[go: up one dir, main page]

ES2166462T3 - Antagonistas del receptor de la endotelina. - Google Patents

Antagonistas del receptor de la endotelina.

Info

Publication number
ES2166462T3
ES2166462T3 ES96928037T ES96928037T ES2166462T3 ES 2166462 T3 ES2166462 T3 ES 2166462T3 ES 96928037 T ES96928037 T ES 96928037T ES 96928037 T ES96928037 T ES 96928037T ES 2166462 T3 ES2166462 T3 ES 2166462T3
Authority
ES
Spain
Prior art keywords
endotheline
receiver
antigonists
piridazines
pirazinas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96928037T
Other languages
English (en)
Inventor
John Duncan Elliott
Deborah Lynne Bryan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of ES2166462T3 publication Critical patent/ES2166462T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN NUEVAS PIRIDINAS, PIRIMIDINAS, PIRAZINAS, PIRIDAZINAS Y TRIAZINAS, COMPOSICIONES FARMACEUTICAS QUE CONTIENEN ESTOS COMPUESTOS Y SU USO COMO ANTAGONISTAS DEL RECEPTOR DE LA ENDOTELINA.
ES96928037T 1995-08-02 1996-08-02 Antagonistas del receptor de la endotelina. Expired - Lifetime ES2166462T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US179195P 1995-08-02 1995-08-02
US1114896P 1996-02-01 1996-02-01

Publications (1)

Publication Number Publication Date
ES2166462T3 true ES2166462T3 (es) 2002-04-16

Family

ID=26669470

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96928037T Expired - Lifetime ES2166462T3 (es) 1995-08-02 1996-08-02 Antagonistas del receptor de la endotelina.

Country Status (6)

Country Link
US (3) US5942516A (es)
EP (1) EP0854721B1 (es)
JP (1) JP2002515854A (es)
DE (1) DE69616364T2 (es)
ES (1) ES2166462T3 (es)
WO (1) WO1997004781A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942516A (en) * 1995-08-02 1999-08-24 Elliott; John Duncan Endothelin receptor antagonists
US6020348A (en) * 1996-02-01 2000-02-01 Smithkline Beecham Corporation Endothelin receptor antagonists
UA76708C2 (uk) * 1999-12-08 2006-09-15 Сінгента Патисипейшонс Аг Антитіло, яке застосовується в імунологічному аналізі зразка для визначення неонікотиноїдного інсектициду, білковий кон'югат для одержання антитіла, спосіб визначення концентрації неонікотиноїдного інсектициду в зразку та набір для визначення кількості неонікотиноїдного інсектициду
AR029489A1 (es) * 2000-03-10 2003-07-02 Euro Celtique Sa Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
AR037233A1 (es) * 2001-09-07 2004-11-03 Euro Celtique Sa Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
AR036873A1 (es) * 2001-09-07 2004-10-13 Euro Celtique Sa Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento
DE60305053T2 (de) * 2002-08-19 2006-08-31 Glaxo Group Ltd., Greenford Pyrimidinderivate als selektive cox-2-inhibitoren
GB0221443D0 (en) * 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3946026A (en) * 1972-03-06 1976-03-23 Bayer Aktiengesellschaft 2-Amino-1,4-dihydropyridine derivatives
DE3716652A1 (de) * 1987-05-19 1988-12-08 Bayer Ag Dioxyalkylenaryl-dihydropyridine, zwischenprodukte zu ihrer herstellung, verfahren zu ihrer herstellung und ihre verwendung
ATE61588T1 (de) * 1987-08-03 1991-03-15 Delagrange Lab 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
US5420133A (en) * 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
JPH11502530A (ja) * 1995-03-27 1999-03-02 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー エンドセリンレセプターアンタゴニストとして有用なフェニル誘導体
US5942516A (en) * 1995-08-02 1999-08-24 Elliott; John Duncan Endothelin receptor antagonists
ZA967800B (en) * 1995-09-20 1997-04-03 Yamanouchi Pharma Co Ltd Heteroaryllsubstituted acryloylguanidine derivatives and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
EP0854721A1 (en) 1998-07-29
DE69616364T2 (de) 2002-07-11
US5985886A (en) 1999-11-16
US6127371A (en) 2000-10-03
EP0854721B1 (en) 2001-10-24
US5942516A (en) 1999-08-24
DE69616364D1 (de) 2001-11-29
WO1997004781A1 (en) 1997-02-13
JP2002515854A (ja) 2002-05-28
EP0854721A4 (en) 1998-12-02

Similar Documents

Publication Publication Date Title
ES2164054T3 (es) Antagonistas de receptores de endotelina.
UY26808A1 (es) Compuestos de succinimida heterocíclicos fusionados y análogos de los mismos, modulares de la función del receptor de hormona nuclear
ES2191187T3 (es) Compuestos heteroaromaticos biciclicos como inhibidores de la proteina tirosin-quinasa.
PL333301A1 (en) Pyrimidine halogens
MX9207074A (es) Piperazinil- y piperidinil -ciclohexanoles y composicion farmaceutica que los comprende
ES2190487T3 (es) Nuevos agonistas y antagonistas del receptor de adenosina a1.
MX9400071A (es) Antagonistas del receptor de endotelina.
DE69942753D1 (de) Peptidantagonist von Zonulin und dessen Verwendung
EA200101177A1 (ru) Производные индола в качестве антагонистов прогестерона
BR9909486A (pt) Compostos calcilìticos
YU59098A (sh) Derivati spiro-piperidina, postupak njihovog dobijanja, njihova upotreba u proizvodnji leka korisnog za lečenje ili prevenciju bolova, upalnih procesa, migrene, povraćanja i postherpetične neuralgije i farmaceutski sastav koji ih sadrži
BR9610823A (pt) Derivados de pirimidina como antagonistas do receptor
MX9204786A (es) Antagonistas del receptor 5-ht4 y composicion farmaceutica que los contiene.
FI961196A7 (fi) Aktiviinin reseptoreita muistuttava kinaasi(alk), joka kuuluu TGF-rese ptoriperheeseen ja/tai BMP-reseptoriperheeseen
NO993350L (no) Vitronectin-reseptor-antagonister
TR199900318T2 (xx) IL-8 resept�r antagonistleri.
BR9813957A (pt) Uso de antagonistas da vasopressina
ES2172535T3 (es) Antagonistas de los receptores de la endotelina.
ES2166462T3 (es) Antagonistas del receptor de la endotelina.
ES2171697T3 (es) Antagonistas del receptor de endotelina.
ES2195002T3 (es) Antagonistas de los receptores de la endotelina.
DE60015187D1 (de) Urotensin-ii rezeptorantagonisten
DE69809242D1 (de) Neue pyrimidinderivate
EA199700223A1 (ru) Бициклические антагонисты тахикининов, их получение и применение в фармацевтической композиции
EP0778833A4 (en) ENDOTHELIN RECEPTOR ANTAGONISTS

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 854721

Country of ref document: ES