ES2166546T3 - Procedimiento para la obtencion de 1-fenil-etilaminas opticamente activas. - Google Patents
Procedimiento para la obtencion de 1-fenil-etilaminas opticamente activas.Info
- Publication number
- ES2166546T3 ES2166546T3 ES97928163T ES97928163T ES2166546T3 ES 2166546 T3 ES2166546 T3 ES 2166546T3 ES 97928163 T ES97928163 T ES 97928163T ES 97928163 T ES97928163 T ES 97928163T ES 2166546 T3 ES2166546 T3 ES 2166546T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- lactic acid
- amine
- mother liquor
- solid product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 8
- 235000014655 lactic acid Nutrition 0.000 abstract 4
- 239000004310 lactic acid Substances 0.000 abstract 4
- 239000012452 mother liquor Substances 0.000 abstract 3
- 239000012265 solid product Substances 0.000 abstract 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 2
- RQEUFEKYXDPUSK-UHFFFAOYSA-N 1-phenylethylamine Chemical class CC(N)C1=CC=CC=C1 RQEUFEKYXDPUSK-UHFFFAOYSA-N 0.000 abstract 2
- 238000004821 distillation Methods 0.000 abstract 2
- 239000007791 liquid phase Substances 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/86—Separation
- C07C209/88—Separation of optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SEGUN UN NUEVO PROCEDIMIENTO SE PUEDEN OBTENER 1 - FENIL ETILAMINAS OPTICAMENTE ACTIVAS DE FORMULA (I * ), EN LA CUAL X ES HALOGENO O METILO Y N ES 0, 1 O 2, HACIENDO REACCIONAR A) 1 - FENIL - ETILAMINAS RACEMICAS DE FORMULA (I) OCN ACIDO (S) - ( - ) - N - FENILCARBAMATO - LACTICO EN PRESENCIA DE UN HIDROCARBURO ALIFATICO O AROMATICO Y EN PRESENCIA DE UN ALCOHOL ALIFATICO DE BAJO PESO MOLECULAR, ESTANDO LAS CANTIDADES DE LOS COMPONENTES DE LA REACCION MEDIDAS DE TAL MANERA, QUE CON CADA MOL DE AMINA RACEMICA HAY ENTRE 0,25 Y 0,5 MOLES DE ACIDO (S) - ( - ) - N FENILCARBAMATO - LACTICO, DESPUES SE CONCENTRA LA MEZCLA HASTA UNA TEMPERATURA EN FASE LIQUIDA DE 40° C, EL PRODUCTO SOLIDO QUE SE OBTIENE SI SE PARA, SE TRATA CON LEJIA ALCALINA DILUIDA CON AGUA Y EN PRESENCIA DE UN HIDROCARBURO, Y SE AISLA POR DESTILACION DE LA FASE ORGANICA LA (R) - AMINA, Y OPCIONALMENTE LA LEJIA QUE SE HA QUEDADO DESPUES DE LA SEPARACION DEL COMPUESTO SOLIDO SE HACE REACCIONAR EN PRESENCIA DE UN ALCOHOL ALIFATICODE BAJO PESO MOLECULAR CON ACIDO (S) - ( - ) N - FENILCARBAMATO - LACTICO, MIDIENDO DE TAL MANERA LAS CANTIDADES DE LOS COMPONENTES, QUE LA CANTIDAD MOLAR DE ACIDO (S) ( - ) - N - FENILCARBAMATO - LACTICO ES EL DOBLE DE GRANDE QUE LA CANTIDAD EN (R) - AMINA PRESENTE EN LA LEJIA, DESPUES LA MEZCLA SE COMPACTA HASTA UNA TEMPERATURA EN FASE LIQUIDA DE HASTA 40° C, EL PRODUCTO SOLIDO SE SEPARA Y SE AISLA POR DESTILACION DE LA LEJIA LA (S) - AMINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19624820A DE19624820A1 (de) | 1996-06-21 | 1996-06-21 | Verfahren zur Herstellung von optisch aktiven 1-Phenyl-ethylaminen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2166546T3 true ES2166546T3 (es) | 2002-04-16 |
Family
ID=7797600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97928163T Expired - Lifetime ES2166546T3 (es) | 1996-06-21 | 1997-06-09 | Procedimiento para la obtencion de 1-fenil-etilaminas opticamente activas. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6034278A (es) |
| EP (1) | EP0906267B1 (es) |
| JP (1) | JP2000512643A (es) |
| KR (1) | KR20000016577A (es) |
| CN (1) | CN1128785C (es) |
| AT (1) | ATE207872T1 (es) |
| AU (1) | AU3256597A (es) |
| DE (2) | DE19624820A1 (es) |
| DK (1) | DK0906267T3 (es) |
| ES (1) | ES2166546T3 (es) |
| WO (1) | WO1997049665A1 (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6439452A (en) * | 1987-08-06 | 1989-02-09 | Nat House Ind | Eaves |
| DE3801113A1 (de) * | 1987-07-23 | 1989-02-02 | Bayer Ag | Substituierte triazine |
| DE3815728A1 (de) * | 1988-05-07 | 1989-11-16 | Bayer Ag | Stereoisomere von n-(r)-(1-aryl-ethyl)-1-alkyl-2,2-dichlor- cyclopropancarbonsaeureamiden |
| DE4038356A1 (de) * | 1990-12-01 | 1992-06-04 | Bayer Ag | Verfahren zur racemisierung von optisch aktiven l-aryl-alkylaminen |
| DE4039447A1 (de) * | 1990-12-11 | 1992-06-17 | Bayer Ag | Verfahren zur aufbereitung der kristallisationsmutterlauge der racematspaltung von 1-(4-chlorphenyl)-ethylamin |
-
1996
- 1996-06-21 DE DE19624820A patent/DE19624820A1/de not_active Withdrawn
-
1997
- 1997-06-09 DK DK97928163T patent/DK0906267T3/da active
- 1997-06-09 AU AU32565/97A patent/AU3256597A/en not_active Abandoned
- 1997-06-09 ES ES97928163T patent/ES2166546T3/es not_active Expired - Lifetime
- 1997-06-09 CN CN97195628A patent/CN1128785C/zh not_active Expired - Fee Related
- 1997-06-09 WO PCT/EP1997/002988 patent/WO1997049665A1/de not_active Ceased
- 1997-06-09 US US09/194,719 patent/US6034278A/en not_active Expired - Fee Related
- 1997-06-09 KR KR1019980710172A patent/KR20000016577A/ko not_active Ceased
- 1997-06-09 AT AT97928163T patent/ATE207872T1/de not_active IP Right Cessation
- 1997-06-09 EP EP97928163A patent/EP0906267B1/de not_active Expired - Lifetime
- 1997-06-09 DE DE59705202T patent/DE59705202D1/de not_active Expired - Fee Related
- 1997-06-09 JP JP10502195A patent/JP2000512643A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU3256597A (en) | 1998-01-14 |
| CN1222140A (zh) | 1999-07-07 |
| CN1128785C (zh) | 2003-11-26 |
| DE59705202D1 (de) | 2001-12-06 |
| EP0906267B1 (de) | 2001-10-31 |
| EP0906267A1 (de) | 1999-04-07 |
| WO1997049665A1 (de) | 1997-12-31 |
| ATE207872T1 (de) | 2001-11-15 |
| DE19624820A1 (de) | 1998-01-02 |
| JP2000512643A (ja) | 2000-09-26 |
| KR20000016577A (ko) | 2000-03-25 |
| US6034278A (en) | 2000-03-07 |
| DK0906267T3 (da) | 2002-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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