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ES2167510T3 - Agentes para mejorar el sueño. - Google Patents

Agentes para mejorar el sueño.

Info

Publication number
ES2167510T3
ES2167510T3 ES96200236T ES96200236T ES2167510T3 ES 2167510 T3 ES2167510 T3 ES 2167510T3 ES 96200236 T ES96200236 T ES 96200236T ES 96200236 T ES96200236 T ES 96200236T ES 2167510 T3 ES2167510 T3 ES 2167510T3
Authority
ES
Spain
Prior art keywords
sub
rent
mono
aminocarbonyl
optionally replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96200236T
Other languages
English (en)
Inventor
Daele Georges H P Van
Freddy F Vlaeminck
Marc G C Verdonck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2167510T3 publication Critical patent/ES2167510T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTA UNA COMPOSICION QUIMICA QUE TIENE LA FORMULA (I''), LAS SALES DE ADICION ACIDAS FARMACOLOGICAMENTE ACEPTABLES Y LAS FORMAS ESTEREOQUIMICAMENTE ISOMERICAS DEL MISMO, EN DONDE R1 Y R2 SON CADA UNA INDEPENDIENTEMENTE HIDROGENO O ALQUILO C{SUB,16}; X ES ALQUILO C{SUB,1-6}, HIDROXIALQUILO C{SUB,1-6}, ALQUILOXI (C{SUB,1-6})ALQUILO (C{SUB,1-6}, AMINOCARBONILO, MONO- Y DIALQUIL(C{SUB,1-6})AMINOCARBONILO, CARBOXILO, ALQUILOXICARBONILO C{SUB,1-6}, AMINOCARBONILALQUILO C{SUB,1-6}, [MONO- Y DIAMINOCARBONILO(C{SUB,1-6})]ALQUILO (C{SUB,1-6}), CARBOXIALQUILO C{SUB,1-6}, (ALQUILOXICARBONIL C{SUB,1-6})ALQUILO C{SUB, 1-6} O (HIDROXIALQUILO C{SUB,1-6})AMINOCARBOXILO; M ES 1 O 2; N ES 1 A 4; AR ES UN FENILO OPCIONALMENTE SUSTITUIDO; UN PIRIDINILO OPCIONALMENTE SUSTITUIDO, UN PIRAZOLILO OPCIONALMENTE SUSTITUIDO; O UN RADICAL DE LA FORMULA (A) EN DONDE Q'' ES ARILETILO, ARILETENILO, ARILOXIMETILO, DIARILMETOXIDO, 2,2-DIARILETENILO, DIARILMETILCARBONILO, ARILCARBONILMETILO, MONO- Y DIARILAMINOCARBONILO,DIARILETILO O ARILAMINOMETILO. TAMBIEN SE PRESENTAN PROCEDIMIENTOS PARA PREPARAR LOS COMPUESTOS Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN.
ES96200236T 1987-04-01 1988-03-29 Agentes para mejorar el sueño. Expired - Lifetime ES2167510T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3412987A 1987-04-01 1987-04-01

Publications (1)

Publication Number Publication Date
ES2167510T3 true ES2167510T3 (es) 2002-05-16

Family

ID=21874492

Family Applications (2)

Application Number Title Priority Date Filing Date
ES88200587T Expired - Lifetime ES2091183T3 (es) 1987-04-01 1988-03-29 Metodo para mejorar el sueño.
ES96200236T Expired - Lifetime ES2167510T3 (es) 1987-04-01 1988-03-29 Agentes para mejorar el sueño.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES88200587T Expired - Lifetime ES2091183T3 (es) 1987-04-01 1988-03-29 Metodo para mejorar el sueño.

