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ES2166954T3 - Derivados de 1-fenilpirazol y su uso como agentes parasiticidas. - Google Patents

Derivados de 1-fenilpirazol y su uso como agentes parasiticidas.

Info

Publication number
ES2166954T3
ES2166954T3 ES97309229T ES97309229T ES2166954T3 ES 2166954 T3 ES2166954 T3 ES 2166954T3 ES 97309229 T ES97309229 T ES 97309229T ES 97309229 T ES97309229 T ES 97309229T ES 2166954 T3 ES2166954 T3 ES 2166954T3
Authority
ES
Spain
Prior art keywords
sub
halogen
atoms
optionally replaced
rent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97309229T
Other languages
English (en)
Inventor
Bernard Joseph Banks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2166954T3 publication Critical patent/ES2166954T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE FORMULA (I), EN LA CUAL: R{SUP,1} ES H, ALQUILO C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO, HALOGENO, CN, (ALCOXI C{SUB,16})CARBONILO OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO, NO{SUB,2}, CHO, CONH{SUB,2}, CSNH{SUB,2} O ALCANOILO C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO; AR ES UN ANILLO A , EN EL CUAL A ES UN GRUPO FENILO, O A ES UN GRUPO HETEROARILO DE 5 O 6 ESLABONES, O AR ES UN RADICAL BICICLICO CONDENSADO AB , EN EL CUAL EL ANILLO A ES COMO SE HA DEFINIDO ANTERIORMENTE, Y EL ANILLO B CONDENSADO CON ESTE EN AB ES UN CARBOCICLO SATURADO O PARCIAL O TOTALMENTE INSATURADO DE 5 O 6 ESLABONES, O UN HETEROCICLO SATURADO O PARCIAL O TOTALMENTE INSATURADO; R{SUP,2} ES H, HALOGENO, ALQUILO C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO, ALQUENILO C{SUB,2-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO, ALQUINILO C{SUB,2-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO, NH{SUB,2}, NH(ALCANOILO C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO), NH((ALCOXI C{SUB,1-6})CARBONILO OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO), N((ALCOXI C{SUB,1-6})CARBONILO OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO){SUB,2}, NH(ALQUILO C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO), N(ALQUILO C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO){SUB,2}, NHCONH(ALQUILO C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO), N CON UNO O MAS ATOMOS DE HALOGENO), N=CH(FENILO OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO), OH, ALCOXI C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO, SH O S(O){SUB,M}(ALQUILO C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO); R{SUP,3}, R{SUP,4}, R{SUP,5}, R{SUP,6} Y R{SUP,7} SON CADA UNO INDEPENDIENTEMENTE H, HALOGENO, NITRO, (ALCOXI C{SUB,16})CARBONILO OPCIONALMENTE SUSTITUIDO CON UNOO MAS ATOMOS DE HALOGENO, ALQUILO C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO, CN, ALCANOILO C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO, CONH{SUB,2}, CSNH{SUB,2}, ALCOXI C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO, S(O){SUB,M}(ALQUILO C{SUB,1-6} OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO) O SF{SUB,5}; ESTOS COMPUESTOS Y SALES PRESENTAN CUALIDADES PARASITICIDAS UTILES.
ES97309229T 1996-11-30 1997-11-17 Derivados de 1-fenilpirazol y su uso como agentes parasiticidas. Expired - Lifetime ES2166954T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9625045.1A GB9625045D0 (en) 1996-11-30 1996-11-30 Parasiticidal compounds

Publications (1)

Publication Number Publication Date
ES2166954T3 true ES2166954T3 (es) 2002-05-01

Family

ID=10803815

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97309229T Expired - Lifetime ES2166954T3 (es) 1996-11-30 1997-11-17 Derivados de 1-fenilpirazol y su uso como agentes parasiticidas.

Country Status (9)

Country Link
EP (1) EP0846686B1 (es)
JP (1) JP3083278B2 (es)
AT (1) ATE211735T1 (es)
CA (1) CA2223237C (es)
DE (1) DE69709532T2 (es)
DK (1) DK0846686T3 (es)
ES (1) ES2166954T3 (es)
GB (1) GB9625045D0 (es)
PT (1) PT846686E (es)

