ES2162561B1 - PHARMACEUTICAL COMPOSITION OF ORAL, LIQUID, TRANSPARENT, STABLE AND ACCEPTABLE FLAVOR METAMIZOL. - Google Patents
PHARMACEUTICAL COMPOSITION OF ORAL, LIQUID, TRANSPARENT, STABLE AND ACCEPTABLE FLAVOR METAMIZOL.Info
- Publication number
- ES2162561B1 ES2162561B1 ES9901431A ES9901431A ES2162561B1 ES 2162561 B1 ES2162561 B1 ES 2162561B1 ES 9901431 A ES9901431 A ES 9901431A ES 9901431 A ES9901431 A ES 9901431A ES 2162561 B1 ES2162561 B1 ES 2162561B1
- Authority
- ES
- Spain
- Prior art keywords
- metamizol
- oral
- transparent
- stable
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940120889 dipyrone Drugs 0.000 title abstract 4
- 239000000796 flavoring agent Substances 0.000 title abstract 4
- 235000019634 flavors Nutrition 0.000 title abstract 4
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 title abstract 4
- 239000007788 liquid Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 229940041616 menthol Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008450 motivation Effects 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 230000009747 swallowing Effects 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composición farmacéutica de metamizol oral, líquida, transparente, estable y de sabor aceptable. Para 10 ml comprende: a) entre 1 y 3 g de metamizol magnésico, preferiblemente 2 g, como principio activo; b) entre 0,01 y 0,15 g de mentol, preferiblemente entre 0,02 y 0,06 g, como correctivo del sabor; c) la cantidad suficiente de un agente conservante, que preferiblemente es entre 1 y 2 g de propilenglicol; d) la cantidad suficiente de una mezcla sorbitol: agua cuya proporción relativa en peso está entre 1:1 y 1:1,5, como vehículo y correctivo del sabor; e) entre 0,5 y 1,5 g de glicerina, como vehículo y correctivo del sabor; y f) entre 0,005 y 0,1 g de sacarina sódica. No es de ingestión desagradable, directamente o tras su dilución en agua, resultando útil para la administración de metamizol a niños, ancianos y pacientes poco motivados o con dificultades para tragar.Pharmaceutical composition of oral metamizol, liquid, transparent, stable and of acceptable flavor. For 10 ml it comprises: a) between 1 and 3 g of magnesium metamizol, preferably 2 g, as active ingredient; b) between 0.01 and 0.15 g of menthol, preferably between 0.02 and 0.06 g, as a flavor corrective; c) the sufficient amount of a preservative agent, which is preferably between 1 and 2 g of propylene glycol; d) the sufficient amount of a sorbitol: water mixture whose relative weight ratio is between 1: 1 and 1: 1.5, as a vehicle and corrective taste; e) between 0.5 and 1.5 g of glycerin, as a vehicle and flavor corrective; and f) between 0.005 and 0.1 g of sodium saccharin. It is not of unpleasant ingestion, directly or after its dilution in water, being useful for the administration of metamizol to children, elderly and patients with little motivation or difficulty swallowing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9901431A ES2162561B1 (en) | 1999-06-28 | 1999-06-28 | PHARMACEUTICAL COMPOSITION OF ORAL, LIQUID, TRANSPARENT, STABLE AND ACCEPTABLE FLAVOR METAMIZOL. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9901431A ES2162561B1 (en) | 1999-06-28 | 1999-06-28 | PHARMACEUTICAL COMPOSITION OF ORAL, LIQUID, TRANSPARENT, STABLE AND ACCEPTABLE FLAVOR METAMIZOL. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2162561A1 ES2162561A1 (en) | 2001-12-16 |
| ES2162561B1 true ES2162561B1 (en) | 2002-07-16 |
Family
ID=8309001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9901431A Expired - Lifetime ES2162561B1 (en) | 1999-06-28 | 1999-06-28 | PHARMACEUTICAL COMPOSITION OF ORAL, LIQUID, TRANSPARENT, STABLE AND ACCEPTABLE FLAVOR METAMIZOL. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2162561B1 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4600708A (en) * | 1985-07-19 | 1986-07-15 | American Home Products Corporation | Propranolol hydrochloride liquid formulations |
| JPH06100602A (en) * | 1992-09-18 | 1994-04-12 | Asahi Chem Ind Co Ltd | Solid oral preparation and production thereof |
| GB9423588D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
| JPH10273435A (en) * | 1997-01-29 | 1998-10-13 | Fujisawa Pharmaceut Co Ltd | Internal liquid preparation |
-
1999
- 1999-06-28 ES ES9901431A patent/ES2162561B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2162561A1 (en) | 2001-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20011216 Kind code of ref document: A1 Effective date: 20011216 |