Country Status (20)

Country Link
EP (2) EP0727421B1 (es)
JP (1) JP2574377B2 (es)
KR (1) KR960016539B1 (es)
AT (2) ATE207474T1 (es)
AU (1) AU609790B2 (es)
CA (1) CA1315790C (es)
DE (2) DE3856501T2 (es)
DK (1) DK174878B1 (es)
ES (2) ES2091183T3 (es)
FI (1) FI97617C (es)
GR (1) GR3020983T3 (es)
HU (2) HUT57740A (es)
IE (1) IE81057B1 (es)
IL (1) IL85919A (es)
NO (1) NO178660C (es)
NZ (1) NZ223847A (es)
PH (1) PH25507A (es)
PT (1) PT87118B (es)
RU (1) RU2014328C1 (es)
ZA (1) ZA882352B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840896A (en) * 1989-11-22 1998-11-24 Janssen Pharmaceutica, N.V. Method of preventing or limiting reperfusion damage
CA2044143C (en) * 1989-11-22 2002-11-19 Herman Van Belle Method of preventing or limiting reperfusion damage
JP2660086B2 (ja) * 1990-07-03 1997-10-08 明治製菓株式会社 脳及び心機能障害改善剤
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
ES2125285T3 (es) * 1992-07-31 1999-03-01 Bristol Myers Squibb Co Derivados inhibidores de la reabsorcion de adenosina de difenil-oxazoles, tiazoles e imidazoles.
SE9202266D0 (sv) * 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel piperazine carboxamides
CA2186023C (en) * 1994-04-20 2006-11-07 Walter Brieden Process for preparing 2-piperazine carboxylic acid derivatives
EP0870502A3 (en) * 1997-04-10 2001-04-04 Kyowa Hakko Kogyo Co., Ltd. Use of adenosine uptake inhibitors for the manufacture of a medicament for the treatment of pancreatitis
EP0999840B1 (en) * 1997-06-16 2003-05-02 Janssen Pharmaceutica N.V. Use of a draflazine analogue for treating pain
UA89503C2 (uk) * 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
ES2639621T3 (es) 2004-12-30 2017-10-27 Janssen Pharmaceutica N.V. Derivados de fenilamida del ácido 4-(bencil)-piperazina-1-carboxílico y compuestos relacionados como moduladores de la amida hidrolasa de ácidos grasos (FAAH) para el tratamiento de la ansiedad, el dolor y otras afecciones
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
CN110511220B (zh) * 2018-05-22 2022-04-01 上海挚盟医药科技有限公司 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795375A1 (de) * 1968-09-21 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia

Also Published As

Publication number Publication date
ATE207474T1 (de) 2001-11-15
IL85919A (en) 1992-12-01
EP0727421A1 (en) 1996-08-21
NO178660B (no) 1996-01-29
IE880989L (en) 1988-10-01
NO881407D0 (no) 1988-03-29
IL85919A0 (en) 1988-09-30
EP0727421B1 (en) 2001-10-24
GR3020983T3 (en) 1996-12-31
NZ223847A (en) 1989-12-21
PH25507A (en) 1991-07-24
HK1006020A1 (en) 1999-02-05
HU211129A9 (en) 1995-10-30
AU609790B2 (en) 1991-05-09
FI97617C (fi) 1997-01-27
NO881407L (no) 1988-10-03
FI97617B (fi) 1996-10-15
DE3855520D1 (de) 1996-10-17
DK174878B1 (da) 2004-01-12
FI881525A0 (fi) 1988-03-31
DE3856501D1 (de) 2001-11-29
KR880012566A (ko) 1988-11-28
HUT57740A (en) 1991-12-30
RU2014328C1 (ru) 1994-06-15
PT87118B (pt) 1992-07-31
ATE142627T1 (de) 1996-09-15
DK179788D0 (da) 1988-03-30
JP2574377B2 (ja) 1997-01-22
AU1384788A (en) 1988-10-06
PT87118A (pt) 1988-04-01
NO178660C (no) 1996-05-08
EP0285219A3 (en) 1991-07-03
JPS63290869A (ja) 1988-11-28
EP0285219B1 (en) 1996-09-11
DE3856501T2 (de) 2004-04-29
EP0285219A2 (en) 1988-10-05
CA1315790C (en) 1993-04-06
ES2091183T3 (es) 1996-11-01
FI881525A7 (fi) 1988-10-02
DK179788A (da) 1988-10-02
DE3855520T2 (de) 1997-02-06
KR960016539B1 (ko) 1996-12-14
IE81057B1 (en) 1999-12-29
ZA882352B (en) 1989-12-27

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