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ES2164119T3 - Procedimiento para la preparacion de 2-metilespiro(1,3-oxatiolan-5,3')quinuclidina. - Google Patents

Procedimiento para la preparacion de 2-metilespiro(1,3-oxatiolan-5,3')quinuclidina.

Info

Publication number
ES2164119T3
ES2164119T3 ES95107738T ES95107738T ES2164119T3 ES 2164119 T3 ES2164119 T3 ES 2164119T3 ES 95107738 T ES95107738 T ES 95107738T ES 95107738 T ES95107738 T ES 95107738T ES 2164119 T3 ES2164119 T3 ES 2164119T3
Authority
ES
Spain
Prior art keywords
quinuclidine
methytipiro
oxatiolan
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95107738T
Other languages
English (en)
Inventor
Koji Hayashi
Sho Tokumoto
Hiroshi Yoshizawa
Tatsuo Isogai
Masaru Kimura
Masahiko Sawaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ishihara Sangyo Kaisha Ltd
Snow Brand Milk Products Co Ltd
Original Assignee
Ishihara Sangyo Kaisha Ltd
Snow Brand Milk Products Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ishihara Sangyo Kaisha Ltd, Snow Brand Milk Products Co Ltd filed Critical Ishihara Sangyo Kaisha Ltd
Application granted granted Critical
Publication of ES2164119T3 publication Critical patent/ES2164119T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D497/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)

Abstract

SE PRESENTA UN METODO PARA PRODUCIR 2-METILSPIRO(1,3OXATIOLANO-5,3'')QUINUCLIDINA, QUE COMPRENDE LOS PASOS DE HACER REACCIONAR 3-HIDROXI-3-MERCAPTOMETILQUINUCLINA O UNA SAL DE LA MISMA Y UN COMPUESTO DE CARBONIL EN LA PRESENCIA DE UN CATALIZADOR HECHO DE AL MENOS UN MIEMBRO SELECCIONADO ENTRE EL GRUPO QUE CONSTA DE HALUROS, OXIACIDOS DE FOSFORO, OXIHALUROS DE FOSFORO Y ACIDOS SULFONICOS ORGANICOS, PARA PRODUCIR 2METILSPIRO(1,3-OXATIOLANO-5,3'')QUINUCLIDINA DE FORMA CIS O UNA SAL DE LA MISMA.
ES95107738T 1994-05-19 1995-05-19 Procedimiento para la preparacion de 2-metilespiro(1,3-oxatiolan-5,3')quinuclidina. Expired - Lifetime ES2164119T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP13090794 1994-05-19
JP15287394 1994-06-10
JP25880294 1994-09-27
JP8746195 1995-03-20

Publications (1)

Publication Number Publication Date
ES2164119T3 true ES2164119T3 (es) 2002-02-16

Family

ID=27467385

Family Applications (2)

Application Number Title Priority Date Filing Date
ES99117275T Expired - Lifetime ES2328754T3 (es) 1994-05-19 1995-05-19 Metodo para preparacion de 2-metilespiro(1,3-oxatiolano-5,3')quinuclidina.
ES95107738T Expired - Lifetime ES2164119T3 (es) 1994-05-19 1995-05-19 Procedimiento para la preparacion de 2-metilespiro(1,3-oxatiolan-5,3')quinuclidina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES99117275T Expired - Lifetime ES2328754T3 (es) 1994-05-19 1995-05-19 Metodo para preparacion de 2-metilespiro(1,3-oxatiolano-5,3')quinuclidina.

Country Status (11)

Country Link
US (1) US5571918A (es)
EP (2) EP0683168B1 (es)
JP (1) JP2782330B2 (es)
KR (3) KR100371892B1 (es)
AT (2) ATE205495T1 (es)
DE (2) DE69535977D1 (es)
DK (2) DK1004586T3 (es)
ES (2) ES2328754T3 (es)
PT (2) PT683168E (es)
SI (1) SI0683168T1 (es)
TW (1) TW394772B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4447685B2 (ja) * 1999-01-14 2010-04-07 第一三共株式会社 皮膚乾燥症治療剤
US8080663B2 (en) * 2007-04-04 2011-12-20 Apotex Pharmachem Inc Process for the preparation of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine
US8143400B2 (en) 2008-01-10 2012-03-27 Apotex Pharmachem Inc. Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride
JP5452165B2 (ja) * 2009-10-23 2014-03-26 第一ファインケミカル株式会社 キヌクリジン類の製造法
US8450487B2 (en) * 2010-06-08 2013-05-28 Apicore, Llc Process for the preparation of cis-2-methylspiro (1,3-oxathiolane 5-3′) quinuclidine
WO2017044693A1 (en) 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
JP2019052093A (ja) * 2016-02-01 2019-04-04 宇部興産株式会社 ２−メチルスピロ（１，３−オキサチオラン−５，３’）キヌクリジン硫酸塩の製造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705134A (en) 1985-04-30 1987-11-10 Fuji Jukogyo Kabushiki Kaisha System for controlling a transfer clutch of a four-wheel drive vehicle
US4855290A (en) * 1985-05-10 1989-08-08 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine
JPH0816111B2 (ja) 1987-07-21 1996-02-21 石原産業株式会社 トランス型２−メチルスピロ（１，３−オキサチオラン−５，３’）キヌクリジン又はこれらの酸付加塩の異性化方法
JP2529576B2 (ja) 1987-07-10 1996-08-28 石原産業株式会社 トランス型２−メチルスピロ（１，３−オキサチオラン−５，３▲’▼）キヌクリジンの異性化方法
US4861886A (en) * 1987-07-10 1989-08-29 Ishahara Sangyo Kaisha Ltd Method for isomerization of trans-form 2-methylspiro (1,3-oxathiolane-5,3')q
JP2529577B2 (ja) 1987-08-13 1996-08-28 石原産業株式会社 トランス型２−メチルスピロ（１，３−オキサチオラン−５，３▲’▼）キヌクリジン又はこれらの酸付加塩の異性化方法
IL87234A (en) * 1987-08-13 1992-02-16 Israel Inst Biolog Res Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them
JPH01290680A (ja) * 1988-05-18 1989-11-22 Ishihara Sangyo Kaisha Ltd シス型キヌクリジン誘導体の分離方法

Also Published As

Publication number Publication date
SI0683168T1 (en) 2002-02-28
EP1004586A3 (en) 2001-09-12
ES2328754T3 (es) 2009-11-17
DE69522603T2 (de) 2002-04-18
EP0683168B1 (en) 2001-09-12
KR100371892B1 (ko) 2003-03-19
KR100371893B1 (ko) 2003-02-12
TW394772B (en) 2000-06-21
JPH08319287A (ja) 1996-12-03
KR950032189A (ko) 1995-12-20
JP2782330B2 (ja) 1998-07-30
ATE205495T1 (de) 2001-09-15
DK0683168T3 (da) 2001-12-03
EP1004586B1 (en) 2009-07-01
US5571918A (en) 1996-11-05
PT1004586E (pt) 2009-07-13
KR100371894B1 (ko) 2003-02-12
ATE435228T1 (de) 2009-07-15
EP0683168A1 (en) 1995-11-22
DE69522603D1 (de) 2001-10-18
EP1004586A2 (en) 2000-05-31
PT683168E (pt) 2001-12-28
DK1004586T3 (da) 2009-09-07
DE69535977D1 (de) 2009-08-13

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