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ES2167464T3 - Procedimiento para la preparacion de n-carboxianhidridos de aminoacidos a partir de n-(n'-nitrosocarbamoil)aminoacidos. - Google Patents

Procedimiento para la preparacion de n-carboxianhidridos de aminoacidos a partir de n-(n'-nitrosocarbamoil)aminoacidos.

Info

Publication number
ES2167464T3
ES2167464T3 ES95934205T ES95934205T ES2167464T3 ES 2167464 T3 ES2167464 T3 ES 2167464T3 ES 95934205 T ES95934205 T ES 95934205T ES 95934205 T ES95934205 T ES 95934205T ES 2167464 T3 ES2167464 T3 ES 2167464T3
Authority
ES
Spain
Prior art keywords
amino acids
procedure
nitrosocarbamoil
carboxianhydrides
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95934205T
Other languages
English (en)
Inventor
Auguste Commeyras
Helene Collet
Louis Mion
Sylvie Benefice
Patrick Calas
Henri Choukroun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Application granted granted Critical
Publication of ES2167464T3 publication Critical patent/ES2167464T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/084—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN NUEVO PROCEDIMIENTO DE SINTESIS PEPTIDICA, QUE UTILIZA UN N-[N''-NITROSO(R'')CARBAMOIL]AMINOACIDO COMO COMPUESTO DE SALIDA. SE DESCOMPONE ESTE COMPUESTO EN N{SUB,2}, R''OH Y N-CARBOXIANHIDRIDO DE FORMULA (II). SE REALIZA A CONTINUACION UNA REACCION DE ADICION ENTRE EL COMPUESTO (II) Y UN AMINOACIDO O UN PEPTIDO QUE TIENE AL MENOS UNA FUNCION {AL}-AMINADO LIBRE, PARA OBTENER UN DIPEPTIDO O U PEPTIDO DE RANGO SUPERIOR RESPECTO AL PEPTIDO ADICIONADO.
ES95934205T 1994-10-24 1995-10-19 Procedimiento para la preparacion de n-carboxianhidridos de aminoacidos a partir de n-(n'-nitrosocarbamoil)aminoacidos. Expired - Lifetime ES2167464T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9412779A FR2725991B1 (fr) 1994-10-24 1994-10-24 Procede de synthese peptidique a partir des n-(n'-(r')-n' -nitrosocarbamoyls) aminoacides

Publications (1)

Publication Number Publication Date
ES2167464T3 true ES2167464T3 (es) 2002-05-16

Family

ID=9468211

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95934205T Expired - Lifetime ES2167464T3 (es) 1994-10-24 1995-10-19 Procedimiento para la preparacion de n-carboxianhidridos de aminoacidos a partir de n-(n'-nitrosocarbamoil)aminoacidos.
ES00109844T Expired - Lifetime ES2173061T3 (es) 1994-10-24 1995-10-19 Procedimiento de sintesis peptidica a partir de n-carboxianhidridos deaminoacidos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES00109844T Expired - Lifetime ES2173061T3 (es) 1994-10-24 1995-10-19 Procedimiento de sintesis peptidica a partir de n-carboxianhidridos deaminoacidos.

Country Status (11)

Country Link
US (1) US5777076A (es)
EP (2) EP1041082B1 (es)
JP (1) JPH10509430A (es)
AT (2) ATE212340T1 (es)
CA (1) CA2201511A1 (es)
DE (2) DE69525169T2 (es)
DK (2) DK1041082T3 (es)
ES (2) ES2167464T3 (es)
FR (1) FR2725991B1 (es)
PT (2) PT1041082E (es)
WO (1) WO1996012729A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0000382D0 (sv) 2000-02-07 2000-02-07 Astrazeneca Ab New process
FR2899583A1 (fr) * 2006-04-05 2007-10-12 Centre Nat Rech Scient Procede de preparation de carboxyanhidrides d'acides amines par nitrosation en phase heterogene
DK2035442T3 (da) * 2006-06-14 2012-01-23 Centre Nat Rech Scient Hidtil ukendte understøttede oxidationsreaktanter, fremgangsmåde til deres fremstilling og anvendelser deraf
JP7356707B2 (ja) * 2018-11-15 2023-10-05 国立大学法人神戸大学 アミノ酸－ｎ－カルボン酸無水物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1037176B (it) * 1975-04-09 1979-11-10 Snam Progetti Procedimento per la preparazione di ammindacidi
JPS584707B2 (ja) * 1977-02-21 1983-01-27 鐘淵化学工業株式会社 光学活性フエニルグリシン類の製造法
IT1204979B (it) * 1987-04-28 1989-03-10 Eniricerche Spa Sintesi di alfa amminoacidi otticamente attivi

Also Published As

Publication number Publication date
DE69526462D1 (de) 2002-05-23
DE69525169D1 (de) 2002-03-14
EP0787137B1 (fr) 2002-01-23
ATE216398T1 (de) 2002-05-15
EP1041082A1 (fr) 2000-10-04
DK0787137T3 (da) 2002-05-06
DK1041082T3 (da) 2002-06-17
WO1996012729A2 (fr) 1996-05-02
ES2173061T3 (es) 2002-10-16
EP0787137A2 (fr) 1997-08-06
FR2725991B1 (fr) 1997-01-17
FR2725991A1 (fr) 1996-04-26
US5777076A (en) 1998-07-07
DE69526462T2 (de) 2002-11-07
CA2201511A1 (fr) 1996-05-02
WO1996012729A3 (fr) 1996-09-06
EP1041082B1 (fr) 2002-04-17
PT1041082E (pt) 2002-09-30
DE69525169T2 (de) 2002-09-05
JPH10509430A (ja) 1998-09-14
PT787137E (pt) 2002-07-31
ATE212340T1 (de) 2002-02-15

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