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CA2288787A1 (en) 1997-05-22 1998-11-26 G.D. Searle And Co. Pyrazole derivatives as p38 kinase inhibitors
US6979686B1 (en) 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
GB9801851D0 (en) * 1998-01-29 1998-03-25 Pfizer Ltd Parasiticidal agents
ES2359973T3 (es) * 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas.
GB9810354D0 (en) 1998-05-14 1998-07-15 Pfizer Ltd Heterocycles
AR021608A1 (es) * 1998-12-11 2002-07-31 Merial Ltd Represion de artropodos en animales
US6531501B1 (en) 1998-12-11 2003-03-11 Aventis Cropscience, S.A. Control of arthropods in animals
CA2356263C (en) 1998-12-25 2009-04-21 Teikoku Hormone Mfg. Co., Ltd. Aminopyrazole derivatives
US6409988B1 (en) 1999-07-01 2002-06-25 3-Dimensional Pharmaceuticals, Inc. Radiolabeled 1-aryl pyrazoles, the synthesis thereof and the use thereof as pest GABA receptor ligands
US6506784B1 (en) 1999-07-01 2003-01-14 3-Dimensional Pharmaceuticals, Inc. Use of 1,3-substituted pyrazol-5-yl sulfonates as pesticides
GB9916052D0 (en) * 1999-07-08 1999-09-08 Pfizer Ltd Anthelmintic compositions
JP2001031509A (ja) 1999-07-15 2001-02-06 Nippon Bayer Agrochem Co Ltd チエニル−ピラゾール類の有害生物防除剤としての利用
WO2001007413A1 (en) 1999-07-22 2001-02-01 3-Dimensional Pharmaceuticals, Inc. 1-aryl-3-thioalkyl pyrazoles, the synthesis thereof and the use thereof as insecticides
US6545033B1 (en) 1999-10-06 2003-04-08 3-Dimensional Pharmaceuticals, Inc. Fused 1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazoles, the synthesis thereof and the use thereof as pesticides
CN1402713A (zh) 1999-12-02 2003-03-12 阿温提斯作物科学股份有限公司 控制动物中的节肢动物
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
MXPA04008546A (es) 2002-03-05 2004-12-06 Bayer Cropscience Sa Derivados de alquilaminopirazol 5-sustituidos como plaguicidas.
AU2003296246B2 (en) 2002-12-03 2009-06-04 Boehringer Ingelheim Animal Health USA Inc. Pesticidal sulphonylaminopyrazoles
CA2508412C (en) 2002-12-03 2011-07-26 Bayer Cropscience S.A. Pesticidal 5-(acylamino) pyrazole derivatives
WO2005023773A1 (en) * 2003-09-04 2005-03-17 Pfizer Limited Process for the preparation of substituted aryl pyrazoles
GB0413970D0 (en) 2004-06-22 2004-07-28 Syngenta Participations Ag Chemical compounds
AU2006257638A1 (en) * 2005-06-15 2006-12-21 Pfizer Limited Substituted arylpyrazoles
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
NZ573758A (en) 2006-07-05 2012-01-12 Aventis Agriculture 1-Phenyl-3-cyano-pyrazole derivatives and pesticidal formulations containing them
DE102006061538A1 (de) 2006-12-27 2008-07-03 Bayer Healthcare Ag Kombinationsprodukt zur Bekämpfung von Parasiten an Tieren
DE102006061537A1 (de) 2006-12-27 2008-07-03 Bayer Healthcare Ag Mittel zur Bekämpfung von Parasiten an Tieren
CN102186809A (zh) * 2008-08-14 2011-09-14 拜尔农作物科学股份公司 杀虫性的4-苯基-1h-吡唑
KR101660068B1 (ko) 2008-11-19 2016-09-26 메리얼 인코포레이티드 기생충 감염 치료를 위한 1-아릴피라졸 단독 또는 포름아미딘과의 조합을 포함하는 조성물
US9173728B2 (en) 2008-11-19 2015-11-03 Merial Inc. Multi-cavity container having offset indentures for dispensing fluids
BR112012002164B1 (pt) 2009-07-30 2021-04-20 Merial, Inc compostos inseticidas de 4-amino-tieno[2,3-d]-pirimidina e métodos para seu uso
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
CA2855954C (en) 2011-11-17 2020-09-01 Merial Limited Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof.
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
TWI579274B (zh) 2012-04-20 2017-04-21 龍馬躍公司 製備１－芳基－５－烷基吡唑化合物的改良方法
EP2967065A4 (en) * 2013-03-15 2016-08-24 Monsanto Technology Llc N-, C-SUBSTITUTED AZOLE FOR COMBATING NEMATODE PENINS
ES2887302T3 (es) 2014-10-31 2021-12-22 Boehringer Ingelheim Animal Health Usa Inc Composiciones parasiticidas que comprenden fipronil
EP3245192A1 (en) * 2015-01-13 2017-11-22 Syngenta Participations AG Pesticidally active heterocyclic derivatives with sulphur containing substituents
SI3395801T1 (sl) 2015-12-16 2021-08-31 Nippon Soda Co., Ltd. Arilazolna spojina in sredstvo za zatiranje škodljivcev
CN106117145A (zh) * 2016-07-12 2016-11-16 潍坊鑫诺化工有限公司 5‑氨基‑1‑（2,6‑二氯‑4‑三氟甲基苯基）‑3‑氰基吡唑的制备方法
AR112672A1 (es) 2017-08-11 2019-11-27 Syngenta Participations Ag Derivados de tiofeno activos como plaguicidas

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FR2326421A1 (fr) * 1975-09-30 1977-04-29 Ugine Kuhlmann Nouveaux trifluoromethyl-3-aryl-4 amino-5 pyrazoles et leur application comme bases diazotables pour la synthese de matieres colorantes
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JPH07500116A (ja) * 1992-03-26 1995-01-05 ダウエランコ 殺菌剤としてのｎ−複素環式ニトロアニリン

Also Published As

Publication number Publication date
DE69709532T2 (de) 2002-10-31
ATE211735T1 (de) 2002-01-15
DK0846686T3 (da) 2002-03-25
EP0846686B1 (en) 2002-01-09
EP0846686A1 (en) 1998-06-10
PT846686E (pt) 2002-05-31
GB9625045D0 (en) 1997-01-22
CA2223237C (en) 2002-08-06
JP3083278B2 (ja) 2000-09-04
CA2223237A1 (en) 1998-05-30
JPH10182614A (ja) 1998-07-07
DE69709532D1 (de) 2002-02-14

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