc. Zero order release and temperature-controlled microcapsules and process for the preparation thereof
US6461672B1 (en) * 2000-08-16 2002-10-08 Genencor International, Inc. Symmetrical fluidization coater for high capacity manufacturing
JP2004509739A (ja) 2000-09-27 2004-04-02 ベリオン　インコーポレイテッド 即時水溶解性カプセルおよびその製法
NL1020469C2 (nl) * 2002-04-25 2003-10-28 Carlisle Process Systems B V Sproeidrooginrichting en toevoermiddel voor een dergelijke sproeidrooginrichting.
RU2240975C2 (ru) * 2002-05-27 2004-11-27 Открытое акционерное общество "Химпром" Способ получения гранулированного перкарбоната и устройство для его осуществления
DE10300046B3 (de) * 2003-01-03 2004-05-06 Universität Karlsruhe (Th) Verfahren zur Befeuchtung von Pulvern oder Granulaten sowie Vorrichtung hierfür
AT412473B (de) * 2003-01-15 2005-03-25 Dsm Fine Chem Austria Gmbh Verfahren zur kontinuierlichen trocknung von n- bzw. amino-, ammonium- oder spirobicyclische ammoniumgruppen haltigen polymeren
US7198653B2 (en) * 2003-07-31 2007-04-03 Delavau Llc Calcium carbonate granulation
JP4589251B2 (ja) * 2006-02-27 2010-12-01 三栄源エフ・エフ・アイ株式会社 粉末の造粒方法及び易溶性顆粒組成物
US8708065B2 (en) * 2009-06-03 2014-04-29 National Oilwell Varco, L.P. Vessel to condition dry drill cuttings
RU2449777C1 (ru) * 2010-12-20 2012-05-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) Способ получения высокодисперсного парацетамола
KR20160114097A (ko) * 2014-01-25 2016-10-04 파이오니어 펫 프로덕츠, 엘엘씨 켄칭된 입상 흡수제 및 켄칭된 입상 흡수제를 제조하기 위한 시스템 및 방법
EP3117720B1 (de) * 2015-05-29 2019-02-20 Symrise AG Grosse agglomeratpartikel
CN105728223A (zh) * 2016-03-14 2016-07-06 刘旭玲 一种蒸汽管道熏烟壳
PL238977B1 (pl) * 2017-09-25 2021-10-25 Zakl Produkcyjny Bempresa Spolka Z Ograniczona Odpowiedzialnoscia Urządzenie do granulowania substancji suchych
MX2023013063A (es) * 2021-05-07 2023-11-15 Nestle Sa Metodo de aglomeracion continua con liquido aglutinante.
PT4333632T (pt) * 2021-05-07 2025-08-26 Nestle Sa Sistema de aglomeração contínua com líquido aglutinante

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2062603A (en) * 1934-03-26 1936-12-01 Rca Corp Tuning indicator
US3143428A (en) * 1962-10-10 1964-08-04 American Sugar Method and apparatus for agglomeration
DE1792752A1 (de) * 1967-11-21 1975-02-06 Orth Gmbh H Verfahren zum fortlaufendem herstellen von agglomeraten
DE1940915C3 (de) * 1969-08-12 1975-06-05 Meiji Seika Kaisha Ltd., Tokio Verfahren zur Herstellung von schnell löslichen und dispergierbaren Granulaten aus einem Pulver
DE2125155B2 (de) * 1971-05-21 1979-10-04 Babcock-Bsh Ag Vormals Buettner- Schilde-Haas Ag, 4150 Krefeld Granulieranlage
US4073838A (en) * 1974-08-12 1978-02-14 Boehringer Ingelheim Gmbh Granulating process
JPS6034517B2 (ja) * 1978-03-03 1985-08-09 宇部興産株式会社 流動層で尿素を造粒する方法
GB2130504B (en) * 1982-09-24 1985-11-13 Freunt Ind Co Ltd Granulating and coating machine
JPS59196726A (ja) * 1983-04-19 1984-11-08 Okawara Mfg Co Ltd 連続流動層造粒装置
DE3565475D1 (en) * 1984-04-07 1988-11-17 Bayer Ag Process and apparatus for the production of granules
FR2581564B1 (fr) * 1985-05-13 1993-05-07 Bp Chimie Sa Appareil a lit fluidise comportant une grille de fluidisation a plusieurs pentes
US4698190A (en) * 1985-09-02 1987-10-06 Kabushiki Kaisha Okawaraseisakusho Method and apparatus of controlling granulation of moisture-absorbing powder material
BR9305863A (pt) * 1992-02-12 1997-02-18 Henkel Kgaa Novo tipo de concentrados tensoativos anionicos pobres em poeira em forma de po ou de granulado com capacidade de dissolução melhorada em meios aquosos
DE4234376A1 (de) * 1992-10-12 1994-04-14 Henkel Kgaa Wertstoffe und Wertstoffgemische für Netz-, Wasch- und/oder Reinigungsmittel in neuer Zubereitungsform
DE4340015C2 (de) * 1993-11-24 1996-07-04 Henkel Kgaa Verfahren zur Herstellung wasserfreier, rieselfähiger Zuckertensidpulver und deren Verwendung
EP0787437A3 (en) * 1996-02-07 1999-01-13 Societe Des Produits Nestle S.A. Granular food product

Also Published As

Publication number Publication date
AR006566A1 (es) 1999-09-08
CA2201808A1 (en) 1997-10-09
US5917081A (en) 1999-06-29
AU1771797A (en) 1997-10-16
EP0800860A1 (de) 1997-10-15
CO4520308A1 (es) 1997-10-15
TR199700281A2 (xx) 1997-10-21
TR199700281A3 (tr) 1997-10-21
AU723590B2 (en) 2000-08-31
BR9701721A (pt) 1998-11-10
DE59705322D1 (de) 2001-12-20
RU2191065C2 (ru) 2002-10-20
CN1087185C (zh) 2002-07-10
EP0800860B1 (de) 2001-11-14
MX9702466A (es) 1998-04-30
CN1166375A (zh) 1997-12-03
HUP9700725A1 (hu) 2000-05-28
PL319399A1 (en) 1997-10-13
US5955036A (en) 1999-09-21
HU9700725D0 (en) 1997-05-28
JPH1033973A (ja) 1998-02-10

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